Article
Oncology
Gian Carlo Mattiucci, Luca Boldrini, Alessia Nardangeli, Andrea D'Aviero, Milly Buwenge, Francesco Cellini, Francesco Deodato, Nicola Dinapoli, Vincenzo Frascino, Gabriella Macchia, Alessio Giuseppe Morganti, Vincenzo Valentini
Summary: The study found that hypofractionated radiotherapy boost in locally advanced pancreatic cancer patients has potential benefits in improving local control and pain relief. All patients completed the planned HRB, with minor early and late toxicity reactions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Loig Vaugier, Xavier Mirabel, Isabelle Martel-Lafay, Severine Racadot, Christian Carrie, Veronique Vendrely, Marc-Andre Mahe, Helene Senellart, Jean-Luc Raoul, Loic Campion, Emmanuel Rio
Summary: The combination treatment of SBRT with irinotecan was well tolerated and showed promising results in improving local response for colorectal cancer patients, allowing for chemotherapy-free periods and potentially serving as an alternative regimen for tumors close to healthy tissues.
Article
Gastroenterology & Hepatology
Amitesh Chandra Roy, M. Nazim Abbas, Timothy Jay Price, Nimit Singhal, Sina Vatandoust, John Leung, Ganessan Kichenadasse, Bogda Koczwara, Shawgi Sukumaran, Rajiv Kumar, Richard Woodman, Alex Scott-Hoy, Christos Stelios Karapetis
Summary: Nab-paclitaxel has a good tolerability when combined with radiotherapy for locally advanced pancreatic cancer. The recommended dose is 75 mg/m(2).
Editorial Material
Medicine, General & Internal
Oladapo O. Yeku, Dan L. Longo
Summary: This editorial discusses the scientific basis of a clinical trial conducted by Prager and colleagues, which tested the efficacy of trifluridine-tipiracil and bevacizumab in treating patients with refractory metastatic colorectal cancer.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Medicine, General & Internal
Ye Zhao, Haiming Feng, Jinhui Tian, Bin Li, Cheng Wang, Long Ge, Jian kai Wang, Kehu Yang, Qin Yu
Summary: This systematic review aims to evaluate the clinical efficacy of different combinations of CCRTs and consolidation therapies. Traditional meta-analysis and network meta-analysis methods will be used to analyze the data. The primary endpoints include overall survival and progression-free survival, while secondary outcomes include tumor response and health-related quality of life. The results of this study will be published in a peer-reviewed journal.
Correction
Oncology
Gian Carlo Mattiucci, Luca Boldrini, Alessia Nardangeli, Andrea D'Aviero, Milly Buwenge, Francesco Cellini, Francesco Deodato, Nicola Dinapoli, Vincenzo Frascino, Gabriella Macchia, Alessio Giuseppe Morganti, Vincenzo Valentini
Summary: This sentence points out an error in the last sentence of the sixth paragraph of the introduction section in the original article.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Jie Lee, Shih-Hua Liu, John Chun-Hao Chen, Yi-Shing Leu, Chung-Ji Liu, Yu-Jen Chen
Summary: This study investigated the association between progressive muscle loss and survival outcomes in patients with advanced-stage oral squamous cell carcinoma. The findings showed that progressive muscle loss was independently associated with worse survival outcomes, which may not be detected by changes in BMI.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Oncology
Jessika Contreras, Amar Srivastava, Pamela Samson, Todd DeWees, Ramaswamy Govindan, Maria Q. Baggstrom, Daniel Morgensztern, Michael Roach, Shahed N. Badiyan, Jeffrey Bradley, Saiama Waqar, Clifford Robinson
Summary: The study aimed to evaluate the maximum tolerated dose of hypofractionated proton beam radiation therapy with concurrent weekly carboplatin/paclitaxel in patients with stage II-III non-small cell lung cancer. The results showed that the treatment was acutely well tolerated, with high rates of locoregional control and overall survival. Late serious adverse events were noted in some patients outside of the dose-escalation window.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Medicine, General & Internal
Wei Zhang, Qing Xie, Bifa Zhu, Xiaokang Wang, Ling He, Yong Zhang
Summary: This retrospective study analyzed the data of 90 inoperable patients with locally advanced esophageal squamous cell carcinoma (ESCC) treated with intensity-modulated radiotherapy (IMRT), and found that a higher radiation dose (>60 Gy) was associated with better survival outcomes.
Article
Medicine, Research & Experimental
He Huang, Cai-Ping Nie, Xiu-Feng Liu, Bin Song, Jian-Hui Yue, Jing-Xiao Xu, Jia He, Kui Li, Yan-Ling Feng, Ting Wan, Min Zheng, Yan-Na Zhang, Wei-Jun Ye, Jun-Dong Li, Yan-Fang Li, Jun-Yun Li, Xin-Ping Cao, Zhi-Min Liu, Xiao-Shi Zhang, Qing Liu, Xi Zhang, Ji-Hong Liu, Jiang Li
Summary: This study explored the safety and feasibility of infusion of autogenous tumor-infiltrating lymphocytes (TILs) following concurrent chemoradiotherapy (CCRT) in patients with locally advanced cervical cancer (CC). The results showed that TIL-based adoptive cell therapy (ACT) may be a potentially effective adjuvant treatment for locally advanced CC patients.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Oncology
Joerg Trojan, Albrecht Hoffmeister, Bruno Neu, Stefan Kasper, Alexander Dechene, Christian Juergensen, Joerg Schirra, Ralf Jakobs, Dan Palmer, Pal Selbo, Hans Olivecrona, Lena Finnesand, Anders Hogset, Per Walday, Richard Sturgess
Summary: Photochemical internalization (PCI) is a novel technology that enhances the local therapeutic effect of cancer drugs by using a specially designed photosensitizing molecule. The main cytotoxic effect of PCI is the disruption of endosomal membranes to release drug molecules, resulting in delivery of chemotherapy drugs. PCI with gemcitabine showed promising results in patients with unresectable perihilar cholangiocarcinoma, with good disease control, response rates, and survival outcomes.
Article
Oncology
Luigi Carlo Turco, Luigi Pedone Anchora, Camilla Fedele, Frediano Inzani, Alessia Piermattei, Maurizio Martini, Mariaconcetta Volpe, Simona Marchetti, Rosaria Santangelo, Nicolo Bizzarri, Francesco Cosentino, Virginia Vargiu, Maria De Ninno, Gabriella Macchia, Vincenzo Valentini, Gianfranco Zannoni, Giovanni Scambia, Gabriella Ferrandina
Summary: This retrospective study found that while HPV plays a significant role in cervical cancer, a considerable percentage of cervical cancers are HPV independent. The study results showed that HPV status at diagnosis is a relevant factor for clinical outcomes in locally advanced cervical cancer patients.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Obstetrics & Gynecology
Chang-Yu Wu, Li-Ming Tseng, Hui-Hua Chen, Chen-Hsi Hsieh, Sheng-Mou Hsiao
Summary: This study presents the detailed clinical history of three cervical cancer patients with rectovaginal fistula after radiotherapy. The cases highlight the occurrence of fatal rectovaginal fistula in post-radiation advanced cervical cancer patients and the potential risks associated with unnecessary colonoscopic biopsy.
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukasz Magrowski, Oliwia Masri, Jakub Ciepal, Gabriela Depowska, Zuzanna Nowicka, Rafal Stando, Krystyna Chimiak, Gabriela Bylica, Barbara Czapla, Malgorzata Masri, Franciszek Cichur, Iwona Jablonska, Marta Gmerek, Piotr Wojcieszek, Tomasz Krzysztofiak, Jacek Sadowski, Rafal Suwinski, Pawel Rajwa, Matthias Moll, Gregor Goldner, Wojciech Majewski, Marcin Miszczyk
Summary: This study aimed to test the prognostic value of hemoglobin concentration and absolute monocyte count in patients with localized intermediate- or high-risk prostate cancer treated with radiotherapy. The results showed that hemoglobin concentration and absolute monocyte count can serve as useful biomarkers for overall survival.
Article
Biochemistry & Molecular Biology
Seth R. Smith, Eric Normandeau, Haig Djambazian, Pubudu M. Nawarathna, Pierre Berube, Andrew M. Muir, Jiannis Ragoussis, Chantelle M. Penney, Kim T. Scribner, Gordon Luikart, Chris C. Wilson, Louis Bernatchez
Summary: In this study, an annotated, chromosome-anchored genome assembly for Lake Trout was generated using various sequencing techniques, resulting in a highly contiguous assembly. Analysis revealed insights into homeologs resulting from a salmonid-specific autotetraploid event and homologous chromosomes in related taxa, providing valuable resources for future genomic research.
MOLECULAR ECOLOGY RESOURCES
(2022)
Review
Oncology
Erik Knutsen, Adrian L. Harris, Maria Perander
Summary: NEAT1 is a highly abundant nuclear architectural long non-coding RNA, playing important roles in cellular stress and developmental processes. Abnormal expression of NEAT1 in many cancers may be associated with therapy resistance and poor clinical outcome.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
N. P. Scott, E. J. Teoh, H. Flight, B. E. Jones, J. Niederer, L. Mustata, G. M. MacLean, P. G. Roy, D. D. Remoundos, C. Snell, C. Liu, F. Gleeson, A. L. Harris, S. R. Lord, D. R. McGowan
Summary: In this study, the uptake of F-18-fluciclovine in breast cancer was evaluated using dynamic PET/CT imaging, with a reversible one-tissue compartment model found to best describe tracer uptake. No significant differences were observed in kinetic or static parameters for different breast cancer receptor subtypes or tumor grades. There was a good correlation between kinetic and static parameters.
BRITISH JOURNAL OF CANCER
(2022)
Article
Genetics & Heredity
Anne-Laure Ferchaud, Claire Merot, Eric Normandeau, Jiannis Ragoussis, Charles Babin, Haig Djambazian, Pierre Berube, Celine Audet, Margaret Treble, Wojciech Walkusz, Louis Bernatchez
Summary: A chromosome-level reference genome for Greenland Halibut was successfully assembled using single-molecule sequencing and chromatin conformation capture sequencing data. The study revealed that Greenland Halibut possesses a male heterogametic XY system for sex determination, similar to other teleost fishes, and identified several candidate genes potentially involved in this process. Additionally, the study suggested a putative Y-autosomal fusion may be associated with reduced recombination during the early steps of sex chromosome evolution in flatfishes.
G3-GENES GENOMES GENETICS
(2022)
Review
Genetics & Heredity
Wejdan M. Alenezi, Caitlin T. Fierheller, Timothee Revil, Corinne Serruya, Anne-Marie Mes-Masson, William D. Foulkes, Diane Provencher, Zaki El Haffaf, Jiannis Ragoussis, Patricia N. Tonin
Summary: The study identified the intronic variant BRCA1 c.5407-25T>A as a likely pathogenic variant in OC cases through WES analysis, emphasizing the importance of investigating intronic sequences for causal variants in families highly suggestive of BRCA1 involvement.
Editorial Material
Oncology
Adrian L. Harris
BRITISH JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Felicia Lazure, Rick Farouni, Korin Sahinyan, Darren M. Blackburn, Aldo Hernandez-Corchado, Gabrielle Perron, Tianyuan Lu, Adrien Osakwe, Jiannis Ragoussis, Colin Crist, Theodore J. Perkins, Arezu Jahani-Asl, Hamed S. Najafabadi, Vahab D. Soleimani
Summary: Adult stem cells play a crucial role in tissue regeneration, but their function declines with age. In this study, we investigated the impact of the stem cell niche environment on their function using muscle stem cells as a model. We found that aging resulted in significant changes in the gene expression of muscle stem cells, and exposure to a young niche environment restored the expression of a large portion of age-altered genes. This emphasizes the potential of targeting the stem cell niche as a therapeutic strategy for enhancing tissue regeneration in aging.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Tong Yu, Archana Chandrabhan Jadhav, Jiabao B. Xu, Adrian L. L. Harris, Venugopal Nair, Wei E. E. Huang
Summary: Understanding the development of cancer resistance to therapies is crucial. Newcastle disease virus (NDV) is a promising oncolytic agent, but some colon cancer cells show resistance to NDV reinfection. By using Raman spectroscopic and stable isotopic techniques, we found that the resistant cells slow down their replication and divert energy to protein and lipid synthesis. Understanding metabolic reprogramming could aid in developing precision cancer treatments that target resistant cells at the single-cell level.
Article
Oncology
Simon R. Lord, Adrian L. Harris
Summary: Over the past 15 years, there has been extensive interest in repurposing the diabetes drug metformin as a cancer treatment. However, despite numerous large clinical trials in various tumor types, the results have been disappointing. This article summarizes the initial interest in metformin's potential in oncology, the current clinical program, and the lessons learned from this experience regarding further investigation of metformin in cancer.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Chen-Chun Pai, Samuel C. Durley, Wei-Chen Cheng, Nien-Yi Chiang, Jennifer Peters, Torben Kasparek, Elizabeth Blaikley, Boon-Yu Wee, Carol Walker, Stephen E. Kearsey, Francesca Buffa, Johanne M. Murray, Timothy C. Humphrey
Summary: Chromosomal instability (CIN) plays a crucial role in cell-to-cell heterogeneity and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been identified as a major driver of CIN, but the exact mechanism behind it is still unclear. Using a fission yeast model, researchers have found that HR genes have a common role in suppressing DNA double-strand break (DSB)-induced CIN. Furthermore, they discovered that an unrepaired single-ended DSB, resulting from failed HR repair or telomere loss, is a potent driver of widespread CIN.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Oncology
Soumya Ghose, Sanghee Cho, Fiona Ginty, Elizabeth McDonough, Cynthia Davis, Zhanpan Zhang, Jhimli Mitra, Adrian L. Harris, Aye Aye Thike, Puay Hoon Tan, Yesim Gokmen-Polar, Sunil S. Badve
Summary: The authors developed a deep learning classification network to predict breast cancer events (BCEs) in patients with ductal carcinoma in situ (DCIS), providing early and accurate predictions for personalized therapy and avoiding over-treatment of low-risk patients.
Editorial Material
Oncology
Nicole D. D. Machado, Lisa C. C. Heather, Adrian L. L. Harris, Geoff S. S. Higgins
Summary: The disappointing termination of clinical trials with potent complex I inhibitors, such as IACS-010759, has raised doubts about the justification for oxidative phosphorylation inhibitors and mitochondrial targeting strategies. Analyzing the potency, tissue selectivity, and toxicity of these agents can provide insights into the lessons learned from this failure and identify new opportunities.
BRITISH JOURNAL OF CANCER
(2023)
Article
Computer Science, Interdisciplinary Applications
Andrea Tangherloni, Simone G. Riva, Brynelle Myers, Francesca M. Buffa, Paolo Cazzaniga
Summary: Single-cell RNA sequencing experiments are valuable for identifying different cell types. This study introduces a fully-automatic framework called MAGNETO, which constructs optimal marker panels for distinguishing desired cell populations. The results demonstrate that MAGNETO outperforms other methods in identifying the cell populations of interest.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Article
Oncology
Rui Zhang, Jiarong Li, Dunarel Badescu, Andrew C. Karaplis, Jiannis Ragoussis, Richard Kremer
Summary: The 5-year survival rate for women with metastatic breast cancer is 29%. A genetically modified breast cancer mouse model was used to study the role of Parathyroid hormone-related peptide (PTHrP) in breast cancer growth and metastasis. A novel long non-coding RNA (lncRNA) was identified as a potential target for fatty acid metabolism regulated by PTHrP. These findings could contribute to the development of targeted strategies for breast cancer treatment.
Article
Oncology
G. P. Ralli, R. D. Carter, D. R. McGowan, W-C Cheng, D. Liu, E. J. Teoh, N. Patel, F. Gleeson, A. L. Harris, S. R. Lord, F. M. Buffa, J. D. Fenwick
Summary: In this study, gene set enrichment analysis was performed to identify KEGG pathways associated with FDG uptake in primary breast cancers. Glycolysis/gluconeogenesis pathway and pathways related to immune response or inflammation were found to be associated with FDG uptake. Patlak K, a kinetic parameter, was associated with more pathways than any other imaging index. These results suggest that Patlak analysis of dynamic FDG-PET scans is advantageous for studying tumor biology.
BREAST CANCER RESEARCH
(2022)