3.9 Article

Cytotoxic T Cell Adoptive Immunotherapy as a Treatment for Nasopharyngeal Carcinoma

Journal

CLINICAL AND VACCINE IMMUNOLOGY
Volume 21, Issue 2, Pages 256-259

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00121-13

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Funding

  1. National Health and Medical Research Council (Australia)
  2. Queensland Cancer Council
  3. Atlantic Philanthropies

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Epstein-Barr virus (EBV) is associated with nasopharyngeal carcinoma (NPC). We assess the safety and tolerability of adoptive transfer of autologous cytotoxic T lymphocytes (CTLs) specific for the EBV latent membrane protein (LMP) in a patient with recurrent NPC. After infusion, the majority of pulmonary lesions were no longer evident, although the primary tumor did not regress.

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