Role of advanced oxidation protein products and Thiol ratio in patients with acute coronary syndromes

Objectives: To identify systemically detectable vascular inflammation associated to redox system unbalance, advanced oxidation protein products (AOPP), formed by HCIO reaction with proteins, Thiol levels, and their ratio (AOPP/Thiol ratio) were measured in patients with acute coronary syndromes (ACS). Design and methods: We evaluated AOPP/Thiol ratio together with CRP and IL-1 beta in 18 acute myocardial infarction (AM!) and in 16 unstable angina (UA) patients at admission, and in 16 control subjects (CTR); the measurements were repeated at 1 and at 6 months. Results: At admission, AMI and UA patients displayed higher AOPP/Thiol ratio and CRP and IL-1 beta compared to CTR subjects. A correlation between AOPP/Thiols and IL-1 beta in AMI was found. At follow-up, in UA only, AOPP/Thiol ratio and IL-1 beta levels still remained high. Conclusions: The AOPP/Thiol ratio seems to affect the inflammatory process in ACS, and may represent a reliable marker of oxidative unbalance in this setting of patients. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.