Journal
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
Volume 155, Issue 2, Pages 147-155Publisher
WILEY
DOI: 10.1111/j.1365-2249.2008.03851.x
Keywords
agammaglobulinaemia; common variable immunodeficiency; interstitial; lung disorders; pneumonia; ronchiectasis
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The sinopulmonary tract is the major site of infection in patients with primary antibody deficiency syndromes, and structural lung damage arising from repeated sepsis is a major determinant of morbidity and mortality. Patients with common variable immunodeficiency may, in addition, develop inflammatory lung disease, often associated with multi-system granulomatous disease. This review discusses the presentation and management of lung disease in patients with primary antibody deficiency.
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