4.7 Editorial Material

Stearoyl Co-A Desaturase 1 as a ccRCC Therapeutic Target: Death by Stress

Journal

CLINICAL CANCER RESEARCH
Volume 19, Issue 12, Pages 3111-3113

Publisher

AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1078-0432.CCR-13-0800

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Funding

  1. NIH [R01 CA142794]
  2. AACR-Kure It Grant for Kidney Cancer Research

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There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC. (C)2013 AACR.

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