Review
Oncology
Francisco Civantos, Zachary M. Helmen, Patrick J. Bradley, Andres Coca-Pelaz, Remco De Bree, Orlando Guntinas-Lichius, Luiz P. Kowalski, Fernando Lopez, Antti A. Makitie, Alessandra Rinaldo, K. Thomas Robbins, Juan P. Rodrigo, Robert P. Takes, Alfio Ferlito
Summary: Skin cancer, especially non-melanoma skin cancer, is the most common malignancy worldwide. The management of different types of skin cancer is not clearly defined in scientific literature. Some require surgical removal, but the management of regional metastasis may vary, and microscopic metastases may be undetectable. This article summarizes the current literature on managing non-melanoma skin cancer that has spread to regional lymph nodes.
Article
Computer Science, Artificial Intelligence
Iam Palatnik de Sousa, Marley M. B. R. Vellasco, Eduardo Costa da Silva
Summary: This study presents a novel evolutionary approach for Explainable Artificial Intelligence, combining Local Interpretable Model Agnostic Explanations (LIME) with Multi-Objective Genetic Algorithms. The results show that this methodology can find high quality explanations and has the advantage of automated parameter fine tuning.
Article
Medicine, General & Internal
Bo Chen, Guochun Zhang, Jianguo Lai, Weikai Xiao, Xuerui Li, Cheukfai Li, Hsiaopei Mok, Kai Li, Yulei Wang, Li Cao, Minghan Jia, Chongyang Ren, Lingzhu Wen, Guangnan Wei, Jiali Lin, Yingzi Li, Yuchen Zhang, Xiaoqing Chen, Xueying Wu, Henghui Zhang, Min Li, Jing Liu, Charles M. Balch, Ning Liao
Summary: This study revealed significant differences in molecular and immune profiles between single lymph node metastases and multiple lymph node metastases in breast cancer patients. Single lymph node metastases were associated with more aggressive tumor characteristics and more favorable immune characteristics compared to multiple lymph node metastases.
Article
Computer Science, Information Systems
Lu Wang, Tian Song, Takafumi Katayama, Xiantao Jiang, Takashi Shimamoto, Jenq-Shiou Leu
Summary: An innovative deep regional metastases segmentation framework is proposed for patient-level classification of lymph node metastasis in breast cancer patients. The framework combines deep segmentation network and density-based spatial clustering algorithm to provide consistent and accurate metastasis diagnosis in histological lymph node section images.
Article
Oncology
Cimarron E. Sharon, Richard J. Straker, Eric H. Li, Giorgos C. Karakousis, John T. Miura
Summary: National rates of CLND have decreased, but patients with head/neck primary tumors who live in rural areas are more likely to undergo CLND, indicating potential non-uniform treatment patterns compared to national practice.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Surgery
Katherine Jackson, Luis Ruffolo, Lauren Kozakiewicz, Shuyang S. Qin, Alexander C. Chacon, Rachel Jewell, Brian Belt, Glynis A. Scott, David C. Linehan, Eva Galka, Peter A. Prieto
Summary: Lymph node involvement is a significant prognostic factor for melanoma, but the significance of few tumor cells within a single node remains unclear. This study investigated the implications of minimal nodal disease on clinical outcomes. Results showed that patients with picomets had better outcomes compared to historical stage matched cohorts, but a small subset still experienced disease recurrence. Further research with a larger population is needed to draw more conclusive results.
Review
Oncology
Kristen E. E. Rhodin, Denisse Porras Fimbres, Danielle N. N. Burner, Shayna Hollander, Margaret H. H. O'Connor, Georgia M. M. Beasley
Summary: This article reviews the prognostic role of melanoma lymph node metastases and their high-risk features, current reporting standards, and their application in practice-changing trials, as well as providing best practices for future clinical trial design and clinical decision-making.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Zhenyu Yang, Xingliang Tan, Yanjun Wang, Yuantao Zou, Dong Chen, Zhiming Wu, Zhuowei Liu, Yonghong Li, Zike Qin, Hui Han, Fangjian Zhou, Kai Yao
Summary: The study evaluated the relationship between deep inguinal lymph node metastasis and pelvic lymph node metastasis in PSCC, finding that deep ILNM is the most accurate factor for predicting PLNM. Patients with deep ILNM should be referred for pelvic lymph node dissection, as it indicates poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Doris Mangiaracina Benbrook, James Randolph Sanders Hocker, Katherine Marie Moxley, Jay S. Hanas
Summary: This study analyzed serum samples from endometrial cancer patients and benign gynecology surgical patients using electron spray ionization mass spectrometry (ES-MS), and evaluated the differences in serum proteins through leave one out cross validation (LOOCV). The study found that serum proteins could distinguish between different groups and predict positive lymph node metastases. Pathways related to metastases include loss of PTEN activation, calcium signaling activation, and estrogen receptor-induced transcription. These findings provide new insights for treatment decisions in endometrial cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Elena Parvez, Farzin Khosrow-Khavar, Teodora Dumitra, Carolyn Nessim, Ericka Bernard-Bedard, Justin Rivard, Vera Pravong, Sara Wang, Mai-Kim Gervais, Sarkis Meterissian, Sinziana Dumitra
Summary: This study examines real-world practices and outcomes of patients with melanoma sentinel lymph node metastases after the publication of the MSLT-II trial. The findings suggest that although practice patterns have changed, completion lymphadenectomy (CLND) does not reduce the risk of recurrence or mortality.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Hilda L. Chan, Xiang H. -F. Zhang
Summary: According to an article in Cell, lymph node metastases can suppress the immune system and promote further cancer spread, which has also been confirmed in patients as described in a letter in this issue of Cancer Cell. This suggests that the lymph node actively creates a cancer-permissive environment and could be a potential target for immune system manipulation.
Review
Biochemistry & Molecular Biology
Giulio Rizzetto, Guendalina Lucarini, Edoardo De Simoni, Elisa Molinelli, Monica Mattioli-Belmonte, Annamaria Offidani, Oriana Simonetti
Summary: Cutaneous melanoma is a severe cancer with early lymph node invasiveness and increased risk of metastasis. Identifying tissue biomarkers, such as VEGF, CD9, LYVE-1, D2-40, and 31-GEP, could help predict the risk of lymph node involvement. Among these, 31-GEP shows potential for distinguishing low and high risk for positive sentinel lymph node (SLN) classes. VEGF receptor-3 and CD9 expression can be independent predictors of positive SLN, while LYVE-1 and D2-40 facilitate assessment of lymph vascular invasion as predictors of SLN status.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Medicine, General & Internal
Elliot L. H. Le, Emma Lamping, Laura Helmkamp, Janice Bone, Martin McCarter, Nicole Kounalakis, Camille Stewart
Summary: This cohort study examines the correlation between the delay in surgery and sentinel lymph node status in patients with cutaneous melanoma stage T1b or higher.
Article
Oncology
Philipp Jansen, Daniel Otero Baguer, Nicole Duschner, Jean Le'Clerc Arrastia, Maximilian Schmidt, Jennifer Landsberg, Joerg Wenzel, Dirk Schadendorf, Eva Hadaschik, Peter Maass, Joerg Schaller, Klaus Georg Griewank
Summary: In this study, a deep learning method was used to analyze histological tissue sections of melanoma patients, enabling accurate detection of lymph node metastasis and providing valuable reference for pathologists. The method was able to identify the size and classify the tumor, which is of great significance for prognosis assessment and treatment planning.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Obstetrics & Gynecology
Tanja Ignatov, Johannes Gassner, Mihaela Bozukova, Stylianos Ivros, Jozsef Meszaros, Olaf Ortmann, Holm Eggemann, Atanas Ignatov
Summary: The risk of contralateral non-SLN metastases in patients with unilateral SLN metastases in vulvar cancer is low, suggesting a need for further investigation into the impact of contralateral lymphadenectomy on patient survival.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2021)
Article
Biology
Stephanie Thermozier, Wen Hou, Xichen Zhang, Donna Shields, Renee Fisher, Hulya Bayir, Valerian Kagan, Jian Yu, Bing Liu, Ivet Bahar, Michael W. Epperly, Peter Wipf, Hong Wang, M. Saiful Huq, Joel S. Greenberger
RADIATION RESEARCH
(2020)
Article
Multidisciplinary Sciences
Diwakar Davar, Amiran K. Dzutsev, John A. McCulloch, Richard R. Rodrigues, Joe-Marc Chauvin, Robert M. Morrison, Richelle N. Deblasio, Carmine Menna, Quanquan Ding, Ornella Pagliano, Bochra Zidi, Shuowen Zhang, Jonathan H. Badger, Marie Vetizou, Alicia M. Cole, Miriam R. Fernandes, Stephanie Prescott, Raquel G. F. Costa, Ascharya K. Balaji, Andrey Morgun, Ivan Vujkovic-Cvijin, Hong Wang, Amir A. Borhani, Marc B. Schwartz, Howard M. Dubner, Scarlett J. Ernst, Amy Rose, Yana G. Najjar, Yasmine Belkaid, John M. Kirkwood, Giorgio Trinchieri, Hassane M. Zarour
Summary: The study demonstrated that fecal microbiota transplantation combined with anti-PD-1 therapy can overcome resistance to anti-PD-1 in a subset of PD-1 refractory melanoma patients, leading to clinical benefits. This approach induced changes in the gut microbiome and reprogrammed the tumor microenvironment, ultimately enhancing the efficacy of anti-PD-1 treatment.
Article
Biology
Michael W. Epperly, Donna Shields, Renee Fisher, Wen Hou, Hong Wang, Diala Fatima Hamade, Amitava Mukherjee, Joel S. Greenberger
Summary: Both 20 Gy thoracic radiation and 8 Gy TBI induce senescent cells in the lungs of mice, while senescence is also observed in bone marrow following 8 Gy TBI. The p16(+/LUC) mouse strain is a valuable system for comparing the kinetics of radiation-induced senescence between organs in vivo and evaluating the potential role of senescent cells in irradiation-induced pulmonary fibrosis.
RADIATION RESEARCH
(2021)
Article
Oncology
Alistair J. Cochran, Duan-Ren Wen, Rong-Rong Huang, Payam Abrishami, Chandra Smart, Scott Binder, Richard A. Scolyer, John F. Thompson, Stacey Stern, Lisa Van Kreuningen, David E. Elashoff, Myung-Shin Sim, He-Jing Wang, Mark B. Faries
Summary: The precise characterization of sentinel lymph node (SLN) metastases is crucial for guiding the management of patients with Stage III melanoma. This study compared various methods of tumor burden quantification and found that the percentage of nodal involvement is a more powerful prognostic factor than the maximum dimension of the largest metastasis.
Article
Oncology
Melissa L. Bastacky, Hong Wang, Dylan Fortman, Zahra Rahman, Gerard P. Mascara, Timothy Brenner, Yana G. Najjar, Jason J. Luke, John M. Kirkwood, Hassane M. Zarour, Diwakar Davar
Summary: This study of 190 metastatic melanoma patients treated with single-agent anti-PD-1 ICI therapy found that 60% experienced at least one immune-related adverse event (irAEs), with irAE occurrence significantly associated with response to anti-PD-1 therapy. Patients with multiple irAEs exhibited distinct patterns, and obesity was distinctly associated with irAE development, while age and gender showed no significant association.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Amitava Mukherjee, Michael W. Epperly, Donna Shields, Wen Hou, Renee Fisher, Diala Hamade, Hong Wang, M. Saiful Huq, Riyue Bao, Tracy Tabib, Daisy Monier, Simon Watkins, Michael Calderon, Joel S. Greenberger
Summary: The study found that upregulated Fgr in radiation-induced senescent cells mediates RIPF and may be a potential therapeutic target for preventing this radiation late effect.
CELL DEATH DISCOVERY
(2021)
Article
Oncology
Lilit Karapetyan, Xi Yang, Andrew D. Knight, Ziyu Huang, Hong Wang, Cindy A. Sander, Christopher P. Minnier, Melissa Wilson, Aofei Li, Arivarasan Karunamurthy, Walter J. Storkus, John M. Kirkwood
Summary: In this study, patients with multiple primary melanomas (MPMs) were found to have worse recurrence-free survival (RFS) and overall survival (OS) compared to patients with single primary melanomas (SPMs). Immunologic differences were also observed, including TIL content and expression of CXCL6/FOXJ1 in PBMCs of patients with MPMs, which warrant further investigation.
Article
Biochemistry & Molecular Biology
Alexis Espinal, Michael W. Epperly, Amitava Mukherjee, Renee Fisher, Donna Shields, Hong Wang, M. Saiful Huq, Diala Fatima Hamade, Anda M. Vlad, Lan Coffman, Ronald Buckanovich, Jian Yu, Brian J. Leibowitz, Jan-Peter van Pijkeren, Ravi B. Patel, Donna Stolz, Simon Watkins, Asim Ejaz, Joel S. Greenberger
Summary: Gavaging Lactobacillus reuteri-Interleukin-22 (LR-IL-22) improves the delivery of IL-22 to the irradiated intestine and effectively mitigates radiation damage. Compared to the control group, gavaging LR-IL-22 improves multiple biomarkers associated with radiation damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Dermatology
Saba S. Shaikh, Xi Yang, Dylan D. Fortman, Hong Wang, Diwakar Davar, Jason J. Luke, Hassane Zarour, John M. Kirkwood, Yana G. Najjar
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Biology
Diala F. Hamade, Alexis Espinal, Jian Yu, Brian J. Leibowitz, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter Van Pijkeren, Amitava Mukherjee, Michael W. Epperly, Anda M. Vlad, Lan Coffman, Hong Wang, M. Saiful Huq, Ravi Patel, Jason Huang, Joel S. Greenberger
Summary: Oral administration of the probiotic Lactobacillus reuteri that releases interleukin-22 (LR-IL-22) can mitigate damage to the intestine and facilitate therapeutic whole-abdomen irradiation (WAI) for ovarian cancer.
RADIATION RESEARCH
(2022)
Article
Dermatology
Martha Matsumoto, Sarah Wack, Martin A. Weinstock, Alan Geller, Hong Wang, Francis X. Solano, John M. Kirkwood, Laura K. Ferris
Summary: Primary care-based melanoma screening is associated with increased detection of thin melanoma, raising concerns about overdiagnosis.
Article
Oncology
Saba S. Shaikh, Yan Zang, Janel Hanmer, Hong Wang, Yan Lin, Diwakar Davar, Hassane M. Zarour, John M. Kirkwood, Yana G. Najjar
Summary: This phase I trial evaluated the safety and efficacy of combined therapy with pembrolizumab, vemurafenib, and cobimetinib in untreated patients with BRAFV600E/K mutant advanced melanoma. The results showed that the triple therapy resulted in prolonged progression-free survival and overall survival, as well as a high objective response rate. However, significant adverse events led to the early closure of the study.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Diala F. Hamade, Michael W. Epperly, Renee Fisher, Wen Hou, Donna Shields, Jan-Peter van Pijkeren, Amitava Mukherjee, Jian Yu, Brian J. Leibowitz, Anda M. Vlad, Lan Coffman, Hong Wang, M. Saiful Huq, Ziyu Huang, Claude J. Rogers, Joel S. Greenberger
Summary: Irradiation can be an effective treatment for ovarian cancer, but its use is limited by intestinal toxicity. Strategies to mitigate toxicity are important and LR-IFN-beta, a genetically engineered probiotic, shows potential as a safe and feasible radiation mitigator. LR-IFN-beta protects the intestine, improves survival, and can potentially revolutionize OC patient management when combined with platinum/taxane-based chemotherapy.
Article
Medicine, Research & Experimental
Amitava Mukherjee, Michael W. Epperly, Renee Fisher, Donna Shields, Wen Hou, Arjun Pennathur, James Luketich, Hong Wang, Joel S. Greenberger
Summary: This study evaluated the earliest cellular and molecular changes in the esophagus that lead to esophageal cancer using a mouse model. The researchers found a significant increase in the levels of RNA for oncostatin-M in senescent cells of the esophagus from mice treated with the chemical carcinogen 4-NQO and human esophagus samples. The induction of OSM in chemically-induced esophageal cancer in mice correlated with the appearance of senescent cells.
Article
Oncology
Lilit Karapetyan, Xi Yang, Hong Wang, Cindy A. Sander, Ashley Moyer, Melissa Wilson, Arivarasan Karunamurthy, John M. Kirkwood
Summary: This study found a significant association between indoor tanning and multiple primary melanoma, with patients with multiple melanomas more likely to be younger and have additional risk factors. Subsequent melanomas tend to be thinner or in situ, and may occur in different anatomic locations.