Journal
CLINICAL AND EXPERIMENTAL NEPHROLOGY
Volume 17, Issue 5, Pages 659-662Publisher
SPRINGER
DOI: 10.1007/s10157-012-0755-7
Keywords
Anti-neutrophil cytoplasmic antibody; Vasculitis; Renal histology; Glomerulonephritis; Classification; Microscopic polyangiitis; Japan
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Funding
- Ministry of Health, Labor, and Welfare of Japan
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The prognostic value of renal biopsy in anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis is widely recognized; however, there is no consensus regarding its pathological classification. Berden et al. proposed a new classification of glomerulonephritis in ANCA-associated vasculitis (AAV) categorized into focal, crescentic, mixed, and sclerotic classes and showed its prognostic value in 100 international multicenter cohorts for 1- and 5-year renal outcomes. In order to evaluate whether this new classification has predictive value and reproducibility in Japanese AAV cases, 87 cohorts with only microscopic polyangiitis in 3 limited centers in Japan were analyzed. In addition, those from Japan, Europe (Berden's cohorts) and China were compared in a recent report.
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