Article
Pharmacology & Pharmacy
Yubing Dong, Yi Lin, Wanyu Liu, Wei Zhang, Yinong Jiang, Wei Song
Summary: The study investigated the lipid profile in hypertensive disorders of pregnancy (HDP) patients, finding significantly altered levels of plasma triglycerides, total cholesterol, LDL-C, and HDL-C compared to normotensive controls. ANP was shown to inhibit ABCA1 and ABCG1 expression at both mRNA and protein levels, leading to impaired cholesterol efflux, possibly explaining the decreased HDL-C levels in HDP patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Liv Tybjaerg Nordestgaard, Mette Christoffersen, Shoaib Afzal, Borge Gronne Nordestgaard, Anne Tybjaerg-Hansen, Ruth Frikke-Schmidt
Summary: Genetic variants in ABCA1 associated with high HDL cholesterol concentrations are also associated with higher risk of AMD, suggesting a role for ABCA1 in AMD pathogenesis.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hiromi Tsushima, Kazuyo Yamada, Daisuke Miyazawa, Takeshi Ohkubo, Makoto Michikawa, Sumiko Abe-Dohmae
Summary: Knockout mice for ABCA1, A7, and apoE showed differences in lipid concentrations, behavior, and responses to thermal stimuli compared to wild-type mice. ABCA1 knockout mice exhibited specific neural function roles and distinct physiological responses.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Fisheries
Simiao Yu, Xue Qiao, Ying Yang, Xiaoyu Gu, Wending Sun, Xiyang Liu, Dan Zhang, Lingling Wang, Linsheng Song
Summary: In this study, a homologue of ABCG2 named CgABCG2 was identified in Pacific oyster C. gigas. CgABCG2 was mainly distributed on the cell membrane of haemocytes and its mRNA expression level increased significantly after Vibrio splendidus stimulation. Interference of CgABCG2 expression led to reduced proliferation of haemocytes, down-regulation of hematopoiesis-related transcription factors, and arrest at the G0/G1 phase of the cell cycle. These findings suggest that CgABCG2 is involved in the proliferation of haemocytes in oyster C. gigas.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Hiromi Uekita, Hiroyasu Yamamoto, Ryu Niinaga, Noriko Yamane, Manami Yoshii, Keiko Yamauchi-Takihara, Shinji Kihara
Summary: The study found a correlation between serum Mac-2BP concentrations and clinical parameters related to metabolic syndrome, but the significance was not evident in multivariate analysis. IFN-gamma stimulation led to increased Mac-2BP and decreased ABCA1 and apo A-I mRNA concentrations in HepG2 cells.
CLINICA CHIMICA ACTA
(2021)
Article
Neurosciences
Min Zhu, Longfei Jia, Jianping Jia
Summary: The study identified miR-96-5p as the upstream miRNA for ABCA1, and inhibition of miR-96-5p in AD models could reduce A beta(42)/A beta(40) ratios by upregulating the expression of ABCA1, indicating an important role of miR-96-5p in regulating A beta content.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Anouar Hafiane, Ioanna Gianopoulos, Mary G. Sorci-Thomas, Stella S. Daskalopoulou
Summary: The primary function of HDL is to remove excess cellular free cholesterol and deliver it to the liver. Recent research has focused on the interaction between apoA-I and ABCA1 in HDL formation and its relevance in atherosclerotic cardiovascular disease. Understanding the key steps in HDL formation may have potential therapeutic implications for ASCVD management.
CURRENT OPINION IN LIPIDOLOGY
(2022)
Review
Chemistry, Medicinal
Meiao Tan, Jintong Ye, Min Zhao, Xuehong Ke, Keer Huang, Huabao Liu
Summary: Dysregulation of cholesterol metabolism poses high risks for NAFLD, dyslipidemia, and AS. Cholesterol transport is crucial for maintaining whole-body cholesterol homeostasis. Natural products and their derived molecules show potential in regulating cholesterol transport and could be therapeutic targets, although further high-quality studies are needed to confirm their clinical efficacies.
PHYTOTHERAPY RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Anouar Hafiane, Ioanna Gianopoulos, Mary G. Sorci-Thomas, Stella S. Daskalopoulou
Summary: The study found that adiponectin plays a protective role in cholesterol efflux, but the involvement of apoA-I residues in this process has not been studied. This study used macrophages and cell models to show that adiponectin requires specific residues of apoA-I and wild-type ABCA1 to restore cholesterol efflux. Adiponectin cannot rescue defective cholesterol efflux in apoA-I or ABCA1 mutant conditions, but it increases cholesterol efflux compared to apoA-I exposure alone in wild-type apoA-I conditions.
CELLULAR SIGNALLING
(2022)
Article
Plant Sciences
Fiza Liaquat, Muhammad Farooq Hussain Munis, Samiah Arif, Muhammad Aamir Manzoor, Urooj Haroon, Iftikhar Hussain Shah, Muhammad Ashraf, Hyun Seok Kim, Shengquan Che, Liu Qunlu
Summary: This study investigated the differential gene expression of Schima superba under Mn metal stress through transcriptomic analysis. The differentially expressed genes were found to be involved in defense, signaling pathways, oxidative burst, transcription factors, and stress responses. The results provide insights into the metal resistance mechanisms and contribute to the understanding of heavy metal tolerance and detoxification.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Yaolei Mi, Xue Cao, Xuewen Zhu, Weiqiang Chen, Xiangxiao Meng, Huihua Wan, Wei Sun, Sifan Wang, Shilin Chen
Summary: This study identified and characterized 113 ABC transporters in C. sativa, and proposed seven core transporters that may participate in cannabinoid transport. These candidate genes showed high correlation with cannabinoid biosynthetic pathway genes and content, and were highly expressed in cannabinoid biosynthesis and accumulation sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Samiksha Kukal, Debleena Guin, Chitra Rawat, Shivangi Bora, Manish Kumar Mishra, Priya Sharma, Priyanka Rani Paul, Neha Kanojia, Gurpreet Kaur Grewal, Shrikant Kukreti, Luciano Saso, Ritushree Kukreti
Summary: ABCG2 is a widely distributed protein in different cell types that plays a crucial role in maintaining cellular homeostasis and protecting tissues against xenobiotic insults, but its expression is influenced by various pathophysiological conditions. Therapeutic interventions should focus on regulating levels of ABCG2 rather than directly inhibiting its function to avoid serious side effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Peripheral Vascular Disease
Rui Lu, Takahiro Ishikawa, Mamoru Tanaka, Tomoe Tsuboi, Shinji Yokoyama
Summary: This study demonstrates that Zn++ can increase ABCA1 stability by enhancing calmodulin binding to ABCA1, leading to increased HDL biogenesis.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Solene Marie, Irene Hernandez-Lozano, Oliver Langer, Nicolas Tournier
Summary: Hepatocyte transporters play a crucial role in the hepatobiliary elimination of various substances, influenced by different pathophysiological conditions and specific drugs; Tc-99m-mebrofenin has been used for hepatobiliary scintigraphy for years, but the specific transporters controlling its liver kinetics have only recently been characterized; Pharmacokinetic modeling offers a translational method to study transporter-mediated drug interactions, providing insights into liver function as a biomarker.
JOURNAL OF NUCLEAR MEDICINE
(2021)
