Article
Peripheral Vascular Disease
RuiJun Chen, Marc A. Suchard, Harlan M. Krumholz, Martijn J. Schuemie, Steven Shea, Jon Duke, Nicole Pratt, Christian G. Reich, David Madigan, Seng Chan You, Patrick B. Ryan, George Hripcsak
Summary: In a large-scale observational study, it was found that ARBs do not significantly differ in effectiveness compared to ACE inhibitors as first-line treatment for hypertension, but present a better safety profile. This supports the preferential prescription of ARBs over ACE inhibitors when initiating treatment for hypertension.
Review
Biochemistry & Molecular Biology
Antonis A. Manolis, Theodora A. Manolis, Antonis S. Manolis
Summary: In patients with heart failure, the activation of neuroendocrine systems like the sympathetic nervous system, renin-angiotensin-aldosterone system, and arginine vasopressin system leads to tachycardia and increased systemic vascular resistance. Sustained neurohormonal activation plays a crucial role in the progression and worsening of heart failure. Biomarkers such as natriuretic peptides, catecholamine levels, and neprilysin can be used to understand heart failure drug mechanisms and identify patients who may benefit from specific therapies. Neurohumoral antagonists, including beta blockers, ACE inhibitors/angiotensin receptor blockers, and vaptans, target these neurohormonal systems. The introduction of the angiotensin receptor-neprilysin inhibitor sacubitril/valsartan has enhanced the actions of natriuretic peptides by combining RAAS inhibition and neprilysin blocking.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Jung Min Choi, Seung-Hwa Lee, Yu Jeong Jang, Mira Kang, Jin-Ho Choi
Summary: The study found that patients taking a fixed-dose combination of ARB and statin showed higher medication persistence and adherence compared to those taking a free combination, but the risk of all-cause death did not differ between the two groups.
CIRCULATION JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ify R. Mordi, Wouter Ouwerkerk, Stefan D. Anker, John G. Cleland, Kenneth Dickstein, Marco Metra, Leong L. Ng, Nilesh J. Samani, Dirk J. van Veldhuisen, Faiez Zannad, Adriaan A. Voors, Chim C. Lang
Summary: The study found that undertreatment is common among patients with heart failure, and increasing the dosage of ACEI/ARB and beta-blockers can improve outcomes. Achieving high doses of ACEI/ARB was associated with better outcomes regardless of age, while higher doses of beta-blockers were only beneficial for younger patients.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Review
Pharmacology & Pharmacy
Gabor Kriszta, Zsofia Kriszta, Szilard Vancsa, Peter Jeno Hegyi, Levente Frim, Balint Eross, Peter Hegyi, Gabor Petho, Erika Pinter
Summary: This study systematically reviewed the relationship between ACEI/ARB administration and ACE2 expression in experimental models, with the majority of studies reporting an increase in ACE2 levels in response to these treatments.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Seok Hui Kang, Bo Yeon Kim, Eun Jung Son, Gui Ok Kim, Jun Young Do
Summary: This study aimed to evaluate patient survival with the use of renin-angiotensin system blockers (RASBs) in maintenance hemodialysis (HD) patients, and found that the use of RASBs was associated with higher patient survival rates.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Michael A. Puskarich, Nathan W. Cummins, Nicholas E. Ingraham, David A. Wacker, Ronald A. Reilkoff, Brian E. Driver, Michelle H. Biros, Fernanda Bellolio, Jeffrey G. Chipman, Andrew C. Nelson, Kenneth Beckman, Ryan Langlois, Tyler Bold, Matthew T. Aliota, Timothy W. Schacker, Helen T. Voelker, Thomas A. Murray, Joseph S. Koopmeiners, Christopher J. Tignanelli
Summary: The study found that losartan did not reduce hospitalizations in low-risk outpatients with mild symptomatic COVID-19, and viral load was not affected by the treatment. This suggests that initiation of losartan treatment for this group is not supported.
Article
Pharmacology & Pharmacy
Elizabeth Alana Gray, Sanket N. Patel, Peter A. Doris, Tahir Hussain
Summary: This study demonstrates that the combination therapy of neprilysin inhibitor sacubitril and angiotensin II type 2 receptor agonist C21 provides superior renal protection compared to the combination therapy of sacubitril and valsartan in obese rats fed a high salt diet. The sacubitril/C21 treatment significantly decreases proteinuria, albuminuria, the expression of nephrin, and kidney weight, independent of hyperfiltration, and completely prevents HSD-induced increases in renal angiotensin II.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kung-Ming Laio, Chuan-Wei Shen, Yun-Hui Huang, Chun-Hui Lu, Hsuan-Lin Lai, Chung-Yu Chen
Summary: The prescription pattern and effectiveness of antihypertensive drugs in surgical patients with aortic dissection were investigated. The study found that no specific type of antihypertensive drug was associated with a better outcome in patients with type A aortic dissection, while the use of beta-blockers and calcium channel blockers (CCBs) was related to a significantly lower risk of the composite outcome in patients with type B aortic dissection.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Monika Maciag, Artur Wnorowski, Malgorzata Mierzejewska, Anita Plazinska
Summary: This study used the zebrafish model to investigate the cardiotoxicity induced by doxorubicin, adrenaline, and terfenadine, as well as the effects of dexrazoxane, metoprolol, carvedilol, and valsartan on zebrafish heart function. The results showed that these drugs caused significant cardiotoxicity, and the blockade of the renin-angiotensin system and beta-adrenergic system improved heart disease in zebrafish.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Neurosciences
Sarah B. Scheinman, Steve Zaldua, Adedoyin Dada, Kateryna Krochmaliuk, Katherine Dye, Felecia M. Marottoli, Gregory R. J. Thatcher, Leon M. Tai
Summary: Evidence suggests that angiotensin receptor blockers (ARBs) could be beneficial for Alzheimer's disease patients, particularly in terms of neuroinflammation. Studies on mice expressing the human APOE4 gene showed that female E4FAD- and E4FAD+ mice exhibited improved memory-related behavior and higher hippocampal presynaptic protein levels after treatment with the ARB prodrug candesartan.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Urology & Nephrology
Kengo Azushima, Jean -Paul Kovalik, Takahiro Yamaji, Jianhong Ching, Tze Wei Chng, Jing Guo, Jian-Jun Liu, Mien Nguyen, Rashidah Binte Sakban, Simi E. George, Puay Hoon Tan, Su Chi Lim, Susan B. Gurley, Thomas M. Coffman
Summary: This study found that in a mouse model of diabetic nephropathy, there were elevated lactate levels and impaired energy metabolism in the kidneys. Treatment with an angiotensin-receptor blocker (ARB) improved these abnormalities. Increased expression of lactate dehydrogenase isoforms, specifically LdhA in the proximal tubule, was also observed. Urinary lactate levels were found to be predictive of clinical outcomes in diabetic patients with kidney disease.
KIDNEY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Xu Zhu, Jing Xue, Zheng Liu, Wenjie Dai, Jingsha Xiang, Hui Xu, Qiaoling Zhou, Quan Zhou, Xinran Wei, Wenhang Chen
Summary: The use of ACEI/ARB treatment in patients with AKI may reduce all-cause mortality but increases the risk of AKD.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Geriatrics & Gerontology
Lorna Caulfield, Philip Heslop, Katherine E. Walesby, Deepa Sumukadas, Avan A. Sayer, Miles D. Witham
Summary: The current evidence does not support the use of ACE inhibitors or angiotensin receptor blockers as a single intervention to improve physical performance in older people, based on a systematic review and meta-analysis of randomized controlled trials.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2021)
Article
Pharmacology & Pharmacy
Fereshteh Asgharzadeh, Asma Mostafapour, Safieh Ebrahimi, Forouzan Amerizadeh, Reihaneh Sabbaghzadeh, Maryam Fakhraei, Alieh Farshbaf, Gordon A. Ferns, Elisa Giovannetti, Amir Avan, Majid Khazaei, Seyed Mahdi Hassanian
Summary: This study found that targeting the RAS pathway using valsartan can interfere with cell proliferation, induce apoptosis, reduce migration, and synergistically interact with 5-FU in the treatment of colorectal cancer.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Peripheral Vascular Disease
Takahiro Komori, Kazuo Eguchi, Toshinobu Saito, Yoshioki Nishimura, Satoshi Hoshide, Kazuomi Kario
AMERICAN JOURNAL OF HYPERTENSION
(2016)
Article
Peripheral Vascular Disease
Taishi Fukushima, Kazuo Eguchi, Akihide Ohkuchi, Hiroshi Miyashita, Kazuomi Kario
JOURNAL OF CLINICAL HYPERTENSION
(2016)
Article
Peripheral Vascular Disease
Paolo Palatini, Gianpaolo Reboldi, Lawrence J. Beilin, Edoardo Casiglia, Kazuo Eguchi, Yutaka Imai, Kazuomi Kario, Takayoshi Ohkubo, Sante D. Pierdomenico, Joseph E. Schwartz, Lindon Wing, Paolo Verdecchia
JOURNAL OF CLINICAL HYPERTENSION
(2016)
Article
Peripheral Vascular Disease
Yuki Imaizumi, Kazuo Eguchi, Takeshi Murakami, Kimika Arakawa, Takuya Tsuchihashi, Kazuomi Kario
JOURNAL OF CLINICAL HYPERTENSION
(2016)
Article
Cardiac & Cardiovascular Systems
Kazuo Eguchi, Satoshi Hoshide, Hiroshi Miyashita, Shoichiro Nagasaka, Kazuomi Kario
Editorial Material
Cardiac & Cardiovascular Systems
Yuki Imaizumi, Kazuo Eguchi, Hiroki Imada, Kiyomi Hidano, Satoshi Niijima, Hirotoshi Kawata, Noriyoshi Fukushima, Tsunenori Saito, Michiaki Hiroe, Kazuomi Kario
CANADIAN JOURNAL OF CARDIOLOGY
(2016)
Article
Urology & Nephrology
Motohiro Shimizu, Norihiro Furusyo, Yuuki Tanaka, Yoshifumi Kato, Fujiko Mitsumoto-Kaseida, Koji Takayama, Kazuya Ura, Satoshi Hiramine, Takeo Hayashi, Hiroaki Ikezaki, Takeshi Ihara, Haru Mukae, Eiichi Ogawa, Kazuhiro Toyoda, Mosaburo Kainuma, Masayuki Murata, Jun Hayashi
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2016)
Article
Cardiac & Cardiovascular Systems
Kazuo Eguchi, Takahiro Komori, Toshinobu Saito, Satoshi Hoshide, Kazuomi Kario
JOURNAL OF ELECTROCARDIOLOGY
(2018)
Article
Medicine, General & Internal
Atsushi Tanaka, Isao Taguchi, Hiroki Teragawa, Nobukazu Ishizaka, Yumiko Kanzaki, Hirofumi Tomiyama, Masataka Sata, Akira Sezai, Kazuo Eguchi, Toru Kato, Shigeru Toyoda, Ryoichi Ishibashi, Kazuomi Kario, Tomoko Ishizu, Shinichiro Ueda, Koji Maemura, Yukihito Higashi, Hirotsugu Yamada, Mitsuru Ohishi, Kotaro Yokote, Toyoaki Murohara, Jun-ichi Oyama, Koichi Node
Review
Critical Care Medicine
Nobuto Nakanishi, Shodai Yoshihiro, Yusuke Kawamura, Gen Aikawa, Haruka Shida, Motohiro Shimizu, Yoshihisa Fujinami, Ayaka Matsuoka, Shinichi Watanabe, Shunsuke Taito, Shigeaki Inoue
Summary: This study found that neuromuscular electrical stimulation (NMES) may reduce the occurrence of ICU-acquired weakness (ICU-AW) and potentially increase muscle strength and decrease muscle mass change in critical illness patients. However, the effects of NMES on pricking sensation in patients and length of ICU stay require further investigation, and the impact on mortality and quality of life remains uncertain.
CRITICAL CARE MEDICINE
(2023)
Review
Medicine, General & Internal
Ayaka Matsuoka, Shodai Yoshihiro, Haruka Shida, Gen Aikawa, Yoshihisa Fujinami, Yusuke Kawamura, Nobuto Nakanishi, Motohiro Shimizu, Shinichi Watanabe, Kensuke Sugimoto, Shunsuke Taito, Shigeaki Inoue
Summary: Previous systematic review and meta-analysis have shown that rehabilitation within a week of ICU admission can improve physical function in critically ill patients. This updated review aimed to examine the effects of initiating rehabilitation within 72 hours of ICU admission on long-term physical, cognitive, and mental health. The results suggest that early rehabilitation may improve muscle strength and cognitive function, but its impact on mental health remains uncertain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Motohiro Shimizu, Hiroshi Adachi, Kenichi Sai
Summary: Acute phlegmonous esophagitis is a rare and life-threatening disease, often requiring surgical intervention to prevent complications. Magnetic resonance imaging (MRI) was found to be useful in planning the treatment strategy of acute phlegmonous esophagitis.
Article
Nutrition & Dietetics
Hiroaki Ikezaki, Norihiro Furusyo, Paul F. Jacques, Motohiro Shimizu, Masayuki Murata, Ernst J. Schaefer, Yoshihisa Urita, Jun Hayashi
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2017)
Article
Immunology
Fujiko Mitsumoto-Kaseida, Masayuki Murata, Kazuya Ura, Koji Takayama, Satoshi Hiramine, Motohiro Shimizu, Kazuhiro Toyoda, Eiichi Ogawa, Norihiro Furusyo
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2017)
Article
Peripheral Vascular Disease
K. Eguchi, T. Ohmaru, A. Ohkuchi, C. Hirashima, K. Takahashi, H. Suzuki, K. Kario, S. Matsubara, Mitsuaki Suzuki
JOURNAL OF HUMAN HYPERTENSION
(2016)
