Review
Cardiac & Cardiovascular Systems
Barry J. Maron, Milind Y. Desai, Rick A. Nishimura, Paolo Spirito, Harry Rakowski, Jeffrey A. Towbin, Ethan J. Rowin, Martin S. Maron, Mark Sherrid
Summary: Hypertrophic cardiomyopathy (HCM) is a common global heart disease with complex phenotypic and genetic expression. Improvements in management strategies have led to better clinical outcomes. Reliable diagnosis with echocardiography and cardiac magnetic resonance, along with family screening and genetic analysis, play important roles in identifying patients and carriers.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiewei Lai, Huixin Tan, Jinliang Wang, Lei Ji, Jun Guo, Baoshi Han, Yajun Shi, Qianjin Feng, Wei Yang
Summary: Cardiovascular disease is a global public health problem, and intelligent diagnostic approaches are important in ECG analysis. Convenient wearable ECG devices can detect transient arrhythmias and enable intervention during continuous monitoring. The researchers collected a large dataset of wearable 12-lead ECGs and developed a model that can classify 60 ECG diagnostic terms using self-supervised learning.
NATURE COMMUNICATIONS
(2023)
Article
Computer Science, Artificial Intelligence
Annisa Darmawahyuni, Siti Nurmaini, Muhammad Naufal Rachmatullah, Bambang Tutuko, Ade Iriani Sapitri, Firdaus Firdaus, Ahmad Fansyuri, Aldi Predyansyah
Summary: This study proposes a deep learning-based model for the classification of ECG signals, automatically classifying 24 patterns of ECG signals based on rhythm and beat. With a ten-fold cross-validation scheme, the model achieves high accuracy in ECG rhythm classification and ECG beat classification.
PEERJ COMPUTER SCIENCE
(2022)
Review
Medicine, General & Internal
Annisa Dewi Nugrahani, Sidik Maulana, Kevin Dominique Tjandraprawira, Dhanny Primantara Johari Santoso, Dani Setiawan, Adhi Pribadi, Amillia Siddiq, Akhmad Yogi Pramatirta, Muhammad Alamsyah Aziz, Setyorini Irianti
Summary: This study systematically investigated and compared clinical factors and echocardiographic findings between women with PPCM, HPD-PPCM, and PPCM-only. The study found that HPD-PPCM was less likely to be associated with LV systolic dysfunction and LV wall thickness reduction, and may have a weaker response to pharmacological treatment. The findings of this study will guide the development of guidelines for the early detection and further management of women with PPCM and HPD-PPCM.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Wondale Tsega, Worku Awoke, Ashenafi Kibret Sendekie, Ephrem Mebratu Dagnew, Habtamu Bayih
Summary: This study assessed the utilization of ECG and Echo findings and outcomes of patients with MI in tertiary care hospitals in Northwest Ethiopia. The study found that the mortality rate of patients with MI was higher than in other reports, and there was a higher degree of inconsistency between ECG and Echo findings. The treatment of patients with MI should be tailored to their specific risk factors and causes.
Article
Medicine, General & Internal
Liang Kang, Yi-Hua Li, Rong Li, Qing-Min Chu
Summary: Apical hypertrophic cardiomyopathy (AHCM) is often missed on echocardiography but can be diagnosed by observing giant negative T waves (GNTs) in left-sided chest leads. By observing 3 cases, it was found that GNTs may appear earlier than cardiac hypertrophy, confirming the early predictive value of ECG for AHCM.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Article
Medicine, General & Internal
Denise Zaffalon, Efstathios Papatheodorou, Ahmed Merghani, Harshil Dhutia, Eleonora Moccia, Aneil Malhotra, Christopher J. Miles, Virginia Attard, Tessa Homfray, Rajan Sharma, Marta Gigli, Matteo Dal Ferro, Marco Merlo, Michael Papadakis, Gianfranco Sinagra, Sanjay Sharma, Gherardo Finocchiaro
Summary: This study investigated the role of electrocardiogram (ECG) in differentiating between physiological and pathological cardiac remodeling. The ECG was abnormal in a high percentage of patients with dilated cardiomyopathy (DCM), while it was usually normal in athletes with significant cardiac remodeling.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Review
Cell Biology
Teresa Campbell, Jesse Slone, Taosheng Huang
Summary: Mitochondria, responsible for generating energy in the form of ATP, have their own genetic material called mtDNA, along with nuclear genome, that determines their structure and function. Pathogenic variants in mtDNA or nuclear genome can cause mitochondrial disease, especially affecting high energy-demanding tissues like the heart. Mitochondrial cardiomyopathy, a result of genetic defects in either nDNA or mtDNA, manifests as hypertrophic or dilated cardiomyopathy and cardiac conduction defects. The complex pathophysiology of mitochondrial cardiomyopathy involves various abnormal processes such as deficient oxidative phosphorylation, ATP depletion, activation of alternative metabolic pathways, accumulation of reactive oxygen species, dysfunctional mitochondrial dynamics, abnormal calcium homeostasis, and mitochondrial iron overload.
Review
Biochemistry & Molecular Biology
Tom Kretzschmar, Jasmine M. F. Wu, P. Christian Schulze
Summary: Heart failure remains the most common cause of death in the industrialized world, and despite new therapeutic interventions, complete prevention of its development and progression is still not possible, highlighting the need for further research to understand the underlying mechanisms. This review provides a detailed overview of the contribution of impaired mitochondrial dynamics and energy homeostasis during heart failure progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Elissandro de Freitas Silva, Augusto Cardinalli-Neto, Luciano Vaccari Grassi, Paulo Roberto Nogueira, Reinaldo Bulgarelli Bestetti
Summary: Late potentials observed in the SAECG were independently predicted by right bundle branch block and left atrial diameter, while ventricular arrhythmias and reduced left ventricular ejection fraction were not associated with late potentials in patients with chronic Chagas heart disease.
JOURNAL OF ELECTROCARDIOLOGY
(2021)
Article
Medicine, General & Internal
P. Krisai, P. Hammerle, S. Blum, P. Meyre, S. Aeschbacher, P. Melchiorre-Mayer, O. Baretella, N. Rodondi, D. Conen, S. Osswald, M. Kuhne, C. S. Zuern
Summary: The presence of atrial fibrillation (AF) on a single surface ECG is significantly associated with increased risk of mortality and hospitalizations for congestive heart failure in AF patients, suggesting that these patients are a high-risk group that may benefit from intensified treatment.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Rui Zhang, Fan Zhao, Jing Wang, Yahong Qin, Tingting Wang, Ai-Ai Chu
Summary: Hypertrophic cardiomyopathy is a genetic heart disease, and left ventricular apical aneurysm is a rare subtype. Echocardiography-guided percutaneous intra-myocardial septal radiofrequency ablation can be an effective treatment for obstructive hypertrophic cardiomyopathy with left ventricular apical aneurysm.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Elisa Silvetti, Oreste Lanza, Fabiana Romeo, Annamaria Martino, Elisa Fedele, Chiara Lanzillo, Cinzia Crescenzi, Francesca Fanisio, Leonardo Calo
Summary: Cardiomyopathies are a group of diseases that affect the structure and function of the heart. Electrocardiogram (ECG) is a useful tool for diagnosing both symptomatic and asymptomatic individuals. Certain ECG findings, like inverted T waves in specific leads or low voltages, can be indicative of specific cardiomyopathies. Other non-specific findings, such as QRS fragmentation or changes in repolarization, can raise clinical suspicion and guide further imaging for a definitive diagnosis. These ECG alterations have prognostic value and can help in risk stratification. This review emphasizes the importance of ECG in the diagnostic workup of different cardiomyopathies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Alberto Aimo, Agnese Milandri, Andrea Barison, Andrea Pezzato, Paolo Morfino, Giuseppe Vergaro, Marco Merlo, Alessia Argiro, Iacopo Olivotto, Michele Emdin, Gherardo Finocchiaro, Gianfranco Sinagra, Perry Elliott, Claudio Rapezzi
Summary: Abnormalities in impulse generation and transmission are early signs of cardiac remodeling in cardiomyopathies, which can be detected by 12-lead electrocardiogram (ECG). Some findings suggest specific disorders, while others can orient towards a specific diagnosis in patients with specific phenotypes.
HEART FAILURE REVIEWS
(2023)
Article
Engineering, Electrical & Electronic
Zuhao Liu, Huan Wang, Yibo Gao, Shunchen Shi
Summary: This article introduces a new attention learning method based on NAS for detecting cardiovascular diseases, which outperforms existing methods in experiments.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Saeed Tofighi, Hamidreza Poorhosseini, Yaser Jenab, Mohammad Alidoosti, Mohammad Sadeghian, Mehdi Mehrani, Zhale Tabrizi, Parisa Hashemi
Summary: This study aimed to predict adverse clinical outcomes in STEMI patients treated with primary PCI using machine learning models. The results showed that the DRF and GBM models had the best performance in predicting major adverse cardiovascular events.
CLINICAL CARDIOLOGY
(2024)
