Journal
CLINICAL AND EXPERIMENTAL NEPHROLOGY
Volume 17, Issue 5, Pages 634-637Publisher
SPRINGER
DOI: 10.1007/s10157-013-0787-7
Keywords
MPO-ANCA-associated glomerulonephritis; Extracellular MPO; MPO-positive cells; In situ immune complex
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Funding
- Ministry of Health, Labor and Welfare of Japan
- Grants-in-Aid for Scientific Research [23591199] Funding Source: KAKEN
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It is well known that antineutrophil cytoplasmic antibodies (ANCAs) are pathogenic and have a diagnostic value for ANCA-associated vasculitis. We demonstrated that a rise in myeloperoxidase (MPO)-ANCA titers during remission is often predictive of a future relapse in MPO-ANCA-associated vasculitis. Pathological examination of renal biopsies indicated that not only MPO-ANCAs, but also extracellular MPO, an in situ immune complex composed of MPO and MPO antibodies, may play important roles in the pathogenesis of glomerular capillary injury in MPO-ANCA-associated vasculitis.
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