Article
Oncology
Lei Mi, Nan Zhang, Jiyun Wan, Ming Cheng, Jianping Liao, Xiao Zheng
Summary: The study demonstrated that remote ischemic post-conditioning (RIPOC) can attenuate the histopathological features of intestinal mucosa in intestinal I/R injury mouse models through the ERK pathway. RIPOC also showed significant antioxidant and anti-inflammatory effects mediated via the ERK pathway, while suppressing the NF-kappa B (p65)/NLRP3 inflammatory pathways in the intestinal I/R injury mouse models.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Multidisciplinary Sciences
Se-Hee Min, Suk Hyung Choe, Won Shik Kim, Soon-Hyun Ahn, Youn Joung Cho
Summary: This study aimed to investigate the role of remote ischemic conditioning (RIC) in head and neck free flap reconstructive surgery. The study found that RIC did not improve tissue oxygenation of the transferred flap, but showed evidence of organ-protective effects in experimental models.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Ava Safaroghli-Azar, Mohammad-Javad Sanaei, Atieh Pourbagheri-Sigaroodi, Davood Bashash
Summary: Lipid signaling refers to the biological process in which a lipid messenger binds to a protein target, converting its effects to specific cellular responses. The family of phosphoinositide 3-kinase (PI3K) plays a crucial role in this pathway, affecting various aspects of cellular biology such as cell survival, proliferation, migration, endocytosis, intracellular trafficking, metabolism, and autophagy. Different classes of PI3Ks have been identified in yeast and mammals, with class I PI3Ks being extensively studied in cancer biology. Abnormal activation of class I PI3Ks has been implicated in human tumors, particularly through activating mutations in the PIK3CA gene. Class II and III PI3Ks are involved in regulating vesicle trafficking and autophagy processes. This review aims to discuss the latest research findings on PI3Ks-mediated cell biological processes and explore the mechanisms by which different types of phosphoinositides derived from PI3Ks act.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Guoning Su, Yan Qu, Gang Li, Min Deng
Summary: The study found that SEV has a protective effect on cerebral ischemia/reperfusion injury (CIRI) by modulating the miR-30 c-5p-HIPK1 axis. Inhibition of HIPK1 can reverse the effect of reduced miR-30 c-5p on CIRI.
Article
Oncology
Yan-Qing Zhang, Rong Li, Shou-Yuan Tian, Jie-Ping Lv, Bao-Zhong Yang, Jin Wang, Li Wang, Xiao-Jie Bai, Chun-Hui Wang, Qiang Wang
Summary: This study found that significant injury had occurred at 3 hours of myocardial ischemia/reperfusion (MI/R), which could be alleviated by Sevoflurane preconditioning (SevoPre) through enhancing the affinity between adiponectin receptor 1 and caveolin-3, and reducing endoplasmic reticulum stress in cardiomyocytes.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hongyan Ma, Baoyi Yang, Lu Yu, Yang Gao, Xiangmei Ye, Ying Liu, Zhengtian Li, Hulun Li, Enyou Li
Summary: Sevoflurane protects the liver from ischemia-reperfusion injury by regulating the Nrf2/HO-1 pathway, reducing tissue damage and cell apoptosis, and promoting Nrf2 nucleation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Cody A. Rutledge, Brett A. Kaufman, Cameron Dezfulian, Jonathan Elmer
Summary: This study found that metformin may provide cardiac and renal protection for diabetic patients during sudden cardiac arrest, as it was associated with lower peak serum troponin and peak serum creatinine levels.
Article
Urology & Nephrology
Yanyang Li, Pan Liu, Yalu Zhou, Hiroshi Maekawa, John B. B. Silva, Mohammed Javeed Ansari, Khaled Boubes, Yazan Alia, Dilip K. K. Deb, Benjamin R. R. Thomson, Jing Jin, Susan E. E. Quaggin
Summary: Background ischemia-reperfusion acute kidney injury (IR-AKI) affects a significant percentage of hospitalized patients. This study investigated the molecular mechanisms underlying kidney injury and protection related to the activation of the angiopoietin-Tie2 signaling pathway. It also explored the potential therapeutic benefits of deleting VE-PTP or injecting a new angiopoietin mimetic.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Medicine, Research & Experimental
Xiaoqun Zhang, Xue Han, Yanan Zhang
Summary: CPNE3 plays an important role in preventing myocardial ischemia/reperfusion injury by interacting with RACK1, providing novel insights into the prevention and treatment of myocardial ischemia/reperfusion injury.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Senlei Xu, Renjun Gu, Xiangyu Bian, Xin Xu, Xuefeng Xia, Yuchen Liu, Chengjie Jia, Yihuang Gu, Hongru Zhang
Summary: This study evaluated the effects of remote tissue compression on infarct size after myocardial infarction and identified its cardioprotective effects. The cardioprotective signal transmission of remote conditioning involves the release of adenosine, essential for its anti-inflammatory properties through the activation of the cAMP/PKA/NF-kappa B axis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Helmut Raphael Lieder, Felix Braczko, Nilgun Gedik, Merlin Stroetges, Gerd Heusch, Petra Kleinbongard
Summary: The study investigated the impact of T3 on infarct size and its underlying signal transduction, finding that T3 reduces infarct size during reperfusion by activating the RISK pathway.
BASIC RESEARCH IN CARDIOLOGY
(2021)
Article
Cell Biology
Yifeng Xu, Boqian Wang, Xiaoxiao Liu, Yunfei Deng, Yanqi Zhu, Feng Zhu, Yanyan Liang, Hongli Li
Summary: This study investigated the role and mechanism of PARP1 in MIRI, demonstrating that inhibition of PARP1 can protect cardiomyocytes from MIRI by regulating autophagy. Additionally, it was found that Sp1, a transcription factor of PARP1, plays a role in this process by binding to the target gene promoter of PARP1 during transcription. These findings suggest that targeting PARP1 has great therapeutic potential for MIRI in the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jiaxuan Wu, Wenfeng Cai, Ruiming Du, Haiyang Li, Bin Wang, Yanqiong Zhou, Daifei Shen, Huimin Shen, Yang Lan, Lesi Chen, Xiaoxia Zheng, Danmei Huang, Ganggang Shi
Summary: This study investigated the protective effect of Sevoflurane on myocardial ischemia reperfusion injury (MIRI) and found that Sevoflurane can reduce myocardial cell damage by inhibiting inflammatory reaction and pyroptosis, providing myocardial protection.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Clinical Neurology
Wenbo Zhao, Derek J. Hausenloy, David C. Hess, Derek M. Yellon, Xunming Ji
Summary: Remote ischemic conditioning (RIC) has shown variable results in the treatment of cerebrovascular and cardiovascular disease. While milestone studies suggest limited roles for RIC in cardiovascular disease patients, recent large trials found promising results in cerebrovascular disease patients. This article discusses important clinical trials of RIC in cardio-cerebrovascular disease and highlights the challenges of clinical translation. It proposes several promising research directions that should be investigated before RIC can be applied in clinical practice.
Article
Genetics & Heredity
Ting Li, Ying Tan, Shao Ouyang, Jin He, Lingling Liu
Summary: Res has been shown to protect against myocardial I/R injury by reducing oxidative stress and inhibiting ferroptosis, potentially through the regulation of USP19-Beclin1 autophagy.
Article
Biotechnology & Applied Microbiology
Qin Gong, Xianjie Wen, Heng Li, Jian He, Yunhua Wang, Huiping Wu, Hanbing Wang, Xiaoping Wang
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2018)
Article
Biotechnology & Applied Microbiology
Xianjie Wen, Yiqun Li, Xingqing Liu, Can Sun, Jinbing Lin, Wenli Zhang, Yabin Wu, Xiaoping Wang
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
(2019)
Article
Medicine, General & Internal
Chen Ling, Xing-Qing Liu, Yi-Qun Li, Xian-Jie Wen, Xu-Dong Hu, Kai Yang
WORLD JOURNAL OF CLINICAL CASES
(2019)
Letter
Infectious Diseases
Xianjie Wen, Yiqun Li
SURGICAL INFECTIONS
(2020)
Letter
Public, Environmental & Occupational Health
Xianjie Wen, Chen Ling, Yiqun Li
AMERICAN JOURNAL OF INFECTION CONTROL
(2020)
Article
Public, Environmental & Occupational Health
Chen Ling, Xianjie Wen
EPIDEMIOLOGY AND INFECTION
(2020)
Article
Immunology
Meixin Chen, Xianjie Wen, Ying Gao, Benquan Liu, Chaoqun Zhong, Jiayi Nie, Hua Liang
Summary: IRF-4 plays a crucial role in the pathogenesis of progressive chronic kidney disease following toxin-induced acute kidney injury (AKI), with its deficiency leading to reduced inflammation and myofibroblast transformation, thereby mitigating the progression of kidney fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Wu Zhaoxia, Wen Xianjie
Summary: PEEP is an important measure in providing effective and safe mechanical ventilation support for patients during surgery, preventing atelectasis, and reducing the incidence of postoperative infections. However, PEEP may also have effects on cardiac function and hemodynamics, indirectly impacting intracranial pressure and renal function.
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2021)
Article
Green & Sustainable Science & Technology
Yushan Li, Ting Wu, Hui Shen, Shiwen Yang, Yi Qin, Zongmin Zhu, Long Zheng, Xianjie Wen, Minggui Xia, Xianze Yin
Summary: A Janus photothermal porous fibrous membrane is developed for efficient solar-driven seawater desalination, showing high salt rejection rate, stable solar-thermal conversion efficiency, and antibacterial activity, with potential applications in environmental protection.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Toxicology
Qi E, Yunlin Wu, Xiaoxia Liang, Meixin Chen, Jiayi Peng, Ziyin Zhou, Xianjie Wen
Summary: Peripheral neurotoxicity injury caused by local anesthetics is a common complication of clinical anesthesia. Previous studies have mainly focused on in vitro cell experiments, and there are few in vivo experimental studies due to the lack of an animal model. In this study, a neurotoxic injury model of the sciatic nerve was created by injecting 1% ropivacaine hydrochloride directly into the nerve. The results showed that 1% ropivacaine hydrochloride caused motor impairment and nerve damage after 48 hours of treatment, providing a research tool for studying the mechanism of neurotoxic injury caused by local anesthetics.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Anesthesiology
Jian He, Lei Zhang, Tao Tao, Xianjie Wen, Daguang Chen, Xueqin Zheng, Changhui Luo, Hua Liang, Hanbing Wang
Summary: This study aimed to evaluate the effect of nalbuphine on emergence agitation in children undergoing adenotonsillectomy. The results showed that nalbuphine group had a lower incidence of emergence agitation compared to the saline group, and the nalbuphine group also had lower FLACC scores and a lower proportion of moderate to severe pain cases. There were no significant differences in extubation time, duration of PACU stay, nausea and vomiting, or respiratory depression between the two groups.
JOURNAL OF CLINICAL ANESTHESIA
(2023)
Article
Engineering, Chemical
Bingbing Cheng, Song Yan, Yushan Li, Long Zheng, Xianjie Wen, Yeqiang Tan, Xianze Yin
Summary: A simple method is developed to grow superhydrophilic nanocoating on a PVDF fiber surface, which enables the fabrication of asymmetric wettable Janus PVDF fibrous membranes with high separation efficiency for oil/water emulsions. These Janus membranes with opposite wettability exhibit excellent separation efficiency, high flux, antibacterial activity, and antifoul properties. They also show remarkable flux cycling stability and retained separation efficiency after multiple cycles, making them promising for oily wastewater treatment and water purification.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Physical
Yushan Li, Song Yan, Ziwei Li, Siwei Xiong, Shiwen Yang, Luoxin Wang, Hua Wang, Xianjie Wen, Pingan Song, Xianze Yin
Summary: This study proposes a strategy to reduce the viscosity of crude oil by using solar-assisted chemical emulsifiers, and modify commercial sponges to achieve rapid adsorption and efficient recovery of crude oil. The modified sponge exhibits a 10% increase in absorption capacity and a three order of magnitude increase in viscous crude oil absorption rate compared to a commercial polyurethane sponge.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Pharmacology & Pharmacy
Wu Zhaoxia, Chen Meixin, Li Yiqun, Yang Shuxuan, Wen Xianjie
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2020)
Article
Pharmacology & Pharmacy
Xianjie Wen, Zhaoxia Wu, Weidong Lin, Yiqun Li, Xiaoping Wang
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2020)