Review
Clinical Neurology
Narat Srivali, Charat Thongprayoon, Supawit Tangpanithandee, Wisit Cheungpasitporn, Christine Won
Summary: This article conducted a systematic review to evaluate the efficacy of continuous positive airway pressure (CPAP) therapy in improving clinical outcomes in patients with chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) overlap syndrome. The results showed that CPAP therapy improved clinical outcomes, including COPD exacerbation, COPD-related hospitalization, and mortality. However, there were variations in the definitions of COPD and OSA across studies, and the definition of CPAP usage was not consistent. Further research is needed to establish the efficacy of CPAP therapy by standardizing the definition of COPD, OSA, and CPAP usage.
Article
Critical Care Medicine
R. Nisha Aurora, Mary R. Rooney, Dan Wang, Elizabeth Selvin, Naresh M. Punjabi
Summary: The use of PAP therapy for patients with type 2 diabetes and moderate-to-severe OSA did not improve glycemic control or variability overall. However, exploratory analyses suggested that PAP therapy may improve glucose variability in female participants. Post-dinner and bedtime glucose levels were higher in those who did not receive PAP therapy.
Article
Respiratory System
Vanessa Bironneau, Pierre Ingrand, Sandrine Pontier, Carmen Iamandi, Laurent Portel, Francis Martin, Anne Mallart, Lionel Lerousseau, Didier Alfandary, Virginie Levrat, Florence Portier, Renaud Tamisier, Frederic Goutorbe, Claudio Rabec, Francois Codron, Guy Auregan, Magalie Mercy, Valerie Attali, Frank Soyez, Claire Launois, Didier Recart, Marie-Francoise Vecchierini, Frederic Gagnadoux, Jean-Claude Meurice, REDIVARIUS Grp
Summary: The aim of this study was to evaluate the efficacy of CPAP used in fixed CPAP or APAP mode for the treatment of severe obstructive sleep apnoea (OSA) over a three-month period. The study found no difference in efficacy between the two modes, with similar rates of residual apnea hypopnea index (AHI) and adherence. Tolerance, quality of life, and blood pressure were also similar between the two groups.
Article
Critical Care Medicine
Jaejin An, Henry A. Glick, Amy M. Sawyer, Jessica Arguelles, Charles J. Bae, Brendan T. Keenan, Samuel T. Kuna, Greg Maislin, Diego R. Mazzotti, Allan I. Pack, Jiaxiao M. Shi, Alexa J. Watach, Dennis Hwang
Summary: This study investigated the association between adherence to positive airway pressure (PAP) therapy and healthcare costs in participants with obstructive sleep apnea (OSA) over a 3-year period. The results showed that higher adherence to PAP therapy was associated with significantly lower healthcare costs.
Article
Pediatrics
Arash Malakian, Mohammad Reza Aramesh, Mina Agahin, Masoud Dehdashtian
Summary: In this study, DUOPAP did not reduce the need for mechanical ventilation within the first 72 hours of birth compared to NCPAP. However, the duration of non-invasive ventilation, oxygen demand, need for multiple doses of surfactant, and length of stay in the DUOPAP group were less than those in the CPAP group.
Article
Biology
Wen-Te Liu, Huei-Tyng Huang, Hsin-Yi Hung, Shang-Yang Lin, Wen-Hua Hsu, Fang-Yu Lee, Yi-Chun Kuan, Yin-Tzu Lin, Chia-Rung Hsu, Marc Stettler, Chien-Ming Yang, Jieni Wang, Ping-Jung Duh, Kang-Yun Lee, Dean Wu, Hsin-Chien Lee, Jiunn-Horng Kang, Szu-Szu Lee, Hsiu-Jui Wong, Cheng-Yu Tsai, Arnab Majumdar
Summary: This study showed that continuous positive airway pressure (CPAP) treatment can alleviate symptoms of obstructive sleep apnea (OSA) and reduce the risk of neurodegenerative diseases. Both sleep quality scores and neurochemical biomarker levels significantly improved in patients treated with CPAP.
Article
Otorhinolaryngology
Hao Wu, Fang Fang, Yaxin Guo, Chan Wu, Yongxiang Wei
Summary: Nasal congestion is an independent predictor of PAP noncompliance, while younger patients with lower body mass index are more likely to have an unfavorable shift of PAP compliance. The severity of OSA affects initial and long-term adherence to PAP therapy.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2022)
Article
Clinical Neurology
Yeliz Celik, Erik Thunstrom, Patrick J. Strollo Jr, Yuksel Peker
Summary: The study showed that CPAP had no significant impact on anxiety in CAD patients with nonsleepy OSA. However, a trend of increased anxiety scores was observed in patients adhering to CPAP treatment at 3 months and 12 months, while patients who were non-adherent to CPAP showed a decrease in anxiety scores.
Article
Critical Care Medicine
Susanna S. S. Ng, Vincent W. S. Wong, Grace L. H. Wong, Winnie C. W. Chu, Tat-On Chan, Kin-Wang To, Fanny W. S. Ko, Ka-Pang Chan, David S. Hui
Summary: This study aimed to investigate the effects of autoadjusting CPAP versus subtherapeutic CPAP on NAFLD in patients with concomitant OSA, showing no significant differences in primary and secondary endpoints between the two treatment groups. Weight change correlated with changes in intrahepatic triglyceride and CAP, suggesting weight reduction through lifestyle modification may be beneficial for improving NAFLD.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Physiology
Fernando Vieira, Frank Silva Bezerra, Remi Coudroy, Annia Schreiber, Irene Telias, Sebastian Dubo, Giulia Cavalot, Sergio Martins Pereira, Thomas Piraino, Laurent Jean Brochard
Summary: High-flow nasal cannula (HFNC) generates positive airway pressure and reduces respiratory rate. These effects are more pronounced when the mouth is kept closed, leading to decreased respiratory workload. Increased resistance to breathing induces longer expiratory phase, which contributes to physiological benefits not observed with continuous positive airway pressure.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Erin K. Reilly, Maurits S. Boon, Swar Vimawala, Chandala Chitguppi, Jena Patel, Kira Murphy, Karl Doghramji, Gurston G. Nyquist, Marc R. Rosen, Mindy R. Rabinowitz, Colin T. Huntley
Summary: The study found that restarting CPAP on the first postoperative day is well-tolerated for patients undergoing septoplasty/turbinectomy or functional endoscopic sinus surgery for OSA. Quality of life and CPAP outcomes improved or remained stable postoperatively, without significant complications.
Article
Pediatrics
Meryl Vedrenne-Cloquet, Sonia Khirani, Lucie Griffon, Charlotte Collignon, Sylvain Renolleau, Brigitte Fauroux
Summary: NIPPV is more effective than CPAP in reducing respiratory effort in infants with severe acute bronchiolitis. Both clinically and physiologically, NIPPV can significantly reduce respiratory effort and improve other indicators compared to CPAP.
PEDIATRIC PULMONOLOGY
(2023)
Article
Medicine, General & Internal
Meseret Gebre, Kassa Haile, Trevor Duke, Md Tanveer Faruk, Mehnaz Kamal, Md Farhad Kabir, Md Fakhar Uddin, Muluye Shimelis, Bethelhem Solomon, Abebe Genetu Bayih, Alemseged Abdissa, Taye Tolera Balcha, Rahel Argaw, Asrat Demtse, Abate Yeshidenber, Abayneh Girma, Bitseat W. Haile, Tahmeed Ahmed, John D. Clemens, Mohammod Jobayer Chisti
Summary: This study aims to assess the effectiveness of BCPAP oxygen therapy compared to low-flow oxygen therapy in children hospitalized with severe pneumonia in Ethiopia. The findings will provide valuable data for addressing the standard of care in developing countries.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Elisa Ceriani, Annalisa Pitino, Dejan Radovanovic, Emanuele Salvi, Maddalena Matone, Thomas Teatini, Antonio Gidaro, Giovanni Tripepi, Pierachille Santus, Mercedes Gori, Chiara Cogliati
Summary: CPAP support can be a feasible therapeutic option for elderly patients with COVID-19, although its effectiveness is reduced in cases of severe respiratory impairment, high frailty, or delirium occurrence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Joyca Lacroix, Jan Tatousek, Niek Den Teuling, Thomas Visser, Charles Wells, Paul Wylie, Russell Rosenberg, Richard Bogan
Summary: This study assessed the effect of providing digitally generated personalized education and feedback on CPAP adherence and the additional effect of tailoring the style of the education and feedback to an individual's psychological profile. The results showed that personalized education and feedback can substantially increase CPAP adherence, but tailoring the style of the intervention to psychological profiles did not further increase adherence.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Pediatrics
Antonia Barcelo, Daniel Morell-Garcia, Caterina Ribot, Monica De la Pena, Jose Antonio Pena-Zarza, Alberto Alonso-Fernandez, Paloma Gimenez, Javier Pierola
Summary: This study found that vitamin D insufficiency and deficiency were common in children, and that there were significant associations between children's serum 25(OH)D levels and their parents' vitamin D status. Furthermore, an inverse association was observed between 25(OH)D levels and the severity of obstructive sleep apnea in children with deficient vitamin D levels. Children with insufficient and deficient vitamin D levels also tended to have a worse metabolic profile, highlighting the importance of strategies to improve their vitamin D status.
PEDIATRIC RESEARCH
(2022)
Article
Medicine, Research & Experimental
Lucia Pinilla, Ivan D. Benitez, Fernando Santamaria-Martos, Adriano Targa, Anna Moncusi-Moix, Mireia Dalmases, Olga Minguez, Maria Aguila, Mariona Jove, Joaquim Sol, Reinald Pamplona, Ferran Barbe, Manuel Sanchez-de-la-Torre
Summary: The study investigated the plasma metabolome and lipidome of patients with suspected OSA to identify potential biomarkers for diagnosis and understand the underlying mechanisms of the disease. Results showed a plasma profile comprising 33 metabolites in OSA patients, with a specific 4-metabolite signature providing high accuracy for OSA detection. CPAP treatment led to changes in 5 plasma metabolites affected by OSA, indicating a potential for personalized OSA management using blood-based biomarkers and suggesting adaptive mechanisms in response to OSA-induced hypoxia.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Peripheral Vascular Disease
Esther Sapina-Beltran, Ivan D. Benitez, Gerard Torres, Ana M. Fortuna-Gutierrez, Paola Ponte Marquez, Juan F. Masa, Luciano F. Drager, Mayara Cabrini, Miquel Felez, Susana Vazquez, Jorge Abad, Ch Lee, Francisco Garcia-Rio, Raquel Casitas, Olga Mediano, Sofia Romero Peralta, Dolores Martinez, Manuel Sanchez-de-la-Torre, Ferran Barbe, Mireia Dalmases
Summary: In patients with resistant hypertension, the blood pressure response to CPAP does not differ based on the blood pressure dipping pattern (dipper and nondipper), but may vary according to the presence of nocturnal hypertension.
HYPERTENSION RESEARCH
(2022)
Article
Medicine, General & Internal
Maria Martin-Vicente, Raquel Almansa, Isidoro Martinez, Ana P. Tedim, Elena Bustamante, Luis Tamayo, Cesar Aldecoa, Jose Manuel Gomez, Gloria Renedo, Jose Angel Berezo, Jamil Antonio Cedeno, Nuria Mamolar, Pablo Garcia Olivares, Ruben Herran-Monge, Ramon Cicuendez, Pedro Enriquez, Alicia Ortega, Noelia Jorge, Cristina Doncel, Amanda de la Fuente, Juan Bustamante-Munguira, Maria Jose Munoz-Gomez, Milagros Gonzalez-Rivera, Carolina Puertas, Vicente Mas, Monica Vazquez, Felipe Perez-Garcia, Jesus Rico-Feijoo, Silvia Martin, Anna Motos, Laia Fernandez-Barat, Jose Maria Eiros, Marta Dominguez-Gil, Ricard Ferrer, Ferran Barbe, Wysali Trapiello, David J. Kelvin, Jesus F. Bermejo-Martin, Salvador Resino, Antoni Torres
Summary: The study found that low levels of anti-SARS-CoV-2 S antibodies are associated with higher mortality in critical COVID-19 patients, while higher antibody levels are linked to reduced viral RNA-load in plasma and lower mortality risk.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Respiratory System
Miguel A. Martinez-Garcia, Manuel Sanchez-de-la-Torre, David P. White, Ali Azarbarzin
Summary: Conventional measures of OSA severity, such as AHI and ODI, have limitations in capturing the severity of OSA and its physiological consequences. The sleep apnea-specific hypoxic burden (HB), which measures the sum of individual areas under the oxygen desaturation curve, shows promise in identifying high-risk individuals with OSA. HB captures the depth and duration of OSA-related hypoxemia, providing important disease characterizing features not captured by conventional metrics.
ARCHIVOS DE BRONCONEUMOLOGIA
(2023)
Letter
Critical Care Medicine
Jessica Gonzalez, Ivan D. Benitez, Anna Motos, Antoni Torres, Ferran Barbe
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Clinical Neurology
Adriano D. S. Targa, Manuel Sanchez-de-la-Torre
SLEEP MEDICINE REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Albert Figueras Castilla, Maria A. Ballesteros Vizoso, Amanda Iglesias Coma, Antonia Barcelo, Jesus A. Barea-Mendoza, Paula Argente del Castillo, Begona Guardiola, Jon Perez-Barcena, Juan A. A. Llompart-Pou
Summary: The mechanisms of thyroid dysfunction in critically ill COVID-19 patients are not clear. This prospective study aimed to explore the correlation between thyroid response and inflammatory cytokines profile in critically ill COVID-19 patients. Seventy-eight patients were included in the study, and the correlation and regression analysis were performed to investigate the relationship between continuous variables. The study found weak correlation between thyroid stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4), and inflammatory cytokines at ICU admission, but an inversely correlation was found between fT4 and IL-10 at day 5.
Letter
Critical Care Medicine
Geoffroy Solelhac, Manuel Sanchez-de-la-Torre, Margaux Blanchard, Ferran Barbe, Frederic Gagnadoux, Raphael Heinzer
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Geoffroy Solelhac, Manuel Sanchez-de-la-Torre, Margaux Blanchard, Mathieu Berger, Camila Hirotsu, Theo Imler, Alicia Sanchez-de-la-Torre, Jose Haba-Rubio, Nicola Andrea Marchi, Virginie Bayon, Sebastien Bailly, Francois Goupil, Adrien Waeber, Gregory Heiniger, Thierry Pigeanne, Esther Gracia-Lavedan, Andrea Zapater, Jorge Abad, Estrella Ordax, Maria Jose Masdeu, Valentin Cabriada-Nuno, Carlos Egea, Sandra Van Den Broecke, Peter Vollenweider, Pedro Marques-Vidal, Julien Vaucher, Giulio Bernardi, Monica Betta, Francesca Siclari, Ferran Barbe, Frederic Gagnadoux, Raphael Heinzer
Summary: This study investigated the value of pulse wave amplitude drops (PWADs) as a biomarker of cardiovascular risk in patients with obstructive sleep apnea (OSA). The results showed that patients with a low PWAD index and OSA had a higher incidence of cardiovascular events compared to other groups.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Respiratory System
Manuel Sanchez-de-la-Torre, Esther Gracia-Lavedan, Ivan David Benitez, Andrea Zapater, Gerard Torres, Alicia Sanchez-de-la-Torre, Albina Aldoma, Jordi de Batlle, Adriano Targa, Jorge Abad, Joaquin Duran-Cantolla, Amaia Urrutia, Olga Mediano, Maria Jose Masdeu, Estrella Ordax-Carbajo, Juan Fernando Masa, Monica De la Pena, Merce Mayos, Ramon Coloma, Josep Maria Montserrat, Eusebi Chiner, Olga Minguez, Lydia Pascual, Anunciacion Cortijo, Dolores Martinez, Mireia Dalmases, Chi-Hang Lee, R. Doug McEvoy, Ferran Barbe
Summary: This study investigates the association between severe obstructive sleep apnea (OSA) and long-term blood pressure increase in patients with acute coronary syndrome (ACS), as well as the impact of continuous positive airway pressure (CPAP) adherence on blood pressure.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2022)
Article
Respiratory System
Marta Marin-Oto, David Sanz-Rubio, Fernando Santamaria-Martos, Ivan Benitez, Ana L. Simon, Marta Forner, Pablo Cubero, Ana Gil, Manuel Sanchez-de-laTorre, Ferran Barbe, Jose M. Marin
Summary: The study found that patients with hypoxia-related diseases (including COPD, OSA, and OSA-COPD overlap) had lower levels of sRAGE compared to healthy individuals. However, patients with OSA who received CPAP treatment, especially those with concurrent COPD, showed a significant increase in sRAGE levels.
RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Mario Henriquez-Beltran, Gonzalo Labarca, Igor Cigarroa, Daniel Enos, Jaime Lastra, Estefania Nova-Lamperti, Adriano Targa, Ferran Barbe
Summary: This study aimed to investigate the prevalence and severity of sleep disorders and circadian alterations in COVID-19 patients four months after the acute phase of the disease. The results showed that sleep quality was impaired in all three groups, with a high prevalence of unhealthy sleep and increased frequency of insomnia. The overall prevalence of obstructive sleep apnea was 60%, and changes in quality of life and circadian rest-activity pattern were observed in all three groups.
JORNAL BRASILEIRO DE PNEUMOLOGIA
(2022)
Article
Critical Care Medicine
Jessica Gonzalez, Ivan D. Benitez, David De Gonzalo-Calvo, Gerard Torres, Jordi de Batlle, Silvia Gomez, Anna Moncusi-Moix, Paola Carmona, Sally Santisteve, Aida Monge, Clara Gort-Paniello, Maria Zuil, Ramon Cabo-Gambin, Carlos Manzano Senra, Jose Javier Vengoechea Aragoncillo, Rafaela Vaca, Olga Minguez, Maria Aguilar, Ricard Ferrer, Adrian Ceccato, Laia Fernandez, Ana Motos, Jordi Riera, Rosario Menendez, Dario Garcia-Gasulla, Oscar Penuelas, Gonzalo Labarca, Jesus Caballero, Carme Barbera, Antoni Torres, Ferran Barbe
Summary: This study evaluated whether the delay in intubation after the first respiratory support is associated with mortality or pulmonary sequelae in patients receiving invasive mechanical ventilation (IMV) due to COVID-19. The results showed that the delay in intubation was associated with an increase in hospital mortality and worse pulmonary sequelae during follow-up.