Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 166, Issue 3, Pages 333-337Publisher
WILEY
DOI: 10.1111/j.1365-2249.2011.04482.x
Keywords
autoimmunity; complement; factor h; genetics; rheumatoid arthritis
Categories
Funding
- LUMC
- LGTC unit
- European Union
- Netherlands Genomics Initiative (NGI) as part of the Netherlands Proteomics Center (NPC)
- Center for Medical Systems Biology (CMSB)
- VENI
- NWO-ZON-MW
- EMBO
- Unesco-L'Oreal for Women in Science Fellowship
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Because activation of the alternative pathway (AP) of the complement system is an important aspect of both age-related macular degeneration (AMD) and rheumatoid arthritis (RA), we wished to address the question whether genetic risk factors of the AP inhibitor complement factor H (CFH) for AMD would also be risk factors for RA. For this purpose we genotyped single nucleotide polymorphisms (SNPs) in a Dutch set of RA patients and controls. Similarly, a meta-analysis using a Spanish cohort of RA as well as six large genome-wide association studies (GWAS) studies was performed. For these SNPs we analysed more than 6000 patients and 20 000 controls. The CFH variants, I62V, Y402H, IVS1 and IVS10, known to associate strongly with AMD, did not show a significant association with the risk of developing RA despite a strong statistical power to detect such differences. In conclusion, the major risk alleles of AMD in CFH do not have a similar effect on developing RA.
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