Article
Ophthalmology
Cristina Arroyo-del Arroyo, Mungunshur Byambajav, Itziar Fernandez, Eilidh Martin, Maria Jesus Gonzalez-Garcia, Alberto Lopez-Miguel, Laura Valencia-Nieto, Suzanne Hagan, Amalia Enriquez-de-Salamanca
Summary: The study found that tear evaporation rate (TER) and tear break-up time do not significantly vary throughout the day or on different days in healthy individuals when humidity and temperature are constant. However, certain tear molecule levels show inter- and intra-day variability and have a moderate correlation with TER diurnal variation.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Veterinary Sciences
Ana Claudia Raposo, Carlito Lebrilla, Ricardo Wagner Portela, Gege Xu, Arianne Pontes Oria
Summary: This study described the glycoproteomic profile of roadside hawk and caiman tears, showing N-type modifications for all identified glycopeptides. The glycoproteins were found to be extracellular, with endopeptidase inhibitor activity as the main molecular function for both species. These differences compared to human tears may be linked to adaptive processes and could be key for future disease biomarker research.
BMC VETERINARY RESEARCH
(2021)
Article
Ophthalmology
Arantxa Acera, Beatriz Abad, Xandra Pereiro, Francisco David Rodriguez, Noelia Ruzafa, Juan Antonio Duran, Elena Vecino
Summary: The tear film lipid layer (TFLL) plays a crucial role in maintaining high-quality vision, protecting the cornea, and promoting wound healing. Plasma rich in growth factor (PRGF) eye drops have emerged as a new treatment for aqueous deficient dry eye. This study compared the lipid profiles of PRGF eye drops with tears and found that the lipids in PRGF eye drops could be used as a supplement for altered tear lipid composition.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Marc Labetoulle, Jose Manuel Benitez-del-Castillo, Stefano Barabino, Rocio Herrero Vanrell, Philippe Daull, Jean-Sebastien Garrigue, Maurizio Rolando
Summary: This review describes the main categories of ingredients in tear substitutes and their effects on the ocular surface. It also provides insights into how to select the appropriate tear substitute formulations based on the predominant causes of dry eye disease (DED).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ophthalmology
Heiko Pult, Farzana S. Khatum, Sonia Trave-Huarte, James S. Wolffsohn
Summary: The study revealed that using a high-concentration phospholipid eye spray significantly improved ocular comfort and tear film stability compared to a low-concentration phospholipid eye spray.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Ophthalmology
Zhenyu Wei, Yuandong Su, Guanyu Su, Christophe Baudouin, Antoine Labbe, Qingfeng Liang
Summary: This study aimed to investigate the change in dynamic optical quality in dry eye patients after the use of artificial tears. The study found that optical quality indices were significantly higher in dry eye patients compared to the control group, but decreased significantly after 5 minutes of artificial tear instillation in severe dry eye patients. There were no significant differences in optical quality parameters among the three groups after 30 minutes.
Article
Pharmacology & Pharmacy
Jiraporn Leanpolchareanchai, Patamaporn Tangteerakoon, Patcharin Supapsophon, Somsiri Sukavatcharin, Pornchai Simaroj, Jiraphong Suksiriworapong
Summary: This study aimed to prepare extemporaneous 20 mg/mL ganciclovir in artificial tears and compare its stability with that of ganciclovir in sterile water for ophthalmic administration. The results showed that ganciclovir/0.1% HYA eyedrops had good stability at different temperatures and could be used as home medications for the treatment of ophthalmic viral infections.
Article
Ophthalmology
Sultan Alotaibi, Eric Papas, Jerome Ozkan, Stuti L. Misra, Maria Markoulli
Summary: This study investigated the behavior of telomerase reverse transcriptase (hTERT) in the tears of healthy individuals wearing contact lenses. The results showed that the levels of hTERT increased after contact lens wear, but this change was small compared to the impact of overnight eye closure. In addition, the inflammatory mediators IL-6 and TNF-alpha showed minimal response at the same time points.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Ophthalmology
Tai-Yuan Su, Shu-Wen Chang
Summary: By constructing normalized ocular surface temperature (NOST) models for different tear film characteristics, it is possible to differentiate tear film types and potentially use them for dry-eye screening. The study found that in dry-eye screening, the NOST order was normal > short-BUT > short BUT with SPK.
Article
Orthopedics
Hanwook Kim, Jong-Min Kim, Seong-Il Bin, Bum-Sik Lee
Summary: Radial tears in the anterior third of the lateral meniscus are more likely to be accompanied by horizontal tears. The incidence of complex tears is significantly higher in the anterior group compared to the comparison group.
ORTHOPAEDICS & TRAUMATOLOGY-SURGERY & RESEARCH
(2022)
Article
Veterinary Sciences
Samantha Palmer, Renata Ramos, Roxanne M. Rodriguez Galarza
Summary: The method of fluorescein solution administration did not affect TFBUT measurement in this population of healthy dogs.
VETERINARY OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Mark Willcox, Nancy Keir, Vinod Maseedupally, Simin Masoudi, Alison McDermott, Rabia Mobeen, Christine Purslow, Jacinto Santodomingo-Rubido, Silvia Tavazzi, Fabrizio Zeri, Lyndon Jones
Summary: Contact lens materials have undergone significant changes in the past 20 years with the introduction of silicone hydrogel materials. However, research is still needed to improve comfort, as the association between contact lens wettability and comfort is not clear. The interactions between lens materials, tear film, and disinfection solution play an important role in biocompatibility, but whether this can be altered to improve comfort remains debatable.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation-and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The study found that IL-10 and SP levels in tears were increased in patients with a history of corneal refractive surgery. IL-9 levels were associated with chronic ocular pain. These findings suggest that tear cytokines and neuromodulators could serve as biomarkers for chronic ocular pain, leading to improved therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Ophthalmology
Marta Blanco-Vazquez, Amanda Vazquez, Itziar Fernandez, Andrea Novo-Diez, Elena Martinez-Plaza, Carmen Garcia-Vazquez, Maria J. Gonzalez-Garcia, Eva M. Sobas, Margarita Calonge, Amalia Enriquez-de-Salamanca
Summary: The purpose of this study was to analyze inflammation- and pain-related molecules in tears of patients suffering from chronic ocular pain associated with dry eye and/or a previous corneal refractive surgery. The results showed that IL-9 tear levels were increased in patients with chronic ocular pain, IL-10, SP, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with previous surgery, and IL-8/CXCL8, MIP-1 alpha/CCL3, IL-2, and IFN-gamma were associated with DE-related inflammation. Higher NGF levels were related to chronic ocular pain and DE in patients with previous surgery. These findings are important for understanding biomarkers of chronic ocular pain and making better therapeutic and disease management decisions.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Orthopedics
Caitlin C. Chambers, John A. Lynch, Brian T. Feeley, Michael C. Nevitt
Summary: This study aimed to compare the impact of root tears (RTs) and nonroot tears (NRTs) on knee osteoarthritis (OA) and identify factors associated with radiographic worsening of OA in knees with RTs. The study found that RTs were associated with the development and progression of OA, especially in knees without pre-existing OA.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Article
Ophthalmology
Micael Alves, Elisabete M. S. Castanheira, Madalena Lira
Summary: The study found that contact lens materials and lens care solutions underwent mutual changes after storage, likely linked to biochemical and biophysical interactions between components and the release of some polymer compounds. These findings offer valuable insights into the interaction between CL materials and LCS in clinical settings.
CONTACT LENS & ANTERIOR EYE
(2021)
Article
Ophthalmology
Jorge Jorge, Alberto Diaz-Rey, Madalena Lira
Summary: The study investigated the prevalence of binocular vision dysfunctions in elite soccer players, finding that the overall prevalence was 36.4%, with esophoria being the most common dysfunction at 13.0%. The results suggest the importance of including binocular vision assessments in the visual evaluation routine for athletes.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2022)
Article
Optics
Kishor Sapkota, Jessica Gomes, Sandra Franco
Summary: Knowledge of the effect of accommodation on image quality of peripheral retina is important, but studies in this area are limited. This study found that accommodation asymmetrically affected higher order aberrations in the central and peripheral retina.
Letter
Ophthalmology
Kishor Sapkota, Sandra Franco, Madalena Lira
JOURNAL OF OPTOMETRY
(2021)
Article
Ophthalmology
Sandra Franco, Alexandra Moreira, Ana Fernandes, Antonio Baptista
Summary: This study aimed to verify the prevalence of non-strabismic binocular dysfunctions in a Portuguese clinical population. The findings showed that approximately one third of the population had binocular vision and/or accommodative disorders, with accommodative insufficiency being the most prevalent.
JOURNAL OF OPTOMETRY
(2022)
Review
Ophthalmology
Filipe Da Silva, Madalena Lira
Summary: Glaucoma is a leading cause of irreversible blindness worldwide, and the measurement of intraocular pressure is crucial for its diagnosis and management. The importance of corneal biomechanical properties in intraocular pressure measurement is increasingly recognized. The development of new instruments has the potential to improve the accuracy and convenience of intraocular pressure measurement.
SURVEY OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Eduardo Insua Pereira, Ana Paula Sampaio, Madalena Lira
Summary: The use of contact lenses can lead to an increase in the concentration of inflammatory molecules in tears. This study found significant changes in IL-1 beta, IL-6, IL-8, IL-17, LTB4, and MMP-9. Rigid gas permeable lenses were found to cause a stronger sub-clinical inflammatory response compared to soft contact lenses, with IL-8, MMP-9, and EGF playing important roles. Reusable lenses worn continuously or on a daily modality were more likely to raise the expression of biomarkers compared to daily disposables.
CONTACT LENS & ANTERIOR EYE
(2022)
Article
Oncology
Lara Diego-Gonzalez, Andrea Fernandez-Carrera, Ana Igea, Amparo Martinez-Perez, M. Elisabete C. D. Real Oliveira, Andreia C. Gomes, Carmen Guerra, Mariano Barbacid, Africa Gonzalez-Fernandez, Rosana Simon-Vazquez
Summary: The combined inhibition of YAP and FOSL-1 mRNA expression has shown superior control over tumor growth in pancreatic cancer, while also reducing the tumor stroma.
Article
Ophthalmology
Craig Woods, Shehzad Naroo, Fabrizio Zeri, May Bakkar, Fakhruddin Barodawala, Vicki Evans, Daddi Fadel, Lavanya Kalikivayi, Madalena Lira, Vinod Maseedupally, Sonia Trave Huarte, Frank Eperjesi
Summary: This narrative literature review aimed to examine the efficacy of teaching, learning, and assessment methods in contact lens skills education (CLE) by reviewing current evidence in healthcare training. The findings suggest that while direct evidence is lacking, there are methods used in other disciplines that could be transferable to CLE and help students achieve their intended learning outcomes.
CONTACT LENS & ANTERIOR EYE
(2023)
Article
Optics
Jessica Gomes, Kishor Sapkota, Sandra Franco
Summary: The study aimed to evaluate the changes in on-axis and off-axis primary and secondary spherical aberrations with accommodation in subjects with accommodative insufficiency (AI) compared to a control group. The results showed differences in the changes of spherical aberrations with accommodation between the two groups.
Article
Computer Science, Artificial Intelligence
Gonzalo de la Cruz, Madalena Lira, Oscar Luaces, Beatriz Remeseiro
Summary: This article introduces a new eye blink detection method called Eye-LRCN, which also evaluates the completeness of the blink. The method combines a convolutional neural network with a recurrent neural network for sequence learning and performs well in blink detection and eye state detection.
IEEE TRANSACTIONS ON NEURAL NETWORKS AND LEARNING SYSTEMS
(2022)
Proceedings Paper
Engineering, Biomedical
Jessica Gomes, Sandra Franco
Summary: The study presents preliminary results of a pilot study to compute the curvature and thickness of the human crystalline lens from images obtained with a slit-scanning system, showing promising initial outcomes.
TRANSLATIONAL BIOPHOTONICS: DIAGNOSTICS AND THERAPEUTICS
(2021)
Article
Ophthalmology
Jessica Rafaela Moreira Gomes, Sandra Maria de Braga Franco
Summary: The study found that near-vision reading tasks can impact the optical quality of the eye, especially when performed on printed paper. Tasks on printed paper resulted in greater changes in wavefront aberrations and root mean square of aberrations, as well as partial loss of compensation mechanism.
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2021)
Review
Ophthalmology
Ana Gomes de Lacerda, Madalena Lira
Summary: Acanthamoeba keratitis is a widespread infection caused by a unicellular protozoan that mainly affects contact lens wearers and is linked to corneal trauma as well. It is essential to deepen the understanding of risk factors, focus on prevention strategies, and enhance the efficacy of disinfection systems to minimize the risk of infection. Additionally, there is a need for the development of effective diagnostic methods and treatments for this type of corneal infection in the near future.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
