Article
Materials Science, Multidisciplinary
Marko Miler, Vladimir Ajdzanovic, Jasmina Zivanovic, Jelena Markovic Filipovic, Branka Sosic-Jurjevic, Verica Milosevic
Summary: This study aimed to determine and elaborate on the changes in old-aged rat thyroids, showing increased volumes of various components and decreased gland activity. Results suggest a depression in synthetic and secretory capacity of the thyroid gland with advancing age.
MICROSCOPY AND MICROANALYSIS
(2021)
Article
Medicine, General & Internal
Zagorka Milovanovic, Dejan Filimonovic, Ivan Soldatovic, Natasa Karadzov Orlic
Summary: This study assessed the clinical utility of subclinical hypothyroidism (SCH) marker, elevated thyroid-stimulating hormone (TSH), and thyroid antibodies in predicting gestational diabetes mellitus (GDM). The results showed a positive correlation between increased TSH levels and the presence of thyroid antibodies with the risk of GDM. Patient age, TSH 4 IU/mL, and anti TPO Ab > 35 IU/mL were identified as significant predictors of GDM, improving the screening performance in the first trimester of pregnancy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Stine Linding Andersen, Niels Henrik Bruun, Peter Astrup Christensen, Simon Lykkeboe, Aase Handberg, Annebirthe Bo Hansen, Maja Hjelm Lundgaard, Louise Knosgaard, Nanna Maria Uldall Torp, Allan Carle, Jesper Karmisholt, Inge Buelow Pedersen, Peter Vestergaard, Stig Andersen
Summary: This study established and evaluated pregnancy-specific cut-offs for TPO-Ab and Tg-Ab, which are important for the classification of exposure in pregnancy and assessment of thyroid autoimmunity.
EUROPEAN THYROID JOURNAL
(2022)
Article
Medical Laboratory Technology
Yuan Meng, Yaozheng Xu, Jianhua Liu, Xiaosong Qin
Summary: The study aimed to establish an early prediction model for the conversion of thyroid autoantibodies. The results showed that certain clinical laboratory indicators were correlated with antibody conversion, and the developed warning model demonstrated stable efficiency in both internal and external validation.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Mirjana Babic Leko, Ivana Gunjaca, Nikolina Pleic, Tatijana Zemunik
Summary: Lifestyle factors like smoking, BMI, and iodine have a significant impact on TSH and thyroid hormone levels. However, there are inconsistencies in studies regarding how environmental factors influence thyroid function, indicating a need for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Blanca Sarzo, Reem Abumallouh, Natalia Marin, Sabrina Llop, Andrea Beneito, Inmaculada Lopez -Flores, Nerea Ferrero, Amrit Kaur Sakhi, Ferran Ballester, Maria-Jose Lopez-Espinosa
Summary: In this study, we found some evidence of an association between phenols and TSH during pregnancy and at birth in single exposure models, with stronger effects in girls. However, no association was observed between maternal levels of phenols and TT3 or FT4. Additionally, we identified potential effect modification by DIO gene polymorphisms in the association between phenols and THs.
ENVIRONMENTAL POLLUTION
(2022)
Article
Endocrinology & Metabolism
Haiyan Yu, Changzhou Li, Xiaoming Niu, Mingying Fan, Shiwei Huo
Summary: The objective of this study was to observe the toxic effects of thyroid peroxidase antibody (TPO-Ab) on human ovarian granulosa cells (KGNs) and investigate the mechanism of endoplasmic reticulum (ER) stress in TPO-Ab-induced apoptosis in KGNs. The results showed that TPO-Ab inhibited KGN proliferation, promoted apoptosis, reduced the levels of estradiol and progesterone, and increased the expressions of ER stress-related proteins while decreasing the expression level of Bcl-2.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Biochemistry & Molecular Biology
Eleonore Froehlich, Richard Wahl
Summary: Thyroid-stimulating hormone (TSH) and thyroid hormone levels are important parameters in blood analysis, but immunoassays used may produce inaccurate results due to interference from certain materials in the sample. Macro-TSH, a complex of TSH with immunoglobulin or albumin, can lead to falsely elevated TSH concentrations. While less well-known, PT-TSH plays a significant role in central regulation of thyroid metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Salvatore Benvenga, Maurizio Nordio, Antonio Simone Lagana, Vittorio Unfer
Summary: Myo-Inositol plays an important role in thyroid function and autoimmune diseases, acting as a precursor in the phosphatidylinositol signaling pathway. Clinical studies have shown that Myo-Inositol supplementation, along with Selenium, can significantly reduce TSH levels in patients with subclinical hypothyroidism and may have a beneficial effect on the management of thyroidal benign nodules.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuerong Yan, Mingtong Xu, Muchao Wu, Xiaoyi Wang, Feng Li, Jin Zhang, Lili You, Xiaofang Pan, Weilian Feng, Jiayun Wu, Caixia Chen, Xiaohui Li, Li Yan
Summary: The relationship between obesity and subclinical hypothyroidism (SCH) is influenced by the presence of thyroid autoantibodies, with obesity being significantly associated with SCH in the presence of thyroid autoantibodies.
BMC ENDOCRINE DISORDERS
(2022)
Article
Surgery
Xiaoyi Liu, Zhengju Fu, Hongmei Xu, Kui Che, Jingwei Chi, Jianxia Hu
Summary: The study investigated the positivity of thyroid antibodies in breast cancer patients, patients with benign breast diseases, and healthy controls. It found that breast cancer patients had a higher rate of TPO-ab positivity compared to the other groups, and those with positive TPO-ab had lower rates of axillary lymph node metastasis. Thyroid peroxidase antibody was identified as a predictor for low axillary lymph node metastasis prevalence in breast cancer patients with luminal A and B subtypes.
INDIAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Hans Surup, Mandy Vogel, Antje Koerner, Andreas Hiemisch, Lea Oelkers, Anja Willenberg, Wieland Kiess, Juergen Kratzsch
Summary: This study aimed to establish age- and sex-specific reference intervals for thyroid hormones in healthy children and adolescents, finding that TSH, fT3, and fT4 levels are influenced by age, sex, BMI, and puberty. Puberty was associated with changes in hormone levels, including decreased TSH, decreased fT3 with a temporary peak in males, and a temporary nadir of fT4. BMI was also found to have significant associations with TSH, fT3, and fT4 levels, with differences between overweight and underweight subjects.
Article
Psychiatry
Yanan Zhou, Yuejiao Ma, Qiuxia Wu, Qianjin Wang, Winson Fu Zun Yang, Yunfei Wang, Dong Yang, Yinli Luo, Kewei Tang, Tieqiao Liu, Dongfang Wang
Summary: A large-scale study in China found that thyroid hormone levels were generally lower in patients with major depressive disorder, compared to healthy controls, indicating a potential association between abnormal thyroid function and depression. Monitoring of thyroid function in MDD patients is important due to the higher rate of thyroid dysfunction found in this group.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Surgery
Yuan Chen, Wen Zhang, Yongqin Pan, Weiju Chen, Cunchuan Wang, Wah Yang
Summary: This study evaluated the changes in thyroid function before and after laparoscopic sleeve gastrectomy (LSG) in obese patients. The results showed decreased levels of FT3, TSH, and iPTH, while FT4 levels significantly increased after LSG. Changes in TSH were positively correlated with LDL, but no significant correlation was found with BMI. Furthermore, FT3, FT4, and iPTH were correlated with VB12, age, and BMI, respectively.
Article
Cardiac & Cardiovascular Systems
Takeshi Yoshimoto, Hiroyuki Ishiyama, Yorito Hattori, Kunihiro Nishimura, Yoko Okada, Hideaki Watanabe, Yasumasa Ohyagi, Yasuhisa Akaiwa, Tomoyuki Miyamoto, Michi Kawamoto, Masahiko Ichijo, Hiroyasu Inoue, Noriyuki Matsukawa, Toshiki Mizuno, Hirofumi Matsuyama, Hidekazu Tomimoto, Daisuke Kawakami, Kazunori Toyoda, Masatoshi Koga, Masafumi Ihara
Summary: This study found a significant association between TPO-Ab levels and the presence of the RNF213 p.R4810K variant in IS/TIA patients, indicating that TPO-Ab may modify the development of IS/TIA in RNF213 p.R4810K variant carriers.
Review
Endocrinology & Metabolism
Claudia Kappes, Robert Stein, Antje Koerner, Andreas Merkenschlager, Wieland Kiess
Summary: This literature review investigates the effects of stress exposure, including the COVID-19 pandemic, on obesity risk in children and adolescents. It highlights the biological and behavioral alterations associated with stress exposure that contribute to the development of obesity. However, there is a lack of longitudinal studies exploring the relationships between environmental, behavioral, and biological factors, and results are mixed. Intervention programs targeting stress reduction through mindfulness may offer a promising approach in preventing and treating childhood and adolescent obesity.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Kathrin Landgraf, Andreas Kuhnapfel, Maria Schlanstein, Ronald Biemann, Berend Isermann, Elena Kempf, Holger Kirsten, Markus Scholz, Antje Korner
Summary: This study found that childhood obesity is associated with dysfunction and early signs of metabolic disease in adipose tissue. By analyzing gene expression profiles in adipose tissue samples from obese children, the researchers identified genes that are associated with obesity and related parameters. They also discovered that EGFL6 gene may play a role in the pathogenesis of metabolic disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Alexandra Kiess, Jessica Green, Anja Willenberg, Uta Ceglarek, Ingo Daehnert, Anne Jurkutat, Antje Koerner, Andreas Hiemisch, Wieland Kiess, Mandy Vogel
Summary: This study aimed to provide reliable pediatric reference values for NT-proBNP and hsTnT, and investigate their associations with sex, pubertal status, BMI, and serum lipid levels. The results showed that NT-proBNP values decreased with age and were strongly associated with BMI and serum lipids. For hsTnT levels, approximately half of the measurements were below the detection limit, with age and gender differences.
PEDIATRIC CARDIOLOGY
(2022)
Article
Environmental Sciences
Susanne Brandstetter, Tanja Poulain, Mandy Vogel, Christof Meigen, Michael Melter, Angela Koeninger, Christian Apfelbacher, Wieland Kiess, Michael Kabesch, Antje Koerner
Summary: The study compared worries related to COVID-19 in families with young children in two different regions in Germany during the first and second waves of the pandemic. The degree of worries varied by region and time, with families expressing more concern about family, friends, and hometown during the second wave, paralleling the increase in SARS-CoV-2 infections. Trust in anti-pandemic policy measures decreased between the waves, with a more significant drop in Regensburg compared to Leipzig.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rafael Heiss, Lina Tan, Sandy Schmidt, Adrian P. Regensburger, Franziska Ewert, Dilbar Mammadova, Adrian Buehler, Jens Vogel-Claussen, Andreas Voskrebenzev, Manfred Rauh, Oliver Rompel, Armin M. Nagel, Simon Levy, Sebastian Bickelhaupt, Matthias S. May, Michael Uder, Markus Metzler, Regina Trollmann, Joachim Woelfle, Alexandra L. Wagner, Ferdinand Knieling
Summary: This study used low-field-strength MRI to characterize the morphologic and functional changes in lung tissue of children and adolescents with long COVID. The results suggest that low-field-strength MRI can help identify persistent pulmonary manifestations in this population.
Review
Nutrition & Dietetics
Sophie Vinoy, Janina Goletzke, Maryam Rakhshandehroo, Lisa Schweitzer, Matthieu Flourakis, Antje Koerner, Ute Alexy, Evert M. van Schothorst, Antonio Ceriello, Julia K. Zakrzewski-Fruer, Anette Buyken
Summary: In June 2021, a workshop organized by the European branch of ILSI addressed the role of postprandial glycaemic response in pediatric health and highlighted research gaps in this area. The workshop emphasized the importance of understanding glycaemic responses in pediatric populations, and the changes in metabolism and dietary needs from infancy to adolescence. The lack of scientific data on glucose and insulin profiles in response to commonly consumed foods by children, as well as the need for long-term evidence and suitable predictors for future health effects, were identified as significant research gaps.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Editorial Material
Endocrinology & Metabolism
Wieland Kiess, Anette Stoltze, Anna S. Kirstein, Julia Gesing, Robert Stein, Antje Koerner, Roland Pfaeffle
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Julius Lars Breinker, Anika Kaspar, Elena Sergeyev, Antje Koerner, Wieland Kiess, Anja Hilbert
Summary: Multimodal obesity treatments for children and adolescents have limited effectiveness and high dropout rates. The impact of clinical and sociodemographic factors on treatment outcomes remains unclear. This study investigated predictors of treatment success and adherence in a multimodal obesity treatment over 12 months. The results suggest the importance of early intervention for juvenile obesity and highlight the potential positive effect of eating disorder psychopathology on controlled food intake. Challenges due to the COVID-19 pandemic also need to be addressed.
Article
Biochemistry & Molecular Biology
Robert Stein, Florian Koutny, Johannes Riedel, Natascha Doerr, Klara Meyer, Marco Colombo, Mandy Vogel, Christian Heinz Anderwald, Matthias Blueher, Wieland Kiess, Antje Koerner, Daniel Weghuber
Summary: The single point insulin sensitivity estimator (SPISE) is a fasting index for insulin sensitivity based on triglycerides, high density lipoprotein cholesterol, and body mass index. This study evaluated the distribution and correlation of SPISE in children and adolescents with overweight or obesity, and assessed its role as a prognostic marker for future dysglycemia. The results showed that SPISE decreased with age and had a modest correlation with established fasting markers of insulin resistance. SPISE was found to be a better prognostic marker for future dysglycemia than other fasting indexes.
Article
Endocrinology & Metabolism
Christian Denzer, Joachim Rosenbauer, Daniela Klose, Antje Koerner, Thomas Reinehr, Christina Baechle, Carmen Schroeder, Susanna W. Wiegand, Reinhard Holl, Nicole Prinz, DPV Initiative
Summary: The incidence of pediatric type 2 diabetes in Germany increased during the COVID-19 pandemic, with a significant increase observed in 2021. Adolescent boys were more affected, resulting in a reversal of the sex ratio of youth-onset T2D.
Article
Biochemistry & Molecular Biology
Sarah Abdul Majeed, Helene Dunzendorfer, Juliane Weiner, John T. T. Heiker, Wieland Kiess, Antje Korner, Kathrin Landgraf
Summary: Obesity in children is associated with adipose tissue dysfunction and metabolic disease, increasing the risk of premature death. The brown adipose tissue (BAT), known for its energy-dissipating function, has been suggested to protect against obesity and metabolic dysfunction. Through genome-wide expression profiling, we identified several genes, including COBL, MKX, and MYOC, which have not been previously characterized in BAT biology and examined their functional role in BAT development. Our findings also reveal an association between the expression of these genes and early metabolic dysfunction in children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Christian Hirsch, Oliver Schierz, Antje Koerner, Wieland Kiess, Ronald Biemann, Annett Schrock, Jens Christoph Turp
Summary: This study investigated the association between sex hormone levels (DHEA-S, SHBG, and TT) and TM pain in male adolescents. The results showed that lower levels of serum free TT and DHEA-S were associated with increased TM pain in more developed male adolescents.
JOURNAL OF ORAL REHABILITATION
(2023)
Article
Endocrinology & Metabolism
Aaron S. Kelly, Silva Arslanian, Dan Hesse, Aske Thorn Iversen, Antje Koerner, Signe Schmidt, Rasmus Sorrig, Daniel Weghuber, Ania M. Jastreboff
Summary: The aim of this study was to examine how improvement in BMI with semaglutide translated to changes in BMI category. The results showed that 44.9% of participants receiving semaglutide achieved weight reduction resulting in reclassification to a normal-weight or overweight BMI category, compared to 12.1% of participants receiving placebo. Most participants receiving semaglutide showed improvement in BMI category, with over 40% reaching a category below the obesity threshold.
Article
Health Care Sciences & Services
Maximiliane Chiara Hammel, Robert Stein, Juergen Kratzsch, Mandy Vogel, Alexander J. Eckert, Rima Destya Triatin, Marco Colombo, Christof Meigen, Ronny Baber, Juraj Stanik, Ulrike Spielau, Anette Stoltze, Kerstin Wirkner, Anke Toenjes, Harold Snieder, Reinhard W. Holl, Michael Stumvoll, Matthias Blueher, Wieland Kiess, Antje Koerner
Summary: The study aimed to establish reference ranges for fasting insulin indices across all age ranges and evaluate their clinical application in predicting glycemic deterioration in children. The results showed that insulin resistance in children with obesity doubled the risk for future glycemic deterioration, and insulin-based indices were better predictors of dysglycemia than fasting glucose alone.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Letter
Health Care Sciences & Services
Robert Stein, Eric Goepel, Daniel Weghuber, Maximiliane Chiara Hammel, Mandy Vogel, Wieland Kiess, Antje Koerner
LANCET REGIONAL HEALTH-EUROPE
(2023)
