Review
Biochemistry & Molecular Biology
Patrycja Zietara, Marta Dziewiecka, Maria Augustyniak
Summary: The sirtuin system, consisting of seven highly conserved regulatory enzymes, plays a crucial role in metabolism, antioxidant protection, and cell cycle regulation. Sirtuins have attracted great interest due to their potential impact on life extension. This article provides a summary of the latest research on the activity of sirtuins and their involvement in the aging process. The effectiveness of compounds that modulate sirtuin activity has been demonstrated in numerous studies, highlighting the importance of carefully considering the risks associated with their manipulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medical Laboratory Technology
Kelly Doyle, Dustin R. Bunch
Summary: Clinical laboratory test results need clinically actionable cutoffs or reference intervals for result interpretation. Reference intervals have limitations, and new indirect methods are being explored to define personalized intervals. Standardized best practices and global collaborations are important for establishing accurate and personalized reference intervals.
CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES
(2023)
Review
Multidisciplinary Sciences
Francesca Chadha-Day, John Ellis, David J. E. Marsh
Summary: This article reviews the development of the axion as a candidate particle for dark matter. It describes the historical roots of the axion in the Standard Model of particle physics and the problem of charge-parity invariance of the strong nuclear force. It discusses the production of the axion as a dark matter candidate and its interactions with ordinary matter.
Article
History & Philosophy Of Science
Brittany A. Gentry
Summary: The paper discusses presentists' perspectives on the duration of the present, exploring various possible answers and viewpoints, and highlighting the need for a more comprehensive theory of the present to understand the concept of time.
Review
Chemistry, Multidisciplinary
Ke Li, Craig M. Crews
Summary: PROTACs are a type of molecules with novel event-driven mechanism, offering multiple advantages over traditional inhibitors, such as catalytic nature and targeted protein degradation, which may lead to improved therapeutic outcomes with reduced toxicity. However, further research and development efforts are needed to fully explore their potential.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Cell Biology
Michael A. Cook, Gerard D. Wright
Summary: Antibiotics have played a crucial role in modern medicine, but they are facing challenges of microbial resistance and traditional reimbursement models. Therefore, innovation is needed in policy, quantitative understanding of societal value, and investment in alternatives. Significant investment in research and development is also necessary to address the antibiotic crisis.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Agronomy
Hyunkyeong Min, Hyeon-Seok Lee, Chun-Kuen Lee, Woo-Jung Choi, Bo-Keun Ha, Hyeongju Lee, Seo-Ho Shin, Kyu-Nam An, Dong-Kwan Kim, Oh-Do Kwon, Jonghan Ko, Jaeil Cho, Han-Yong Kim
Summary: Based on past and current experiments on rice cultivation, it has been found that increasing CO2 concentration and temperature can promote rice growth but may also have adverse effects on yield. While yield remained unchanged, the harvest index decreased significantly. Rice crops show realistic responses to elevated CO2 concentration and moderate warming in the absence of adaptation measures.
Article
Biology
Miikka Tallavaara, Erlend Kirkeng Jorgensen
Summary: Estimates of hunter-gatherer population growth rates differ significantly between archaeological and ethnographic sources, with archaeological proxies lacking the resolution to detect actual population dynamics observed in historical and ethnographic data. This suggests that hunter-gatherer populations cannot exhibit long-term growth independently of increasing environmental productivity.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Sameek Singh, Wenzhi Tian, Zachary C. Severance, Santosh K. Chaudhary, Viktoriya Anokhina, Basudeb Mondal, Rajaiah Pergu, Prashant Singh, Uttam Dhawa, Santanu Singha, Amit Choudhary
Summary: Living systems regulate biochemical processes through proximity. Inspired by this, bifunctional modalities have been developed to redirect cellular processes. An emerging example is molecules that induce ubiquitin-dependent proteasomal degradation of a protein of interest, sparking discovery for other bifunctional modalities. Recent advances include modalities that can change protein phosphorylation, glycosylation, and acetylation states, modulate gene expression, and recruit components of the immune system. This review highlights non-degradation bifunctional modalities with potential to revolutionize disease treatment and explore new aspects of biology in basic research.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Materials Science, Multidisciplinary
Joseph Rich, Zhenhua Tian, Tony Jun Huang
Summary: The research in intracellular delivery technologies has surged with the advancement in cell-based therapies and reprogramming. Physical cell membrane permeabilization techniques, especially sonoporation, show promise in delivering functional cargos to various cells, but bubble-based methods may have limitations such as requiring contrast agents and potential damage to cell components. Development of non-bubble-based sonoporation mechanisms aims to overcome these limitations and improve intracellular delivery efficiency.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Review
Chemistry, Multidisciplinary
Wentao Jiang, Ziyu Wu, Zheng Gao, Mimi Wan, Min Zhou, Chun Mao, Jian Shen
Summary: Artificial cells are constructed to imitate natural cells and can be used for studying biological processes and the origin of life. They can be endowed with various functions through the incorporation of proteins and genes, and have great potential in therapeutic applications.
Article
Immunology
Shubham Upadhayay, Richmond Arthur, Divya Soni, Poonam Yadav, UmaShanker Navik, Randhir Singh, Thakur Gurjeet Singh, Puneet Kumar
Summary: Monkeypox is a zoonotic disease similar to smallpox, transmitted through direct contact with infected animals or individuals with infectious sores, scabs, or body fluids. There is currently no definitive treatment, but antiviral medication can be used to alleviate symptoms and reverse skin lesions.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Regina Brigelius-Flohe
Summary: The early history of vitamin E, its discovery and chemical synthesis, as well as the development of the concept of its antioxidant properties are recounted. Recent research has cast doubt on this hypothesis, including the effects of vitamin E on enzyme activities, signaling cascades, gene expression, and biomembrane structure. Overall, our knowledge of vitamin E's mechanism of action remains incomplete, with discussions on its metabolism, bioactivity of its metabolites, and implications for future clinical trials.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Chemistry, Medicinal
Yasuhiro Nishida, Pernilla Christina Berg, Behnaz Shakersain, Karen Hecht, Akiko Takikawa, Ruohan Tao, Yumeka Kakuta, Chiasa Uragami, Hideki Hashimoto, Norihiko Misawa, Takashi Maoka
Summary: This review article provides a comprehensive exploration of the history, chemical and physical attributes, distribution, and biosynthesis of astaxanthin (AX). It also delves into the health benefits, biofunctional characteristics, and market status of AX, aiming to provide a robust foundation for future scientific endeavors addressing societal needs for sustainable nutritional and medicinal solutions.
Article
Multidisciplinary Sciences
Alberto Montanari, Hung Nguyen, Sara Rubinetti, Serena Ceola, Stefano Galelli, Angelo Rubino, Davide Zanchettin
Summary: Based on a 216-year river flow time series at the Po River outlet in Italy, this study reveals that the 2022 hydrological drought is the most severe event, exceeding previous droughts by 30% and having a return period of six centuries. The decline in summer river flows, attributed to changes in precipitation regime, snow fraction, and snowmelt, as well as increasing evaporation rate and irrigated areas, highlights the combined impact of climate change and local changes in hydrologic seasonality and water use.
Editorial Material
Hematology
Giuseppe Lippi, Brandon M. Henry, Emmanuel J. Favaloro
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2023)
Review
Medical Laboratory Technology
Emmanuel J. Favaloro, Leonardo Pasalic, Giuseppe Lippi
Summary: The platelet function analyser (PFA) is a widely used instrument for screening platelet function. It has two models, the PFA-100 and the PFA-200, with similar outputs and normal reference ranges. The PFA-100 has been in use for nearly 50 years, while the PFA-200 is expected to replace it in the future. The test system is highly sensitive to von Willebrand disease and aspirin therapy, but only moderately sensitive to platelet function defects and deficiencies. Its clinical utility varies according to user experience, with some researchers using it to assess thrombosis risk or pre-operative bleeding risk.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Medical Laboratory Technology
Giuseppe Lippi, Francois Mullier, Emmanuel J. Favaloro
Summary: D-dimer measurement is important in the diagnosis, exclusion, and prognostication of venous thromboembolism and disseminated intravascular coagulation. Its clinical applications are expanding to include other diseases such as acute aortic dissection, acute intestinal ischemia, and cerebral venous thrombosis, as well as the management of COVID-19.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Respiratory System
Alice Rossi, Alessandra Bragonzi, Melessike Medede, Ida De Fino, Giuseppe Lippi, Marco Prosdocimi, Anna Tamanini, Giulio Cabrini, Maria Cristina Dechecchi
Summary: We have previously demonstrated that beta-sitosterol (BSS) inhibits the expression of IL-8 in CF bronchial epithelial cells exposed to P. aeruginosa. In this study, we show that BSS significantly reduces leukocyte recruitment and bacterial colonization in the airways of a mouse model with chronic lung infection. BSS treatment also decreases the expression of key cytokines involved in immune response in the lung tissue. Our findings suggest that BSS has the potential to be a new drug for targeting excessive neutrophil recruitment in chronically infected lungs and further investigations on its protective mechanisms are encouraged.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Letter
Medical Laboratory Technology
Giuseppe Lippi
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Editorial Material
Medical Laboratory Technology
Mario Plebani, Giuseppe Lippi
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Giuseppe Lippi, Brandon M. Henry, Mario Plebani
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Francesca Lucca, Valentino Bezzerri, Elisa Danese, Debora Olioso, Denise Peserico, Christian Boni, Giulia Cucchetto, Martina Montagnana, Gloria Tridello, Ilaria Meneghelli, Mirco Ros, Giuseppe Lippi, Marco Cipolli
Summary: This study investigated the immunogenicity and safety of the BNT162b2 vaccine in patients with cystic fibrosis (pwCF) and found that pwCF exhibited a similar immune response to the vaccine as the general population, while lung transplant recipients (LTR) showed impaired immunogenicity, especially in patients undergoing immunosuppressive treatment. The study results highlight the importance of longitudinal assessment of the immune response to COVID-19 vaccination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Dentistry, Oral Surgery & Medicine
Riccardo Nocini, Giuseppe Lippi, Camilla Mattiuzzi
JOURNAL OF DENTAL SCIENCES
(2023)
Letter
Peripheral Vascular Disease
Camilla Mattiuzzi, Giuseppe Lippi
INTERNATIONAL JOURNAL OF ANGIOLOGY
(2023)
Letter
Medical Laboratory Technology
Laura Pighi, Brandon M. Henry, Camilla Mattiuzzi, Simone De Nitto, Gian Luca Salvagno, Giuseppe Lippi
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Laura Pighi, Brandon M. Henry, Simone De Nitto, Gianluca Gianfilippi, Gian Luca Salvagno, Mario Plebani, Giuseppe Lippi
Summary: In this study, the clinical performance of the SNIBE Maglumi SARS-CoV-2 antigen fully-automated chemiluminescent immunoassay (MAG-CLIA SARS-CoV-2 Ag) was reported. The results showed satisfactory analytical performance of MAG-CLIA SARS-CoV-2 Ag, which could be used as a surrogate for molecular testing in identifying high viral load samples.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Letter
Medical Laboratory Technology
Gian Luca Salvagno, Laura Pighi, Brandon M. Henry, Simone De Nitto, Mario Plebani, Giuseppe Lippi
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Editorial Material
Medical Laboratory Technology
Giuseppe Lippi, Brandon M. Henry, Julien Favresse, Mario Plebani
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Oncology
Dan-Ni Yang, Yan Niu, Jian-Xun Wen, Xu-Hui Wen, Ya-Fei Wang, Li Yan, Ting-Wang Jiang, Jin-Hong Huang, Hong Chen, Giuseppe Lippi, Wen-Qi Zheng, Zhi-De Hu
Summary: This study aimed to investigate the long-term stability of pleural fluid carcinoembryonic antigen (CEA) at -80 degrees C to -70 degrees C and analyze the effects of frozen storage on the diagnostic accuracy of CEA for malignant pleural effusion (MPE). The results showed that CEA remains stable when stored at -80 degrees C to -70 degrees C for 1-3 years, and frozen storage does not significantly affect the diagnostic accuracy of CEA for MPE.
