Article
Gastroenterology & Hepatology
Flavia Baldacchini, Lauro Bucchi, Orietta Giuliani, Silvia Mancini, Alessandra Ravaioli, Rosa Vattiato, Paolo Giorgi Rossi, Cinzia Campari, Debora Canuti, Enza Di Felice, Francesca Mezzetti, Priscilla Sassoli de Bianchi, Stefano Ferretti, Fabio Falcini
Summary: The study revealed a significant decrease in the proportion of men with a positive FIT result and detection rates of advanced adenoma between the second and third rounds of screening. There was a slight decrease in positive predictive values for advanced adenoma, CRC, and advanced neoplasia by the fourth and fifth rounds. These findings suggest that FIT screening can prevent the progression of some advanced adenomas, allowing for a risk-based screening strategy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Soo-Yoon Sung, Hyun Ho Choi, Sukil Kim, Bo Ram Park, Young Ki Kim, Hyung-Keun Kim, Young-Seok Cho, Sang Woo Kim, Sung Soo Kim, Hiun-Suk Chae
Summary: A Korean study found that colonoscopy is more effective in reducing mortality in patients with colorectal cancer compared to FIT.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Oncology
Nivedita Rattan, Laura Willmann, Diana Aston, Shani George, Milan Bassan, David Abi-Hanna, Sulakchanan Anandabaskaran, George Ermerak, Watson Ng, Jenn Hian Koo
Summary: This study aimed to determine the prevalence of advanced neoplasia and identify clinical and endoscopic predictors in patients with positive immunochemical fecal occult blood test (iFOBT) following a recent colonoscopy. The results showed that a previous colonoscopy, regardless of its result, was associated with a low prevalence of advanced neoplasia and provided protection against colorectal cancer (CRC) if performed within four years of a positive iFOBT result.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Ming Lu, Le Wang, Yuhan Zhang, Chengcheng Liu, Bin Lu, Lingbin Du, Xianzhen Liao, Dong Dong, Donghua Wei, Yi Gao, Jufang Shi, Jiansong Ren, Hongda Chen, Min Dai
Summary: The risk-adapted screening combining Asia-Pacific Colorectal Screening score, FIT, and colonoscopy showed higher sensitivity for advanced neoplasm but lower specificity compared to FIT alone. Adjusting the positivity threshold tailored to clinical practice could save colonoscopy resources and cost.
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Wen-Feng Hsu, Chi-Yang Chang, Chun-Chao Chang, Li-Chun Chang, Chien-Hua Chen, Chun-Che Lin, Yu-Min Lin, Chia-Long Lee, Hong-Yuan Wu, Hsin-Chung Lee, Yi-Chia Lee, Ming-Yao Su, Li-Ju Lin, Shu-Li Chia, Ming-Shiang Wu, Han-Mo Chiu
Summary: The study found that FIT-colonoscopy was associated with more than two-fold risk of significant bleeding, especially when polypectomy was performed.
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Article
Medicine, General & Internal
Erica K. Barnell, Elizabeth M. Wurtzler, Julie La Rocca, Thomas Fitzgerald, Jessica Petrone, Yansheng Hao, Yiming Kang, Faith L. Holmes, David A. Lieberman
Summary: This study evaluated the sensitivity and specificity of a noninvasive multitarget stool RNA test for colorectal cancer and precancerous lesions. The results showed that the test had a sensitivity of 94% for detecting colorectal cancer and 46% for detecting advanced adenomas, with a specificity of 88%.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Gastroenterology & Hepatology
Yu Jin Kim, Jeong-Im Shim, Eunjung Park, Minjoo Kang, Sinhee Kang, Jessie Lee, Ha Jin Tchoe, Kyeong Ae Kong, Duk Hwan Kim, Byung Chang Kim, Kui Son Choi, Chang Mo Moon
Summary: This retrospective cohort study evaluated the impact of adherence to follow-up examination after a fecal occult blood test (FOBT) on clinical outcomes in individuals with positive results. Those who underwent confirmative examination within a year had higher 5-year survival rates compared to those who did not. The study highlights the importance of timely follow-up examinations for early detection and improved survival outcomes in colorectal cancer patients.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Public, Environmental & Occupational Health
Zilin Luo, Xuesi Dong, Chenran Wang, Wei Cao, Yadi Zheng, Zheng Wu, Yongjie Xu, Liang Zhao, Fei Wang, Jibin Li, Jiansong Ren, Jufang Shi, Wanqing Chen, Ni Li
Summary: This study systematically reviewed observational studies on the association between socioeconomic status (SES) and adherence to colorectal cancer (CRC) screening. The findings showed that individuals with high SES had higher adherence to screening compared to those with low SES. Neighborhood SES or small-area SES was more effective in assessing the association between SES and adherence than individual SES.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Biochemistry & Molecular Biology
Jacopo Troisi, Maria Tafuro, Martina Lombardi, Giovanni Scala, Sean M. Richards, Steven J. K. Symes, Paolo Antonio Ascierto, Paolo Delrio, Fabiana Tatangelo, Carlo Buonerba, Biancamaria Pierri, Pellegrino Cerino
Summary: The objective of this study was to develop a novel screening approach for colorectal cancer using serum metabolomic profiles, and to evaluate the metabolic alterations associated with the disease. The results showed that the metabolomic signature can be used as a non-invasive screening tool for colorectal cancer, and identified differences primarily associated with cell glucose metabolism.
Article
Public, Environmental & Occupational Health
Tingting Yao, Qin Sun, Kangwei Xiong, Yuan Su, Qian Zhao, Chenhong Zhang, Lijiu Zhang, Xuejun Li, Haiming Fang
Summary: This study compares different testing strategies for colorectal cancer screening, including multi-target fecal DNA testing, quantitative and qualitative fecal immunoassay tests (FITs). The efficacy of these strategies was examined in different populations, and it was found that single testing strategy is more suitable for general population screening, while combined testing strategy is more suitable for high-risk populations screening.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Ulysses Ribeiro Jr, Adriana Vaz Safatle-Ribeiro, Mauricio Sorbello, Poliana Helena Rosolem Kishi, Diane Dede Cohend, Rejane Mattar, Vera Lucia Pagliusi Castilho, Elenice Messias Do Nascimento Goncalves, Fabio Kawaguti, Carlos Frederico Sparapan Marques, Venancio Avancini Ferreira Alves, Sergio Carlos Nahas, Jose Eluf-Neto
Summary: In an urban low-income community in Brazil, an organized CRC screening using FIT followed by colonoscopy achieved a high participation rate and high positive predictive value for both adenoma and CRC.
Article
Medicine, General & Internal
Lian-Jing Cao, Xiao-Lin Peng, Wen-Qiong Xue, Rong Zhang, Jiang-Bo Zhang, Ting Zhou, Zi-Yi Wu, Gai-Rui Li, Tong-Min Wang, Yong-Qiao He, Da-Wei Yang, Ying Liao, Xia-Ting Tong, Fang Wang, Ke-Xin Chen, Shi-Hong Zhang, Li-Qing Zhu, Pei-Rong Ding, Wei-Hua Jia
Summary: This study identified biomarkers for CRC and AA detection, and developed a prediction score for distinguishing AA and CRC from healthy subjects with high sensitivity and specificity. The noninvasive approach showed promising results in both validation and screening cohorts, indicating its potential for wide application in diagnostic and screening tests.
Article
Public, Environmental & Occupational Health
Kenta Tanaka, Tomotaka Sobue, Ling Zha, Tetsuhisa Kitamura, Norie Sawada, Motoki Iwasaki, Manami Inoue, Taiki Yamaji, Shoichiro Tsugane
Summary: This study analyzed data from 30,381 middle-aged Japanese adults and found that fecal occult blood test (FOBT) and colonoscopy both reduced the risk of death and incidence of colorectal cancer (CRC).
JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ann G. Zauber, Sidney J. Winawer, Michael J. O'Brien, Glenn M. Mills, John I. Allen, Andrew D. Feld, Paul A. Jordan, Martin Fleisher, Irene Orlow, Reinier G. S. Meester, Iris Lansdorp-Vogelaar, Carolyn M. Rutter, Amy B. Knudsen, Margaret Mandelson, Aasma Shaukat, Robin B. Mendelsohn, Anne I. Hahn, Stephanie M. Lobaugh, Brittany Soto Palmer, Victoria Serrano, Julie R. Kumar, Sara E. Fischer, Jennifer C. Chen, Sharon Bayuga-Miller, Deborah Kuk, Kelli O'Connell, Timothy R. Church
Summary: This study compared the adherence and pathology findings of a single screening colonoscopy with sequential and nonsequential high sensitivity fecal occult blood testing (HSgFOBT). The results showed that adherence to a single screening colonoscopy was higher than sequential HSgFOBT, and the detection of advanced neoplasia or large serrated lesions (ADN-SERs) was inferior when nonsequential HSgFOBT adherence was compared with sequential adherence. Therefore, the effectiveness of an HSgFOBT screening program may be enhanced if crossover to screening colonoscopy is permitted.