Review
Oncology
Ke Wu, Juan Tan, Chao Yang
Summary: Neuroblastoma (NB) is the most common solid malignant tumor in children, accounting for 15% of childhood cancer mortality. Non-coding RNA plays an important role in NB pathogenesis. Abnormal regulation of circRNA expression, a newly identified non-coding RNA, is involved in the tumorigenesis of various tumors, including NB. It primarily regulates the expression of miRNA target genes by acting as a miRNA sponge. Clinical evidence suggests that certain circRNAs are associated with NB prognosis and clinical features, making them potential biomarkers or therapeutic targets. This review focuses on circRNAs that have demonstrated a role in NB.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Luka Roskar, Irena Roskar, Tea Lanisnik Rizner, Spela Smrkolj
Summary: Endometrial cancer is the most common gynecological cancer in developed countries, requiring invasive evaluation and surgery. Angiogenesis plays a key role in cancer growth, and understanding the characteristics of angiogenic factors can aid in early diagnosis and personalized therapy.
Article
Engineering, Electrical & Electronic
Hang Zou, Chao Zhang, Samson Lasaulce, Lucas Saludjian, H. Vincent Poor
Summary: This paper discusses the problem of executing a task from a quantized version of the information source. The task is modeled by minimizing a general goal function with quantized parameters. The paper shows how to design a quantizer to minimize the gap between the quantized version and the optimal result. The analysis provides quantization strategies and allows a practical algorithm to be designed.
IEEE JOURNAL ON SELECTED AREAS IN COMMUNICATIONS
(2023)
Review
Oncology
Gillianne G. Y. Lai, Robin Guo, Alexander Drilon, Daniel Shao Weng Tan
Summary: Dysregulated MET signaling plays an important role in lung oncogenesis. MET overexpression, gene amplification, or mutation can all lead to MET dysregulation. METex14 is a reliable predictor of response to selective MET tyrosine kinase inhibitors (TKIs), and MET amplification is associated with the response to MET-TKIs. Therefore, the detection methods for METex14, MET amplification, and MET overexpression are crucial, but there are challenges and evidence gaps in their clinical application.
CANCER TREATMENT REVIEWS
(2022)
Review
Oncology
Elizabeth Ahern, Ben J. Solomon, Rina Hui, Nick Pavlakis, Ken O'Byrne, Brett G. M. Hughes
Summary: Neoadjuvant therapies, including immune checkpoint inhibitors, show promise in the treatment of non-small cell lung cancer (NSCLC); however, challenges remain in defining optimal treatment combinations, validating biomarkers, and timing of surgery.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Polymer Science
Sheng-Lin Qiao, Muhetaerjiang Mamuti, An Hong-Wei, Hao Wang
Summary: This review highlights the construction and applications of in vivo thermoresponsive polymer assemblies. The authors provide an overview of the basic building blocks for constructing these assemblies and review recent advances in methods for building them in vitro, with a focus on their relevance to in vivo self-assembly. The review also emphasizes the key techniques and advantages of in vivo self-assembled thermoresponsive materials.
PROGRESS IN POLYMER SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Xujun Feng, Yanxia Hu, Lingling Cao, Liangle Liu
Summary: Tracheal tissue engineering is a challenging medical technology aimed at promoting tracheal replacement therapy through the use of biomaterials. This review critically evaluates the development history, materials used, and future research directions in tracheal tissue engineering, providing valuable insights for interdisciplinary exchange between clinical medicine, tissue engineering technology, and biomaterials.
APPLIED MATERIALS TODAY
(2023)
Article
Oncology
Miok Kim, Yong Ki Min, Jinho Jang, Hyejin Park, Semin Lee, Chang Hoon Lee
Summary: This study reveals the distinct immune modulation effects of CD73 inhibition compared to PD-1 blockade, suggesting that AB680 may serve as a novel anticancer immunotherapy for CRC with potential synergistic effects when combined with PD-1 blockers.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Pharmacology & Pharmacy
Jingtao Chen, Chao Niu, Ning Yang, Chunyan Liu, Shan-shan Zou, Shan Zhu
Summary: Liver cancer is a common malignancy, with high morbidity and mortality. Despite progress in treatment, the overall survival rate of patients has not significantly improved. This review highlights the importance of identifying specific liver cancer biomarkers for early screening, accurate diagnosis, prognosis, and prevention of tumor progression. It also discusses the latest research progress and potential applications in biomarker discovery.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Health Care Sciences & Services
Kim Tenfelde, Nadine Bol, Guus G. Schoonman, Jan Erik H. Bunt, Marjolijn L. Antheunis
Summary: The study found that patients were generally satisfied with video consultations, with factors such as experiencing fewer technical issues, having positive attitudes towards online communication, valuing reduced travel time, and being satisfied with physicians' communication contributing to higher satisfaction levels.
Article
Engineering, Multidisciplinary
Rafael M. Lins, Gabriela M. Fonseca, Felicio B. Barros
Summary: An efficient improvement for calculating Stress Intensity Factors (SIFs) is proposed for two-dimensional fracture mechanics problems, which significantly improves the accuracy and ensures path independence.
INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN ENGINEERING
(2023)
Article
Oncology
Wei Guo, Tao Zhang, Runze Li, Xiaoxi Chen, Jiaohui Pang, Hua Bao, Xue Wu, Yang Shao, Bin Qiu, Shugeng Gao, Jie He
Summary: Locoregional recurrence is a high-risk factor for poor prognosis in NSCLC, and its associated genomic biomarkers have been inadequately studied. This study identified genomic biomarkers from tumor and ctDNA samples that showed promising prognostic value for patients with locoregional recurrence only.
Article
Polymer Science
Qi Sun, Zhenzhen Yang, Xianrong Qi
Summary: This article summarizes the advantages and challenges of polymer-protein systems in cancer therapy, presents the key considerations in designing polymer-protein systems, and summarizes the development of hybrid polymer-protein systems in cancer therapy over the past decades. Furthermore, it exemplifies the challenges for hybrid polymer-protein systems in cancer therapy and discusses the future perspectives of the field.
Article
Biochemistry & Molecular Biology
Arnaud Bayle, Laila Belcaid, Lola-Jade Palmieri, Diego Teysonneau, Sophie Cousin, Mariella Spalato-Ceruso, Mihaela Aldea, Damien Vasseur, Melissa Alame, Laura Blouin, Isabelle Soubeyran, Claudio Nicotra, Maud Ngocamus, Antoine Hollebecque, Yohann Loriot, Benjamin Besse, Ludovic Lacroix, Etienne Rouleau, Fabrice Barlesi, Fabrice Andre, Antoine Italiano
Summary: Despite the effectiveness of targeted therapies for solid tumors, acquired resistance remains a challenge. Through analyzing circulating tumor DNA, we found that up to 34% of patients treated with targeted therapies exhibited emerging alterations associated with secondary resistance, with up to 14% of patients showing polyclonal resistance. These alterations were associated with significantly shorter overall survival in certain tumor types.
Review
Medicine, General & Internal
Wang-Lin Duan, Li-Ning Zhang, Raghvendra Bohara, Sergio Martin-Saldana, Fei Yang, Yi-Yang Zhao, Yong Xie, Ya-Zhong Bu, Abhay Pandit
Summary: This review summarizes the advances in using adhesive hydrogel for osteoarthritis (OA) treatment, including commonly used hydrogels with their adhesion mechanisms and components, as well as bioactive therapeutic strategies. By presenting an interdisciplinary perspective, this review aims to provide a comprehensive insight for designing novel bioadhesive systems for OA therapy.
MILITARY MEDICAL RESEARCH
(2023)
Review
Oncology
Sunil S. Badve, Frederique Penault-Llorca, Jorge S. Reis-Filho, Regula Deurloo, Kalliopi P. Siziopikou, Corrado D'Arrigo, Giuseppe Viale
Summary: Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer. Increased tumor-infiltrating lymphocyte counts have been found to be prognostic for survival in TNBC. Anti-PD-L1 and anti-PD-1 antibodies have been approved for the treatment of TNBC, and PD-L1 testing is becoming increasingly important in guiding treatment options.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Rafael Caparica, Yaohua Ma, Claudia De Angelis, Francois Richard, Christine Desmedt, Ahmad Awada, Martine Piccart, Edith A. Perez, Alvaro Moreno-Aspitia, Sunil Badve, E. Aubrey Thompson, Evandro de Azambuja
Summary: In this post-hoc analysis of the NCCTG-N9831 trial, a high expression of the beta 2AR gene (ADRB2) was associated with longer disease-free survival and identified patients who benefited from adjuvant trastuzumab in HER2-positive breast cancer.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A. Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice Andre, Carsten Denkert, Martine Piccart, Elvire Roblin, Stefan Michiels
Summary: The importance of integrating biomarkers such as TILs into the TNM staging system for TNBC has been emphasized in the AJCC 8th Edition. Studies show that TILs can significantly influence the traditional pathological staging, suggesting that considering TILs in addition to stage can lead to better outcomes for TNBC patients.
Article
Oncology
Milan Radovich, Jeffrey P. Solzak, Chao J. Wang, Bradley A. Hancock, Sunil Badve, Sandra K. Althouse, Steven M. Bray, Anna Maria V. Storniolo, Tarah J. Ballinger, Bryan P. Schneider, Kathy D. Miller
Summary: The combination of gedatolisib and cofetuzumab pelidotin, targeting both the PI3K and Wnt pathways, demonstrates promising clinical activity in metastatic TNBC. This phase I clinical trial shows that the treatment is well tolerated and has potential efficacy in inhibiting disease progression.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, Research & Experimental
Candace C. Liu, Marc Bosse, Alex Kong, Adam Kagel, Robert Kinders, Stephen M. Hewitt, Sushama Varma, Matt van de Rijn, Stanislaw H. Nowak, Sean C. Bendall, Michael Angelo
Summary: The study validated the use of MIBI-TOF for imaging proteins in human tissue and compared it to traditional immunohistochemistry methods. The results showed that MIBI-TOF can generate consistent and quantitative annotations of clinically relevant cell states and provide a scalable benchmark for multiplexed immunohistochemistry approaches.
LABORATORY INVESTIGATION
(2022)
Article
Medicine, Research & Experimental
Sandeep K. Singhal, Jung S. Byun, Tingfen Yan, Ryan Yancey, Ambar Caban, Sara Gil Hernandez, Sediqua Bufford, Stephen M. Hewitt, Joy Winfield, Jaya Pradhan, Vesco Mustkov, Jasmine A. McDonald, Eliseo J. Perez-Stable, Anna Maria Napoles, Nasreen Vohra, Adriana De Siervi, Clayton Yates, Melissa B. Davis, Mei Yang, Yien Che Tsai, Allan M. Weissman, Kevin Gardner
Summary: Women of African ancestry have higher rates of breast cancer mortality, and differences in tumor biology may play a role in these disparities. The protein gp78, found in patient breast cancer cells, is associated with poor survival outcomes in both ER+ and ER- tumors. Breast cancers with high levels of gp78 are enriched in gene expression pathways related to cell cycle, metabolism, signaling, and stress response. Gp78 protein is an independent predictor of poor outcomes in women of African ancestry, and gene expression signatures stratified by gp78 expression are strong predictors of recurrence and treatment response.
Article
Oncology
Sherry X. Yang, Stephen M. Hewitt, John Yu
Summary: The role of lymph node involvement and tumor size in metastatic disease, including breast cancer, is examined in this study. The findings suggest that nodal involvement and T stage are independent risk factors for mortality in patients with de novo metastatic breast cancer. The study also highlights the significance of positive lymph node count, tumor size, and chest wall involvement in breast cancer-specific mortality. These findings have important implications for the management and treatment of metastatic breast cancer patients.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Lan Zheng, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The nonsurgical management of ductal carcinoma in situ (DCIS) is controversial with limited understanding of its long-term consequences. This study aimed to assess the risk of upstaging to invasive carcinoma and ipsilateral breast cancer events in patients eligible for nonsurgical management trials. The results showed that these patients had a significantly high risk of developing ipsilateral breast events within 5 years of diagnosis, indicating the need for better selection criteria to identify patients at very low risk for the development of invasive breast cancer (IBC).
Article
Pathology
Balazs Acs, Samuel C. Y. Leung, Kelley M. Kidwell, Indu Arun, Renaldas Augulis, Sunil S. Badve, Yalai Bai, Anita L. Bane, John M. S. Bartlett, Jane Bayani, Gilbert Bigras, Annika Blank, Henk Buikema, Martin C. Chang, Robin L. Dietz, Andrew Dodson, Susan Fineberg, Cornelia M. Focke, Dongxia Gao, Allen M. Gown, Carolina Gutierrez, Johan Hartman, Zuzana Kos, Anne-Vibeke Laenkholm, Arvydas Laurinavicius, Richard M. Levenson, Rustin Mahboubi-Ardakani, Mauro G. Mastropasqua, Sharon Nofech-Mozes, C. Kent Osborne, Frederique M. Penault-Llorca, Tammy Piper, Mary Anne Quintayo, Tilman T. Rau, Stefan Reinhard, Stephanie Robertson, Roberto Salgado, Tomoharu Sugie, Bert van der Vegt, Giuseppe Viale, Lila A. Zabaglo, Daniel F. Hayes, Mitch Dowsett, Torsten O. Nielsen, David L. Rimm
Summary: This study demonstrates certain comparability differences between core biopsy samples and corresponding resection specimens in Ki67 measurement, likely due to pre-analytical factors. Therefore, Ki67 immunohistochemistry should be tested on core biopsy samples as a priority to better reflect the biological status of the tumor.
Article
Oncology
Sunil S. Badve, Sanghee Cho, Xiaoyu Lu, Sha Cao, Soumya Ghose, Aye Aye Thike, Puay Hoon Tan, Idris Tolgay Ocal, Daniele Generali, Fabrizio Zanconati, Adrian L. Harris, Fiona Ginty, Yesim Gokmen-Polar
Summary: The study investigated the prognostic role of tumor-infiltrating lymphocytes (TILs) in ductal carcinoma in situ (DCIS) in multi-national cohorts from Asian and European women. It found that older women with circumferential TILs were less likely to develop second breast cancer events (BCE) at a 5-year follow-up. The spatial arrangement of TILs may serve as a better prognostic indicator in DCIS cases.
Article
Cell Biology
Kyungeun Kim, Kris Ylaya, Candice Perry, Mi-Yeon Lee, Jeong Won Kim, Joon-Yong Chung, Stephen M. Hewitt
Summary: Water is a crucial factor for protein and RNA degradation in stored tissue sections, and storage conditions can affect the expression of certain key proteins and RNA integrity in breast tissue.
BIOPRESERVATION AND BIOBANKING
(2023)
Article
Multidisciplinary Sciences
Lichun Ma, Sophia Heinrich, Limin Wang, Friederike L. Keggenhoff, Subreen Khatib, Marshonna Forgues, Michael Kelly, Stephen M. Hewitt, Areeba Saif, Jonathan M. Hernandez, Donna Mabry, Roman Kloeckner, Tim F. Greten, Jittiporn Chaisaingmongkol, Mathuros Ruchirawat, Jens U. Marquardt, Xin Wei Wang
Summary: Intratumor heterogeneity arises from the evolution of tumor cells and their interactions with the tumor microenvironment. This study uses single-cell RNA sequencing to analyze liver cancer patients, identifying cellular dynamics and communication networks between malignant cells and tumor-associated immune cells. The findings validate the stable molecular networks of malignant ecosystems and potentially open up new therapeutic opportunities.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Oncology
Sunil S. Badve
Summary: This article discusses the use of artificial intelligence methods for analyzing pathology slides. The authors describe a reliable second reader system that can differentiate in situ and advanced invasive carcinomas from non-neoplastic lesions of the breast.
Article
Oncology
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The authors developed a deep learning classification network to predict breast cancer events (BCEs) in patients with ductal carcinoma in situ (DCIS), providing early and accurate predictions for personalized therapy and avoiding over-treatment of low-risk patients.
Article
Pharmacology & Pharmacy
Sunil S. S. Badve, Yesim Gokmen-Polar
Summary: Cancer development and progression is a complex process influenced by the co-evolution of cancer cells and their microenvironment. Traditional anti-cancer therapy mainly targets cancer cells, but considering the complex interactions between the tumor and its microenvironment may improve drug efficacy.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)