Review
Cell Biology
David A. Lewis, Tony Ly
Summary: CD8(+) T cells are crucial in immunity and immuno-oncology, as they undergo complex cellular growth, cell cycle entry, and differentiation to produce antigen-specific cytotoxic T lymphocytes. Some activated T cells will differentiate into memory T cells which are essential in adaptive immunity. This review explores the control of cell cycle entry in CD8(+) T cells and the interaction between these mechanisms and pathways regulating immunological phenotypes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biology
Risa Ebina-Shibuya, Erin E. West, Rosanne Spolski, Peng Li, Jangsuk Oh, Majid Kazemian, Daniel Gromer, Phillip Swanson, Ning Du, Dorian B. McGavern, Warren J. Leonard
Summary: TSLP plays a crucial role in the development of diseases such as asthma, atopic dermatitis, and allergic inflammation, but its role in CD8(+) T-cell primary responses and memory CD8(+) T cell responses to secondary viral infection is still controversial. Research has shown that TSLP limits the primary CD8(+) T-cell response to influenza, but has little effect on T cell function and the number of memory CD8(+) T cells generated after influenza infection, while inhibiting memory CD8(+) T-cell responses to secondary viral infections.
Article
Biology
Scott M. Anthony, Natalija Van Braeckel-Budimir, Steven J. Moioffer, Stephanie van de Wall, Qiang Shan, Rahul Vijay, Ramakrishna Sompallae, Stacey M. Hartwig, Isaac J. Jensen, Steven M. Varga, Noah S. Butler, Hai-Hui Xue, Vladimir P. Badovinac, John T. Harty
Summary: IAV infection generates Trm CD8(+)T cells in mice, while repeated antigen exposure produces 4M CD8(+)T cells with enhanced protective capacity. Enhanced protection by 4M cells is associated with increased expression of granzyme A/B and stable maintenance of CD69(+)CD103(+) 4M CD8(+)T cells, improving control of viral infections in mLN.
Article
Biochemistry & Molecular Biology
Solhwi Lee, Junhui Ma, Se Jin Im
Summary: CD51 is expressed on CD8 T cells and plays a crucial role in cell expansion and function, making it a potential immunomodulatory target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biology
Isaac J. Jensen, Xiang Li, Patrick W. McGonagill, Qiang Shan, Micaela G. Fosdick, Mikaela M. Tremblay, Jon Cd Houtman, Hai-Hui Xue, Thomas S. Griffith, Weiqun Peng, Vladimir P. Badovinac
Summary: The study found that sepsis leads to a reduction in memory CD8 T cells, but surviving cells proliferate quickly, especially a subpopulation called central memory CD8 T cells, thereby changing the overall composition of the memory CD8 T cell pool. This increased proliferation results in long-term changes in the quantity and composition of immune cells, potentially affecting the host's ability to respond to re-infection.
Article
Biotechnology & Applied Microbiology
Chenli Qiu, Jing Wang, Lingyan Zhu, Xiaobo Cheng, Bili Xia, Yanling Jin, Ran Qin, LinXia Zhang, Huiliang Hu, Jia Yan, Chen Zhao, Xiaoyan Zhang, Jianqing Xu
Summary: This study investigates the utility of TLR agonists in ex vivo expansion of tumor-targeting CD8(+) T cells, finding that a new formulation performs better than the conventional one and shows robust anti-tumor activity in an in vitro co-culturing system.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Cell Biology
Ahto Salumets, Liina Tserel, Anna P. Rumm, Lehte Turk, Kulli Kingo, Kai Saks, Astrid Oras, Raivo Uibo, Riin Tamm, Hedi Peterson, Kai Kisand, Part Peterson
Summary: Age-related changes in T-cell populations play an important role in immunosenescence. CD8(+) TEMRA cells and their subsets have characteristics of cellular senescence and increase in older individuals and age-related chronic inflammatory diseases. CD8(+) TEMRA proportions correlate with cytomegalovirus (CMV) antibody levels but not with chronological age. TRANCE/RANKL levels are associated with differentiated T-cell populations, including CD8(+) TEMRA and its CD28(-) subsets. Deep-amplicon bisulfite sequencing can be used to predict CD8(+) TEMRA cell proportions as a biomarker of immunosenescence.
Article
Multidisciplinary Sciences
Mladen Jergovic, Christopher P. Coplen, Jennifer L. Uhrlaub, David G. Besselsen, Shu Cheng, Megan J. Smithey, Janko Nikolich-Zugich
Summary: Infections can lead to the expansion of a subpopulation of long-lived, Ly6C(+) CD8(+) Tn cells with accelerated effector function, depending on the action of IFN-I. This highlights the significant role of infection-driven IFN-I in regulating Tn homeostasis and function, with potential implications for immunotherapy.
NATURE COMMUNICATIONS
(2021)
Article
Veterinary Sciences
Akinori Yamauchi, Sho Yoshimoto, Ayano Kudo, Satoshi Takagi
Summary: This study reveals the characteristics of immunosenescence in dogs and the effects of aging on the differentiation and proliferation of CD8(+) T cells. It provides valuable insights for the development of immune therapies in dogs.
VETERINARY SCIENCES
(2023)
Article
Medicine, Research & Experimental
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily Defranco, Sandra Andorf, Tamara Tilburgs
Summary: Decidual CD8(+) T cells play a critical role in providing immunity to infection and immune tolerance for fetal and placental antigens. These cells include shared blood T cells and unique decidual T cells, and the specificity of decidual CD8(+) T cells is closely related to their function and tissue residency.
Article
Multidisciplinary Sciences
Z. Shen, M. Rodriguez-Garcia, M. V. Patel, C. R. Wira
Summary: Sex hormones play a crucial role in regulating endometrial CD8+T cells, with estradiol directly suppressing cytotoxic activity and progesterone indirectly inducing TGF beta production. Understanding these mechanisms is essential for optimizing reproductive success and developing strategies to prevent infections and cancers.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Leeana D. Peters, Wen- Yeh, Juan M. Arnoletti, Matthew E. Brown, Amanda L. Posgai, Clayton E. Mathews, Todd M. Brusko
Summary: The autoimmune pathogenesis of T1D involves immune cell infiltration into pancreatic islets. CD8(+) T cells play a primary role in killing insulin-producing beta-cells. This study demonstrates the engineering of human T cells to improve the specificity and function of autoreactive CD8(+) T cells, potentially leading to cellular therapeutics for treating autoimmunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Genevieve T. Clutton, Ann Marie K. Weideman, Melissa A. Mischell, Sallay Kallon, Shayla Z. Conrad, Fiona R. Shaw, Joanna A. Warren, Lin Lin, JoAnn D. Kuruc, Yinyan Xu, Cynthia M. Gay, Paul M. Armistead, Michael G. Hudgens, Nilu P. Goonetilleke
Summary: CD8 T cells recognize infected and cancerous cells through their T-cell receptor (TCR) and the affinity between TCR and peptide-MHC complexes contributes to antigen sensitivity. CD3 and CD8 downmodulation are strongly correlated with functional avidity in CD8 T cells. A simple flow cytometry assay can be used to identify high-avidity CD8 T cells.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Microbiology
Leiqiong Gao, Jing Zhou, Lilin Ye
Summary: HIV infection can be suppressed by lifelong administration of combination antiretroviral therapy, but viral rebound can occur upon cessation due to the presence of HIV reservoirs. HIV-specific CD8(+) T cells can sustain long-term disease-free and transmission-free HIV control, but cure strategies relying on them may fail.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Helena Nunes-Cabaco, Andreia Ramalho-dos-Santos, Ana R. Pires, Leila R. Martins, Joao T. Barata, Ana E. Sousa
Summary: IL-4 plays a role in the regulation of human thymocyte plasticity and is involved in the generation of CD8+ T cells in the thymus. IL-4 also has implications in neonatal immunity.
FRONTIERS IN IMMUNOLOGY
(2022)