Article
Food Science & Technology
Luanying He, Hui Weng, Qing Li, Guojun Shi, Xiuping Liu, Yushi Du, Jiakun Zheng, Wenhua Ling, Dongliang Wang
Summary: Lactucopicrin inhibits NF-kappa B activation in inflammed macrophages, reduces atherosclerotic plaque area and macrophage accumulation in mice, and does not affect serum lipid levels. It suggests that dietary supplementation with lactucopicrin is a promising strategy to inhibit atherosclerotic cardiovascular disease.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Immunology
Michal Konwerski, Agnieszka Gromadka, Adam Arendarczyk, Marta Koblowska, Roksana Iwanicka-Nowicka, Radoslaw Wilimski, Pawel Czub, Krzysztof Jerzy Filipiak, Piotr Hendzel, Piotr Zielenkiewicz, Grzegorz Opolski, Aleksandra Gasecka, Tomasz Mazurek
Summary: Perivascular release of inflammatory mediators may accelerate coronary lesion formation and contribute to plaque instability. The study revealed altered gene expression in PCAT of CAD patients, with upregulation of genes involved in inflammation and atherosclerosis, and downregulation of genes related to cardiac ischemia, remodeling, platelet function, and mitochondrial function. This suggests that genes in PCAT may play a role in CAD development and progression.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Hematology
Lasse G. Lorentzen, Gorm M. Hansen, Kasper K. Iversen, Henning Bundgaard, Michael J. Davies
Summary: Proteomic analysis of proteins captured on angioplasty balloons during percutaneous coronary interventions can provide information on coronary artery lesion protein profiles and distinguish between different types of coronary artery disease.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xin-Fang Leong, Ker Woon Choy, Aspalilah Alias
Summary: Atherosclerosis poses serious health problems and requires long-term medication for prevention. Thymoquinone, a bioactive compound from Nigella sativa L., shows potential anti-inflammatory effects in atherosclerosis, but further studies are needed to determine its effectiveness and safety.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Yongjie Jin, Eun Nim Kim, Ji Hee Lim, Hyung Duk Kim, Tae Hyun Ban, Chul Woo Yang, Cheol Whee Park, Bum Soon Choi
Summary: Cellular senescence and aging are closely related, with chronic inflammation playing a key role in cellular senescence. There is a positive feedback loop between LPAR1 and NF-kappa B, exacerbating the inflammatory response, and blocking LPAR1 may alleviate renal aging.
Article
Radiology, Nuclear Medicine & Medical Imaging
Turki B. Albacker, Abdulaziz M. Alhothali, Majid Alhomeidan, Amr A. Arafat, Khaled D. Algarni, Ahmed Eldemerdash, Bakir Bakir
Summary: This retrospective case-control study analyzed 405 patients who underwent primary isolated coronary artery bypass grafting. The study found that the only significant predictor of postoperative stroke was a history of preoperative stroke or transient ischemic attack. However, further prospective studies are needed to investigate the role of computed tomography in preventing postoperative stroke.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Rakan Nazer, Ali M. Albarrati
Summary: Early detection and personalized therapeutic strategies for severe atherosclerosis of the ascending aorta can effectively reduce athero-embolic brain injury, leading to better prognosis for patients undergoing coronary artery bypass grafting.
CLINICAL CARDIOLOGY
(2022)
Article
Cell Biology
Magdalena Kopytek, Michal Zabczyk, Piotr Mazur, Anetta Undas, Joanna Natorska
Summary: This study aimed to investigate the effect of LDL cholesterol on plasminogen activator inhibitor 1 (PAI-1) expression in aortic stenosis (AS). Results showed that PAI-1 expression in stenotic valves was correlated with lipid accumulation and AS severity, and co-expressed with nuclear factor-κB (NF-κB). In vitro experiments demonstrated that LDL stimulation increased PAI-1 levels and prolonged clot lysis time (CLT). Inhibition of PAI-1 activity or NF-κB pathway shortened CLT. These findings suggest that valvular PAI-1 overexpression driven by lipid accumulation contributes to hypofibrinolysis and AS severity in severe AS patients.
Article
Medicine, Research & Experimental
Kebin Xu, Ziyi Chen, Jialong Hou, Chenlin Dong, Chengge Shi, Linglin Gao, Zhixian Huang, Ge Shen, Te Wang, Yan Zhou
Summary: The study showed that Praeruptorin B, a major component in the roots of Peucedanum praeruptorum Dunn, could suppress osteoporosis and alleviate symptoms in patients. This finding offers potential for using Praeruptorin B in the treatment of osteoporosis in the future.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jin-Kyu Kang, Hyun-Kyu Kang, Chang-Gu Hyun
Summary: Spiramycin has anti-inflammatory effects by inhibiting the production of pro-inflammatory mediators and cytokines in macrophages, suggesting its potential as a candidate for topical anti-inflammatory agents.
Article
Medicine, General & Internal
Aysegul Idil Soylu, Ufuk Avcioglu, Fatih Uzunkaya, Korhan Soylu
Summary: The study evaluated mesenteric artery stenosis in patients with severe aortic stenosis scheduled for TAVI, finding a higher risk of MAS in AS patients.
JOURNAL OF INVESTIGATIVE MEDICINE
(2021)
Review
Medicine, Research & Experimental
Soudeh Ghafouri-Fard, Afete Abak, Faranak Fattahi, Bashdar M. Hussen, Zahra Bahroudi, Hamed Shoorei, Mohammad Taheri
Summary: NF-κB, a group of inducible transcription factors, interacts with miRNAs and lncRNAs to regulate gene expression, playing a crucial role in various diseases, including both neoplastic and nonneoplastic disorders.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Reza Mohebi, Cian P. McCarthy, Hanna K. Gaggin, Roland R. J. van Kimmenade, James L. Januzzi
Summary: Four distinct clusters of inflammatory biomarkers were identified, with higher levels of these biomarkers associated with increased risk of major adverse cardiovascular events. Individuals with high levels of inflammation markers were more likely to experience cardiovascular events.
AMERICAN HEART JOURNAL
(2022)
Article
Surgery
Akos Berczi, Miklos Vertes, Tin Dat Nguyen, Viktor Berczi, Balazs Nemes, Kalman Huttl, Edit Dosa
Summary: This study retrospectively analyzed 40 symptomatic patients with IIAS who underwent endovascular intervention. The results showed that endovascular therapy for IIAS is a safe and effective long-term treatment strategy, despite most patients having comorbidities such as hypertension and smoking. The overall complication rate was low.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Microbiology
Hye Won Lee, Yongwook Choi, Ah Ram Lee, Cheol-Hee Yoon, Kyun-Hwan Kim, Byeong-Sun Choi, Yong Kwang Park
Summary: This study found that HGF-induced ACK1 inhibits HBV replication at the transcriptional level through activation of the MAPK-HNF signaling pathway, leading to suppression of viral gene expression and transcription, as well as decreased viral enhancer activity.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Saeed Tofighi, Hamidreza Poorhosseini, Yaser Jenab, Mohammad Alidoosti, Mohammad Sadeghian, Mehdi Mehrani, Zhale Tabrizi, Parisa Hashemi
Summary: This study aimed to predict adverse clinical outcomes in STEMI patients treated with primary PCI using machine learning models. The results showed that the DRF and GBM models had the best performance in predicting major adverse cardiovascular events.
CLINICAL CARDIOLOGY
(2024)
