Review
Medicine, Research & Experimental
Toshiaki Iba, Yutaka Umemura, Hideo Wada, Jerrold H. Levy
Summary: The diagnostic criteria for overt DIC were established by ISTH in 2001, with recent research shedding light on the role of coagulation disorders in sepsis progression. The introduction of SIC as a pragmatic scoring system aims to detect early-stage sepsis-associated DIC, while globally agreed anticoagulant therapy for DIC is still lacking. International collaborative studies are deemed necessary for future advancements in diagnostic tools and treatment strategies.
ARCHIVES OF MEDICAL RESEARCH
(2021)
Article
Oncology
Lan-Ting Yuan, Wei-Jiunn Lee, Yi-Chieh Yang, Bo-Rong Chen, Ching-Yao Yang, Min-Wei Chen, Ji-Qing Chen, Michael Hsiao, Ming-Hsien Chien, Kuo-Tai Hua
Summary: This study evaluated the potential of targeting histone methyltransferase G9a in hepatocellular carcinoma (HCC) and confirmed the prognostic values of G9a expression. The results suggest that G9a plays a role in promoting HCC progression and discovered a novel liver-specific miR-122-G9a regulatory axis.
Article
Medicine, Research & Experimental
Yun Xie, Yi Zhang, Rui Tian, Wei Jin, Jiang Du, Zhigang Zhou, Ruilan Wang
Summary: Recent studies have shown a correlation between antithrombin III (ATIII) and sepsis-associated acute kidney injury (AKI) and established a predictive model based on ATIII levels. Factors such as male sex, cardiovascular disease, and low ATIII levels were identified as independent risk factors for AKI, while age, immune disease, and low ATIII levels were identified as independent risk factors for mortality in sepsis patients. ATIII reduction was closely related to the prognosis of sepsis patients.
CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, General & Internal
Georgia-Athanasia Lavranou, Spyros Mentzelopoulos, Paraskevi Katsaounou, Ilias Siempos, Ioannis Kalomenidis, Aikaterini Geranaki, Christina Routsi, Spyros Zakynthinos
Summary: This study investigated the predictive value of inflammatory and coagulation factors in clinical deterioration and improvement of patients with suspected infection diagnosis. The results show that in different groups of septic patients, certain coagulation factors and cytokines have significant predictive value.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Huifang Wang, Yichen Li, Shuqi Jiang, Nan Liu, Qiuping Zhou, Qian Li, Zhuo Chen, Yiyan Lin, Chunbo Chen, Yiyu Deng
Summary: miR-122-5p is significantly decreased in the cerebrospinal fluid of patients with intracranial infection, while the expression of IL-1 beta and TNF-alpha is increased. miR-122-5p can regulate neuroinflammation in the periventricular white matter of CLP rats by modulating lncRNA xist and PKC eta.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Mona A. Eldosoky, Reham Hammad, Asmaa A. Elmadbouly, Reda Badr Aglan, Sherihan G. Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A. Shaheen, Areej Rushdi, Reem M. Ahmed, Alzahra Abdelbadea, Neamat A. Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I. Abo-Elkheir, Samy Zaky, Nadia M. Hamdy, Claude Lambert
Summary: Early HCC diagnosis is challenging, especially for AFP-negative cases. miRNA profiles may serve as potential molecular markers for HCC. This study aimed to evaluate the expression levels of four miRNAs (hsa-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p) as biomarkers for HCC in CHCV patients with liver cirrhosis, particularly AFP-negative HCC cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Veterinary Sciences
Andrzej Milczak, Dagmara Winiarczyk, Stanislaw Winiarczyk, Diana Bochynska, Lukasz Adaszek, Mateusz Winiarczyk, Roman Lechowski
Summary: This study evaluated the levels of selected plasma haemostatic parameters in dogs with diabetes, finding elevated levels of ATIII. This may suggest a protective role against thrombotic events.
BMC VETERINARY RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Christian J. Wiedermann
Summary: Recent research has made significant contributions to the understanding of the pathogenesis of acute disseminated intravascular coagulation. COVID-19 is considered a new potential underlying cause of disseminated intravascular coagulation. Differences in biomarkers between sepsis-induced and COVID-19-associated coagulopathies have been identified, highlighting the importance of acquired antithrombin deficiency in early diagnosis and its potential impact on treatment with endogenous anticoagulants. Developing new scoring systems in combination with endogenous anticoagulant biomarker activities may help identify those sepsis patients who are more likely to benefit from targeted specific treatment interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Tomohiko Akahoshi, Noriyuki Kaku, Yuji Shono, Yuzo Yamamoto, Keita Takahashi, Takeshi Iyonaga, Kenta Momii, Masaaki Nishihara, Jun Maki, Kentaro Tokuda, Ken Yamaura
Summary: This study aimed to determine the appropriate dose and targeted AT activity of recombinant antithrombin gamma (rAT) for sepsis-induced DIC. The results showed that patients who achieved AT activity >= 70% or 80% had significantly higher recovery and survival rates. The AT activity on day 3 post administration served as a predictive indicator for 28-day survival and 5-day recovery from DIC.
CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS
(2022)
Article
Pharmacology & Pharmacy
Yuanyuan Sun, Fanrong Ye, Ding Li, Hongjing Yang, Tingting Xu, Xincun Zhong, Yilun Lu, Hongmin Zhou, Jingye Pan
Summary: This study demonstrates the therapeutic role of Fibroblast growth factor-2 (FGF2) in ameliorating coagulation abnormalities during sepsis. FGF2 administration inhibits coagulation activity, reduces organ damage, and increases survival in septic mice. FGF2 also regulates the expression of coagulation-related factors through the AKT/mTOR/S6K1 signaling pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Review
Critical Care Medicine
Toshiaki Iba, Julie Helms, Jean Marie Connors, Jerrold H. Levy
Summary: The International Society on Thrombosis and Haemostasis (ISTH) released overt DIC diagnostic criteria in 2001. However, DIC includes early stages with systemic activation in coagulation, and thus the ISTH recently released SIC criteria that can diagnose the compensated-phase of coagulopathy.
JOURNAL OF INTENSIVE CARE
(2023)
Article
Hematology
William J. Wulftange, Erdem Kucukal, Yuncheng Man, Ran An, Karamoja Monchamp, Charlotte D. Sevrain, Himanshu R. Dashora, Amma T. Owusu-Ansah, Allison Bode, Anton Ilich, Jane A. Little, Nigel S. Key, Umut A. Gurkan
Summary: This study utilized a biomimetic microfluidic device to investigate the role of endothelial cell damage and red blood cell adhesion in sickle cell disease, and found that the use of antithrombin-III (ATIII) can alleviate these symptoms.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Health Care Sciences & Services
Jae Sik Chung, Myoung Jun Kim, Young Un Choi, Jun Gi Kim, Keum Seok Bae
Summary: This study aimed to investigate the effects of antithrombin III (AT-Ⅲ) administration on the prognosis of severe trauma patients with disseminated intravascular coagulation (DIC). A retrospective analysis was conducted on the medical records of 4023 patients admitted to the ICU at a regional trauma center. Of the 140 included patients, 61 were treated with AT-Ⅲ. The improvement of the sequential organ failure assessment (SOFA) score was significantly greater in the administered group. However, there was no statistical difference between the two groups for organ support treatments, mortality, or length of hospital stay.
Article
Gastroenterology & Hepatology
Shanshou Liu, Jiangang Xie, Chujun Duan, Xiaojun Zhao, Zhusheng Feng, Zheng Dai, Xu Luo, Yu Li, Minghe Yang, Ran Zhuang, Junjie Li, Wen Yin
Summary: ADAR1 attenuates macrophage apoptosis and sepsis-induced liver injury through the miR-122/BCL2A1 signaling pathway.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2023)