Article
Medical Laboratory Technology
Anna Maria Ciaccio, Luisa Agnello, Bruna Lo Sasso, Rosaria Vincenza Giglio, Alessandro Iacona, Caterina Maria Gambino, Concetta Scazzone, Antonino Tuttolomondo, Marcello Ciaccio
Summary: Monocyte Distribution Width (MDW) is a new cell blood count parameter that measures the anisocytosis of monocytes. It has emerged as a reliable biomarker for sepsis in emergency departments and intensive care units. MDW has advantages such as low-cost and quick measurement compared to other sepsis biomarkers.
CLINICA CHIMICA ACTA
(2023)
Article
Ethics
Richard Owen, Rene von Schomberg, Phil Macnaghten
Summary: Reflecting on a decade of Responsible Research and Innovation (RRI) as a discourse emerging from the European Commission (EC) ten years ago, we discuss its foundations, emergence during the Seventh Framework programme, and evolution during Horizon 2020. The original vision for RRI became framed around five 'keys': gender, open access, science communication, ethics and public engagement. RRI has contributed to debates concerning the relationship between science, innovation and society over the last decade.
JOURNAL OF RESPONSIBLE INNOVATION
(2021)
Review
Medicine, General & Internal
Thilo von Groote, Melanie Meersch-Dini
Summary: Sepsis and septic shock are major public health concerns, but current treatment strategies often lack precision. Biomarkers provide opportunities to improve patient care and clinical research, by predicting and evaluating these conditions. They can potentially pave the way for precision medicine in sepsis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Hayoung Choi, Jin Young Lee, Hongseok Yoo, Kyeongman Jeon
Summary: This study aimed to compare gene expression profiles between patients with sepsis and healthy volunteers to determine the accuracy of these profiles in diagnosing sepsis and predicting sepsis outcomes. Certain upregulated genes showed high accuracy in diagnosing sepsis and predicting in-hospital mortality, while downregulated genes showed high accuracy in predicting mortality of patients with sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
M. Petrisasno, F. B. Mercuri, S. Sestito, A. A. Crispino, M. Miraglia Del Giudice, F. Borgia, R. De Sarro, L. Oreto, C. Cuppari, A. Salpietro, E. Murone, L. Pensabene, D. Concolino
Summary: Sepsis is a common and serious condition in pediatric patients, and early recognition is essential to prevent fatal outcomes. However, most research on novel serum biomarkers of infection has been conducted in adults. This article provides an overview of the current knowledge on the diagnostic efficacy of novel biomarkers of infection in pediatric patients.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Review
Biochemistry & Molecular Biology
Ahlam Fatmi, Wiam Saadi, Jesus Beltran-Garcia, Jose Luis Garcia-Gimenez, Federico Pallardo
Summary: Sepsis in newborns, especially preterm-born neonates, carries a significant risk of morbidity and mortality. Endothelial glycocalyx (eGC) shedding is an essential pathophysiological process in sepsis, contributing to microvascular dysfunction and organ failure. These processes have been extensively studied in adults, but are poorly understood in neonatal sepsis. Further research is needed to understand the composition, development, and mechanisms of eGC disruption in neonates, and to explore eGC dysfunction as a diagnostic and prognostic biomarker.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rebeca Osca-Verdegal, Jesus Beltran-Garcia, Federico V. Pallardo, Jose Luis Garcia-Gimenez
Summary: Sepsis-associated encephalopathy is a common neurological complication in septic patients, but its diagnosis remains challenging. miRNAs have shown potential as biomarkers for improving diagnosis and prognosis in SAE.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Geng Lu, Jiawei Zhou, Ting Yang, Jin Li, Xinrui Jiang, Wenjun Zhang, Shuangshuang Gu, Jun Wang
Summary: This study compared the metabolic features between sepsis and control groups and identified differentially expressed metabolites. Risk scores based on these metabolites were established to distinguish different stages of sepsis. The findings suggest that these metabolites can aid in personalized treatment and improve current therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jesus Villar, Ruben Herran-Monge, Elena Gonzalez-Higueras, Miryam Prieto-Gonzalez, Alfonso Ambros, Aurelio Rodriguez-Perez, Arturo Muriel-Bombin, Rosario Solano, Cristina Cuenca-Rubio, Anxela Vidal, Carlos Flores, Jesus M. Gonzalez-Martin, M. Isabel Garcia-Laorden, Ramon Adalia, Gerard Sanchez-Etayo, Alfonso Ambros, Carmen Martin-Rodriguez, Elena Gonzalez-Higueras, Rosario Solano, Laura Martinez-Garcia, M. Isabel Garcia-Laorden, Jesus Villar, Jesus M. Gonzalez-Martin, Aurelio Rodriguez-Perez, Angel Becerra, Lucia Valencia, Demetrio Carriedo, Francisco Javier Diaz Dominguez, Anxela Vidal, Jose M. Anon, Pablo Millan, Domingo Martinez, Miryam Prieto-Gonzalez, Cristina Cuenca-Rubio, Ana Isabel Garcia-Sanchez, Braulio Alvarez-Martinez, Perfectino Fernandez-Perez, Efren Otero-Alvarin, Carlos Flores, Gerardo Aguilar, Nasara Segura, Marina Soro, Ruben Herran-Monge, Arturo Muriel-Bombin, Marta M. Garcia-Garcia, Concepcion Tarancon, Teresa Alvarez
Summary: This study found that certain biomarkers can help predict the risk of septic patients developing acute respiratory distress syndrome (ARDS), and can improve the accuracy of clinical markers in predicting ARDS. Panels including indicators such as RAGE, CXCL16, and Ang-2 show good performance in predicting ARDS. The presence of ARDS, need for invasive mechanical ventilation, and pulmonary/extrapulmonary origin of sepsis are factors related to ICU death in septic patients.
SCIENTIFIC REPORTS
(2021)
Article
Biophysics
Zoe Bradley, Nikhil Bhalla
Summary: Sepsis is a life-threatening immune response caused by various sources and is a major cause of global mortality. Current molecular diagnostic techniques for sepsis are time-consuming and require trained personnel, and there is a lack of rapid point-of-care (POC) devices for sepsis detection. This review explores the use of microfluidics devices for POC testing and the potential of current and novel biomarkers for early sepsis diagnosis, aiming to develop more rapid and accurate methods.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Immunology
Shuai Hao, Miao Huang, Xiaofan Xu, Xulin Wang, Yuqing Song, Wendi Jiang, Liqun Huo, Jun Gu
Summary: This study identified six critical mitochondria-related genes and developed a novel diagnostic model for early sepsis diagnosis. These genes were found to be associated with different immune cells. Furthermore, mitochondrial dysfunction was observed in sepsis patients and in an in vitro sepsis model.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Analytical
Andrea Bonini, Angela Gilda Carota, Noemi Poma, Federico Maria Vivaldi, Denise Biagini, Daria Bottai, Alessio Lenzi, Arianna Tavanti, Fabio Di Francesco, Tommaso Lomonaco
Summary: Sepsis, a systemic inflammatory dysfunction associated with infectious diseases, is a significant health issue with increasing incidence globally. Traditional diagnostic techniques for sepsis management present challenges, making biosensing technologies a valuable alternative.
Article
Economics
Safia Aggarwal, Anne Larson, Constance McDermott, Pia Katila, Lukas Giessen
Summary: The urgent need to restore and sustainably manage land and forests to combat social and environmental threats like climate change, COVID-19, and biodiversity loss highlights the critical role of tenure reform, particularly strengthening collective forest tenure. However, there are still challenges in providing robust tenure for community forestry in terms of legal protections, barriers to rights usage, access to justice, and administrative support, despite some successful cases showcasing the potential of communities and smallholders in sustainable forest management and climate change mitigation. Governments are urged to strengthen community and local rights within their legal frameworks and mainstream implementation in policies and practices, with support from NGOs, civil society organizations, donors, research institutions, and academia.
FOREST POLICY AND ECONOMICS
(2021)
Article
Immunology
Chumei Huang, Jiahui Chen, Xiaoxia Zhan, Laisheng Li, Shu An, Guijun Cai, Nan Yu
Summary: This study identified the optimal combination of biomarkers for diagnosing neonatal sepsis, distinguishing culture-positive cases, and predicting the time of confirmation. The findings have significant implications for personalized therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Chemistry, Analytical
Xiaoting Xu, Xuan Li, Juncong Miao, Lei Liu, Xinyi Huang, Qin Wei, Wei Cao
Summary: A label-free electrochemical immunosensor based on DPV and i-t dual-mode analysis was developed for early quantitative detection of PCT. Using materials with high stability and biocompatibility as sensing interface, the sensor showed wide linear response and low detection limit through an advanced sensing strategy.
