Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy

Increased amount of bone marrow-derived smooth muscle-like cells and accelerated atherosclerosis in diabetic apoE-deficient mice

(2012) J.O. Fledderus et al.   ATHEROSCLEROSIS

Association of Fetuin-A With Incident Diabetes Mellitus in Community-Living Older Adults

(2012) Joachim H. Ix et al.   CIRCULATION

Alagebrium Reduces Glomerular Fibrogenesis and Inflammation Beyond Preventing RAGE Activation in Diabetic Apolipoprotein E Knockout Mice

(2012) A. M. D. Watson et al.   DIABETES

Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes

(2012) S. Hazra et al.   DIABETES

Exacerbation of diabetic nephropathy by hyperlipidaemia is mediated by Toll-like receptor 4 in mice

(2012) T. Kuwabara et al.   DIABETOLOGIA

Accelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model

(2012) C. Martinez-Garcia et al.   Disease Models & Mechanisms

Endoplasmic Reticulum Stress Induces the Expression of Fetuin-A to Develop Insulin Resistance

(2012) Horng-Yih Ou et al.   ENDOCRINOLOGY

A compound (DW1182v) protecting high glucose/palmitate-induced glucolipotoxicity to INS-1 beta cells preserves islet integrity and improves hyperglycemia in obese db/db mouse

(2012) Soo-Jin Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Fc  Receptor Deficiency Attenuates Diabetic Nephropathy

(2012) V. Lopez-Parra et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

(2012) Durba Pal et al.   NATURE MEDICINE

Oleanolic Acid Reduces Hyperglycemia beyond Treatment Period with Akt/FoxO1-Induced Suppression of Hepatic Gluconeogenesis in Type-2 Diabetic Mice

(2012) Xiao-Yi Zeng et al.   PLoS One

Endoplasmic Reticulum Stress and Glycogen Synthase Kinase-3β Activation in Apolipoprotein E–Deficient Mouse Models of Accelerated Atherosclerosis

(2011) Cameron S. McAlpine et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Glucosamine-supplementation promotes endoplasmic reticulum stress, hepatic steatosis and accelerated atherogenesis in apoE−/− mice

(2011) Daniel R. Beriault et al.   ATHEROSCLEROSIS

Phenotypic Changes in Diabetic Neuropathy Induced by a High-Fat Diet in Diabetic C57Bl/6 Mice

(2011) B. L. Guilford et al.   Experimental Diabetes Research

Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice

(2011) Katsuhito Fujiu et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct Macrophage Phenotypes Contribute to Kidney Injury and Repair

(2011) S. Lee et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Lipotoxicity in Diabetic Nephropathy: The Potential Role of Fatty Acid Oxidation

(2010) M. Murea et al.   Clinical Journal of the American Society of Nephrology

Genetic Deletion or Pharmacological Inhibition of Dipeptidyl Peptidase-4 Improves Cardiovascular Outcomes After Myocardial Infarction in Mice

(2010) M. Sauve et al.   DIABETES

Evaluation of loganin, iridoid glycoside from Corni Fructus, on hepatic and renal glucolipotoxicity and inflammation in type 2 diabetic db/db mice

(2010) Noriko Yamabe et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Circulating sphingolipid biomarkers in models of type 1 diabetes

(2010) Todd E. Fox et al.   JOURNAL OF LIPID RESEARCH

The Toll-like receptor 4 ligands Mrp8 and Mrp14 are crucial in the development of autoreactive CD8+ T cells

(2010) Karin Loser et al.   NATURE MEDICINE

The acetyl-coenzyme A carboxylase beta (ACACB) gene is associated with nephropathy in Chinese patients with type 2 diabetes

(2010) S. C. W. Tang et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

A Single Nucleotide Polymorphism within the Acetyl-Coenzyme A Carboxylase Beta Gene Is Associated with Proteinuria in Patients with Type 2 Diabetes

(2010) Shiro Maeda et al.   PLoS Genetics

Double-Stranded DNA Activates Glomerular Endothelial Cells and Enhances Albumin Permeability via a Toll-Like Receptor-Independent Cytosolic DNA Recognition Pathway

(2009) Holger Hägele et al.   AMERICAN JOURNAL OF PATHOLOGY

Myeloid-Related Protein-8/14 Is Critical for the Biological Response to Vascular Injury

(2009) Kevin Croce et al.   CIRCULATION

Involvement of Per-Arnt-Sim Kinase and Extracellular-Regulated Kinases-1/2 in Palmitate Inhibition of Insulin Gene Expression in Pancreatic  -Cells

(2009) G. Fontes et al.   DIABETES

Hyperglycemia-Induced Reactive Oxygen Species Increase Expression of the Receptor for Advanced Glycation End Products (RAGE) and RAGE Ligands

(2009) D. Yao et al.   DIABETES

Lipid abnormalities predict progression of renal disease in patients with type 1 diabetes

(2009) N. Tolonen et al.   DIABETOLOGIA

Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier

(2009) Rahul D. Pawar et al.   IMMUNOLOGY

IL-10-Dependent S100A8 Gene Induction in Monocytes/Macrophages by Double-Stranded RNA

(2009) Y. Endoh et al.   JOURNAL OF IMMUNOLOGY

Mouse Models of Diabetic Nephropathy

(2009) F. C. Brosius et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Viral RNA and DNA Trigger Common Antiviral Responses in Mesangial Cells

(2009) R. Allam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Glucose Amplifies Fatty Acid-Induced Endoplasmic Reticulum Stress in Pancreatic β-Cells via Activation of mTORC1

(2009) Etti Bachar et al.   PLoS One

Decreased Lipoprotein Clearance Is Responsible for Increased Cholesterol in LDL Receptor Knockout Mice With Streptozotocin-Induced Diabetes

(2008) I. J. Goldberg et al.   DIABETES

Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue

(2008) Ayaka Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage diversity in renal injury and repair

(2008) Sharon D. Ricardo et al.   JOURNAL OF CLINICAL INVESTIGATION

Diabetes Reduces Aortic Endothelial Gap Junctions in ApoE-deficient Mice: Simvastatin Exacerbates the Reduction

(2008) Charles Jia-Yin Hou et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

TLR4 Links Podocytes with the Innate Immune System to Mediate Glomerular Injury

(2008) M. C. Banas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY