Article
Cell Biology
Zucheng Luo, Yujie Bian, Gang Zheng, Huijing Wang, Bingqian Yan, Wenting Su, Wei Dong, Zhichao Hu, Jian Ding, Anyuan Wang, Shi Li, Wei Fu, Jixin Xue
Summary: Random skin flaps are commonly used in plastic and reconstructive surgery for soft tissue defects, but issues with ischemia and necrosis limit their clinical application. Fibroblasts engineered to express modified mRNA encoding SDF-1 alpha have been found to improve vascularization and survival of therapeutic skin flaps. This approach shows promise for enhancing random skin flap regeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiazhou Li, Hao Chen, Lang Cai, Daimo Guo, Demao Zhang, Xuedong Zhou, Jing Xie
Summary: This study reveals that SDF-1 alpha promotes chondrocyte autophagy through the CXCR4/mTOR signaling axis, highlighting the importance of autophagy in the survival of chondrocytes in harsh environments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Shigeki Ito, Tsuyoshi Sato, Takahiro Maeta
Summary: The SDF-1 alpha/CXCR4 axis plays crucial roles in multiple myeloma, affecting various physiological processes of tumor cells such as proliferation, survival, invasion, dissemination, and drug resistance. This review highlights the pleiotropic role of this axis and discusses potential targeted therapies in multiple myeloma.
Article
Biochemistry & Molecular Biology
Kristian-Christos Ngamsri, Rizki A. Putri, Christoph Jans, Katharina Schindler, Anika Fuhr, Yi Zhang, Jutta Gamper-Tsigaras, Sabrina Ehnert, Franziska M. Konrad
Summary: This study identified the protective effects of CXCR4 and CXCR7 modulation on PNC and NET formation during acute inflammation, which were linked with Adora2b signaling. The inhibition of CXCR4 and CXCR7 reduced PNC formation in both blood and tissues, while no protective effects were observed in animals lacking Adora2b.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Hematology
Malgorzata Cebo, Kristina Dittrich, Xiaoqing Fu, Mailin C. Manke, Frederic Emschermann, Johannes Rheinlaender, Hendrik von Eysmondt, Nerea Ferreiros, Jessica Sudman, Alexander Witte, Lisann Pelzl, Oliver Borst, Tobias Geisler, Dominik Rath, Tamam Bakchoul, Meinrad Gawaz, Tilman E. Schaeffer, Michael Laemmerhofer, Madhumita Chatterjee
Summary: Platelet ACKR3/CXCR7 surface expression is enhanced in coronary artery disease (CAD) patients, and it influences the prognosis. This study shows that ACKR3/CXCR7 regulates thromboinflammatory response by impacting the platelet lipidome. The findings suggest that ACKR3/CXCR7 may be a potential therapeutic target for cardiovascular diseases and CAD.
Article
Pathology
Hailing Tang, Qianfa Long, Kun Zhuang, Kun Han, Xin Zhang, Hanqing Guo, Xiaolan Lu
Summary: RB1 was downregulated in gastric cancer cell lines, and overexpression of RB1 enhanced chemosensitivity to 5-FU in gastric cancer cells by regulating cell autophagy via the SDF-1/CXCR4 pathway. RB1 may serve as a promising therapeutic target in gastric cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Engineering, Environmental
Dongdong Xiao, Mengbo Yang, Ming Zhang, Liduo Rong, Yamei Wang, Huan Cheng, Xiaofeng Sui, Soren Paludan Sheikh, Mujun Lu
Summary: The tri-layer hydrogel scaffold, consisting of bladder acellular matrix graft-alginate di-aldehydegelatin hydrogel-silk mesh (BAMG-HS), shows excellent mechanical and biodegradable properties, promoting angiogenesis and bladder morphological regeneration, as well as facilitating functional restoration without fibrosis or inflammation. Human ASCs-EVs activate the bladder CXCR4/SDF-1 alpha pathway, enhancing proliferation, invasiveness, and tube-like structure formation of HUVEC, ultimately increasing VEGF secretion through ERK1/2 phosphorylation.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Neurosciences
Guannan Jiang, Xiang Li, Meirong Liu, Haiying Li, Haitao Shen, Juan Liao, Wanchun You, Qi Fang, Gang Chen
Summary: The study investigates the protective effect of Remote Ischemic Postconditioning (RIPostC) on rats after ischemic stroke. RIPostC was found to improve neurological recovery and brain injury in rats by upregulating the expression levels of CXCR4 and SDF-1 alpha. The neuroprotective effect of RIPostC was diminished when the SDF-1 alpha/CXCR4 signaling axis was inhibited. RIPostC can be used as an intervention strategy for stroke, and the SDF-1 alpha/CXCR4 signaling axis can be a potential target for intervention.
BRAIN RESEARCH BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Martyna Parol-Kulczyk, Arkadiusz Gzil, Joanna Ligmanowska, Dariusz Grzanka
Summary: The tendency for chronic inflammation to convert into malignancy is a characteristic trait of tumors that promotes their progression to the metastatic stage. Inflammatory cells within the tumor communicate with cancer cells and become cells that support tumor growth. Epithelial-mesenchymal transition (EMT) is a program that allows malignant cells to switch into a metastatic form, enabling them to loosen cell-cell adhesion and enhance migratory and invasive features. Tumor cells that undergo EMT become more aggressive and resistant to apoptosis. Furthermore, malignant cells can stimulate the production of proinflammatory factors through the EMT program. Chronic inflammation is responsible for inducing EMT in malignancies. Developing tumors induce inflammatory responses by releasing cytokines, chemokines, and growth factors, which recruit populations of infiltrating immune cells to the tumor microenvironment. This inflammatory reaction potentially exerts tumor control but can also be intercepted by the tumor to stimulate its own development towards a metastatic form. Our study confirmed that the SDF-1 chemokine and its receptors, CXCR4 and CXCR7, may contribute to the initiation of metastasis formation and the EMT process.
Article
Cell & Tissue Engineering
Yan Wu, Yuan-jin Li, Liu-liu Shi, Yun Liu, Yan Wang, Xin Bao, Wei Xu, Lu-yuan Yao, Magdaleena Naemi Mbadhi, Long Chen, Shan Li, Xing-yuan Li, Zhi-feng Zhang, Sen Zhao, Ruo-nan Zhang, Shi-You Chen, Jing-xuan Zhang, Jun-ming Tang
Summary: The study discovered that Meox1 expression increased time-dependently during neointimal formation after vascular injury, with simultaneous increases in the adventitia, media, and neointima. Sca-1+ progenitor cells in the vascular adventitia also increased in a time-dependent manner and peaked on the 7th day after injury, but this effect was abolished by Meox1 knockdown with shRNA.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Xuehui Ma, Zhengbo Zhang, Xiayu Qin, Lingjing Kong, Wen Zhu, Lingzhi Xu, Xin Zhou
Summary: CAG is an essential process in the development of gastric cancer. Timely diagnosis, treatment, and monitoring of CAG to identify individuals at risk of gastric cancer is an effective way to prevent its occurrence. Curcumol, the main active component in Fuzheng Huowei Decoction, plays an important role in treating CAG and gastric cancer. This study investigated the effects of Curcumol on CAG model, gastric cancer cells, and nude mice. The results showed that Curcumol not only reduced the expressions of VEGF, SDF-1 alpha, CXCR4, and CD34 in the CAG model, but also inhibited the activity, migration, and invasion of gastric cancer cells and induced their apoptosis. However, the inhibitory effects of Curcumol were reversed when SDF-1 alpha was overexpressed. Overall, Curcumol effectively protects gastric tissues and suppresses the viability of gastric cancer cells through downregulating SDF-1 alpha/CXCR4/VEGF expression.
JOURNAL OF ONCOLOGY
(2022)
Article
Clinical Neurology
Yazhou Yan, Jiachao Xiong, Fengfeng Xu, Chuanchuan Wang, Zhangwei Zeng, Haishuang Tang, Zhiwen Lu, Qinghai Huang
Summary: This study investigated the role of the SDF-1 alpha/CXCR4 pathway in the development of intracranial aneurysm induced by hemodynamic forces. The results suggested that abnormal hemodynamics could activate this signaling pathway to induce the phenotypic transformation of vascular smooth muscle cells, leading to aneurysm formation.
TRANSLATIONAL STROKE RESEARCH
(2022)
Article
Cell Biology
Fatemeh Salimian, Mohammad Nabiuni, Ensieh Salehghamari
Summary: This study investigated the effects of melittin on the migration and metastasis of EGF-induced MDA-MB-231 cells, and found that melittin can reduce cell migration and invasion by suppressing the SDF-1 alpha/CXCR4 signaling pathway.
Article
Oncology
Xiang Li, Zitao Li, Caijuan Li, Yi Fang, Gaosen Zhang, Yudie Yan, Xiaodi Zhao, Xiaole Song, Zhen Zhang
Summary: The study reveals that miRNA-524-5p/CXCR7 axis regulates angiogenesis in colon cancer cells through AKT and ERK pathways, affecting cell proliferation, migration, and angiogenesis.
JOURNAL OF ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Junfei Gu, Ruolan Sun, Qiaohan Wang, Fuyan Liu, Decai Tang, Xiangwei Chang
Summary: The herbal drug pair ACE can effectively suppress colon cancer progression through modification of gut microbiota, repairing intestinal barrier damage.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Genetics & Heredity
Jochen Bauer, Melanie Rothley, Anja Schmaus, Luca Quagliata, Markus Ehret, Moritz Biskup, Veronique Orian-Rousseau, David G. Jackson, Ronald J. Pettis, Alfred Harvey, Stefan Braese, Wilko Thiele, Jonathan P. Sleeman
JOURNAL OF MOLECULAR MEDICINE-JMM
(2018)
Editorial Material
Oncology
Jonathan P. Sleeman
CLINICAL & EXPERIMENTAL METASTASIS
(2019)
Article
Oncology
Maren Voglstaetter, Andreas R. Thomsen, Jerome Nouvel, Arend Koch, Paul Jank, Elena Grueso Navarro, Tanja Gainey-Schleicher, Richa Khanduri, Andrea Gross, Florian Rossner, Carina Blaue, Clemens M. Franz, Marina Veil, Gerhard Puetz, Andreas Hippe, Jochen Dindorf, Jubin Kashef, Wilko Thiele, Bernhard Homey, Celine Greco, Claude Boucheix, Andreas Baur, Thalia Erbes, Cornelius F. Waller, Marie Follo, Ghamartaj Hossein, Christine Sers, Jonathan Sleeman, Irina Nazarenko
JOURNAL OF PATHOLOGY
(2019)
Article
Genetics & Heredity
Caroline Schreiber, Supriya Saraswati, Shannon Harkins, Annette Gruber, Natascha Cremers, Wilko Thiele, Melanie Rothley, Diana Plaumann, Claudia Korn, Olivier Armant, Hellmut G. Augustin, Jonathan P. Sleeman
Article
Veterinary Sciences
Wilko Thiele, Lenka Kyjacova, Almut Koehler, Jonathan P. Sleeman
LABORATORY ANIMALS
(2020)
Review
Oncology
Amelia Foss, Leonel Munoz-Sagredo, Jonathan Sleeman, Wilko Thiele
CLINICAL & EXPERIMENTAL METASTASIS
(2020)
Editorial Material
Oncology
Joerg Haier, Jonathan Sleeman, Juergen Schaefers
CLINICAL & EXPERIMENTAL METASTASIS
(2019)
Article
Oncology
Nicole Grau, Sandra D. Scherer, Melanie Rothley, Sven Rosswag, Wilko Thiele, Nikolas H. Stoecklein, Natascha Cremers, Sonja Thaler, Boyan K. Garvalov, Jonathan P. Sleeman
INTERNATIONAL JOURNAL OF CANCER
(2020)
Editorial Material
Oncology
Joerg Haier, Jonathan Sleeman, Juergen Schaefers
CLINICAL & EXPERIMENTAL METASTASIS
(2020)
Correction
Multidisciplinary Sciences
Ruo-Lin Wu, Georg Sedlmeier, Lenka Kyjacova, Anja Schmaus, Julia Philipp, Wilko Thiele, Boyan K. Garvalov, Jonathan P. Sleeman
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Sofia Spataro, Concetta Guerra, Andrea Cavalli, Jacopo Sgrignani, Jonathan Sleeman, Lina Poulain, Andreas Boland, Leonardo Scapozza, Solange Moll, Marco Prunotto
Summary: CEMIP, also known as KIAA1199 or HYBID, is a protein involved in the depolymerization of hyaluronic acid and has been shown to play a key role in tumor progression and various inflammatory diseases. Despite its association with these diseases, the biology of CEMIP remains elusive. This review article summarizes the scientific evidence regarding its structure, function, and expression, aiming to shed light on the protein's role in inflammation-related conditions.
Article
Oncology
Cristina L. Cotarelo, Arno Schad, Marcus Schmidt, Arnd Hoenig, Jonathan P. Sleeman, Sonja Thaler
Summary: Oncogene-induced senescence can prevent carcinogenesis by arresting cells at risk of malignant transformation. However, recent findings suggest that senescent cells may promote tumor growth and metastatic progression through the senescence-associated secretory phenotype (SASP). In patients with breast cancer, similarities were observed between primary tumors and their corresponding metastases, indicating a potential role for senescent tumor cells in metastatic progression. Targeting senescent tumor cells with anti-senescent drugs may represent a novel approach for cancer treatment.
Article
Biochemistry & Molecular Biology
Rafael Saup, Nidhi Nair, Jingyi Shen, Anja Schmaus, Wilko Thiele, Boyan K. Garvalov, Jonathan P. Sleeman
Summary: The role of circulating osteopontin (cOPN) in melanoma progression was studied. It was found that increased cOPN promotes primary tumor growth but does not significantly affect spontaneous metastasis of melanoma cells to lymph nodes or lungs.
Article
Biotechnology & Applied Microbiology
Florian Falkner, Simon Andreas Mayer, Benjamin Thomas, Sarah Onon Zimmermann, Sonja Walter, Patrick Heimel, Wilko Thiele, Jonathan Paul Sleeman, Amir Khosrow Bigdeli, Herbert Kiss, Bruno Karl Podesser, Ulrich Kneser, Helga Bergmeister, Karl Heinrich Schneider
Summary: This study evaluated the use of decellularized submillimeter vascular grafts from the human placenta for vascular replacement. The grafts were modified to prevent thrombotic events and implanted into rats for evaluation. The grafts showed a patency rate of 71% and induced no immunological responses, indicating their potential for use as super-microsurgical vascular replacements.
BIOENGINEERING-BASEL
(2023)
Article
Multidisciplinary Sciences
Michael Albrecht, Carsten Sticht, Tabea Wagner, Steffen A. Hettler, Carolina De la Torre, Jiedong Qiu, Norbert Gretz, Thomas Albrecht, Benito Yard, Jonathan P. Sleeman, Boyan K. Garvalov
Summary: In this study, a co-culture system was used to investigate the effects of high glucose and methylglyoxal on gene expression in glomerular endothelial cells (GECs) and podocytes. The results showed that these metabolic factors have distinct effects on the two cell types, and the interaction between GECs and podocytes plays a central role in regulating these responses.
SCIENTIFIC REPORTS
(2023)