Article
Immunology
Juping Du, Liyuan Zheng, Shuaishuai Chen, Na Wang, Xia Pu, Die Yu, Haixi Yan, Jiaxi Chen, Donglian Wang, Bo Shen, Jun Li, Shaobiao Pan
Summary: This study found that the expression level of nuclear-factor, interleukin 3 regulated (NFIL3) is significantly increased in rheumatoid arthritis (RA) patients, and its expression is correlated with abnormal inflammatory cytokines and inflammatory responses. NFIL3 is involved in the regulation of multiple signaling pathways and is positively correlated with key genes associated with RA.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Hosam M. Ahmad, Zaki M. Zaki, Asmaa S. Mohamed, Amr E. Ahmed
Summary: This study compared the association between two polymorphisms of the vitamin D receptor gene and parathyroid hormone and inflammation markers in patients with rheumatoid arthritis. The study found that the FokI gene may play a role in controlling parathyroid hormone levels, but there was no significant correlation between serum parathyroid hormone levels and the severity of rheumatoid arthritis. There were no differences in terms of susceptibility to rheumatoid arthritis for the two gene polymorphisms.
BMC MEDICAL GENOMICS
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Zhaid Hussain, Ishrat Mahjabeen, Muhammad Shahid Khan, Naila Mumtaz, Syed Uzair Maqsood, Farooq Ikram, Syed Nazir Ahmed, Qurrat-Ul-Ain Kalim, Rabia Abbas, Ahmed Ammar Cheema
Summary: The study identified significant involvement of VDR and IL-6 gene variations in the pathogenesis of rheumatoid arthritis, with mutant allele frequencies observed to be significantly higher in RA patients compared to controls. Additionally, the study found that upregulation of IL-6 and downregulation of VDR gene could serve as good diagnostic markers for detecting arthritis.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Ana Triguero-Martinez, Emilia Roy-Vallejo, Nuria Montes, Hortensia de la Fuente, Ana Maria Ortiz, Santos Castaneda, Isidoro Gonzalez-Alvaro, Amalia Lamana
Summary: A study found that genetic variants in the LGALS1 gene are associated with Gal1 serum levels, and these genetic variants can explain the differences in Gal1 levels among patients, with higher levels of Gal1 being associated with lower levels of IL-6.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Maryam Mukhtar, Nadeem Sheikh, Andleeb Batool, Muhammad Babar Khawar, Naz Fatima, Rabia Mehmood
Summary: The study reveals that PADI-4 gene polymorphisms are associated with the onset of both rheumatoid arthritis (RA) and osteoarthritis (OA). Polymorphisms on targeted sites alter the functioning of PADIs, which play a role in the development of arthritis.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Cell Biology
Zhicheng Yang, Weixi Liu, Ting Yan, Ruiping Liu
Summary: The study revealed that HLA-DPB1 rs9277535 polymorphism is associated with a decreased risk of rheumatoid arthritis in the Chinese population, particularly among women and those at least 55 years old. Additionally, certain genotypes were linked to inflammatory markers and levels of HLA-DPB1 plasma and mRNA in RA patients.
Article
Rheumatology
Young Bin Joo, Soo Min Ahn, So-Young Bang, Youngho Park, Su Jin Hong, Youkyung Lee, Soo-Kyung Cho, Chan-Bum Choi, Yoon-Kyoung Sung, Tae-Hwan Kim, Jae-Bum Jun, Dae Hyun Yoo, Sang-Cheol Bae, Hye-Soon Lee
Summary: The MUC5B variant rs35705950 is a rare but significant risk factor for Asian patients with RA-ILD with usual interstitial pneumonia (UIP), suggesting a shared genetic background between Asian and Western populations.
Article
Rheumatology
Ankita Singh, Harikrishnan Gangadharan, Vikas Gupta, Pradeepta S. Patro, Ramnath Misra, Amita Aggarwal
Summary: In Indian RA patients, polymorphisms of genes ATIC and ITPA are associated with response to MTX therapy, and can serve as independent predictors of treatment response.
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Rabaa Takala, Dipak P. Ramji, Robert Andrews, You Zhou, James Burston, Ernest Choy
Summary: The study demonstrates the anti-inflammatory effects of pinolenic acid (PNLA) in human cell lines and peripheral blood mononuclear cells (PBMCs), and its impact on cell migration and macrophage function.
Article
Rheumatology
Antti Palomaki, Aarno Palotie, Jukka Koskela, Kari K. Eklund, Matti Pirinen, Samuli Ripatti, Tarja Laitinen, Nina Mars
Summary: The study utilized Finnish national hospital and biobank databases to link MUC5B variant with increased risk of RA-ILD. In patients with RA, MUC5B promoter variant was also identified as a strong risk factor for ILD.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Rheumatology
Eunji Ha, Sang-Cheol Bae, Kwangwoo Kim
Summary: A large trans-ancestral meta-analysis identified 11 new susceptibility loci for RA, explaining a significant portion of the heritability in East Asians and Europeans, and confirmed 71 known non-HLA susceptibility loci. The study also highlighted the importance of CD4(+) T-cell activation and potential non-immune organs in RA pathogenesis, providing insights into genetic etiology and variant-driven RA pathogenesis.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Health Care Sciences & Services
Beatriz Rioseras, Marco Antonio Moro-Garcia, Alejandra Garcia-Torre, Eva Bueno-Garcia, Rocio Lopez-Martinez, Maria Iglesias-Escudero, Roberto Diaz-Pena, Patricia Castro-Santos, Miguel Arias-Guillen, Rebeca Alonso-Arias
Summary: Expanded CD4+CD28(null) T lymphocytes in patients with autoimmune diseases, such as rheumatoid arthritis (RA), exhibit potent inflammatory activity and favor migration to inflammatory sites, potentially contributing to disease progression. Interleukin 15 (IL-15) plays a critical role in the functional activity of these cells and may act as a selective attractor to damaged tissues. Understanding the migratory properties and transcriptional motility profile of these cells, along with the role of IL-15, may lead to the development of targeted therapeutic strategies in autoimmune disorders.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiaoke Yang, Bo Chen, Mingyue Zhang, Shengqian Xu, Zongwen Shuai
Summary: The study explored the association between TTP gene polymorphisms and mRNA levels with RA susceptibility in Chinese populations. The results indicated that the T allele of rs3746083 in the TTP gene increased susceptibility to RA, with a significant difference found under the dominant model. However, the association of rs251864 with RA was not statistically significant. Furthermore, TTP expression levels were significantly reduced in RA patients, supporting its potential involvement in RA pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Jing Ni, Peng Wang, Kang-Jia Yin, Xiao-Ke Yang, Han Cen, Cong Sui, Guo-Cui Wu, Hai-Feng Pan
Summary: Our study identified 47 significant candidate genes for RA through a cross-tissue and single-tissue transcriptome-wide association study, with 13 genes located outside of previously reported significant loci. Enrichment analyses showed shared genetic determinants among autoimmune thyroid disease, asthma, type I diabetes mellitus, and RA.
Article
Oncology
Gyu Jin Lee, Yukyung Jun, Yoon Kyung Jeon, Daekee Lee, Sanghyuk Lee, Jaesang Kim
Summary: The CTLA4-CD28 gene fusion occurs in various types of T cell lymphoma, and it can convert inhibitory signals to activating signals, promoting T cell proliferation and transformation. A murine model expressing this fusion gene specifically in T cells showed shorter lifespans, inflammatory responses, and higher levels of T cell activation and infiltration in various organs. The gene expression pattern in CD4+ T cells in this model resembled that of ATLL and AITL tissues.
Article
Medicine, Research & Experimental
Hwayoung Lee, Hansol Won, Jiyun Im, Young Ock Kim, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2016)
Article
Clinical Neurology
Minhee Jang, Min Jung Lee, Jong Hee Choi, Eun-Jeong Kim, Seupg-Yeol Nah, Hak-Jae Kim, Sanghyun Lee, Sang Won Lee, Young Ock Kim, Ik-Hyun Cho
Article
Medicine, Research & Experimental
Hwayoung Lee, Jiyun Im, Hansol Won, Jun Young Kim, Hyung-Ki Kim, Jun-Tack Kwon, Young Ock Kim, Sanghyun Lee, Ik-Hyun Cho, Sang Won Lee, Hak-Jae Kim
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Article
Pharmacology & Pharmacy
Hwayoung Lee, Jiyun Im, Hansol Won, Wooyoung Nam, Young Ock Kim, Sang Won Lee, Sanghyun Lee, Ik-Hyun Cho, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2017)
Article
Oncology
Hwayoung Lee, Seong-Su Nah, Sung-Hae Chang, Hyung-Ki Kim, Jun-Tack Kwon, Sanghyun Lee, Ik-Hyun Cho, Sang Won Lee, Young Ock Kim, Seung-Jae Hong, Hak-Jae Kim
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Seong-Su Nah, Hwayoung Lee, Yeongseon Hong, Jiyun Im, Hansol Won, Sung-Hae Chang, Hyung-Ki Kim, Jun-Tack Kwon, Hak-Jae Kim
MOLECULAR MEDICINE REPORTS
(2017)
Article
Plant Sciences
Dong Gu Lee, Jaemin Lee, Ik-Hyun Cho, Hak-Jae Kim, Sang-Won Lee, Young-Ock Kim, Chun-Gun Park, Sanghyun Lee
JOURNAL OF GINSENG RESEARCH
(2017)
Article
Biology
Hak-Jae Kim, Chun-Geon Park, Rakesh Varghese, Ji Yeon Lee, YoungOck Kim, Gi-Ho Sung
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2017)
Article
Psychiatry
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Shohyun Park, Hae Jeong Park, Su Kang Kim, Jin Kyung Park, Won Sub Kang, Young Jong Kim, Joo-Ho Chung, Jong Woo Kim, Hak-Jae Kim
PSYCHIATRY RESEARCH
(2018)
Article
Plant Sciences
Dong Gu Lee, Jaemin Lee, Kyung-Tack Kim, Sang-Won Lee, Young-Ock Kim, Ik-Hyun Cho, Hak-Jae Kim, Chun-Gun Park, Sanghyun Lee
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Plant Sciences
Jong Hee Choi, Min Jung Lee, Minhee Jang, Hak-Jae Kim, Sanghyun Lee, Sang Won Lee, Young Ock Kim, Ik-Hyun Cho
JOURNAL OF GINSENG RESEARCH
(2018)
Article
Biology
Hak-Jae Kim, Kyeong-Hun Park, Dong-Hwi Kim, Han-Jung Chae, Gi-Ho Sung, Young-Ock Kim
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2018)
Article
Neurosciences
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Young Ock Kim, Jonghoon Seo, Sanghyun Lee, Ik-Hyun Cho, Hak-Jae Kim
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2018)
Article
Oncology
Hak-Jae Kim, Hansol Won, Jiyun Im, Hwayoung Lee, Jiwoo Park, Sanghyun Lee, Young-Ock Kim, Hyung-Ki Kim, Jun-Tack Kwon
MOLECULAR MEDICINE REPORTS
(2018)
Article
Biology
R. Usha Kalyani, K. Perinbam, P. Jeyanthi, Naif Abdullah Al-Dhabi, Mariadhas Valan Arasu, Galal Ali Esmail, Young Ock Kim, Hyungsuk Kim, Hak-Jae Kim