Foxc2 enhances proliferation and inhibits apoptosis through activating Akt/mTORC1 signaling pathway in mouse preadipocytes

Impact of the Obesity Epidemic on Cancer

(2015) Pamela J. Goodwin et al.   Annual Review of Medicine

Targeting the PI3K/Akt/mTOR Pathway – Beyond Rapalogs

(2015)   Oncotarget

Diabetes Enhances the Proliferation of Adult Pancreatic Multipotent Progenitor Cells and Biases Their Differentiation to More β-Cell Production

(2014) Rozita Razavi et al.   DIABETES

Hepatic Cyclooxygenase-2 Expression Protects Against Diet-Induced Steatosis, Obesity, and Insulin Resistance

(2014) Daniel E. Francés et al.   DIABETES

Protein kinase A-mediated cell proliferation in brown preadipocytes is independent of Erk1/2, PI3K and mTOR

(2014) Yanling Wang et al.   EXPERIMENTAL CELL RESEARCH

Functionally Significant, Rare Transcription Factor Variants in Tetralogy of Fallot

(2014) Ana Töpf et al.   PLoS One

Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206

(2014) Mohd Rehan et al.   PLoS One

Prostaglandin E2 stimulates β1-integrin expression in hepatocellular carcinoma through the EP1 receptor/PKC/NF-κB pathway

(2014) Xiaoming Bai et al.   Scientific Reports

Foxc2 induces Wnt4 and Bmp4 expression during muscle regeneration and osteogenesis

(2013) M C Gozo et al.   CELL DEATH AND DIFFERENTIATION

Targeting integrins to promote bone formation and repair

(2013) Pierre J. Marie   Nature Reviews Endocrinology

BSTA Promotes mTORC2-Mediated Phosphorylation of Akt1 to Suppress Expression of FoxC2 and Stimulate Adipocyte Differentiation

(2013) Y. Yao et al.   Science Signaling

Dietary obesity-induced Egr-1 in adipocytes facilitates energy storage via suppression of FOXC2

(2013) Jifeng Zhang et al.   Scientific Reports

Identification of direct forkhead box O1 targets involved in palmitate-induced apoptosis in clonal insulin-secreting cells using chromatin immunoprecipitation coupled to DNA selection and ligation

(2012) H. Y. Lin et al.   DIABETOLOGIA

Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes

(2012) M. Skrzypski et al.   FEBS LETTERS

Embelin inhibits growth and induces apoptosis through the suppression of Akt/mTOR/S6K1 signaling cascades

(2012) Seong Won Kim et al.   PROSTATE

Next-generation Akt inhibitors provide greater specificity: effects on glucose metabolism in adipocytes

(2011) Shixiong Tan et al.   BIOCHEMICAL JOURNAL

The Adipocyte-Expressed Forkhead Transcription Factor Foxc2 Regulates Metabolism Through Altered Mitochondrial Function

(2011) M. E. Lidell et al.   DIABETES

Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling

(2011) Mitsunori Miyazaki et al.   JOURNAL OF PHYSIOLOGY-LONDON

Adipocyte mitochondrial genes and the forkhead factor FOXC2 are decreased in type 2 diabetes patients and normalized in response to rosiglitazone

(2011) Joakim Håkansson et al.   Diabetology & Metabolic Syndrome

ERK1/2 Phosphorylate Raptor to Promote Ras-dependent Activation of mTOR Complex 1 (mTORC1)

(2010) Audrey Carriere et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MK-2206, an Allosteric Akt Inhibitor, Enhances Antitumor Efficacy by Standard Chemotherapeutic Agents or Molecular Targeted Drugs In vitro and In vivo

(2010) H. Hirai et al.   MOLECULAR CANCER THERAPEUTICS

The Role of Mitochondria in Apoptosis

(2009) Chunxin Wang et al.   Annual Review of Genetics

Mesenchymal–epithelial transition in epithelial response to injury: the role of Foxc2

(2009) C Hader et al.   ONCOGENE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Inhibition of Foxo1 Protects Pancreatic Islet  -Cells Against Fatty Acid and Endoplasmic Reticulum Stress-Induced Apoptosis

(2008) S. C. Martinez et al.   DIABETES

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo

(2008) A. C. Minella et al.   GENES & DEVELOPMENT