Article
Medicine, General & Internal
Eun Jung Jung, Ju-Yeon Kim, Jae-Myung Kim, Han Shin Lee, Seung-Jin Kwag, Ji-Ho Park, Taejin Park, Sang-Ho Jeong, Chi-Young Jeong, Young-Tae Ju, Young-Joon Lee, Soon-Chang Hong
Summary: This study retrospectively reviewed the medical records of 715 breast cancer patients and found that LN-negative ER-positive patients had slightly poorer metastasis-free survival rates compared to ER-negative patients, and this was associated with tumor size and age.
Article
Oncology
Hengqiang Zhao, Yiping Gong
Summary: Single estrogen receptor (ER)+ and progesterone receptor (PR)+ tumors account for about 10% of all breast cancers. The prognosis of these tumors varies based on HER2 status, with single ER+ and PR+ patients showing different survival outcomes in different HER2 subtypes. In HER2- subtype, single PR+ patients had poorer prognoses than single ER+ patients, while in HER2+ subtype, single ER+ and PR+ patients showed similar prognoses compared with ER-PR- patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
D. Gareth Evans, Kelly-Anne Phillips, Roger L. Milne, Robert Fruscio, Cezary Cybulski, Jacek Gronwald, Jan Lubinski, Tomasz Huzarski, Zerin Hyder, Claire Forde, Kelly Metcalfe, Leigha Senter, Jeffrey Weitzel, Nadine Tung, Dana Zakalik, Maria Ekholm, Ping Sun, Steven A. Narod
Summary: This study aimed to estimate the impact of different treatments on breast cancer-specific survival among patients with a germline BRCA2 mutation. The results indicated that bilateral oophorectomy was associated with a reduced risk of death from breast cancer.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
Fei Fei, Gene P. Siegal, Shi Wei
Summary: The study analyzed clinicopathologic features and clinical outcomes of ER-low-positive breast cancers. ER-low-positive tumors showed significantly better prognosis compared to ER-negative tumors, with overlapping survival outcomes with ER-positive tumors in the entire cohort.
BREAST CANCER RESEARCH AND TREATMENT
(2021)
Article
Oncology
Meng Zhou, Jin-qi Yan, Qian-xin Chen, Yuan-zhong Yang, Yue-lin Li, Yue-xiang Ren, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang, Ze-fang Ren
Summary: This study revealed a close association between the prognostic value of H3K9me3 in breast cancer and ER status and expression level. High levels of H3K9me3 were associated with a better prognosis among ER-positive tumors, particularly ER-high positive tumors.
CLINICAL EPIGENETICS
(2022)
Article
Oncology
Shinsuke Sasada, Naoto Kondo, Hiroya Hashimoto, Yuko Takahashi, Kaori Terata, Kumiko Kida, Yasuaki Sagara, Takayuki Ueno, Keisei Anan, Akihiko Suto, Chizuko Kanbayashi, Mina Takahashi, Rikiya Nakamura, Toshiyuki Ishiba, Michiko Tsuneizumi, Seiichiro Nishimura, Yoichi Naito, Fumikata Hara, Tadahiko Shien, Hiroji Iwata
Summary: The prognosis for estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative T1a/bN0M0 breast cancers is excellent, but the necessity of adjuvant endocrine therapy (ET) is uncertain.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Oncology
William Sebastian, Lauren Forchette, Kelsey Donoughe, Yibei Lun, Anisha Verma, Tuoen Liu
Summary: In this review paper, various important aspects of hormone receptor (HR)-positive breast cancer were discussed, including HR structure and signaling, genetics (epigenetics and gene mutations), gene expression-based assays, traditional and new drugs for treatment, and new technological uses in diagnosis and treatment. Particularly, the commonly mutated genes and abnormally methylated genes in HR-positive breast cancer were summarized, and the common gene expression-based assays used in breast cancer as prognostic and/or predictive tools were compared in detail. These topic discussions have not been fully described and summarized within other research or review articles.
Review
Instruments & Instrumentation
Mayur Aalhate, Srushti Mahajan, Hoshiyar Singh, Santosh Kumar Guru, Pankaj Kumar Singh
Summary: Breast cancer is the most commonly diagnosed cancer in women worldwide, and early-stage non-metastatic cases have a high cure rate. However, there is a high risk of recurrence with endocrine therapy. Nanomedicine, which improves drug delivery and reduces toxicity, has become a promising approach for breast cancer treatment.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Article
Multidisciplinary Sciences
Rares Drula, Barbara Pardini, Xiao Fu, Mireia Cruz De los Santos, Ancuta Jurj, Lan Pang, Sherien M. El-Daly, Linda Fabris, Erik Knutsen, Mihnea P. Dragomir, Recep Bayraktar, Yongfeng Li, Meng Chen, Filippo Del Vecchio, Lea Berland, Jessica Dae, Daniel Fan, Masayoshi Shimizu, Anh M. Tran, Mercedes Barzi, Carlotta Pioppini, Angelica M. Gutierrez, Cristina Ivan, Salyna Meas, Carolyn S. Hall, Suresh K. Alahari, Ioana Berindan-Neagoe, Muller Fabbri, Anthony Lucci, Banu Arun, Simone Anfossi, George A. Calin
Summary: The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) in breast cancers (BCs), especially estrogen receptor-positive (ER+) BCs, have been investigated. It was found that physiological doses of estrogen can promote EV secretion from ER+ BC cells by inhibiting miR-149-5p, which affects the regulatory activity of SP1 on the EV biogenesis factor nSMase2. In addition, the downregulation of miR-149-5p promotes the expression of hnRNPA1, responsible for loading let-7's miRNAs into EVs. This estrogen-driven mechanism leads to the elimination of tumor suppressor miRNAs in EVs, affecting tumor-associated macrophages in the microenvironment.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Oncology
Michal Kunc, Marta Popeda, Wojciech Biernat, Elzbieta Senkus
Summary: ER alpha(+)/PgR(-) phenotype is not rare in breast cancer, and loss of PgR expression may signify resistance to endocrine therapy and poorer outcomes. Different mechanisms of PgR loss have distinct consequences on cancer cell biology.
Article
Chemistry, Multidisciplinary
Xue Chen, Jian-cheng Ding, Guo-sheng Hu, Xing-yi Shu, Yan Liu, Jun Du, Zi-jing Wen, Jun-yi Liu, Hai-hua Huang, Guo-hui Tang, Wen Liu
Summary: This study identifies a highly expressed estrogen-induced lncRNA, LINC02568, in ER-positive breast cancer, which plays important roles in cell growth, tumorigenesis, and endocrine therapy drug resistance. Mechanistically, LINC02568 regulates estrogen/ERα-induced gene transcriptional activation by stabilizing ESR1 mRNA through sponging miR-1233-5p in the cytoplasm. Additionally, LINC02568 contributes to tumor-specific pH homeostasis by regulating carbonic anhydrase CA12 in the nucleus. The dual functions of LINC02568 contribute to breast cancer progression and drug resistance.
Article
Cell Biology
Zhiguo Niu, Jianing Fan, Fengzhe Chen, Huijie Yang, Xin Li, Ting Zhuang, Chunlei Guo, Qi Cao, Jian Zhu, Hui Wang, Qingsong Huang
Summary: Breast cancer is the most common malignancy in women globally. Abnormal expression of RBCK1 protein in breast tumors makes it a valuable diagnostic marker and drug target. Hypoxic regions in breast cancer activate the HIF1 pathway, influencing tumor recurrence and metastasis. Targeting RBCK1 could be a promising treatment strategy for ER-positive breast cancer.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Ting Xu, Ding Ma, Sheng Chen, Rui Tang, Jianling Yang, Chunhui Meng, Yang Feng, Li Liu, Jiangfen Wang, Haojun Luo, Keda Yu
Summary: GPER has been found to mediate estrogenic actions in TNBC and is correlated with clinical variables, survival, and metastasis. High GPER expression is associated with high-risk TNBC subtype and poor prognosis, providing new insights and potential strategies for endocrine therapy in TNBC.
Review
Endocrinology & Metabolism
Esmael Besufikad Belachew, Dareskedar Tsehay Sewasew
Summary: The estrogen receptor is crucial in the treatment of estrogen receptor-positive breast cancer, with endocrine resistance posing a challenge. Combining drugs that target different signaling pathways and coregulatory proteins with endocrine therapy may offer a novel therapeutic approach to combat endocrine resistance.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Gastroenterology & Hepatology
Iddo Bar-Yishay, Neal Shahidi, Sunil Gupta, Sergei Vosko, W. Arnout van Hattem, Scott Schoeman, Mayenaaz Sidhu, David J. Tate, Luke F. Hourigan, Rajvinder Singh, Alan Moss, Spiro C. Raftopoulos, Gregor Brown, Simon Zanati, Steven J. Heitman, Eric Y. T. Lee, Nicholas Burgess, Stephen J. Williams, Karen Byth, Michael J. Bourke
Summary: The study evaluated the outcomes of intra-procedural deep mural injury (DMI) in large non-pedunculated colorectal polyps (LNPCPs) undergoing endoscopic mucosal resection (EMR). It found that significant DMI can be managed endoscopically with high success rates and does not impact technical success or recurrence.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Rehabilitation
Ian J. Baguley, Hannah L. Barden, Karen Byth
Summary: The study revealed that hand relaxation deteriorated during repetitive movements in people with spasticity, but the deterioration improved after controlling for inducible muscle overactivity.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Obstetrics & Gynecology
Rachel A. Bradbury, Darshika Christie-David, Howard C. Smith, Karen Byth, Creswell J. Eastman
Summary: The study found that women taking iodine supplements for >= 6 months had a significant increase in TSH levels during COH, similar to LT4-dependent patients. However, iodine supplementation did not affect oocyte count, fertilisation, or implantation rates.
AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY
(2022)
Review
Pathology
C. van Dooijeweert, P. J. van Diest, I. O. Ellis
Summary: Histologic grading is a simple and cost-effective method to assess tumor behavior in invasive breast cancer, with important prognostic value. Properly performed histologic grading is crucial for guiding treatment decisions in breast cancer patients.
Article
Genetics & Heredity
Sarah Norris, Andrea Belcher, Kirsten Howard, Robyn L. Ward
Summary: MSAC is an independent committee established by the Australian government to provide recommendations on public reimbursement of non-pharmaceutical technologies and services. Their recent publication on clinical utility cards for genetic testing identified methodological and policy challenges, including how to incorporate patient and societal preferences for genomic testing outcomes in global health technology assessments.
JOURNAL OF COMMUNITY GENETICS
(2022)
Article
Gastroenterology & Hepatology
Oliver Cronin, Mayenaaz Sidhu, Neal Shahidi, Sunil Gupta, Timothy O'Sullivan, Anthony Whitfield, Hunter Wang, Puja Kumar, Luke F. Hourigan, Karen Byth, Nicholas G. Burgess, Michael J. Bourke
Summary: This study suggests that compared with LNPCPs in the rest of the colon, rectal LNPCPs are more likely to be larger and contain more advanced pathology. These findings have implications for curative endoscopic resection techniques particularly where early cancer is present.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Genetics & Heredity
Esther Danenberg, Helen Bardwell, Vito R. T. Zanotelli, Elena Provenzano, Suet-Feung Chin, Oscar M. Rueda, Andrew Green, Emad Rakha, Samuel Aparicio, Ian O. Ellis, Bernd Bodenmiller, Carlos Caldas, H. Raza Ali
Summary: Imaging mass cytometry profiling of 693 breast tumors revealed 10 recurrent tumor microenvironment spatial structures, associated with genomic profiles and outcomes. These multicellular structures within the TME, varying in vascular content, stromal activation, and leukocyte composition, could improve patient stratification and link spatial organization to local TME function.
Article
Cell Biology
Islam M. Miligy, Michael S. Toss, Kylie L. Gorringe, Ian O. Ellis, Andrew R. Green, Emad A. Rakha
Summary: High AURKA expression is associated with aggressiveness features in DCIS and may be a predictive marker for DCIS progression to invasive disease.
Review
Oncology
Gabrielle Metz, Kylie Snook, Samriti Sood, Sally Baron-Hay, Andrew Spillane, Gillian Lamoury, Susan Carroll
Summary: This article reviews and summarizes the evidence for oncoplastic breast surgery in the treatment of breast cancer and its implications for other therapies. While the outcomes of oncoplastic breast surgery are promising, it adds complexity to the treatment paradigm and can impact decision-making for adjuvant therapies.
Article
Endocrinology & Metabolism
Thora Y. Chai, Difei Deng, Karen Byth, Jacob George, Dharmintra Pasupathy, Ngai Wah Cheung
Summary: This study aimed to determine the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) and its impact on adverse pregnancy outcomes in women with gestational diabetes mellitus (GDM). The results showed that almost 40% of women in the GDM cohort had MAFLD detected in mid-to-late gestation. However, MAFLD was not associated with worse pregnancy outcomes.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Oncology
Nicola S. Meagher, Kylie L. Gorringe, Matthew Wakefield, Adelyn Bolithon, Chi Nam Ignatius Pang, Derek S. Chiu, Michael S. Anglesio, Kylie-Ann Mallitt, Jennifer A. Doherty, Holly R. Harris, Joellen M. Schildkraut, Andrew Berchuck, Kara L. Cushing-Haugen, Ksenia Chezar, Angela Chou, Adeline Tan, Jennifer Alsop, Ellen Barlow, Matthias W. Beckmann, Jessica Boros, David D. L. Bowtell, Alison H. Brand, James D. Brenton, Ian Campbell, Dane Cheasley, Joshua Cohen, Cezary Cybulski, Esther Elishaev, Ramona Erber, Rhonda Farrell, Anna Fischer, Zhuxuan Fu, Blake Gilks, Anthony J. Gill, Charlie Gourley, Marcel Grube, Paul R. Harnett, Arndt Hartmann, Anusha Hettiaratchi, Claus K. Hogdall, Tomasz Huzarski, Anna Jakubowska, Mercedes Jimenez-Linan, Catherine J. Kennedy, Byoung-Gie Kim, Jae-Weon Kim, Jae-Hoon Kim, Kayla Klett, Jennifer M. Koziak, Tiffany Lai, Angela Laslavic, Jenny Lester, Yee Leung, Na Li, Winston Liauw, Belle W. X. Lim, Anna Linder, Jan Lubinski, Sakshi Mahale, Constantina Mateoiu, Simone McInerny, Janusz Menkiszak, Parham Minoo, Suzana Mittelstadt, David Morris, Sandra Orsulic, Sang-Yoon Park, Celeste Leigh Pearce, John Pearson, Malcolm C. Pike, Carmel M. Quinn, Ganendra Raj Mohan, Jianyu Rao, Marjorie J. Riggan, Matthias Ruebner, Stuart Salfinger, Clare L. Scott, Mitul Shah, Helen Steed, Colin J. R. Stewart, Deepak Subramanian, Soseul Sung, Katrina Tang, Paul Timpson, Robyn L. Ward, Rebekka Wiedenhoefer, Heather Thorne, Paul A. Cohen, Philip Crowe, Peter A. Fasching, Jacek Gronwald, Nicholas J. Hawkins, Estrid Hogdall, David G. Huntsman, Paul A. James, Beth Y. Karlan, Linda E. Kelemen, Stefan Kommoss, Gottfried E. Konecny, Francesmary Modugno, Sue K. Park, Annette Staebler, Karin Sundfeldt, Anna H. Wu, Aline Talhouk, Paul D. P. Pharoah, Lyndal Anderson, Anna DeFazio, Martin Kobel, Michael L. Friedlander, Susan J. Ramus
Summary: Clinical and gene expression data were analyzed to identify prognostic and diagnostic features of advanced-stage mucinous ovarian carcinoma (MOC) and differentiate it from gastrointestinal (GI) metastases. An infiltrative growth pattern was associated with poor prognosis, and high expression of THBS2 and TAGLN was linked to adverse prognosis in MOC. HER2 amplification or high mRNA expression was detected in some MOC cases, suggesting the potential of HER2-targeted therapy. MOC samples clustered with upper GI tumors, indicating similar biology and treatment strategies.
CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Qi Xu, Jaspreet Kaur, Dennis Wylie, Karuna Mittal, Hongxiao Li, Rishab Kolachina, Mohammed Aleskandarany, Michael S. Toss, Andrew R. Green, Jianchen Yang, Thomas E. Yankeelov, Shristi Bhattarai, Emiel A. M. Janssen, Jun Kong, Emad A. Rakha, Jeanne Kowalski, Ritu Aneja
Summary: This study explores the intratumoral heterogeneity (ITH) in triple-negative breast cancer (TNBC) by evaluating gene expression and imaging differences within the same tumor. The results show extensive intertumoral heterogeneity and regional ITH in gene expression and image-derived features in TNBC. Concerns are raised regarding gene expression based TNBC subtyping.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ian O. Ellis, Emad A. Rakha, Gary M. Tse, Puay Hoon Tan
Summary: The International Collaboration on Cancer Reporting (ICCR) has developed an international dataset for breast cancer pathology reporting, aiming to provide a unified approach worldwide. The dataset includes essential and optional data items based on a critical review and discussion of current evidence. The process concludes with international public consultation and publication on the ICCR website to promote high-quality, standardised pathology reporting globally.
Article
Oncology
Yousif A. Kariri, Chitra Joseph, Mansour A. Alsaleem, Khloud A. Elsharawy, Sami Alsaeed, Michael S. Toss, Nigel P. Mongan, Andrew R. Green, Emad A. Rakha
Summary: Breast cancer exhibits genetic and clinical heterogeneity. This study evaluates the prognostic and biological value of Cell Division Cycle Associated 5 (CDCA5) in breast cancer. The results demonstrate that CDCA5 plays an important role in breast cancer development and metastasis, and could be used as a potential biomarker for disease progression.
Article
Endocrinology & Metabolism
Nitesh D. Dhanekula, Gareth Crouch, Karen Byth, Sue Lynn Lau, Albert Kim, Edward Graham, Andrew Ellis, Roderick J. Clifton-Bligh, Christian M. Girgis
Summary: Asian ethnicity is a strong independent risk factor for atypical femur fractures (AFF), possibly associated with bisphosphonate use and not influenced by femoral geometry.
