Article
Medicine, General & Internal
Maryam Eslami, Farhad Ghaseminejad, Paul J. Dubord, Sonia N. Yeung, Alfonso Iovieno
Summary: This study analyzed the long-term topographic and refractive outcomes of corneal cross-linking (CXL) in keratoconus. The results showed improvements in corrected distance visual acuity, spherical and cylindrical refraction, average and steepest keratometry, and corneal aberrations over the follow-up period. The improvement was more pronounced in patients with more severe keratoconus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Ophthalmology
Mohammad Karam, Abdulmalik Alsaif, Ahmed Aldubaikhi, Meshaal Aljebreen, Rand Alazaz, Nahlaa Alkhowaiter, Tariq Almudhaiyan, Faisal Aljassar
Summary: The aim of this study was to compare the outcomes of 18 mW/cm(2) (5 minutes) versus 9 mW/cm(2) (10 minutes) accelerated corneal collagen cross-linking protocols in patients with progressive keratoconus. The study found that the 10-minute protocol had better outcomes in terms of K1, K2, and HOA compared to the 5-minute protocol, but there were no statistically significant differences in other outcomes.
Article
Ophthalmology
Daniel F. P. Larkin, Kashfia Chowdhury, Jennifer M. Burr, Mathew Raynor, Matthew Edwards, Stephen J. Tuft, Catey Bunce, Emilia Caverly, Caroline Dore
Summary: The study demonstrates that corneal cross-linking (CXL) can effectively halt the progression of keratoconus in the majority of young patients, positioning it as a first-line treatment for progressive disease and potentially offering the benefit of avoiding later need for contact lens wear or corneal transplantation.
Article
Ophthalmology
Atikah Haneef, Ramprasad Obula Giridhara Gopalan, Divya T. Rajendran, Jessica Nunes, Dharmalingam Kuppamuthu, Naveen Radhakrishnan, Tai-Horng Young, Hao-Ying Hsieh, Namperumalsamy Venkatesh Prajna, Colin E. Willoughby, Rachel Williams
Summary: The novel chemical cross-linker treatment for keratoconus involving carbodi-imide chemistry showed clinically relevant increase in corneal stiffness without removal of corneal epithelium. Histochemical analysis indicated no gross morphology changes or apoptosis in porcine and human corneas. In vivo treatment of rabbit eyes resulted in initial corneal epithelium thinning which recovered over time, with irregular cell distribution. The cross-linker demonstrated lower cytotoxicity to stromal cells than traditional ultraviolet A treatment, suggesting potential as a treatment for keratoconus.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Ophthalmology
Siddharth Nath, Carl Shen, Alex Koziarz, Laura Banfield, Behnam Nowrouzi-Kia, Mark A. Fava, William G. Hodge
Summary: Transepithelial and epithelium-off corneal cross-linking show significant differences in corneal ectasia treatment, with the latter being more effective but less safe in comparison.
Article
Ophthalmology
Romina Fasciani, Emanuele Crincoli, Chiara Fedeli, Maria Teresa Rebecchi, Marco Senneca, Luigi Mosca, Laura Guccione, Stanislao Rizzo
Summary: This study aimed to assess the differences in binocular visual performance before and after corneal collagen cross-linking (CXL) treatment in patients with keratoconus. The results showed that CXL led to a reduction in high-order aberrations (HOAs) and significant improvements in Lang and TNO stereopsis tests.
Article
Ophthalmology
Nazan Acar Eser, Ozlem Dikmetas, Sibel Kocabeyoglu, Cagman Tan, Murat Irkec
Summary: Comparing tear cytokine and chemokine levels in keratoconus (KC) patients and controls can help us understand the etiology more clearly and clarify the molecular changes after cross-linking (CXL).
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Medicine, General & Internal
Farhad Hafezi, Nan-Ji Lu, Jad F. Assaf, Nikki L. Hafezi, Carina Koppen, Riccardo Vinciguerra, Paolo Vinciguerra, Mark Hillen, Shady T. Awwad
Summary: This study aimed to evaluate the depth of the demarcation line following accelerated epithelium-off corneal cross-linking (A-CXL) performed at the slit lamp with the patient sitting in an upright position. The results showed that the demarcation line depth achieved with patients sitting upright, receiving CXL at the slit lamp, is similar to published data on CXL performed in the supine position.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Eren Aytekin, Sibel Bozdag Pehlivan
Summary: Current treatment approaches for keratoconus include options such as penetrating keratoplasty, deep anterior lamellar keratoplasty, and corneal collagen cross-linking. Early diagnosis and halting the disease with CXL methods are becoming crucial in clinical practice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Ophthalmology
Marcony R. Santhiago, J. Bradley Randleman
Summary: Corneal crosslinking (CXL) surgery halts the progression of keratoconus through a photochemical reaction involving UV light and riboflavin-induced apoptosis of corneal cells. The stiffening effect of CXL primarily occurs in the anterior third of the cornea, and shorter irradiation times may not have the same biological effect.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Medicine, General & Internal
Pasquale Napolitano, Fausto Tranfa, Luca D'Andrea, Ciro Caruso, Michele Rinaldi, Alberto Mazzucco, Nicola Ciampa, Antonietta Melenzane, Ciro Costagliola
Summary: This study compared the effectiveness of iontophoresis epi-on and epi-off techniques in corneal collagen cross-linking (CXL) and found that both techniques are valid for mid-term corneal stabilization. The advantage of the iontophoresis epi-off technique lies in a faster imbibing time of the cornea, reducing surgical times and lowering the risk of complications.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Ayesha Gulzar, Erdost Yildiz, Humeyra N. Kaleli, Muhammad A. Nazeer, Noushin Zibandeh, Anjum N. Malik, Ayse Y. Tas, Ismail Lazoglu, Afsun Sahin, Seda Kizilel
Summary: This study proposes a new method for corneal crosslinking using a ruthenium-based water-soluble photoinitiator and visible light. The results demonstrate that the ruthenium-based approach has superior biomechanical properties, biocompatibility, and optical transparency compared to the riboflavin/UV-A method. It offers a promising non-surgical therapy option for all ectatic corneal pathologies.
ACTA BIOMATERIALIA
(2022)
Article
Ophthalmology
Ruth Donner, Maria Laggner, Julia Aschauer, Jan Lammer, Gerald Schmidinger
Summary: This study aimed to evaluate the effects of modified corneal cross-linking protocols on the peripheral cornea. The results showed that increases in energy and supplemental oxygen improved the effect of CXL.
OPHTHALMOLOGY AND THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Mihaela Monica Constantin, Catalina Gabriela Corbu, Sorin Mocanu, Elena Irina Popescu, Marin Micutz, Teodora Staicu, Raluca Somoghi, Bogdan Trica, Vlad Tudor Popa, Aurica Precupas, Iulia Matei, Gabriela Ionita
Summary: Riboflavin under UVA radiation generates reactive oxygen species (ROS) that can induce various changes in biological systems. This study provides evidence of the effect of riboflavin on collagen fibril formation, and the importance of adding polysaccharides like hyaluronic acid to reduce the damaging effects of ROS.
Article
Ophthalmology
David Maskill, Arthur Okonkwo, Charlotte Onsiong, Stella Hristova, Amy Dodd, Seema Anand
Summary: This study compared 10 years of repeat corneal collagen cross-linking (CXL) with primary CXL and found that younger age is associated with failure of primary CXL. Repeat CXL is a safe and effective treatment for progressive keratoconus, even after primary CXL.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Vassilios Kozobolis, Eleni Kalogianni, Haris Sideroudi
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
George D. Kymionis, Michael A. Grentzelos, Nafsika Voulgari, Kate Hashemi, Dimitrios Mikropoulos
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2019)
Article
Ophthalmology
Montserrat Garcia-Gonzalez, Pilar Canadas, Juan Gros-Otero, Isabel Rodriguez-Perez, Rafael Canones-Zafra, Vassilios Kozobolis, Miguel A. Teus
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2019)
Review
Medicine, Research & Experimental
Eleftherios Loukovitis, Nikolaos Kozeis, Zisis Gatzioufas, Athina Kozei, Eleni Tsotridou, Maria Stoila, Spyros Koronis, Konstantinos Sfakianakis, Paris Tranos, Miltiadis Balidis, Zacharias Zachariadis, Dimitrios G. Mikropoulos, George Anogeianakis, Andreas Katsanos, Anastasios G. Konstas
ADVANCES IN THERAPY
(2019)
Article
Ophthalmology
Georgios Bontzos, Nektaria Moysaki, Michael Tsatsos, Vassilios Kozobolis, Efstathios T. Detorakis
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2019)
Article
Ophthalmology
George D. Kymionis, Nafsika Voulgari, Kattayoon Hashemi, Michael A. Grentzelos, Dimitrios Mikropoulos
JOURNAL OF CATARACT AND REFRACTIVE SURGERY
(2019)
Correction
Medicine, Research & Experimental
Anastasios-Georgios Konstas, Konstadinos G. Boboridis, Paraskevas Kapis, Konstantinos Marinopoulos, Irini C. Voudouragkaki, Dimitrios Panayiotou, Dimitrios G. Mikropoulos, Eirini Pagkalidou, Anna-Bettina Haidich, Andreas Katsanos, Luciano Quaranta
ADVANCES IN THERAPY
(2020)
Article
Ophthalmology
Panagiota Papadakou, Irini Chatziralli, Miltiadis Papathanassiou, Vaia Lambadiari, Charalambos S. Siganos, Panagiotis Theodossiadis, Vassilios Kozobolis
OPHTHALMIC RESEARCH
(2020)
Article
Ophthalmology
Antonios Ragkousis, Vassilios Kozobolis, Stamatina Kabanarou, Georgios Bontzos, George Mangouritsas, Ioannis Heliopoulos, Irini Chatziralli
SEMINARS IN OPHTHALMOLOGY
(2020)
Article
Ophthalmology
George D. Kymionis, Nafsika Voulgari, George A. Kontadakis, Dimitrios Mikropoulos, Aleksandra Petrovic, Konstantinos Droutsas
INDIAN JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Ophthalmology
Irini Chatziralli, Aristotelis Karamaounas, Eleni Dimitriou, Dimitrios Kazantzis, George Theodossiadis, Vassilios Kozobolis, Panagiotis Theodossiadis
SEMINARS IN OPHTHALMOLOGY
(2020)
Article
Ophthalmology
George D. Kymionis, Nafsika Voulgari, Michael A. Grentzelos, Konstantinos Aliferis, Kate Hashemi, Dimitrios Mikropoulos
OPEN OPHTHALMOLOGY JOURNAL
(2019)
Article
Ophthalmology
Dimitrios G. Mikropoulos, George D. Kymionis, Nafsika Voulgari, Eirini Kaisari, Konstantinos A. Nikolakopoulos, Andreas Katsanos, Anastasios G. Konstas
OPHTHALMOLOGY AND THERAPY
(2019)
Article
Ophthalmology
Dimitrios G. Mikropoulos, George D. Kymionis, Michael A. Grentzelos, Nafsika Voulgari, Andreas Katsanos, Anastasios G. Konstas
OPHTHALMOLOGY AND THERAPY
(2019)
Article
Ophthalmology
Aspasia Adamopoulou, Dimitris Sakellaris, Spyridon Koronis, Miltos Balidis, Zachos Zachariadis, Paris Tranos, Nikos Kozeis, Zisis Gatzioufas, George Anogeianakis, Dimitrios G. Mikropoulos, Anastasios-Georgios Konstas
OPHTHALMOLOGY AND THERAPY
(2019)