3.9 Article

Mannose-Binding Lectin Genotypes and Susceptibility to Epstein-Barr Virus Infection in Infancy

Journal

CLINICAL AND VACCINE IMMUNOLOGY
Volume 17, Issue 9, Pages 1484-1487

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00527-09

Keywords

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Funding

  1. Danish Medical Research Council
  2. Commission for Scientific Research in Greenland (KVUG)
  3. Nordic Cancer Union
  4. Danish Cancer Foundation
  5. Gangsted Foundation
  6. Einer Willumsen Grant
  7. Dagmar Marshall Foundation
  8. Aase and Ejnar Danielsen Foundation
  9. Foundation for Promotion of Medical Science
  10. Novo-Nordisk Research Foundation
  11. University Hospital Rigshospitalet
  12. Copenhagen Hospital Cooperation Research Foundation

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In a cohort study of children < 4 years of age in Greenland, mannose-binding lectin (MBL2) genotypes and Epstein-Barr virus (EBV) antibody levels were determined. EBV seropositivity was significantly lower and time to seroconversion increased in MBL-insufficient compared with MBL-sufficient children, indicating that MBL may be involved in primary EBV infection in infancy.

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