Effect of interleukin-6 receptor blockade on the balance between regulatory T cells and T helper type 17 cells in rheumatoid arthritis patients

Brief Report: Inhibition of interleukin-6 function corrects Th17/Treg cell imbalance in patients with rheumatoid arthritis

(2012) Maxime Samson et al.   ARTHRITIS AND RHEUMATISM

Evidence of the transient nature of the Th17 phenotype of CD4+CD161+ T cells in the synovial fluid of patients with juvenile idiopathic arthritis

(2011) Lorenzo Cosmi et al.   ARTHRITIS AND RHEUMATISM

Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients--REACTION 52-week study

(2011) T. Takeuchi et al.   RHEUMATOLOGY

Loss of CD4 + T Cell IL-6R Expression during Inflammation Underlines a Role for IL-6 Trans Signaling in the Local Maintenance of Th17 Cells

(2010) Gareth W. Jones et al.   JOURNAL OF IMMUNOLOGY

Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease

(2010) Xuebin Liu et al.   NATURE MEDICINE

Th17 plasticity in human autoimmune arthritis is driven by the inflammatory environment

(2010) K. Nistala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequency and phenotype of peripheral blood Th17 cells in ankylosing spondylitis and rheumatoid arthritis

(2009) Hui Shen et al.   ARTHRITIS AND RHEUMATISM

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Proinflammatory Cytokines Synergistically Enhance the Production of Chemokine Ligand 20 (CCL20) from Rheumatoid Fibroblast-like Synovial Cells in vitro and Serum CCL20 Is Reduced in vivo by Biologic Disease-modifying Antirheumatic Drugs

(2009) S.-Y. KAWASHIRI et al.   JOURNAL OF RHEUMATOLOGY

Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis

(2009) K. Nistala et al.   RHEUMATOLOGY

Interleukin-6 blockade suppresses autoimmune arthritis in mice by the inhibition of inflammatory Th17 responses

(2008) Minoru Fujimoto et al.   ARTHRITIS AND RHEUMATISM

Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase

(2008) Keiichi Iwanami et al.   ARTHRITIS AND RHEUMATISM

A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

(2008) Elisabetta Volpe et al.   NATURE IMMUNOLOGY

The differentiation of human TH-17 cells requires transforming growth factor-β and induction of the nuclear receptor RORγt

(2008) Nicolas Manel et al.   NATURE IMMUNOLOGY