Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 167, Issue 1, Pages 108-119Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2249.2011.04461.x
Keywords
diagnostic protocol; immunological evaluation; primary immunodeficiency; update
Categories
Funding
- NIHR Biomedical Research Centre
- BMBF PIDNET
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Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among doctors working in different fields. Prompt identification of PID is important for prognosis, but this may not be an easy task. The protocol therefore starts from the clinical presentation of the patient. Because PIDs may present at all ages, this protocol is aimed at both adult and paediatric physicians. The multi-stage design allows cost-effective screening for PID of the large number of potential cases in the early phases, with more expensive tests reserved for definitive classification in collaboration with a specialist in the field of immunodeficiency at a later stage.
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