Journal
CLINICAL AND VACCINE IMMUNOLOGY
Volume 16, Issue 1, Pages 142-145Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/CVI.00358-08
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- Ciberehd, Instituto de Salud Carlos III
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We report the first case of hemophagocytic lymphohistiocytosis (HLH) induced by the monoclonal expansion of Epstein-Barr virus (EBV)-negative NK cells. Consanguinity of the patient's parents made it necessary to discard familial HLH in the patient and her sister with identical HLA markers and demonstrate that no cause other than the expansion of NK cells, which secrete high levels of gamma interferon, was inducing HLH in this patient.
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