Article
Medicine, General & Internal
Hosub Park, Seungyun Jee, Hwangkyu Son, Hyebin Cha, Seongsik Bang, Byung Kyu Ahn, Jaekyung Myung, Seungsam Paik, Hyunsung Kim
Summary: This study evaluated the clinicopathological significance and prognostic value of MTUS1 in colorectal adenocarcinoma. The results showed that low MTUS1 protein expression is associated with adverse clinicopathological characteristics and poor survival outcomes in patients with colorectal adenocarcinoma. These results suggest that MTUS1 functions as a tumor suppressor in colorectal adenocarcinoma and could be a potential prognostic biomarker.
Article
Biochemistry & Molecular Biology
Tiegang Li, Zheng Yan, Weiqi Wang, Rixin Zhang, Wenqiang Gan, Silin Lv, Zifan Zeng, Yufang Hou, Min Yang
Summary: The study revealed that high SEMA6B expression was associated with poor prognosis and the tumor immunosuppressive microenvironment in CRC patients, suggesting SEMA6B as a potential novel prognostic biomarker for CRC and providing insights for developing CRC-targeted immunotherapies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Yuan Nie, Mei-chun Jiang, Cong Liu, Qi Liu, Xuan Zhu
Summary: The study found that CXCL5 expression is associated with the survival and TMN classification of hepatocellular carcinoma patients. Immune-related activities were enriched in the high-expression group, while metabolic pathways were enriched in the low-expression group. Analysis using CIBERSORT revealed that CXCL5 expression was correlated with the proportion of activated NK cells, macrophages M0, resting mast cells, and neutrophils.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Guoshun Zhang, Hua Shang, Bin Liu, Guikai Wu, Diyang Wu, Liuqing Wang, Shengnan Li, Zhiyuan Wang, Suying Wang, Juxiang Yuan
Summary: ATP2A1 is a potential prognostic biomarker in colorectal cancer, with high expression associated with significantly lower overall survival rates. Inhibiting the autophagy process by ATP2A1 can significantly suppress the proliferation of colorectal cancer cells.
FRONTIERS IN GENETICS
(2022)
Article
Gastroenterology & Hepatology
Yiming Tao, Jia Luo, Hongyi Zhu, Yi Chu, Lei Pei
Summary: This study found that the expression of C12ORF49 is closely related to the prognosis of colorectal cancer, and high expression of C12ORF49 is associated with poor prognosis in CRC.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Immunology
Xiaonan Shen, Chunhua Zhou, Haoran Feng, Jialu Li, Tianxue Xia, Xi Cheng, Ren Zhao, Duowu Zou
Summary: The upregulation of PEA3 members ETV1 and ETV5 is associated with poor prognosis in CRC patients. ETV1 and ETV5 may play significant roles in the development of CRC, and ETV1 is specifically associated with the infiltration of cancer-associated fibroblasts and M2 macrophages in CRC. Targeting ETV1 could be a potential approach for treating CRC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Li, Tao Yang, Qihong Wang, Yuedan Li, Haiyan Wu, Mei Zhang, Hong Qi, Hongxin Zhang, Jinfeng Li
Summary: This study demonstrates that SQLE plays a vital role in the progression of head and neck squamous cell carcinoma (HNSCC). High expression of SQLE is associated with aggressive tumor features and poor prognosis. Additionally, overexpression of SQLE enhances the proliferation, migration, and invasion abilities of HNSCC cells. The PI3K/Akt signaling pathway is implicated in the SQLE-mediated progression of HNSCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Spyridon Christodoulou, Christina D. Sotiropoulou, Panteleimon Vassiliu, Nikolaos Danias, Nikolaos Arkadopoulos, Diamantis C. Sideris
Summary: This study aimed to investigate the prognostic potential of miR-675-5p as a molecular biomarker in colorectal cancer (CRC). The results showed that miR-675-5p was downregulated in CRC tissue samples and its high expression was associated with shorter disease-free and overall survival in CRC patients. Additionally, high miR-675-5p expression was correlated with TNM staging. In conclusion, miR-675-5p overexpression may serve as an independent molecular biomarker for unfavorable prognosis in CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Xiaopeng Wang, Ruirong Lin, Yi Zeng, Yi Wang, Shenghong Wei, Zhitao Lin, Shu Chen, Zaisheng Ye, Luchuan Chen
Summary: In this study, the potential prognostic value of FCRLB in colorectal cancer (CRC) was identified through TCGA database analysis. FCRLB was found to be highly expressed in CRC tissues compared to normal tissues. High expression of FCRLB correlated with adverse clinicopathological features such as elevated CEA levels, advanced tumor stage, lymphatic invasion, perineural invasion, and incomplete resection. Additionally, high expression of FCRLB was associated with poorer overall survival, disease-specific survival, and progression-free survival. Further validation using tissue microarray confirmed these findings.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Chun Zhuang, Xiaoqi Li, Linxi Yang, Xinli Ma, Yanying Shen, Chen Huang, Tao Pan, Jianzhi Cui, Bo Ni, Ming Wang
Summary: This study analyzed the expression of ferroptosis-related genes in gastrointestinal stromal tumor (GIST) and found that transferrin receptor (TFRC) was significantly upregulated in high-risk patients. Further enrichment analysis revealed that TFRC expression was closely associated with cell growth pathways and metabolism-related pathways. High TFRC expression in GIST patients indicated an unfavorable state of patient relapse and could serve as a powerful independent predictor of recurrence-free survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Health Care Sciences & Services
Miaoqing Wu, Xiaoliang Wu, Xing Wang, Xiangchan Hong, Yifan Liu, Guangzhao Lv, Cong Li, Zhizhong Pan, Rongxin Zhang, Gong Chen
Summary: This study investigated the correlation between the expression levels of IDO1 and COX2 and overall survival (OS) and progression-free survival (PFS) in colorectal cancer (CRC) patients with liver oligometastases. The results showed that the coexpression of IDO1/COX2 was significantly associated with the survival rate of patients and may serve as a potential prognostic biomarker for CRC patients with liver oligometastases.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao
Summary: This study investigated the expression of phosphorylated Focal adhesion kinase (p-FAK) in colorectal cancer (CRC) and its association with prognosis. The results showed that high p-FAK expression was associated with poor prognosis and poor chemotherapeutic response in CRC. Therefore, the expression level of p-FAK can serve as an independent prognostic biomarker for CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Siyi Lu, Zhenzhen Liu, Bingyan Wang, Fei Li, Yan Meng, Junwei Wang, Yuxia Wang, Hao Wang, Xin Zhou, Wei Fu
Summary: This study revealed that the CFP scoring system is a more reliable marker for predicting OS, DFS, and NCRT efficacy in LARC patients, and it significantly improves the predictive efficacy of the nomogram.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Meilin Weng, Wenling Zhao, Ying Yue, Miaomiao Guo, Ke Nan, Qingwu Liao, Minli Sun, Di Zhou, Changhong Miao
Summary: The study revealed that a high preoperative white blood cell count is an independent risk factor for poor prognosis in colorectal cancer patients and is associated with an immunosuppressive tumor microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Jinfeng Zhu, Chen Luo, Jiefeng Zhao, Xiaojian Zhu, Kang Lin, Fanqin Bu, Zhonglin Yu, Feilong Zou, Zhengming Zhu
Summary: The study revealed that high expression of LOX in gastric cancer tissues is significantly associated with poor overall survival, LOX overexpression is closely correlated with T-stage progression in gastric cancer, and LOX is an independent factor affecting the prognosis of gastric cancer patients.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
T. Susanna Meijer, Mark C. Burgmans, Eleonora M. de Leede, Lioe-Fee de Geus-Oei, Bas Boekestijn, Henricus J. M. Handgraaf, Denise E. Hilling, Jacob Lutjeboer, Jaap Vuijk, Christian H. Martini, Arian R. van Erkel, Rutger W. van der Meer, Fred G. J. Tijl, Frank M. Speetjens, Ellen Kapiteijn, Alexander L. Vahrmeijer
Summary: This study aimed to evaluate the efficacy and safety of M-PHP treatment for patients with liver-only ocular melanoma metastases. The results showed that this treatment can achieve a high overall response rate and prolonged survival, with significantly longer survival in responders.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Danielle Krijgsman, Jessica Roelands, Wouter Hendrickx, Davide Bedognetti, Peter J. K. Kuppen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Chemistry, Medicinal
Cansu de Muijnck, Yoren van Gorkom, Maurice van Duijvenvoorde, Mina Eghtesadi, Geeske Dekker-Ensink, Shadhvi S. Bhairosingh, Alessandra Affinito, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Cornelis F. M. Sier
Article
Computer Science, Information Systems
Danielle Krijgsman, Marinus B. van Leeuwen, John van der Ven, Vanda Almeida, Ruud Vlutters, David Halter, Peter J. K. Kuppen, Cornelis J. H. van de Velde, Reinhold Wimberger-Friedl
Summary: In order to support therapy selection in oncology, a reliable and reproducible quantification of immune infiltrate within tumor microenvironments is needed. The automated method presented in this study allows for whole-slide image analysis of tumor-infiltrating CD8-positive lymphocytes, showing highly heterogeneous spatial density distributions in post-menopausal, estrogen receptor-positive invasive breast cancer patients receiving adjuvant tamoxifen therapy. Statistically significant correlation with clinical outcome was found for the standard deviation of the CD8 density distribution, suggesting potential clinical relevance for larger cohort studies.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2021)
Review
Oncology
Zeger Rijs, A. Naweed Shifai, Sarah E. Bosma, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Stijn Keereweer, Judith V. M. G. Bovee, Michiel A. J. van de Sande, Cornelis E. M. Sier, Pieter B. A. A. van Driel
Summary: Near-infrared imaging technology facilitates tumor identification during surgery, allowing surgeons to distinguish malignant tissue using specific biomarkers. By evaluating clinically targeted biomarkers on soft tissue sarcomas, potential candidates for near-infrared fluorescence imaging have been identified to improve surgical outcomes and enhance tumor resection accuracy. Promising biomarkers have been found in common and aggressive soft tissue sarcoma subtypes, showing potential for future clinical applications.
Article
Oncology
Richard E. Evenhuis, Ibtissam Acem, Anja J. Rueten-Budde, Diederik S. A. Karis, Marta Fiocco, Desiree M. J. Dorleijn, Frank M. Speetjens, Jakob Anninga, Hans Gelderblom, Michiel A. J. van de Sande
Summary: Age is an important prognostic factor for overall survival in patients with skeletal osteosarcoma, with poor survival associated with increasing age. Differences in outcome among different age groups can be partially explained by patient characteristics and treatment characteristics.
Article
Medicine, General & Internal
Daan Linders, Marion Deken, Maxime van der Valk, Willemieke Tummers, Shadhvi Bhairosingh, Dennis Schaap, Gesina van Lijnschoten, Elham Zonoobi, Peter Kuppen, Cornelis van de Velde, Alexander Vahrmeijer, Arantza Farina Sarasqueta, Cornelis Sier, Denise Hilling
Summary: Rectal cancer patients with a complete response after neoadjuvant therapy show low expression of CEA and EpCAM in the primary tumor bed compared to the diagnostic biopsy and adjacent mucosa, indicating their potential as suitable targets for response evaluation.
Review
Biochemistry & Molecular Biology
Ricky B. van de Water, Danielle Krijgsman, Ruben D. Houvast, Alexander L. Vahrmeijer, Peter J. K. Kuppen
Summary: Tumor HLA-G expression is associated with poor clinical outcomes in breast, esophageal, gastric, and hepatocellular carcinoma patients, but not in ovarian and oral carcinoma patients. Discrepancies in cervical, colorectal, lung, and pancreatic carcinoma patients make it inconclusive. Standardized methodologies are recommended to clarify the relationship between tumor HLA-G expression and clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Martijn A. van Dam, Floris A. Vuijk, Judith A. Stibbe, Ruben D. Houvast, Saskia A. C. Luelmo, Stijn Crobach, Shirin Shahbazi Feshtali, Lioe-Fee de Geus-Oei, Bert A. Bonsing, Cornelis F. M. Sier, Peter J. K. Kuppen, Rutger-Jan Swijnenburg, Albert D. Windhorst, Jacobus Burggraaf, Alexander L. Vahrmeijer, J. Sven D. Mieog
Summary: Pancreatic cancer patients have a poor prognosis with a low survival rate, emphasizing the need for better imaging tools to support surgical resection. Tumor-targeted PET/CT before surgery and real-time fluorescence-guidance during surgery could potentially improve patient outcomes, but further research is needed to determine their actual value in clinical practice.
Article
Oncology
Ruben D. Houvast, Kira Thijse, Jesse Groen, JiaXin Chua, Mireille Vankemmelbeke, Lindy G. Durrant, J. Sven D. Mieog, Bert A. Bonsing, Alexander L. Vahrmeijer, Peter J. K. Kuppen, A. Stijn L. P. Crobach, Cornelis F. M. Sier
Summary: The study found that several specific sugar molecules and mucins are significantly higher on pancreatic cancer cells compared to surrounding tissues, making them potential targets for visualization of lymph node metastases and improving pancreatic cancer treatment. Targeted molecular imaging may overcome current challenges in preoperative and intraoperative delineation of pancreatic ductal adenocarcinoma (PDAC).
Review
Biology
Lisanne K. A. Neijenhuis, Lysanne D. A. N. de Myunck, Okker D. Bijlstra, Peter J. K. Kuppen, Denise E. Hilling, Frank J. Borm, Danielle Cohen, J. Sven D. Mieog, Willem H. Steup, Jerry Braun, Jacobus Burggraaf, Alexander L. Vahrmeijer, Merlijn Hutteman
Summary: Lung cancer, particularly non-small cell lung cancer (NSCLC), is prevalent worldwide. Near-infrared (NIR) fluorescence imaging has been tested as an intraoperative technique to localize pulmonary nodules, allowing tumor identification, detection of additional lesions, and prevention of positive resection margins.
Article
Biochemistry & Molecular Biology
Simone van de Weerd, Marloes A. Smit, Jessica Roelands, Wilma E. Mesker, Davide Bedognetti, Peter J. K. Kuppen, Hein Putter, Rob A. E. M. Tollenaar, Jeanine M. L. Roodhart, Wouter Hendrickx, Jan Paul Medema, J. Han J. M. van Krieken
Summary: This study evaluated the association between four distinct histopathological features and two gene expression-based classifiers. The presence of tumor infiltrating lymphocytes and a mucinous phenotype were strongly correlated with certain subtypes. Higher budding counts were seen in specific subtypes. However, identifying molecular subtypes solely based on histopathology proved to be infeasible.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jessica Roelands, Peter J. K. Kuppen, Eiman I. Ahmed, Raghvendra Mall, Tariq Masoodi, Parul Singh, Gianni Monaco, Christophe Raynaud, Noel F. C. C. de Miranda, Luigi Ferraro, Tatiana C. Carneiro-Lobo, Najeeb Syed, Arun Rawat, Amany Awad, Julie Decock, William Mifsud, Lance D. Miller, Shimaa Sherif, Mahmoud G. Mohamed, Darawan Rinchai, Marc Van den Eynde, Rosalyn W. Sayaman, Elad Ziv, Francois Bertucci, Mahir Abdulla Petkar, Stephan Lorenz, Lisa Sara Mathew, Kun Wang, Selvasankar Murugesan, Damien Chaussabel, Alexander L. Vahrmeijer, Ena Wang, Anna Ceccarelli, Khalid A. Fakhro, Gabriele Zoppoli, Alberto Ballestrero, Rob A. E. M. Tollenaar, Francesco M. Marincola, Jerome Galon, Souhaila Al Khodor, Michele Ceccarelli, Wouter Hendrickx, Davide Bedognetti
Summary: The lack of multi-omics cancer datasets with extensive follow-up information hinders the identification of accurate biomarkers of clinical outcome. In this cohort study, comprehensive genomic analyses were performed on fresh-frozen samples from 348 patients with primary colon cancer. The study revealed a gene expression signature called Immunologic Constant of Rejection that outperformed conventional prognostic molecular biomarkers. Additionally, a favorable outcome was associated with a microbiome signature driven by Ruminococcus bromii.
Article
Biochemistry & Molecular Biology
Zeger Rijs, Esther Belt, Gijsbert M. M. Kalisvaart, Cornelis F. M. Sier, Peter J. K. Kuppen, Arjen H. G. Cleven, Alexander L. L. Vahrmeijer, Michiel A. J. van de Sande, Pieter B. A. A. van Driel
Summary: This study aims to evaluate the expression of eight promising biomarkers for FGS in MFS tissue samples and adjacent healthy tissue. The results show that TEM-1 is the most suitable biomarker for FGS in MFS and should be further investigated to optimize MFS treatment.
Article
Hematology
Rayna J. S. Anijs, El Houari Laghmani, Betul Unlu, Szymon M. Kielbasa, Hailiang Mei, Suzanne C. Cannegieter, Frederikus A. Klok, Peter J. K. Kuppen, Henri H. Versteeg, Jeroen T. Buijs
Summary: This study aimed to identify novel tumor-expressed miRNAs associated with VTE in colorectal cancer. Through sequencing analysis, 19 differentially regulated tumor-expressed miRNAs were identified, which may provide insights into the biological mechanism and serve as potential predictive biomarkers.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS
(2022)