Journal
CLINICAL BIOCHEMISTRY
Volume 41, Issue 4-5, Pages 306-312Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.clinbiochem.2007.11.011
Keywords
gene; single nucleotide polymorphisms; reverses cholesterol transport pathway; lipids; haplotype
Categories
Funding
- NCRR NIH HHS [M01 RR000645, 2 M01 RR00645] Funding Source: Medline
- NINDS NIH HHS [R01 NS040807, R01 NS 047655, R01 NS047655, R01 NS 40807, R01 NS047655-01, R01 NS029993, R01 NS 29993] Funding Source: Medline
Ask authors/readers for more resources
Objectives: To identify candidate genes in relation to plasma lipid levels in Caribbean Hispanics. Design and methods: A total of 114 single nucleotide polymorphisms (SNPs) at 17 lipid-related genes were genotyped in 477 Caribbean Hispanics from the Northern Manhattan Study (NOMAS). Analyses for each SNP and haplotype were performed to evaluate the associations with four lipid traits: high- and low-density lipoprotein cholesterol (HDL-C, LDL-Q, triglyceride (TG) and total cholesterol (TC). Results: We identified 19 SNPs at 10 genes that were significantly related to lipids (p<0.01), including nine involved in the reverse cholesterol transport pathway, and one involved in bile acid synthesis. Three genes, namely the apolipoprotein A5, apolipoprotein B and cytochrome p450 polypeptide 7Al genes, accounted for the largest proportion of variation in HDL-C/TG, TC and LDL-C respectively. Conclusions: The cumulative effects of multiple genetic variants led to a substantially better prediction of inter-individual variations in lipid levels. (C) 2007 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available