Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Rosemary Nustas, Ahmed A. Messallam, Theresa Gillespie, Steven Keilin, Saurabh Chawla, Vaishali Patel, Qiang Cai, Field F. Willingham
Summary: In a large national cohort in the US, factors such as lymphovascular invasion, high-grade histology, T stage, and tumor size were independently associated with lymph node metastasis in early gastric adenocarcinoma. Patients with low-grade tumors, smaller than 3 cm, and without lymphovascular invasion had a very low risk of nodal involvement, suggesting they may be considered for endoscopic resection.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiacheng Song, Qiming Hu, Zhanlong Ma, Meng Zhao, Ting Chen, Haibin Shi
Summary: The study demonstrates that a radiomics model based on T2WI can be used to predict normal-sized pelvic lymph node metastasis in cervical cancer patients, with Models 2 and 3 showing significantly higher diagnostic accuracy compared to Model 1. The radiomics nomogram incorporating LN radiomics signature with clinical morphological LN features holds promise for predicting normal-sized pelvic LNM in cervical cancer patients.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Kai Yao, Yue Chen, Yunlin Ye, Zhiming Wu, Dong Chen, Hui Han, Zaishang Li, Zhuowei Liu, Yanjun Wang, Zike Qin, Yonghong Li, Zhiyong Li, Fangjian Zhou
Summary: The study provides a detailed map of pelvic lymph node metastasis in patients with penile carcinoma, showing that the external iliac and obturator packages are most commonly involved. Pelvic lymph node metastasis is associated with advanced T-stage. Some patients have crossover metastasis.
JOURNAL OF UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nathan E. Reticker-Flynn, Weiruo Zhang, Julia A. Belk, Pamela A. Basto, Nichole K. Escalante, Genay O. W. Pilarowski, Alborz Bejnood, Maria M. Martins, Justin A. Kenkel, Ian L. Linde, Sreya Bagchi, Robert Yuan, Serena Chang, Matthew H. Spitzer, Yaron Carmi, Jiahan Cheng, Lorna L. Tolentino, Okmi Choi, Nancy Wu, Christina S. Kong, Andrew J. Gentles, John B. Sunwoo, Ansuman T. Satpathy, Sylvia K. Plevritis, Edgar G. Engleman
Summary: Lymph node metastasis plays an active role in shaping distant metastasis in solid malignancies, and this mechanism involves the evasion of immune cells, colonization in lymph nodes, and subsequent colonization in other tissues. This mechanism is conserved in human cancers and murine cancer models.
Article
Oncology
Philipp Thoenissen, Anja Heselich, Stefanie Deeg, Sarah Al-Maawi, Anna Tanneberger, Robert Sader, Shahram Ghanaati
Summary: This study aims to identify lymph node involvement in OSCC performed in a bilateral systematic approach based on presurgical MRI and CT. The results showed positive lymph node involvement in levels 1 and 2, while no involvement was seen in level 5. Therefore, without any clinical or imaging suspicion, expanding to 5-level MRND should be avoided.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Mengting Wang, Min Ma, Liju Yang, Chengtong Liang
Summary: This study investigated the risk factors and prognosis of lymph node metastasis (LNM) in cervical cancer patients using data from the SEER database. Predictive nomogram models were established and their performance was evaluated. The study provides clinicians with a reference for diagnosis and treatment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
B. H. E. Jansen, Y. J. L. Bodar, G. J. C. Zwezerijnen, D. Meijer, J. P. van der Voorn, J. A. Nieuwenhuijzen, M. Wondergem, T. A. Roeleveld, R. Boellaard, O. S. Hoekstra, R. J. A. van Moorselaar, D. E. Oprea-Lager, A. N. Vis
Summary: The study found that F-18-DCFPyL PET/CT has high specificity but limited sensitivity for detecting pelvic lymph-node metastases in primary prostate cancer patients. Therefore, current PSMA PET/CT imaging cannot fully replace diagnostic ePLND. Further research is needed to determine the exact role of PSMA PET/CT imaging in the primary staging of prostate cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jing Zhao, Jing Cai, Hongbo Wang, Weihong Dong, Yuan Zhang, Shaohai Wang, Xiaoqi He, Si Sun, Yuhui Huang, Bangxing Huang, Kay C. Willborn, Ping Jiang, Zehua Wang
Summary: Tumor size, lymph-vascular space invasion, and age are region-specific risk factors for pelvic lymph node metastasis in patients with stage IB1 cervical cancer, which can be used to determine the appropriate extent of pelvic lymphadenectomy.
Article
Oncology
Tamiris Dezen, Rodrigo Ribeiro Rossini, Marcelo Dimas Spadin, Carlos Eduardo Mattos Da Cunha Andrade, Ronaldo Schimidt, Marcelo A. Vieira, Marcos A. Lima, Diocesio Alves Pinto De Andrade, Ricardo Dos Reis
Summary: The study evaluated the accuracy of diffusion-weighted imaging and morphological aspects on MRI at different Tesla strengths for diagnosing metastatic lymph nodes in cervical cancer. The results showed substantial concordance between MRI and histological findings, with specific MRI characteristics indicating a likelihood of positive lymph node metastasis.
Article
Endocrinology & Metabolism
Wenlong Wang, Ying Ding, Wei Jiang, Xinying Li
Summary: This study aimed to evaluate the impact of N stage subclassification on different distant metastasis sites based on age stratification, especially for patients with papillary thyroid microcarcinoma (PTMC). The results showed that the risk of distant metastasis increased with the progress of N disease, and N1b disease had a higher risk of lung metastasis in younger patients and an increased risk of both lung and bone metastasis in older patients. N1a disease did not increase the risk of distant metastasis in PTMC patients. Combining N stage with risk stratification can be beneficial for predicting distant metastasis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Matteo Tantari, Stefano Bogliolo, Matteo Morotti, Vincent Balaya, Florent Bouttitie, Annie Buenerd, Laurent Magaud, Fabrice Lecuru, Benedetta Guani, Patrice Mathevet
Summary: In early-stage cervical cancer, lymphatic spread does not require the proliferation of new lymphatic endothelial cells, highlighting the importance of pre-existing peritumoral lymphatic vessels in the metastatic process. None of the markers of lymphangiogenesis and proliferation evaluated were predictive of pelvic lymph node metastasis or tumor recurrence.
Article
Oncology
Alejandra Martinez, Elodie Chantalat, Martina Aida Angeles, Gwenael Ferron, Anne Ducassou, Manon Daix, Justine Attal, Sarah Betrian, Amelie Lusque, Erwan Gabiache
Summary: This study aimed to assess the impact of PET/CT functional parameters on survival, locoregional, and distant failure in patients with cervical cancer. The results showed that lymph node uptake on PET/CT was associated with patient prognosis, but there was no significant association between tumor metabolic parameters and survival outcome. Cervical MTV was found to be a more accurate predictor of survival outcome.
Article
Endocrinology & Metabolism
Wen-Hui Li, Wei-Ying Yu, Jia-Rui Du, Deng-Ke Teng, Yuan-Qiang Lin, Guo-Qing Sui, Hui Wang
Summary: This study developed and validated an ultrasound radiomics nomogram for predicting the risk of cervical lymph node metastasis in patients with micropapillary thyroid microcarcinoma (mPTMC) based on factors such as sex, age, tumor size, invasion, and ultrasound scores. The model showed favorable predictive value and reliability, and can assist in surgical decision making.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Letter
Oncology
Lilu Ding, Marcel J. W. Greuter, Guido Van Hal, Geertruida H. de Bock
Article
Dermatology
Marjolijn S. Haisma, Mathanhy Logendran, Jens Bos, Bert V.d. Vegt, Barbara Horvath, Stijn DE Vos, Geertruida H. D. E. Bock, Eelko Hak, Emoke Racz
Summary: This study investigated the association between hydrochlorothiazide use and skin cancer incidence. It found a clear association between high cumulative hydrochlorothiazide use and the risk of different types of skin cancer.
ACTA DERMATO-VENEREOLOGICA
(2023)
Article
Surgery
Nadia Sadok, Irene S. Krabbe-Timmerman, Nina H. Buisman, Vera C. van Aalst, Geertruida H. de Bock, Paul M. N. Werker
Summary: Contrary to expectations, autologous breast reconstruction leads to higher levels of breast satisfaction, psychosocial well-being, and sexual well-being compared to alloplastic breast reconstruction, despite lower preoperative satisfaction and higher risk of severe complications.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Multidisciplinary Sciences
Hendrik Wisselink, Danielle J. D. A. Steerenberg, Mieneke Rook, Gert-Jan H. Pelgrim, Marjolein Heuvelmans, Maarten van den Berge, Geertruida de Bock, Rozemarijn Vliegenthart
Summary: Predicted lung volumes based on the GLI model are used in pulmonary disease detection and monitoring. This study aimed to compare the GLI-2021 model predictions of TLC with CT-derived TLV.
Article
Multidisciplinary Sciences
H. L. Lancaster, M. A. Heuvelmans, G. H. de Bock, Y. Du, F. A. A. Mohamed Hoesein, K. Nackaerts, J. E. Walter, R. Vliegenthart, M. Oudkerk
Summary: We evaluated the impact of the influenza season on the outcome of new lung nodules in a lung cancer screening trial population. There was no statistically significant association between the influenza season and the resolution or persistence of new lung nodules. Hence, the management strategy for new nodules should not be influenced by the season in which they are detected.
SCIENTIFIC REPORTS
(2023)
Article
Geriatrics & Gerontology
Han Zhao, Xinlin Lu, Senshuang Zheng, Danmei Wei, Lizhong Zhao, Yuan Wang, Geertruida H. de Bock, Wenli Lu
Summary: This study aimed to compare the performance of Geriatric 8 (G8) and Korean Cancer Study Group Geriatric Score (KG-7) in identifying patients who need a full Geriatric Assessment. The results showed that G8 had higher accuracy and predictive ability compared to KG-7, making it more suitable for identifying patients in need of comprehensive assessment.
Article
Oncology
J. de Waard, A. Bhattacharya, M. T. de Boer, B. M. van Hemel, M. D. Esajas, K. M. Vermeulen, G. H. de Bock, E. Schuuring, G. B. A. Wisman
Summary: This study designed a methylation marker panel to detect CIN3+ in hrHPV-positive self-samples from the Dutch PBS as an alternative triage test for cytology.
CLINICAL EPIGENETICS
(2023)
Article
Public, Environmental & Occupational Health
Kelly M. Castaneda, Grigory A. Sidorenkov, Jolien de Waard, Marcel J. W. Greuter, Bert Van der Vegt, Inge M. C. M. de Kok, Albert G. Siebers, Karin M. Vermeulen, G. Bea A. Wisman, Ed Schuuring, Geertruida H. de Bock
Summary: This study aimed to evaluate the true participation rate of cervical cancer screening (CCS) by extending the time window for defining participation and to analyze the impact of sociodemographic determinants on participation delays. The findings showed that a 36-month window better reflected the actual participation rate and that delayed participation was associated with younger age, higher education, the high-risk human papillomavirus test-based program, and pregnancy. This suggests the importance of considering these factors when designing and promoting CCS programs.
PREVENTIVE MEDICINE REPORTS
(2023)
Review
Oncology
Keris Poelhekken, Yixuan Lin, Marcel J. W. Greuter, Bert van der Vegt, Monique Dorrius, Geertruida H. de Bock
Summary: The purpose of this review is to identify and analyze the assumptions made in modeling studies on the natural history of DCIS in women in order to improve estimates of overdiagnosis. The most important assumptions include the addition of non-progressive DCIS, classification of DCIS into three grades, and regression possibilities depending on age and grade. Other risk factors for progression of DCIS to IBC were also identified.
Article
Oncology
D. S. Spoor, V. A. B. van den Bogaard, N. M. Sijtsema, P. van der Meer, G. H. de Bock, J. A. Langendijk, J. H. Maduro, A. P. G. Crijns
Summary: This study compares morbidity and risk factors between breast cancer survivors and age-matched controls, aiming to provide more insight into late treatment-related toxicities among breast cancer survivors. The results show that despite having a lower cardiovascular risk profile, breast cancer survivors still face the risk of late treatment-related toxicities.
Article
Multidisciplinary Sciences
Jacobien Niebuur, Judith M. Vonk, Yihui Du, Geertruida H. de Bock, Gerton Lunter, Paul F. M. Krabbe, Behrooz Z. Alizadeh, Harold Snieder, Nynke Smidt, Marike Boezen, Eva Corpeleijn
Summary: This study conducted in the northern Netherlands found that patients with multimorbidity are more likely to have unhealthy lifestyle factors such as physical inactivity, chronic stress, and inadequate sleep. These findings are of great importance for improving the lifestyle of patients with multiple chronic diseases.
Article
Oncology
Jenske Geerling, Yvette M. van der Linden, Natasja J. H. Raijmakers, Karin M. Vermeulen, Veronique E. M. Mul, Ellen J. M. de Nijs, Paulien G. Westhoff, Geertruida H. de Bock, Alexander de Graeff, Anna K. L. Reyners
Summary: This study investigated the additional effect of a nurse-led pain education program on pain control and quality of life for patients with bone metastases. The results showed that the pain education program reduced pain and led to faster pain control.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Cell Biology
Ying Wang, Shinichi Namba, Esteban Lopera, Sini Kerminen, Kristin Tsuo, Kristi Lall, Masahiro Kanai, Wei Zhou, Kuan-Han Wu, Marie-Julie Fave, Laxmi Bhatta, Philip Awadalla, Ben Brumpton, Patrick Deelen, Kristian Hveem, Valeria Lo Faro, Reedik Magi, Yoshinori Murakami, Serena Sanna, Jordan W. Smoller, Jasmina Uzunovic, Cristen Willer, Eric R. Gamazon, Nancy J. Cox, Ida Surakka, Yukinori Okada, Alicia R. Martin, Jibril Hirbo
Summary: This study utilized data from GBMI to explore methodological considerations and performance of PRS for 14 disease endpoints across global populations. The study provides lessons for PRS construction, evaluation, and interpretation and highlights the importance of PRS in the biobank-scale genomics era.
Review
Radiology, Nuclear Medicine & Medical Imaging
Yifei Mao, Jiali Cai, Marjolein A. Heuvelmans, Rozemarijn Vliegenthart, Harry J. M. Groen, Matthijs Oudkerk, Marleen Vonder, Monique D. Dorrius, Geertruida H. de Bock
Summary: This systematic review and meta-analysis evaluated the performance of Lung-RADS (versions 1.0 and 1.1) in detecting lung cancer in different populations. The results showed that studies in high-risk populations had higher sensitivity and lower specificity than studies in general populations. Non-Asian studies tended to have better diagnostic performance than Asian studies. Limited evidence was available for the performance of Lung-RADS version 1.1 and its applicability to Asian populations.
EUROPEAN RADIOLOGY
(2023)
Article
Surgery
Rianne N. M. Hogenbirk, Willemijn Y. van der Plas, Judith E. K. R. Hentzen, Laura van Wijk, Allard G. Wijma, Carlijn Buis, Alain R. Viddeleer, Geertruida H. de Bock, Cees P. van der Schans, Gooitzen M. van Dam, Schelto Kruijff, Joost M. Klaase
Summary: This study aimed to identify the incidence and risk factors for surgery-related muscle loss (SRML) after major abdominal surgery, and to study the impact of SRML on fatigue and survival. The study found that preoperative weight loss, postoperative nutritional intake, and physical activity were associated with SRML. SRML was also associated with decreased 1-year survival.
BRITISH JOURNAL OF SURGERY
(2023)
