Review
Oncology
Sosuke Sahara, Alexandra E. Herzog, Jacques E. Nor
Summary: Adenoid cystic carcinoma (ACC) is a rare cancer with no standard chemotherapy currently available. Response rates to cytotoxic agents are around 10%, while combination therapies like CAP and cisplatin-vinorelbine have response rates of 18-31%. Inhibitors targeting VEGFR show relatively high response rates of 11-17%. Targeting cancer stem cells (CSC), drivers of chemoresistance and recurrence, could lead to valuable therapies for ACC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Vivian P. Wagner, Colin D. Bingle, Lynne Bingle
Summary: Adenoid cystic carcinoma is a common type of salivary gland cancer characterized by a recurrent chromosomal translocation involving the MYB oncogene and the NFIB transcription factor. Studying the MYB-NFIB translocation can contribute to improving the therapeutic options for this cancer.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Review
Oncology
Carolina Emerick, Fernanda Viviane Mariano, Pablo Agustin Vargas, Jacques E. Nor, Cristiane H. Squarize, Rogerio M. Castilho
Summary: Adenoid cystic carcinoma (ACC) is a malignant lesion that can occur in various anatomical sites. ACC in salivary and lacrimal glands has a high risk of invasion and metastasis, while ACC in the breast is rarer and less aggressive. Perineural invasion is a major predictor of mortality in ACC, and the prognosis differs between different anatomical sites. The genetic variations and prognostic differences of ACC are still not well understood, but there are available treatments and emerging strategies being developed.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Oncology
Helen Adderley, Samuel Rack, Brindley Hapuarachi, Laura Feeney, David Morgan, Tracy Hussell, Andrew J. Wallace, Guy Betts, Clare Hodgson, Kevin Harrington, Robert Metcalf
Summary: This study aimed to determine the utility of TP53 and PIK3CA mutations as prognostic biomarkers in SACC patients. The results showed that TP53-mutated SACC patients had significantly shorter overall survival and a higher incidence of solid-pattern histopathology.
Article
Pathology
Shinsuke Fujii, Tatsufumi Fujimoto, Kana Hasegawa, Ryoko Nagano, Takuma Ishibashi, Kari J. Kurppa, Yurie Mikami, Megumi Kokura, Yudai Tajiri, Toshiro Kibe, Hiroko Wada, Naohisa Wada, Shosei Kishida, Yoshinori Higuchi, Tamotsu Kiyoshima
Summary: Sema3A plays an important role in submandibular gland (SMG) development and promotes cell growth through AKT activation. Its increased expression in adenoid cystic carcinoma (ACC) suggests its involvement in SMG morphogenesis and pathogenesis.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Genetics & Heredity
Maicon Fernando Zanon, Cristovam Scapulatempo-Neto, Ricardo Ribeiro Gama, Marcia Maria Chiquitelli Marques, Rui Manuel Reis, Adriane Feijo Evangelista
Summary: This study examined the miRNA expression profile in salivary gland ACC patients and identified differential miRNA associated with pathological features and clinical progression. The findings revealed miRNA expression patterns associated with aggressiveness in adenoid cystic carcinoma, providing important new insights into the aggressive behavior of this tumor type.
Article
Biochemistry & Molecular Biology
Bing-jun Chen, Jian Jiang, Tan Li, Hong-jie Jiang, Xin-hua Liang, Ya-ling Tang
Summary: The invasion and metastasis of salivary adenoid cystic carcinoma (SACC) is closely related to collective invasion. The downregulation of FAT1 and upregulation of YAP1 are associated with collective invasion and distant metastasis in SACC. The miR-183-5p/FAT1/YAP1 signaling pathway plays a critical role in SACC collective invasion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Review
Oncology
Boon Fei Tan, Wei Chang Colin Tan, Fu Qiang Wang, Matt Lechner, Volker Hans Schartinger, Daniel Shao Weng Tan, Kelvin Siu Hoong Loke, Wen Long Nei
Summary: This systematic review explores the potential role of PSMA PET imaging and therapy as a theranostic tool for adenoid cystic carcinoma (ACC) and other salivary gland cancers (SGCs). Despite a limited number of studies, PSMA PET shows promising prospects in detecting lesions in ACC and SGC that are not detected on standard imaging. Further research is needed to guide its real-world use.
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Oncology
Cong-Gai Huang, Meng-Ze Li, Shao-Hua Wang, Yun Liu, Hui-Ling Zhang, Johannes Haybaeck, Zhi-Hui Yang
Summary: This study retrospectively analyzed 32 cases of adenoid cystic carcinoma (ACC) of salivary gland, diagnosed by FNA and surgical biopsy. The accuracy of FNA in diagnosing ACC was 71.9%. Therefore, identifying cytomorphological features is crucial for accurate diagnosis of ACC.
Article
Acoustics
Huan-Zhong Su, Feng Zhang, Xiao-Dong Zhang, Long-Cheng Hong, Shu-Jing Huang, Yu-Qing Su, Yi-Ming Su
Summary: This study investigated the ultrasonographic findings of adenoid cystic carcinoma (ACC) in major salivary glands and the value of polar vessel in color Doppler flow imaging (CDFI) for ACC diagnosis. It was found that ACC in major salivary glands was more likely to be associated with pain symptoms, unclear borders, and rough edges. Compared to benign tumors, ACC tended to have a homogeneous internal echo. The incidence of polar vessel sign was significantly higher in ACC than in non-ACC cases. The polar vessel sign showed good performance in distinguishing ACC from non-ACC, with high sensitivity, specificity, and accuracy.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Oncology
Naruhiko Morita, Takayuki Murase, Kaori Ueda, Toshitaka Nagao, Kimihide Kusafuka, Masato Nakaguro, Makoto Urano, Ken-ichi Taguchi, Hidetaka Yamamoto, Satoshi Kano, Yuichiro Tada, Kiyoaki Tsukahara, Kenji Okami, Tetsuro Onitsuka, Yasushi Fujimoto, Daisuke Kawakita, Kazuo Sakurai, Toru Nagao, Nobuhiro Hanai, Ryo Kawata, Naohito Hato, Naoki Otsuki, Ken-ichi Nibu, Hiroshi Inagaki
Summary: The study introduces the minAmax system as a simple, objective, and highly reproducible grading system useful for prognostic stratification in salivary AdCC. After a central pathology review of AdCC cases, it was found that the minAmax system and van Weert system were independent prognostic tools.
Article
Oncology
Mengjiao Zhou, Tingyao Ma, Xuelian Wang, Shujing Zhang, Guoliang Yang, Ruohui Song, Xiaohong Chen
Summary: Compared with parotid gland adenoid cystic carcinoma (ACC) patients, submandibular gland ACC patients are more likely to have cervical lymph node metastasis and distant metastasis within 1 year after diagnosis, leading to a worse overall prognosis. They also have a higher rate of MYB/MYBL1 mutations and abnormal upregulation of the PI3K pathway.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Kentaro Takada, Yoshihiro Aizawa, Daisuke Sano, Ryo Okuda, Keisuke Sekine, Yasuharu Ueno, Shoji Yamanaka, Jun Aoyama, Kaname Sato, Tatsu Kuwahara, Takashi Hatano, Hideaki Takahashi, Yasuhiro Arai, Goshi Nishimura, Hideki Taniguchi, Nobuhiko Oridate
Summary: The study developed new in vitro and in vivo models of adenoid cystic carcinoma (ACC) using organoid culture and patient-derived tumor xenograft (PDX) techniques. Human ACC-derived organoids were successfully generated, providing insights into understanding the biology of ACC and creating personalized therapy design for patients.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Lauren E. Miller, Vivienne Au, Tara E. Mokhtari, Deborah Goss, Daniel L. Faden, Mark A. Varvares
Summary: This review discusses the advances in molecular targets for adenoid cystic carcinoma (ACC), with MYB-NFIB translocation being the most researched pathway, and other molecular targets showing limited efficacy. The ongoing investigation of molecular abnormalities underlying ACC is critical for identifying and developing novel targeted therapies.
Article
Oncology
Agnieszka A. Rucki, Kelly Foley, Pingbo Zhang, Qian Xiao, Jennifer Kleponis, Annie A. Wu, Rajni Sharma, Guanglan Mo, Angen Liu, Jennifer Van Eyk, Elizabeth M. Jaffee, Lei Zheng
Article
Pathology
Enrico Munari, Giulio Rossi, Giuseppe Zamboni, Gianluigi Lunardi, Marcella Marconi, Marco Sommaggio, George J. Netto, Mohammad O. Hoque, Matteo Brunelli, Guido Martignoni, Michael C. Haffner, Francesca Moretta, Maria C. Pegoraro, Alberto Cavazza, Giuseppina Samogin, Vanna Furlan, Francesca R. Mariotti, Paola Vacca, Lorenzo Moretta, Giuseppe Bogina
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2018)
Article
Oncology
Leonel Maldonado, Mariana Brait, Evgeny Izumchenko, Shahnaz Begum, Aditi Chatterjee, Tanusree Sen, Myriam Loyo, Alvaro Barbosa, Maria Luana Poeta, Eugene Makarev, Alex Zhavoronkov, Vito M. Fazio, Roberto Angioli, Carla Rabitti, Mate Ongenaert, Wim Van Criekinge, Maartje G. Noordhuis, Pauline de Graeff, G. Bea A. Wismann, Ate G. J. van der Zee, Mohammad O. Hoque
Article
Pathology
Deyin Xing, Natalie Banet, Rajni Sharma, Russell Vang, Brigitte M. Ronnett, Peter B. Illei
Review
Oncology
Masahiro Shibata, Kendall Ham, Mohammad Obaidul Hoque
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Oncology
Akira Ooki, Asma Begum, Luigi Marchionni, Christopher J. VandenBussche, Shifeng Mao, Max Kates, Mohammad Obaidul Hoque
INTERNATIONAL JOURNAL OF CANCER
(2018)
Article
Oncology
Enrico Munari, Giuseppe Zamboni, Gianluigi Lunardi, Luigi Marchionni, Marcella Marconi, Marco Sommaggio, Matteo Brunetti, Guido Martignoni, George J. Netto, Mohammad O. Hoque, Francesca Moretta, Maria Cristina Mingari, Maria Cristina Pegoraro, Alessandro Inno, Simona Paiano, Alberto Terzi, Alberto Cavazza, Giulio Rossi, Francesca Romana Mariotti, Paola Vacca, Lorenzo Moretta, Giuseppe Bogina
JOURNAL OF THORACIC ONCOLOGY
(2018)
Article
Oncology
Wenyue Sun, Bishwanath Chatterjee, Jack F. Shern, Rajesh Patidar, Young Song, Yonghong Wang, Robert L. Walker, Bruce R. Pawel, Corinne M. Linardic, Peter Houghton, Stephen M. Hewitt, Daniel C. Edelman, Javed Khan, Paul S. Meltzer, Frederic G. Barr
INTERNATIONAL JOURNAL OF CANCER
(2019)
Review
Oncology
Masahiro Shibata, Mohammad Obaidul Hoque
Review
Oncology
Pritam Sadhukhan, M. Talha Ugurlu, Mohammad O. Hoque
Review
Oncology
Sarah E. Mudra, Pritam Sadhukhan, M. Talha Ugurlu, Shorna Alam, Mohammad O. Hoque
Summary: Resistance to cancer therapy is a significant obstacle, with cancer stem cells (CSCs) playing a key role in resistance and the need for novel targeted agents to combat CSCs.
Article
Oncology
Katie E. Hebron, Xiaolin Wan, Jacob S. Roth, David J. Liewehr, Nancy E. Sealover, William J. E. Frye, Angela Kim, Stacey Stauffer, Olivia L. Perkins, Wenyue Sun, Kristine A. Isanogle, Christina M. Robinson, Amy James, Parirokh Awasthi, Priya Shankarappa, Xiaoling Luo, Haiyan Lei, Donna Butcher, Roberta Smith, Elijah F. Edmondson, Jin-Qiu Chen, Noemi Kedei, Cody J. Peer, Jack F. Shern, W. Douglas Figg, Lu Chen, Matthew D. Hall, Simone Difilippantonio, Frederic G. Barr, Robert L. Kortum, Robert W. Robey, Angelina V. Vaseva, Javed Khan, Marielle E. Yohe
Summary: This study found that the combination of MEK1/2 inhibitor and IGF1R inhibitor has a synergistic effect and inhibits tumor growth in RAS-mutated PAX-fusion negative rhabdomyosarcoma (FN RMS). It is well-tolerated and shows promising results in both cell line and animal models. Therefore, this combination therapy holds potential for clinical trials in pediatric patients with relapsed or refractory RAS-mutated FN RMS.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Akira Ooki, Maria Del Carmen Rodriguez Pena, Luigi Marchionni, Wikum Dinalankara, Asma Begum, Noah M. Hahn, Christopher J. VandenBussche, Zeshaan A. Rasheed, Shifeng Mao, George J. Netto, David Sidransky, Mohammad O. Hoque
Article
Oncology
Akira Ooki, Zahra Maleki, Jun-Chieh J. Tsay, Chandra Goparaju, Mariana Brait, Nitesh Turaga, Hae-Seong Nam, William N. Rom, Harvey I. Pass, David Sidransky, Rafael Guerrero-Preston, Mohammad Obaidul Hoque
CLINICAL CANCER RESEARCH
(2017)
Article
Oncology
E. Izumchenko, K. Paz, D. Ciznadija, I. Sloma, A. Katz, D. Vasquez-Dunddel, I. Ben-Zvi, J. Stebbing, W. McGuire, W. Harris, R. Maki, A. Gaya, A. Bedi, S. Zacharoulis, R. Ravi, L. H. Wexler, M. O. Hoque, C. Rodriguez-Galindo, H. Pass, N. Peled, A. Davies, R. Morris, M. Hidalgo, D. Sidransky
ANNALS OF ONCOLOGY
(2017)