Article
Peripheral Vascular Disease
Takashi Matsuyama, Naro Ohashi, Taro Aoki, Sayaka Ishigaki, Shinsuke Isobe, Taichi Sato, Tomoyuki Fujikura, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
Summary: The circadian fluctuation disorder of the intrarenal renin-angiotensin system is affected by AGT filtered through damaged glomeruli due to glomerular capillary pressure. Glomerular permeability is more affected by glomerular hypertension than systemic hypertension, leading to fluctuations in intrarenal RAS activity.
HYPERTENSION RESEARCH
(2021)
Article
Obstetrics & Gynecology
Natalie S. Colon, Ahmed F. Pantho, Syeda H. Afroze, A. H. M. Zuberi Ashraf, Roksana Akter, Thomas J. Kuehl, Mohammad N. Uddin
Summary: The study found that urinary angiotensinogen levels were reduced in preeclampsia patients compared to normal pregnant women, along with lower levels of plasma angiotensin II. This phenomenon was also observed in a rat model of preeclampsia.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Review
Cell Biology
Yihao Tian, Jian Ming
Summary: Osteoporosis is a common and impactful disease with no known treatments. Recent studies have shown that melatonin can be used to treat osteoporosis by regulating biological rhythms in bone tissue, promoting bone formation and inhibiting bone resorption. This review provides an overview of these processes and offers treatment and management strategies for individuals with osteoporosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ryousuke Satou, Martha Franco, Courtney M. Dugas, Akemi Katsurada, L. Gabriel Navar
Summary: This study demonstrates the beneficial effects of immunosuppression by mycophenolate mofetil (MMF) on the augmentation of intrarenal angiotensinogen (AGT) in hypertension. MMF treatment attenuates the activation of renal macrophages and the production of pro-inflammatory cytokines, leading to the normalization of AGT levels and the amelioration of hypertensive kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Marlene Cervantes, Robert G. Lewis, Maria Agnese Della-Fazia, Emiliana Borrelli, Paolo Sassone-Corsi
Summary: The circadian clock and metabolism are closely linked, relying on interactions between organ systems for proper timing. Substance use disrupts communication between organs and alters rhythmic activities. This study finds that alterations in dopamine signaling in the brain can affect circadian metabolism in peripheral organs. Drugs like cocaine that increase dopamine levels disrupt circadian metabolic profiles in the liver, especially when dopamine D2 receptors are lost.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Endocrinology & Metabolism
Latifa A. Bazzi, Lara G. Sigurdardottir, Sigurdur Sigurdsson, Unnur Valdimarsdottir, Johanna Torfadottir, Thor Aspelund, Charles A. Czeisler, Steven W. Lockley, Eirikur Jonsson, Lenore Launer, Tamara Harris, Vilmundur Gudnason, Lorelei A. Mucci, Sarah C. Markt
Summary: This study found that there is a moderate correlation between pineal parenchyma volume and urinary 6-sulfatoxymelatonin levels, but no significant association between parenchyma volume tertile and prostate cancer risk. Men with high parenchyma volume, pineal cysts and calcifications, and low urinary 6-sulfatoxymelatonin levels have almost twice the risk of total prostate cancer compared to men with low parenchyma volume, no pineal calcifications or cysts, and low urinary 6-sulfatoxymelatonin levels.
Article
Biochemistry & Molecular Biology
Aissatou Bailo Diallo, Soraya Mezouar, Asma Boumaza, Oksana Fiammingo, Benjamin Coiffard, Pierre Pontarotti, Benoit Desnues, Jean-Louis Mege
Summary: A study has found the expression of circadian rhythm molecular clock genes in Escherichia coli, which could potentially lead to new perspectives in antibacterial treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Viktoria Nemeth, Szabina Horvath, Agnes Kinyo, Rolland Gyulai, Zsuzsanna Lengyel
Summary: In this study, perturbations in clock gene transcripts were observed in both uninvolved and lesional psoriatic areas, suggesting their potential as therapeutic targets and the development of chronotherapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Fabio Moretti, Jvan Gianini, Rosaria Del Giorno, Luca Gabutti
Summary: This study investigated the impact of white-coat effect on the circadian rhythm of urinary water and salt excretion. It found a higher night/day ratio of urinary water excretion in the white-coat effect group, but no significant differences in the circadian pattern of urinary sodium excretion. This has potential implications for hypertension prevention, but further research is needed to understand the clinical significance of the impact on the night/day ratio of water excretion.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Xiaomeng Liu, Niuben Cao, Xinchan Liu, Yu Deng, Yu Xin, Ruobing Fu, Xirui Xin, Yubo Hou, Weixian Yu
Summary: Circadian rhythms play a crucial role in regulating the body's homeostasis, and circadian rhythm disorders can have detrimental effects on metabolic and immune functions. However, the relationship between circadian rhythm disorders and periodontitis has not been well studied. This research aimed to investigate the role of the circadian rhythm control gene BMAL1 in periodontitis. The results showed that downregulation of BMAL1 in circadian rhythm disorder-induced periodontitis led to significant alveolar bone resorption, increased osteoclast differentiation, upregulation of the inflammatory signaling molecule NF-kappa B, elevated apoptosis and oxidative stress levels in periodontal tissues. This study suggests that BMAL1 is a key regulator in periodontitis exacerbated by circadian rhythm disorders, highlighting a potential avenue for periodontitis treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Obstetrics & Gynecology
Joost H. N. Schuitemaker, Rik H. J. Beernink, Thomas I. F. H. Cremers, Sicco A. Scherjon, Maria G. Van Pampus, Marijke M. Faasa
Summary: This study found that the urinary angiotensinogen levels were lower in preeclampsia patients compared to normal pregnant women, and the plasma angiotensin II levels were also decreased in preeclampsia patients. This result was consistent in the rat model of preeclampsia.
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
(2022)
Article
Agriculture, Dairy & Animal Science
C. Matamoros, I. J. Salfer, P. A. Bartell, K. J. Harvatine
Summary: This study investigated the effects of the timing of acetate infusion on peripheral rhythms of milk synthesis and plasma metabolites in dairy cows. The results showed that the timing of acetate infusion can influence the daily rhythms of milk synthesis and plasma metabolites in cows.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Biology
Veronika Lang, Sebastian Ferencik, Bharath Ananthasubramaniam, Achim Kramer, Bert Maier
Summary: Local circadian clocks play a role in the body's immune response, with light affecting susceptibility to endotoxic shock. Conditional knockout mice showed rhythmic patterns of immune response even without a myeloid clock. This suggests that systemic time cues can orchestrate immune functions.
Review
Plant Sciences
Alena Patnaik, Hemasundar Alavilli, Jnanendra Rath, Kishore C. S. Panigrahi, Madhusmita Panigrahy
Summary: Circadian clock components exhibit structural variations in different plant systems, and functional variations during various abiotic stresses. These variations are crucial for plant fitness and adaptation.
Article
Medicine, General & Internal
Ya-Guang Peng, Jing-Jing Feng, Ying Zhang, Kun Li, Si-Yu Cai, Ruo-Hua Yan, Xiao-Xia Peng
Summary: This study explored the circadian rhythm of urinary sodium, potassium, and creatinine excretion in healthy young Chinese adults. While the circadian rhythm patterns differed for each substance, urinary creatinine excretion showed significant parameters, in contrast to sodium. There was some synchronization between the circadian rhythms of sodium and creatinine excretion, with both peaking at night, while potassium peaked in the morning. Hourly urine excretion also followed a similar circadian rhythm.
CHINESE MEDICAL JOURNAL
(2021)
Article
Urology & Nephrology
Yoshitaka Isaka, Hiromitsu Hayashi, Kazutaka Aonuma, Masaru Horio, Yoshio Terada, Kent Doi, Yoshihide Fujigaki, Hideo Yasuda, Taichi Sato, Tomoyuki Fujikura, Ryohei Kuwatsuru, Hiroshi Toei, Ryusuke Murakami, Yoshihiko Saito, Atsushi Hirayama, Toyoaki Murohara, Akira Sato, Hideki Ishii, Tadateru Takayama, Makoto Watanabe, Kazuo Awai, Seitaro Oda, Takamichi Murakami, Yukinobu Yagyu, Nobuhiko Joki, Yasuhiro Komatsu, Takamasa Miyauchi, Yugo Ito, Ryo Miyazawa, Yoshihiko Kanno, Tomonari Ogawa, Hiroki Hayashi, Eri Koshi, Tomoki Kosugi, Yoshinari Yasuda, Yoshitaka Isaka, Masaru Horio, Yoshio Terada, Kent Doi, Yoshihide Fujigaki, Hideo Yasuda, Taichi Sato, Tomoyuki Fujikura, Nobuhiko Joki, Yasuhiro Komatsu, Takamasa Miyauchi, Yugo Ito, Yoshihiko Kanno, Tomonari Ogawa, Hiroki Hayashi, Eri Koshi, Tomoki Kosugi, Yoshinari Yasuda, Hiromitsu Hayashi, Ryohei Kuwatsuru, Hiroshi Toei, Ryusuke Murakami, Kazuo Awai, Seitaro Oda, Takamichi Murakami, Yukinobu Yagyu, Ryo Miyazawa, Kazutaka Aonuma, Yoshihiko Saito, Makoto Watanabe, Atsushi Hirayama, Toyoaki Murohara, Akira Sato, Hideki Ishii, Tadateru Takayama
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2020)
Article
Urology & Nephrology
Takayuki Tsuji, Naro Ohashi, Taichi Sato, Daiki Goto, Soichiro Nagata, Takashi Matsuyama, Yoshitaka Naito, Naoko Tsuji, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Yoshihide Fujigaki, Akira Shimizu, Hideo Yasuda
CLINICAL NEPHROLOGY
(2020)
Article
Medicine, General & Internal
Naro Ohashi, Taro Aoki, Takashi Matsuyama, Sayaka Ishigaki, Shinsuke Isobe, Naoko Katahashi, Taichi Sato, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda
Article
Urology & Nephrology
Yuriko Shiozaki, Tomoyuki Fujikura, Shinsuke Isobe, Ibuki Takatsuka, Taichi Sato, Daiki Goto, Sayaka Ishigaki, Naro Ohashi, Hideo Yasuda
Article
Peripheral Vascular Disease
Takashi Matsuyama, Naro Ohashi, Taro Aoki, Sayaka Ishigaki, Shinsuke Isobe, Taichi Sato, Tomoyuki Fujikura, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
Summary: The circadian fluctuation disorder of the intrarenal renin-angiotensin system is affected by AGT filtered through damaged glomeruli due to glomerular capillary pressure. Glomerular permeability is more affected by glomerular hypertension than systemic hypertension, leading to fluctuations in intrarenal RAS activity.
HYPERTENSION RESEARCH
(2021)
Article
Medicine, General & Internal
Naro Ohashi, Hiroyuki Takase, Taro Aoki, Takashi Matsuyama, Sayaka Ishigaki, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda
Summary: The study found a positive relationship between daily salt intake and plasma BNP levels in individuals without hypertension and heart diseases. High salt intake was associated with elevated BNP levels, suggesting that BNP levels may serve as a surrogate marker for salt-induced heart diseases in the general population. Multiple linear regression analyses confirmed a significant positive association between plasma BNP levels and daily salt intake levels after adjustments.
Article
Medicine, General & Internal
Sayaka Ishigaki, Naro Ohashi, Taro Aoki, Takashi Matsuyama, Shinsuke Isobe, Taichi Sato, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda
Summary: The activation of intrarenal RAS, indicated by urinary AGT levels, is associated with changes in eGFR and may serve as a predictor for renal dysfunction in patients with CKD. Plasma Ang II levels do not show a correlation with annual changes in eGFR. Patients with higher urinary AGT levels demonstrate a progressive decline in eGFR.
Article
Multidisciplinary Sciences
Takamasa Iwakura, Chiemi Ema, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda
Summary: Membranous nephropathy is the leading cause of adult nephrotic syndrome. Enhanced staining of PLA2R, THSD7A, NELL-1, and Ext1/Ext2 in renal samples can aid in differentiating primary and secondary membranous nephropathy.
SCIENTIFIC REPORTS
(2022)
Article
Urology & Nephrology
Yukitoshi Sakao, Naro Ohashi, Taichi Sato, Sayaka Ishigaki, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda
Summary: We investigated the relationship between adrenal function and relevant clinical parameters, and found a significant negative correlation between dialysis vintage and adrenal function.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2022)
Article
Peripheral Vascular Disease
Naro Ohashi, Hiroyuki Takase, Taro Aoki, Sayaka Ishigaki, Takamasa Iwakura, Shinsuke Isobe, Tomoyuki Fujikura, Akihiko Kato, Hideo Yasuda
Summary: Excessive salt intake is associated with heart diseases, and plasma BNP levels are positively correlated with daily salt intake. Restricting salt intake can suppress plasma BNP levels, and monitoring plasma BNP can prevent heart diseases and improve prognosis.
HYPERTENSION RESEARCH
(2022)
Article
Medicine, General & Internal
Yuma Hirano, Tomoyuki Fujikura, Kenichi Kono, Naro Ohashi, Tomoya Yamaguchi, Wataru Hanajima, Hideo Yasuda, Katsuya Yamauchi
Summary: This study found that during the induction phase of dialysis, 16.1% of patients experienced a decline in walking independence, which was associated with older age, higher CCI, higher inflammation, and emergency dialysis start. Therefore, early identification of these patients and early rehabilitation is recommended.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Physiology
Daiki Goto, Soichiro Nagata, Yoshitaka Naito, Shinsuke Isobe, Takamasa Iwakura, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Ken Sugimoto, Hideo Yasuda
Summary: This study found that nicotinic acetylcholine receptor agonists can reduce circulating IL-6 and acute lung injury after renal ischemia-reperfusion injury in mice by acting on splenic macrophages.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Takamasa Iwakura, Chiemi Ema, Taichi Sato, Shinsuke Isobe, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hideo Yasuda
Summary: Technological advances have led to the discovery of 6 subtypes of membranous nephropathy based on target antigens, including M-type phospholipase A2 receptor (PLA(2)R) and thrombospondin type 1 domain-containing 7A (THSD7A). This study presents two cases of primary membranous nephropathy with enhanced glomerular staining of EXT1/EXT2, both of which achieved clinical remission with immunosuppressive therapy, despite the absence of autoimmune diseases and antinuclear antibodies in their sera.
Article
Urology & Nephrology
Saki Hayashi, Naro Ohashi, Daiki Goto, Naomi Isomura, Shinsuke Isobe, Tomoyuki Fujikura, Yoshihide Fujigaki, Akira Shimizu, Hiroaki Ito, Hideo Yasuda
Summary: The case describes a 35-year-old Japanese woman who developed hypertensive disorders of pregnancy before 20 weeks of gestation, leading to abortion at 20 weeks. This case emphasizes the importance of considering HDP as a differential diagnosis in pregnant women with symptoms before 20 weeks of gestation.
Article
Physiology
Yoshitaka Naito, Takayuki Tsuji, Soichiro Nagata, Naoko Tsuji, Tomoyuki Fujikura, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)