Review
Medical Laboratory Technology
Matthew S. Karafin, Joanne L. Becker, Mary Berg, Robert A. DeSimone, Nicole L. Draper, Jay Hudgins, Ryan A. Metcalf, Monica B. Pagano, Yara A. Park, Susan N. Rossmann, Joseph Schwartz, Rhona Souers, Lamont Thomas, Lynne Uhl, Glenn E. Ramsey
Summary: The survey reveals significant heterogeneity in approaches for ABO-type switching during an MTP. Specific expert guidance on this issue is limited, and best practices have not been established or rigorously investigated.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Chien-Sung Tsai, Mei-Hua Hu, Yung-Chi Hsu, Go-Shine Huang
Summary: This study investigated the role of platelet TLR4 in transfusion reactions and found that blood mixing can upregulate platelet TLR4 and certain DAMPs, potentially leading to innate immune responses and transfusion reactions.
Review
Hematology
Kristen N. Ruby, Sarah K. Harm, Nancy M. Dunbar
Summary: In recent decades, there have been significant changes in the approach to resuscitating bleeding patients, including the use of ABO-incompatible plasma transfusion. Studies have found that the risk for recipients of ABO-incompatible plasma is low, but the results are still limited.
TRANSFUSION MEDICINE REVIEWS
(2021)
Article
Computer Science, Artificial Intelligence
Amir Aghsami, Yaser Samimi, Abdollah Aghaie
Summary: This paper develops a two-echelon blood bank network considering ABO/Rh factors and substitution priority. By modeling blood inventory levels and using queueing-inventory models, it analyzes various challenges in blood supply and demand and proposes an optimization algorithm to solve the problem. Through a case study in Tehran, it identifies the blood types with the most lost sales and provides practical implications.
EXPERT SYSTEMS WITH APPLICATIONS
(2022)
Editorial Material
Hematology
France Pirenne
Summary: The study demonstrates that heme released during hemolysis inhibits human plasma B-cell differentiation, but this pathway is inhibited in B cells from alloimmunized patients with sickle cell disease. Insensitivity to heme inhibition in B cells may pose a potential alloimmunization risk factor.
Article
Immunology
Kayvan Mohkam, Raef Abdallah, Gisele N'kontchou, Nathalie Ganne, Louise Barbier, Ephrem Salame, Petru Bucur, Michel Rayar, Fabien Robin, Karim Boudjema, Daniel Pietrasz, Daniel Cherqui, Rene Adam, Chetana Lim, Eric Savier, Olivier Scatton, Charlotte Maulat, Bertrand Suc, Fabrice Muscari, Alexis Laurent, Christophe Duvoux, Bruno Heyd, Celia Turco, Alexandre Doussot, Philippe Merle, Teresa Antonini, Mickael Lesurtel, Cyril Cosse, Francois Durand, Olivier Soubrane, Francois Cauchy, Jean-Yves Mabrut
Summary: The ABO blood group system may have an impact on tumor recurrence and survival rates in liver transplantation for hepatocellular carcinoma. Incorporating the ABO blood group system into the prognostic model for liver transplantation for hepatocellular carcinoma could improve the management of transplant candidates.
Article
Biophysics
Adriana Balduzzi, Halvard Boenig, Andrea Jaerisch, Tiago Nava, Marc Ansari, Alessandro Cattoni, Giulia Prunotto, Giovanna Lucchini, Gergely Krivan, Toni Matic, Krzyzstof Kalwak, Akif Yesilipek, Marianne Ifversen, Peter Svec, Jochen Buechner, Kim Vettenranta, Roland Meisel, Anita Lawitschka, Christina Peters, Brenda Gibson, Arnaud Dalissier, Selim Corbacioglu, Andre Willasch, Jean-Hugues Dalle, Peter Bader
Summary: Up to 40% of donor-recipient pairs in SCT have some degree of ABO incompatibility, which can result in severe complications. Major ABO incompatibility usually requires interventions such as RBC depletion from the graft or recipient plasma-exchange. Minor incompatible grafts may be managed by removing isohemagglutinins from the graft.
BONE MARROW TRANSPLANTATION
(2021)
Article
Medical Laboratory Technology
Sooin Choi, Jungwon Hyun, HongBi Yu, Duck Cho
Summary: Fatal ABO-incompatible (ABOi) transfusion is a common cause of transfusion-related death in Korea, with 32 cases identified through comprehensive review. Errors mainly occurred at the administration stage, leading to four deaths out of the 32 cases.
ANNALS OF LABORATORY MEDICINE
(2021)
Article
Hematology
Razan Hayati Zulkeflee, Mohd Nazri Hassan, Rosline Hassan, Nur Ilyia Syazwani Saidin, Zefarina Zulkafli, Marini Ramli, Marne Abdullah, Salfarina Iberahim, Wardah Roslan, Noor Haslina Mohd Noor, Wan Suriana Wan Ab Rahman
Summary: This study presents two cases of thrombocytopenic patients who experienced acute hemolytic transfusion reaction (AHTR) following ABO-incompatible platelet transfusion. Both patients exhibited symptoms such as decreased hemoglobin levels, spherocytosis, small agglutinations on blood film, and positive direct Coombs test. The importance of ABO-compatible platelet transfusion, especially in children and vigilant patient groups, is emphasized.
TRANSFUSION AND APHERESIS SCIENCE
(2023)
Article
Medicine, Research & Experimental
Xiaozhen Hong, Yanling Ying, Jingjing Zhang, Shu Chen, Xianguo Xu, Ji He, Faming Zhu
Summary: Three novel splice site variations in the ABO gene were identified in Chinese individuals, resulting in decreased A or B antigen expression and the formation of ABO subtypes.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hannah L. McRae, Michelle Warren Millar, Spencer A. Slavin, Neil Blumberg, Arshad Rahman, Majed A. Refaai
Summary: The effects of ABO-IC on endothelial cells were investigated, revealing an increase in EC barrier permeability due to stress fiber formation and loss of cell surface VE-cadherin. Inhibiting ROCK activation can protect EC against IC-induced barrier disruption.
Article
Pharmacology & Pharmacy
Ludwika Piwowarczyk, Szymon Tomczak, Patryk Antkowiak, Anna Jelinska, Maciej Stawny
Summary: Epilepsy is a group of nervous system-related problems characterized by a predisposition to epileptic seizures. In intensive care units (ICU), the frequency of seizures can range from 3.3% to 34%, and antiepileptic treatment is common practice. However, co-administration of drugs through the same infusion line, especially in ICU, poses risks to patient safety. In this study, the compatibility of sodium valproate (VPA) with parenteral nutrition admixtures (PNAs) was investigated, and the lipid emulsion composition was found to significantly influence drug-PN compatibility. Most tested PNAs showed particles above 1000 nm, disqualifying their simultaneous administration with VPA.
Article
Hematology
Jorn Gerritsma, Vera Bongaerts, Corien Eckhardt, Harriet Heijboer, Erfan Nur, Bart Biemond, Ellen van der Schoot, Karin Fijnvandraat
Summary: Delayed haemolytic transfusion reaction (DHTR) is a potentially life-threatening complication of red blood cell (RBC) transfusions in sickle cell disease (SCD), with a high incidence rate despite extended donor RBC matching. Early diagnosis is crucial for improving outcomes.
BRITISH JOURNAL OF HAEMATOLOGY
(2022)
Article
Medicine, General & Internal
Munira Borhany, Muhammad Shujat Ali, Zainab Ghias, Madiha Abid, Sidra Zafar, Tahir Shamsi
Summary: This study evaluated the impact of ABO compatibility on outcomes and complications related to hematopoietic stem cell transplantation. The results showed that ABO incompatibility did not have a negative impact on the clinical outcomes in patients undergoing this procedure.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2023)
Review
Hematology
Eric A. Gehrie, Bipin N. Savani, Garrett S. Booth
Summary: Advancements in laboratory testing, pathogen reduction, and donor qualification have significantly reduced the risk of infection from blood transfusions. However, the prevention and recognition of hemolytic reactions, particularly due to donor-recipient incompatibility, have seen little recent progress. The article discusses the role of compatibility testing and transfusion practices in acute hemolysis, emphasizing clinical scenarios with increased risk and outlining initial clinical management for severe hemolytic reactions.
