Article
Infectious Diseases
Hayet Bouchaib, Achour Amrane, Jacques Sevestre, Idir Bitam, Phillipe Parola
Summary: Mediterranean spotted fever (MSF), caused by Rickettsia conorii, is an ancient tick-borne disease primarily found in the Mediterranean region. It is transmitted by the brown dog tick Rhipicephalus sanguineus and typically presents with a skin rash, high fever, and characteristic eschar at the site of the tick bite. The disease can have a benign or life-threatening course, and neurological manifestations are uncommon. We report a case of isolated peripheral facial nerve palsy as a complication of R conorii conorii infection.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Biochemistry & Molecular Biology
Yu-Xin Fan, Li -Rong Chen, Run-Xin Gan, Sun-Jun Yin, Ping Wang, Rui Meng, Yan-Hua Huang, Fang-Fang Jiang, Gong-Hao He
Summary: This meta-analysis found that IL-10 polymorphisms, specifically rs1800896 and rs1800872, were associated with increased risk of acute leukemia.
Article
Biochemistry & Molecular Biology
Leila Saremi, Marziyeh Shafizadeh, Emran Esmaeilzadeh, Mohammad Ebrahim Ghaffari, Mohammad Hosein Mahdavi, Reza Amid, Mahdi Kadkhodazadeh
Summary: Peri-implantitis (PI) is a multifactorial condition caused by the interactions of pathogens and the host immune response. Studies have shown that specific gene polymorphisms of IL-10 819 C/T, IL-10 592 C/A, and IL-1 beta + 3954 C/T may play a significant role in the pathogenesis of PI.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Multidisciplinary Sciences
Renata Rocha da Silva, Fernanda de Santana Fontes Vasconcelos, Debora dos Santos Tavares, Priscila Lima dos Santos
Summary: This study conducted a systematic review and meta-analysis to investigate the association between IL-10 single nucleotide polymorphisms (SNPs) and the progression of leishmaniasis. The results showed that IL-10 SNPs were not significantly associated with leishmaniasis progression and were not considered a risk factor.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Liwei Cheng, Fan Zhang, Ying Wang, Jing Chen, Xiaoping Yuan
Summary: This meta-analysis study found an association between IFNGR1 gene polymorphisms and tuberculosis susceptibility. The rs2234711 polymorphism was associated with increased tuberculosis susceptibility in Africans and decreased susceptibility in Asians. Additionally, the rs7749390 polymorphism was associated with decreased tuberculosis susceptibility in Africans.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pediatrics
Jianrong Shi, Lin He, Huiwen Zheng, Wei Li, Shuangshuang Huang, Yunling Li, Ran Tao
Summary: This study investigated the association of IL-4 and IL-18 gene polymorphisms with the susceptibility and severity of atopic dermatitis (AD) in Chinese children. The results showed that IL-4 rs2243283 G allele, CG genotype, and CG+GG genotype were significantly decreased in AD patients, while IL-18 rs7106524 A allele, AA genotype, and AG+AA genotype were significantly increased in severe AD patients.
FRONTIERS IN PEDIATRICS
(2023)
Article
Biochemistry & Molecular Biology
Olga M. Koper-Lenkiewicz, Kinga Sutkowska, Natalia Wawrusiewicz-Kurylonek, Ewa Kowalewska, Joanna Matowicka-Karna
Summary: Studies have shown that the relationship between SNPs in proinflammatory cytokines genes and susceptibility to developing RA is inconclusive and varies among different ethnic populations. These polymorphisms also have an impact on clinicopathological features of RA and patients' response to treatment. Further research on larger cohorts and diverse populations is needed to elucidate the role of these SNPs in RA patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Ivan Baltadzhiev, Zaprian Zaprianov, Atanas Baltadjiev
Summary: Mediterranean spotted fever (MSF) is a tick-borne rickettsial infection endemic to the Mediterranean coastline countries. This study focused on the renal impairment in patients with MSF and found that kidney involvement was more severe in malignant cases of MSF, especially in fatal cases, with a higher incidence of acute renal failure.
MEDICAL PRINCIPLES AND PRACTICE
(2021)
Article
Infectious Diseases
Nikolaos Spernovasilis, Ioulia Markaki, Michail Papadakis, Nikolaos Mazonakis, Despo Ierodiakonou
Summary: Mediterranean spotted fever is an emerging tick-borne rickettsiosis in the Mediterranean basin, caused by Rickettsia conorii subspecies conorii. The brown dog tick is the arthropod vector of this bacterium. Typical symptoms include fever, rash, and eschar, with atypical features and severe complications also possible.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2021)
Article
Immunology
Anna Zaninoni, Bruno Fattizzo, Loredana Pettine, Cristina Vercellati, Anna P. Marcello, Wilma Barcellini
Summary: This study investigated cytokine single-nucleotide polymorphisms (SNPs) and serum levels in patients with autoimmune hemolytic anemia (AIHA), and found complex interplay between genetic factors and disease features.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Joerg C. Henes, Sebastian Saur, David M. Kofler, Claudia Kedor, Christoph Meisner, Marion Schuett, Martin Krusche, Ina Koetter, Theodoros Xenitidis, Hendrik Schulze-Koops, Eugen Feist
Summary: This study evaluated the effectiveness and safety of the IL-6 receptor antibody Tocilizumab in treating Familial Mediterranean Fever. The results showed that more patients in the Tocilizumab group achieved an adequate treatment response compared to the placebo group. Tocilizumab also normalized the serum amyloid A levels, which is important in preventing amyloidosis. These findings need to be confirmed in a larger trial.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Stamatia Papoutsopoulou, Liam Pollock, Catherine Walker, William Tench, Sakim Shakh Samad, Francois Bergey, Luca Lenzi, Raheleh Sheibani-Tezerji, Phillip Rosenstiel, Mohammad Tauqeer Alam, Vitor A. P. Martins Dos Santos, Werner Mueller, Barry J. Campbell
Summary: The study showed that IL-10 plays a crucial role in regulating the NF kappa B signaling pathway in intestinal epithelial cells, contributing to the maintenance of intestinal homeostasis, especially in an inflammatory environment. Deficiency of IL-10 affects NF kappa B activity and related gene transcription, thereby impacting intestinal homeostasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Shuhei Yoshida, Yuya Sumichika, Kenji Saito, Haruki Matsumoto, Jumpei Temmoku, Yuya Fujita, Naoki Matsuoka, Tomoyuki Asano, Shuzo Sato, Kiyoshi Migita
Summary: This study investigated the clinical features and treatment response of Japanese patients with FMF. It found that colchicine was effective in the majority of patients, but some patients showed resistance to colchicine. Canakinumab showed good efficacy in colchicine-resistant patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Dentistry, Oral Surgery & Medicine
Mabelle Freitas Monteiro, Marcio Zaffalon Casati, Enilson Antonio Sallum, Karina Gonzales Silverio, Francisco Humberto Nociti-Jr, Renato Correa Viana Casarin
Summary: This study found that aggressive periodontitis (GAgP) patients and their children have a different local inflammatory response compared to healthy controls, and there is a familial aggregation. The cytokine profile and subgingival response imbalance characterized by decreased IFN-gamma/IL-4 and IL-10/IL-1 beta ratios were observed in both GAgP patients and their children.
Article
Medicine, General & Internal
Ming-Han Chen, Huai-Chia Chuang, Yi-Chen Yeh, Chung-Tei Chou, Tse-Hua Tan
Summary: This study investigated the potential roles of dual-specificity phosphatase (DUSPs) in ankylosing spondylitis (AS). Results showed that mRNA levels of DUSP4, DUSP5, DUSP6, DUSP7, and DUSP14 in peripheral T cells were significantly higher in AS patients compared to healthy controls, while DUSP22 mRNA levels were significantly lower. DUSP22 was found to play a crucial role in the pathogenesis and regulation of disease activity of AS.
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Maurizio Soresi, Giuseppina Candore, Chiara Garlisi, Francesca Fayer, Caterina Maria Gambino, Francesco La Blasca, Aurelio Seidita, Alberto D'Alcamo, Bruna Lo Sasso, Ada Maria Florena, Girolamo Geraci, Giacomo Caio, Umberto Volta, Roberto De Giorgio, Marcello Ciaccio, Antonio Carroccio
Summary: The study found that approximately one in four patients with NCWS had autoimmune diseases, with a high positivity rate for autoimmune antibodies, suggesting a potential association between NCWS and autoimmune diseases.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Jamie Zhen, Juan Pablo Stefanolo, Maria de la Paz Temprano, Sebastian Tedesco, Caroline Seiler, Alberto Fernandez Caminero, Enrique de-Madaria, Miguel Montoro Huguet, Santiago Vivas, Sonia Isabel Niveloni, Premysl Bercik, Edgardo Smecuol, Luis Uscanga, Elena Trucco, Virginia Lopez, Carolina Olano, Pasquale Mansueto, Antonio Carroccio, Peter H. R. Green, Andrew Day, Jason Tye-Din, Julio Cesar Bai, Carolina Ciacci, Elena F. Verdu, Benjamin Lebwohl, Maria Ines Pinto-Sanchez
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jamie Zhen, Juan Pablo Stefanolo, Maria de la Paz Temprano, Caroline L. Seiler, Alberto Caminero, Enrique De-Madaria, Miguel Montoro Huguet, Vivas Santiago, Sonia Isabel Niveloni, Edgardo Gustavo Smecuol, Luis Uzcanga Dominguez, Elena Trucco, Virginia Lopez, Carolina Olano, Pasquale Mansueto, Antonio Carroccio, Peter H. Green, Donald Duerksen, Andrew S. Day, Jason A. Tye-Din, Julio Cesar Bai, Carolina Ciacci, Elena F. Verdu, Benjamin Lebwohl, M. Ines Pinto-Sanchez
Summary: The survey found that over half of celiac disease patients perceive themselves to be at a higher risk of contracting COVID-19 compared to the general population, resulting in some taking additional precautions. Older age, male gender, and strict adherence to a gluten-free diet were associated with lower risk perception, while patients with comorbidities tended to perceive a higher risk.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Health Care Sciences & Services
Valentina Bravata, Walter Tinganelli, Francesco P. Cammarata, Luigi Minafra, Marco Calvaruso, Olga Sokol, Giada Petringa, Giuseppe A. P. Cirrone, Emanuele Scifoni, Giusi I. Forte, Giorgio Russo
Summary: This study aims to uncover the biomarker network in a hypoxic GBM cell line that shows radioresistance after proton therapy, highlighting gene expression and biological processes involved, as well as describing cell survival response, deregulated pathways, and gene signatures. The findings may suggest new molecular targets for overcoming treatment resistance and developing targeted drugs in association with proton therapy.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Gaia Pucci, Giusi Irma Forte, Vincenzo Cavalieri
Summary: Radiotherapy is not yet personalized in cancer treatment plans, as its effectiveness varies depending on the radiosensitivity of tumor cells. Research is focusing on enhancing cancer cell response to ionizing radiation and protecting healthy tissues, using zebrafish as an effective model system for testing radiation modifiers for potential radiotherapeutic purposes in humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Giada Petringa, Marco Calvaruso, Valeria Conte, Pavel Blaha, Valentina Bravata, Francesco Paolo Cammarata, Giacomo Cuttone, Giusi Irma Forte, Otilija Keta, Lorenzo Manti, Luigi Minafra, Vladana Petkovic, Ivan Petrovic, Selene Richiusa, Aleksandra Ristic Fira, Giorgio Russo, Giuseppe Antonio Pablo Cirrone
Summary: CATANA is the first Italian protontherapy facility dedicated to treating ocular neoplastic pathologies, having successfully treated 500 patients. The study aimed to compare RBE values obtained from in-vitro experimental data with predictions made by different models to accurately predict the effects of irradiations.
APPLIED SCIENCES-BASEL
(2021)
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Gabriele Spagnuolo, Silvia Calderone, Carmela Cinzia D'Agate, Salvatore Cosenza, Giuseppe Leonardi, Salvatore Camilleri, Mirco Pistone, Giovanna Seminara, Carlo Alaimo, Maurizio Soresi, Antonio Carroccio, Serena Garufi
Summary: This study retrospectively evaluated the data of 369 patients with CD from the Sicilian Network and found that non-classical CD presentation was more common, there was a diagnostic delay of approximately 9 years, most patients did not undergo multiple duodenal biopsies, and 59.9% of the patients received unrecommended CD serology assays.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Genetics & Heredity
Marco Guarneri, Letizia Scola, Rosa Maria Giarratana, Manuela Bova, Caterina Carollo, Loredana Vaccarino, Leonardo Calandra, Domenico Lio, Carmela Rita Balistreri, Santina Cottone
Summary: This study analyzed a group of gene SNPs in ESRD patients and controls and found that IL6 rs180795 and MIF rs755622 SNPs may be markers of genetic susceptibility to chronic kidney disease. In addition, MIF rs755622 may interact with diabetes or hypercholesterolemia in increasing susceptibility to ESRD.
Review
Nutrition & Dietetics
Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio, Emanuele Amodio
Summary: This narrative review analyzed the correlation between diet and clinical outcomes of familial Mediterranean fever (FMF). Conflicting results were found regarding the association between high-fat and high-salt food intake and FMF attack recurrence. Wheat was suggested to potentially play a role in FMF. A diet rich in antioxidants and anti-inflammatory supplements may partly reduce symptoms and improve the well-being of FMF patients. However, further studies are needed to clarify the impact of diet on FMF symptom triggering.
Article
Medicine, General & Internal
Aurelio Seidita, Pasquale Mansueto, Alessandra Giuliano, Marta Chiavetta, Francesca Mandreucci, Maurizio Soresi, Mattia Pistone, Stella Compagnoni, Daniele Castellucci, Gianluca Bisso, Francesco Faraci, Salvatore Maestri, Rosaria Disclafani, Anna Sapone, Alessio Fasano, Antonio Carroccio
Summary: This observational study found that Non-celiac Wheat Sensitivity (NCWS) patients who consume ancient grains may have a delayed diagnosis due to the clinical benefit (tolerability) obtained with these grains. Even after diagnosis, some patients continue to consume ancient grains and have mild or no symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Health Care Sciences & Services
Aurelio Seidita, Pasquale Mansueto, Stella Compagnoni, Daniele Castellucci, Maurizio Soresi, Giorgio Chiarello, Giorgia Cavallo, Gabriele De Carlo, Alessia Nigro, Marta Chiavetta, Francesca Mandreucci, Alessandra Giuliano, Rosaria Disclafani, Antonio Carroccio
Summary: This study assessed the frequency, severity, morphologic features, and pathogenic factors of anemia in patients with Celiac Disease (CD) and found that iron deficiency anemia (IDA) is common, especially in women. The study also showed that some women with CD continue to have IDA despite following a strict gluten-free diet, and low body mass index and menstrual abnormalities might contribute to the persistence of anemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Nutrition & Dietetics
Aurelio Seidita, Pasquale Mansueto, Alessandra Giuliano, Marta Chiavetta, Maurizio Soresi, Antonio Carroccio
Summary: Inflammatory/allergic conditions should be considered in self-reported milk intolerance patients who test negative and/or are asymptomatic at Lactose Hydrogen Breath Test. Fecal calprotectin values were analyzed in these patients and suggest the existence of an allergic/inflammatory pathogenetic mechanism in a subset of self-reported milk intolerance subjects. Fecal calprotectin results are in keeping with this hypothesis, but cannot differentiate lactose tolerant from intolerant patients.
Article
Geriatrics & Gerontology
Francesco Saverio Ragusa, Luisa Solimando, Caterina Mandala, Roberta Masnata, Gregorio Ciulla, Stefano Ciriminna, Francesco La Blasca, Pasquale Mansueto, Nicola Veronese, Mario Barbagallo
Summary: The study found a positive association between higher multidimensional prognostic index (MPI) values, indicating frailty, and the prevalence of infectious diseases, including multidrug-resistant pathogens, resulting in increased antibiotic costs.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Gastroenterology & Hepatology
M. Pistone, A. Seidita, P. Mansueto, M. Soresi, F. La Blasca, L. Giannitrapani, A. Carroccio
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
A. Seidita, P. Mansueto, M. Soresi, G. Chiarello, F. La Blasca, L. Giannitrapani, A. Carroccio
DIGESTIVE AND LIVER DISEASE
(2022)