Article
Engineering, Environmental
Jun Xu, Shengli Guo, Lei Jia, Tinghui Zhu, Xiangzhen Chen, Tongqian Zhao
Summary: The emergence of “superbugs” due to antibiotic pollution in the environment has highlighted the need for a portable, on-site, and simple method for detecting antibiotics. A dual-channel fluorescent nanoprobe based on laponite was developed for the detection of tetracycline, with successful detection from 30 nM to 54 μM and a detection limit of 9.5 nM. Visual probes based on paper and gloves were also devised for detecting tetracycline, showing promising potential for real-world application in smart devices.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Materials Science, Ceramics
JunYu Chen, LianJie Li, Tao Pang, Hai Guo, LiPing Chen
Summary: Multi-mode optical thermometry demonstrates great potential in accurate temperature measurement. Through the elaboration of Na2GdMg2V3O12:Sm3+ phosphors, the material with dual-emission centers is successfully achieved. By irradiation of 349 nm light, NGMVO:Sm3+ can generate emissions from VO43- and Sm3+ due to energy transfer between them. The designed fluorescence intensity (FI), fluorescence intensity ratio (FIR), and Commission Internationale de L'Eclairage coordinate modes of NGMVO:Sm3+ thermometer exhibit high relative sensitivities (S-R) up to 2.21 %K-1, 2.12 %K-1, and 0.244 %K-1, respectively. Furthermore, the S-R values of FI and FIR modes decrease slowly with increasing temperature, maintaining above 1.36 %K-1 and 1.08 %K-1, respectively, between 303 and 513 K. These findings highlight the promising applications of NGMVO:Sm3+ phosphors in multimode temperature sensors.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Respiratory System
Florian Guisier, Gaetan Deslee, Philippe Birembaut, Bruno Escarguel, Francoise Chapel, Suzanna Bota, Josette Metayer, Samy Lachkar, Frederique Capron, Jean Paul Homasson, Marc Taulelle, Marie Quintana, Christophe Raspaud, Daniel Messelet, Jonathan Benzaquen, Paul Hofman, Jamal Baddredine, Christophe Paris, Valerie Cales, Philippe Laurent, Jean-Michel Vignaud, Olivier Menard, Marie-Christine Copin, Philippe Ramon, Brigitte Bouchindhomme, Jean-Yves Tavernier, Isabelle Quintin, Jean-Jacques Quiot, Francoise Galateau-Salle, Gerard Zalcman, Nicolas Piton, Luc Thiberville
Summary: Patients with moderate dysplasia are at a very high risk of developing lung cancer within 5 years, and quitting smoking significantly reduces this risk. Identifying dysplasia using initial bronchoscopy may be useful for risk stratification strategies in lung cancer screening programs.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Optics
Guoru Li, Xiangshan Li, Ragini Singh, Guiwei Zhang, Bingyuan Zhang, Santosh Kumar
Summary: A localized surface plasmon resonance (LSPR)-based fiber biosensor, named WaveFlex Biosensor, is proposed for accurate detection of low-concentration alpha-fetoprotein (AFP). The combination of a slide-type fiber structure and low-dimensional materials enhances the LSPR signal generated by gold nanoparticles (AuNPs), improving the sensitivity of the biosensor and enabling rapid detection. The developed fiber probe, utilizing AFP antibodies, achieves a sensitivity of 32 pm/(ng/mL) and a limit of detection of 6.65 ng/mL, demonstrating great potential for rapid and accurate AFP detection.
Article
Spectroscopy
Yanan Yan, Lin Li, Huilin Zhang, Fangfang Du, Yating Meng, Shaomin Shuang, Ruibing Wang, Shengmei Song, Chuan Dong
Summary: The B,N dual-doped carbon dots (B,N-CDs) were prepared using a single-step hydrothermal method for ratiometric fluorescence detection of morin, exhibiting optimal excitation and emission wavelengths. The fluorescence intensity of B,N-CDs showed a linear relationship with morin concentration and excellent selectivity. B,N-CDs were effective in detecting morin in urine samples with high recoveries.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Computer Science, Information Systems
Javad Abbasi Aghamaleki
Summary: This paper presents a new optimized algorithm for extracting shadows from aerial images, which combines two color spaces and utilizes the blue color from the sky to enhance the performance of the ratio map. The algorithm reduces computational cost and can be used in online applications.
MULTIMEDIA TOOLS AND APPLICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Jiajun Chen, Zhinan Fan, Chi Zhang, Huatian Duan, Li-Juan Fan
Summary: A fluorescence sensing system based on an amphiphilic conjugated polyelectrolyte was successfully constructed to detect neomycin, a common antibiotic in the environment and food. The system showed excellent sensing performance towards neomycin at a neutral pH value, with a blue-to-green fluorescence color change observed by the naked eye. The mechanism study confirmed that polymer aggregation played a crucial role in inducing the visually fluorescent color change.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Analytical
Haibo Liang, Yumin Wang, Li Zhang, Yujuan Cao, Manli Guo, Ying Yu, Bixia Lin
Summary: In this study, a portable fluorescence sensor that integrated various components was designed and successfully applied in the detection of nitrite. By measuring the RGB values of fluorescence color, a linear detection of nitrite concentration was achieved. Furthermore, the detection results of the fluorescence sensor were consistent with traditional fluorescence method and spectrophotometry.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Optics
JunYu Chen, LianJie Li, JianQuan Chen, Tao Pang, LiPing Chen, Hai Guo
Summary: In this work, a novel optical thermometry with four modes was designed using Ca3LiZnV3O12:Eu3+ (CLZVO:Eu3+) phosphors. The luminescent intensities of VO43-and Eu3+ show different downward trends with temperature increase, resulting in a color change with temperature. The different modes of CLZVO:Eu3+ thermometry obtained include FI, FIR, CIE coordinate, and EIR, with maximum relative sensitivity (SR) values ranging from 0.492 %K-1 to 2.56 %K-1. The minimal SR values of FI and FIR modes are higher than 1.38 %K-1 and 1.08 %K-1 in the temperature range of 303-513 K. These outstanding properties indicate the potential of CLZVO:Eu3+ for temperature monitoring.
JOURNAL OF LUMINESCENCE
(2023)
Article
Chemistry, Analytical
Jialin Wen, Yuxuan Hu, Na Li, Dan Li, Guangfan Zheng, Yongjian Zou, Minmin Zhang, Lingling Shui
Summary: In this study, a novel ratiometric fluorescent probe based on in situ fluorogenic reaction was developed for alkaline phosphatase (ALP) activity sensing. The probe showed high sensitivity for ALP activity with a detection limit of 0.08 U/L.
ANALYTICA CHIMICA ACTA
(2022)
Article
Engineering, Environmental
Shanshan Wei, Bin Wang, Hongyuan Zhang, Chenzhao Wang, Shufeng Cui, Xiangyu Yin, Chunzhu Jiang, Guoying Sun
Summary: Amino acids are crucial in various physiological processes and the accurate monitoring of their metabolism remains a challenge. This study successfully synthesized multi-color emission carbon dots (CDs) that demonstrated bright and steady luminescence. These CDs exhibited low cytotoxicity and excellent multi-color cell imaging ability. Specifically, chiral red emissive CDs (R-L-CDs) were able to quickly identify specific amino acids in water and biological samples. The introduction of a smart phone color recognizer application improved the accuracy of visual detection. Overall, these findings have far-reaching prospects for the application of R-L-CDs as biosensors.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Spectroscopy
Zhihua Li, Lin Chen, Jiaxi Deng, Jing Zhang, Cailin Qiao, Mei Yang, Guoren Xu, Xiaogang Luo, Danqun Huo, Changjun Hou
Summary: This article presents a novel fluorescent probe, Eu-BTB, for the efficient detection of Cu2+ ions in water. The probe demonstrates exceptional fluorescence characteristics and utilizes an antenna effect triggered by the interaction between the probe ligand BTB and Eu3+. It offers a rapid and accurate measurement of Cu2+ ions concentration.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2024)
Article
Materials Science, Multidisciplinary
Sen Liao, Jiaxin Liu, Junjie Luo, Yu Li, Qingbi Li, Shuangshuang Chen, Guoping Wang
Summary: In this study, a ratio fluorescent probe was synthesized for the selective detection of tetracycline, which demonstrated good performance in real samples.
Article
Chemistry, Analytical
Zi Yi Xu, Xiao Dong He, Hong Qun Luo, Li Qun Xu, Nian Bing Li
Summary: This article describes an efficient fluorogenic strategy for ultrasensitive detection of dopamine (DA). The method offers rapid response, wide linear range, good selectivity, and sensitivity, and has been successfully applied for the measurement of DA content in practical urine samples and evaluation of DA levels in a rat model of depression.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Wenyue Ma, Zijian Gu, Guocui Pan, Chunjuan Li, Yu Zhu, Zhaoyang Liu, Leijing Liu, Yupeng Guo, Bin Xu, Wenjing Tian
Summary: The detection of acid in different solution environments is crucial in chemical, environmental, and biological fields. However, the challenge lies in detecting acid in various environments such as aqueous, organic solvents, and their mixtures. To address this, a covalent organic framework (COF) called TPBD-TA COF was created by combining TPBD and TA. This COF exhibited color change and fluorescence quenching in response to increasing acid contents, regardless of the detection environment. The detection limit for acid using TPBD-TA COF was found to be 0.4 μmol/L and 58 nmol/L, respectively.
Article
Rheumatology
M. den Braber-Ymker, M. C. Vonk, K. Grunberg, M. Lammens, I. D. Nagtegaal
Summary: The histological evaluation of intestinal involvement in systemic sclerosis (SSc) revealed differences in vascular changes, muscle layer fibrosis, and neuronal reduction between SSc patients and controls. The diversity among patients suggests parallel pathological processes, explaining the variety of histological features and clinical symptoms observed in SSc.
CLINICAL RHEUMATOLOGY
(2021)
Article
Pathology
Pierre Moulin, Katrien Grunberg, Erio Barale-Thomas, Jeroen van der Laak
Summary: The goal of the project is to drive digital transformation in pathology by establishing a whole slide imaging platform, connecting pathologists, researchers, AI developers, patients, and industry participants, with an emphasis on sustainable development and reciprocal cooperation.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Oncology
Elisabeth M. P. Steeghs, Hans Gelderblom, Vincent K. Y. Ho, Quirinus J. M. Voorham, Stefan M. Willems, Katrien Grunberg, Marjolijn J. L. Ligtenberg
Summary: The study found that in the Netherlands, predictive mutation analysis is mainly conducted in high-risk or metastatic GIST patients, with a higher testing rate in patients treated at expertise centers. However, not all patients who have received imatinib therapy have received mutation-tailored treatment according to the guidelines.
Article
Health Care Sciences & Services
Clemence T. B. Pasmans, Bastiaan B. J. Tops, Elisabeth M. P. Steeghs, Veerle M. H. Coupe, Katrien Grunberg, Eiko K. de Jong, Ed M. D. Schuuring, Stefan M. Willems, Marjolijn J. l. Ligtenberg, Valesca P. Retel, Hans van Snellenberg, Ewart de Bruijn, Edwin Cuppen, Geert W. J. Frederix
Summary: This study calculated and compared the total cost of current diagnostic techniques and WGS in the treatment of NSCLC, melanoma, CRC, and GIST in the Netherlands. The results showed that operational costs accounted for over 90% of the total cost per technique, with variations ranging from euro 58 to euro 2925 per cancer patient. Detailed cost differences and value comparisons between these diagnostic techniques enable future economic evaluations to support decision-making.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2021)
Article
Oncology
Peter H. J. Slootbeek, Iris S. H. Kloots, Minke Smits, Inge M. van Oort, Winald R. Gerritsen, Jack A. Schalken, Marjolijn J. L. Ligtenberg, Katrien Grunberg, Leonie Kroeze, Haiko J. Bloemendal, Niven Mehra
Summary: The study found that almost half of advanced prostate cancer patients receive recommendations for genetically matched therapies, with over 40% of them showing durable responses to the treatment. These findings support the routine referral of selected prostate cancer patients to molecular tumour boards.
BRITISH JOURNAL OF CANCER
(2022)
Article
Cell & Tissue Engineering
Jitske Jansen, Katharina C. Reimer, James S. Nagai, Finny S. Varghese, Gijs J. Overheul, Marit de Beer, Rona Roverts, Deniz Daviran, Liline A. S. Fermin, Brigith Willemsen, Marcel Beukenboom, Sonja Djudjaj, Saskia von Stillfried, Larissa E. van Eijk, Mirjam Mastik, Marian Bulthuis, Wilfred den Dunnen, Harry van Goor, Jan-Luuk Hillebrands, Sergio H. Triana, Theodore Alexandrov, Marie-Cherelle Timm, Bartholomeus T. van den Berge, Martijn van den Broek, Quincy Nlandu, Joelle Heijnert, Eric M. J. Bindels, Remco M. Hoogenboezem, Fieke Mooren, Christoph Kuppe, Pascal Miesen, Katrien Grunberg, Ties Ijzermans, Eric J. Steenbergen, Jan Czogalla, Michiel F. Schreuder, Nico Sommerdijk, Anat Akiva, Peter Boor, Victor G. Puelles, Juergen Floege, Tobias B. Huber, Ronald P. van Rij, Ivan G. Costa, Rebekka K. Schneider, Bart Smeets, Rafael Kramann
Summary: The study found that SARS-CoV-2 can directly infect kidney cells, leading to cell injury and fibrosis, causing kidney failure. Inhibitors can alleviate the infection.
Article
Pathology
Elisabeth M. P. Steeghs, Geraldine R. Vink, Marloes A. G. Elferink, Quirinus J. M. Voorham, Hans Gelderblom, Iris D. Nagtegaal, Katrien Grunberg, Marjolijn J. L. Ligtenberg
Summary: The study in the Netherlands showed an increase in mutation testing rates for CRC patients over time, with anti-EGFR therapy mainly used in KRAS/NRAS wild-type patients after the third treatment line. The national average mutation rate was 63.9%, and NGS-based approaches detected more potential biomarkers.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Correction
Oncology
Peter H. J. Slootbeek, Iris S. H. Kloots, Minke Smits, Inge M. van Oort, Winald R. Gerritsen, Jack A. Schalken, Marjolijn J. L. Ligtenberg, Katrien Grunberg, Leonie I. Kroeze, Haiko J. Bloemendal, Niven Mehra
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Elisabeth M. P. Steeghs, Harry J. M. Groen, Ed Schuuring, Mieke J. Aarts, Ronald A. M. Damhuis, Quirinus J. M. Voorham, Path Consortium, Marjolijn J. L. Ligtenberg, Katrien Grunberg
Summary: This study evaluated molecular testing and treatment selection in stage IV NSCLC patients in the Netherlands. The results showed that predictive molecular testing rates were highest for adenocarcinomas and lowest for squamous cell carcinomas. Next-generation sequencing (NGS) approaches had a higher detection rate of therapeutic alterations compared to non-NGS approaches.
Review
Cell Biology
Melek Huyuk, Marta Fiocco, Pieter E. Postmus, Danielle Cohen, Jan H. von der Thusen
Summary: This systematic review and meta-analysis investigated the association between lymph node micrometastases in stage I-IIIA NSCLC patients and overall survival (OS) and disease-free survival (DFS) after surgical resection. The study found that patients with lymph node micrometastases detected through ancillary techniques had significantly poorer OS and DFS compared to patients without micrometastases. The 5-year OS and DFS rates were lower in the micrometastasis group compared to the no micrometastasis group.
Article
Oncology
Lieke L. van der Woude, Mark A. J. Gorris, Inge M. N. Wortel, Jeroen H. A. Creemers, Kiek Verrijp, Kim Monkhorst, Katrien Grunberg, Michel M. van den Heuvel, Johannes Textor, Carl G. Figdor, Berber Piet, Willemijn S. M. E. Theelen, I. Jolanda M. de Vries
Summary: This study found that lymphocyte infiltration in the tumor microenvironment is associated with response to therapy in NSCLC patients, regardless of the specific lymphocyte subset. Additionally, the combination of anti-PD-1 and SBRT induced a higher infiltration of cytotoxic T cells compared to anti-PD-1 monotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Gerben Lassche, Sjoerd van Helvert, Astrid Eijkelenboom, Martijn J. H. Tjan, Erik A. M. Jansen, Patricia H. J. van Cleef, Gerald W. Verhaegh, Eveline J. Kamping, Katrien Grunberg, Adriana C. H. van Engen-van Grunsven, Marjolijn J. L. Ligtenberg, Carla M. L. van Herpen
Summary: This research aimed to assess the prevalence of actionable aberrations in salivary gland cancer (SGC) and identified several new gene fusions. Targets for genetically matched therapies were found in different SGC subtypes. This highlights the potential importance of molecular diagnostics in selecting systemic treatment for SGC.
Article
Oncology
Henri B. Wolff, Elisabeth M. P. Steeghs, Zakile A. Mfumbilwa, Harry J. M. Groen, Eddy M. Adang, Stefan M. Willems, Katrien Grunberg, Ed Schuuring, Marjolijn J. L. Ligtenberg, Bastiaan B. J. Tops, Veerle M. H. Coupe
Summary: This study evaluates the efficacy of parallel next generation sequencing (NGS)-based testing compared to sequential single-gene-based testing in patients with stage IV nonsquamous non-small-cell lung cancer. The results show that parallel testing is cheaper and more effective than sequential testing, with the ability to detect additional relevant genetic aberrations.
JCO PRECISION ONCOLOGY
(2022)
Article
Respiratory System
Guus R. M. van den Heuvel, Leonie I. Kroeze, Marjolijn J. L. Ligtenberg, Katrien Grunberg, Erik A. M. Jansen, Daniel von Rhein, Richarda M. de Voer, Michel M. van den Heuvel
Summary: This study investigated mutational signatures in NSCLC patients using tumor DNA samples, revealing a prominent presence of SBS4 signature in tumors associated with smoking, and SBS2 and/or SBS13 signatures linked to AID/APOBEC enzyme activity. SBS4 signature was significantly more present in early stages of NSCLC, indicating potential clinical significance. Further studies are needed to determine the clinical utility of mutational signature analyses.
RESPIRATORY RESEARCH
(2021)
Article
Oncology
Bart Koopman, Harry J. M. Groen, Marjolijn J. L. Ligtenberg, Katrien Grunberg, Kim Monkhorst, Adrianus J. de Langen, Mirjam C. Boelens, Marthe S. Paats, Jan H. von der Thusen, Winand N. M. Dinjens, Nienke Solleveld, Tom van Wezel, Hans Gelderblom, Lizza E. Hendriks, Ernst-Jan M. Speel, Tom E. Theunissen, Leonie I. Kroeze, Niven Mehra, Berber Piet, Anthonie J. van der Wekken, Arja ter Elst, Wim Timens, Stefan M. Willems, Ruud W. J. Meijers, Wendy W. J. de Leng, Anne S. R. van Lindert, Teodora Radonic, Sayed M. S. Hashemi, Danielle A. M. Heideman, Ed Schuuring, Leon C. van Kempen
Summary: This study evaluates the methods and agreement in treatment recommendations among Molecular Tumor Boards (MTBs) from tertiary cancer referral centers in The Netherlands. It found that these MTBs are similar in setup and demonstrate high agreement in recommendations for rare or complex mutational cancer profiles. The proposed Dutch MTB model focuses on collaborative and nationally aligned workflow with interinstitutional collaboration and data sharing.