Review
Immunology
Junli Li, Lingjun Zhan, Chuan Qin
Summary: BCG vaccine, proven to be effective against tuberculosis, also shows non-specific protective effects against various diseases. The recent COVID-19 outbreak has brought BCG vaccine, a classic vaccine, back into the spotlight, prompting further research into its specific and non-specific protection mechanisms.
Article
Biochemistry & Molecular Biology
Boli Ma, Xueyi Nie, Lei Liu, Mengyuan Li, Qi Chen, Yueyang Liu, Yuxin Hou, Yi Yang, Jinrui Xu
Summary: The inhibition of PERK alleviated pyroptosis induced by BCG infection, showing an effect of resistance against infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Lei Zhang, Yuqing Li, Lingli Zhou, Houhong Zhou, Liefu Ye, Tong Ou, Huaishan Hong, Shiwen Zheng, Ziyu Zhou, Kang Wu, Zeqin Yan, Jean Paul Thiery, Jun Cui, Song Wu
Summary: YTHDF2 is upregulated in bladder cancer and promotes tumor growth by inhibiting RIG-I-mediated immune signaling, highlighting the significance of m(6)A modifications in bladder cancer and providing therapeutic opportunities.
Article
Immunology
Reginaldo G. Bastos, Heba F. Alzan, Vignesh A. Rathinasamy, Brian M. Cooke, Odir A. Dellagostin, Raul G. Barletta, Carlos E. Suarez
Summary: This article discusses the potential use of BCG TI as a strategy to control babesiosis infection more efficiently, supported by experimental evidence and the possibility of vaccine development.
Article
Immunology
Huanhuan Ning, Jian Kang, Yanzhi Lu, Xuan Liang, Jie Zhou, Rui Ren, Shan Zhou, Yong Zhao, Yanling Xie, Lu Bai, Linna Zhang, Yali Kang, Xiaojing Gao, Mingze Xu, Yanling Ma, Fanglin Zhang, Yinlan Bai
Summary: In this study, researchers constructed a recombinant BCG vaccine (rBCG-DisA) with di-adenylate cyclase (DisA) and found that it induced enhanced immune responses in mice, leading to trained immunity and adaptive immunity. Additionally, rBCG-DisA showed promising potential in protecting against M. tuberculosis infection.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Maria A. Duarte C., Jeismar M. Carballo O., Yetsenia M. De Gouveia, Angie Garcia, Diana Ruiz, Teresa Gledhill, Eglys Gonzalez-Marcano, Ana F. Convit
Summary: ConvitVax is a personalized vaccine for breast cancer treatment, which has been shown to be safe and effective in preclinical studies on BALB/c mice.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Emilie Jalbert, Cuining Liu, Vidya Mave, Nancy Lang, Anju Kagal, Chhaya Valvi, Mandar Paradkar, Nikhil Gupte, Rahul Lokhande, Renu Bharadwaj, Vandana Kulkarni, Amita Gupta, Adriana Weinberg
Summary: There is a need for more effective vaccines against tuberculosis (TB) than the currently licensed BCG vaccine. This study aimed to identify new vaccine benchmarks by examining immune responses in individuals able to eradicate the infection (TB-resisters) and individuals with latent infection (LTBI-participants). Results showed that TB-resisters had higher frequencies of certain T cells and higher proportions of polyfunctional T cells expressing specific markers, while LTBI-participants had higher expression of activation markers and cytokines. The findings suggest that specific T cell responses may be desirable for new TB vaccines.
Review
Medicine, Research & Experimental
Benjamin N. Koleske, William R. Jacobs, William R. Bishai
Summary: The complete genome sequence of Mycobacterium tuberculosis, achieved in 1998, has provided invaluable insights and tools for understanding tuberculosis. Whole-genome sequencing has improved our ability to predict antibacterial susceptibility and track epidemics. It also helps in studying the effectiveness of TB vaccines and identifying targets for new treatments.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Chemistry, Applied
Zhijun Song, Yu Liu, Jieyu Gao, Jiansen Hu, Hongtao He, Shengwang Dai, Luoqiang Wang, Huanqin Dai, Lixin Zhang, Fuhang Song
Summary: During the systematic screening of bioactive compounds, a marine-derived fungus strain exhibited moderate bioactivities against several bacteria. Further chemical investigation led to the discovery of new compounds along with known compounds, one of which displayed potential antitubercular activity.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
Jiang Pi, Zhiyi Zhang, Enzhuo Yang, Lingming Chen, Lingchan Zeng, Yiwei Chen, Richard Wang, Dan Huang, Shuhao Fan, Wensen Lin, Hongbo Shen, Jun-Fa Xu, Gucheng Zeng, Ling Shen
Summary: Engineering Mycobacterium tuberculosis into nanoscale particles improves the safety and efficacy of the TB vaccine, providing better protection against TB infection.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sergio Fabian Mosquera-Restrepo, Sophie Zuberogoitia, Lucie Gouxette, Emilie Layre, Martine Gilleron, Alexandre Stella, David Rengel, Odile Burlet-Schiltz, Ana Cecilia Caro, Luis F. Garcia, Cesar Segura, Carlos Alberto Pelaez Jaramillo, Mauricio Rojas, Jerome Nigou
Summary: An estimated one-third of tuberculosis (TB) cases go undiagnosed or unreported. Developing non-sputum-based point-of-care biomarker-based diagnostics for TB is a major priority. In this study, patient exhaled breath condensate (EBC) samples were analyzed to detect pulmonary TB. The presence of specific lipids, lipoglycan, and proteins in EBCs efficiently differentiated TB patients from controls. EBC analysis has the potential to facilitate clinical diagnosis of TB and monitor treatment efficacy.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Nilofer Naqvi, Rahul Srivastava, Pieu Naskar, Niti Puri
Summary: The early interactions between the BCG vaccine and host MCs play a crucial role in generating protective immune responses, but the multi-pronged effector responses of MCs on encountering BCG, such as killing, phagocytosis, and trap release, may influence the success or failure of long-term immunity provided by the BCG vaccine.
CELLULAR IMMUNOLOGY
(2021)
Article
Microbiology
Juan Wu, Zhidong Hu, Shui-Hua Lu, Xiao-Yong Fan
Summary: This study examined the ability of a DNA vaccine expressing a fusion of antigens Rv2299c and Ag85A to boost BCG immunity and protection against tuberculosis. The results showed that the DNA boost significantly amplified Th1-type cell-mediated immunity and reduced bacterial loads and histological damage in the lung.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Margaret G. Taylor, Sarah K. Nicholas, Lisa R. Forbes Satter, Caridad Martinez, Lindsay H. Cameron
Summary: This article reports a case of an infant with inborn errors of immunity who developed infectious complications following BCG vaccination. The diagnosis of disseminated BCG infection was made using plasma metagenomic next-generation sequencing, and early antimycobacterial treatment improved the clinical outcome. The authors suggest that plasma mNGS testing should be considered as a noninvasive screen for infectious pathogens in children with IEIs before stem cell transplantation.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Leontine van Balveren, Eugene P. van Puijenbroek, Linda Davidson, Florence van Hunsel
Summary: Reactivation of BCG scar is observed after COVID-19 vaccination with mRNA and viral vector vaccines, characterized by erythema and pain within a few days. The exact mechanism remains unknown, but heat shock protein 65 may be involved.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Anna Savitskaya, Akihito Nishiyama, Takehiro Yamaguchi, Yoshitaka Tateishi, Yuriko Ozeki, Masaaki Nameta, Tomohiro Kon, Shaban A. Kaboso, Naoya Ohara, Olga V. Peryanova, Sohkichi Matsumoto
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Yukiko Ohara, Yuriko Ozeki, Yoshitaka Tateishi, Tsukasa Mashima, Fumio Arisaka, Yasuo Tsunaka, Yoshie Fujiwara, Akihito Nishiyama, Yutaka Yoshida, Kengo Kitadokoro, Haruka Kobayashi, Yukihiro Kaneko, Ichiro Nakagawa, Ryoji Maekura, Saburo Yamamoto, Masato Katahira, Sohkichi Matsumoto
Article
Immunology
Mariko Naito, Takashi Tominaga, Mikio Shoji, Koji Nakayama
MICROBIOLOGY AND IMMUNOLOGY
(2019)
Article
Infectious Diseases
Desak Nyoman Surya Suameitria Dewi, Ni Made Mertaniasih, Soedarsono, Yuriko Ozeki, Wayan Tunas Artama, Fihiruddin, Mamiko Niki, Yoshitaka Tateishi, Manabu Ato, Sohkichi Matsumoto
BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Biochemistry & Molecular Biology
Mohammad Tanvir Sarwar, Yuko Ohara-Nemoto, Takeshi Kobayakawa, Mariko Naito, Takayuki K. Nemoto
BIOLOGICAL CHEMISTRY
(2020)
Review
Immunology
Mikio Shoji, Satoshi Shibata, Takayuki Sueyoshi, Mariko Naito, Koji Nakayama
MICROBIOLOGY AND IMMUNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Shymaa Enany, Manabu Ato, Sohkichi Matsumoto
Summary: This study utilized proteomics technology to analyze the changes in the whole proteome of Mycobacterium avium 104 during different growth phases, identifying 12 dys-regulated proteins and implicating the functional adaptation of the cells to the environment.
Article
Microbiology
Mariko Naito, B. Ross Belvin, Mikio Shoji, Qin Gui, Janina P. Lewis
Summary: The study reported the first mutant in the P. intermedia OMA14 strain, which is severely impaired in its ability to grow with host cells and oxidative stress. Transcriptome analysis revealed that the major deregulated genes are involved in the alkylhydroperoxide reductase system and other related proteins.
Article
Biochemistry & Molecular Biology
Keiko Sato, Masami Naya, Yuri Hatano, Naoki Kasahata, Yoshio Kondo, Mari Sato, Katsuki Takebe, Mariko Naito, Chikara Sato
Summary: The study reveals that the colony surface structure of Flavobacterium johnsoniae depends on the capability to expand biofilm. WT cells form spreading colonies with sparse interspersed cells covered by EPM, while sprB, gldG, and gldK cells form different colonies with more densely packed cells and various EPM coverings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tohru Abe, Mariko Hakamata, Akihito Nishiyama, Yoshitaka Tateishi, Sohkichi Matsumoto, Hisashi Hemmi, Daijiro Ueda, Tsutomu Sato
Summary: In this study, a new type of Z,E-mixed prenyl reductase, HepR, was identified and functionally analyzed. HepR is widely distributed in mycobacteria and has different substrate specificity from PR-Dol, suggesting it is a new enzyme. This discovery will promote further research on Z,E-mixed isoprenoids.
Article
Microbiology
Ryoji Maekura, Keisuke Miki, Yoshitaka Tateishi, Sohkichi Matsumoto, Seigo Kitada, Mari Miki, Hiroshi Kida
Summary: The natural history of MAC-PD is difficult to predict at diagnosis in immunocompetent patients, and current multidrug chemotherapy options are not effective enough. This study found that anti-MBGL antibody titers are useful for assessing refractory MAC-PD, and when combined with clinical poor prognostic characteristics, they enhance the accuracy of predicting treatment outcomes and mortality.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Yukiko Nishiuchi, Yoshitaka Tateishi, Hiroshi Hirano, Yuriko Ozeki, Takehiro Yamaguchi, Mari Miki, Seigo Kitada, Fumito Maruyama, Sohkichi Matsumoto
Summary: This study found that pathogenic mycobacteria colocalized with erythrocytes at the sites of lung infection and demonstrated that erythrocytes enhance the extracellular proliferation of mycobacteria. Erythrocyte-attached mycobacteria are an efficient infectious source for macrophages, highlighting the clinical significance of erythrocyte-mediated mycobacterial growth for disease progression and latent infection.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Mariko Naito, Mikio Shoji, Keiko Sato, Koji Nakayama
Summary: Prevotella intermedia, a Gram-negative oral anaerobic bacterium, has been found to be involved in both respiratory tract infections and oral infections. The bacterium possesses the interpain A proteinase as a potent virulence factor, which is translocated by the type IX secretion system (T9SS) across the outer membrane. In this study, targeted mutagenesis revealed that T9SS is functional in P. intermedia and that interpain A is a cargo protein of the T9SS, playing a role in colony pigmentation, hemagglutination, and biofilm formation.
JOURNAL OF BACTERIOLOGY
(2022)
Article
Immunology
Ryoji Maekura, Seigo Kitada, Mayuko Osada-Oka, Yoshitaka Tateishi, Yuriko Ozeki, Takeya Fujikawa, Mari Miki, Jyunnko Ogawa, Masahide Mori, Sohkichi Matsumoto
MICROBIOLOGY AND IMMUNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Yu Yamaguchi, Eiko Sakai, Kuniaki Okamoto, Hiroshi Kajiya, Koji Okabe, Mariko Naito, Tomoko Kadowaki, Takayuki Tsukuba
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
