Review
Pharmacology & Pharmacy
Dan Zhang, Bo Li, Muxin Zhao
Summary: Hypertrophic scar and keloid are fibroproliferative disorders of the skin caused by aberrant wound healing, with inflammation being recognized as the initiator of their formation. Interleukins, known for their role in inflammatory and immune responses, are being explored as potential therapeutic targets for their treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Jie Li, Jiayi Wu, Catherine Hall, Xiao-chen Bai, Eunhee Choi, Emily J. Gallagher
Summary: The insulin receptor (IR) and insulin-like growth factor 1 receptor (IGF1R) play crucial roles in metabolic homeostasis and cell growth. This study reveals that the structural rigidity of the disulfide-linked alpha CTs is critical for optimal IR and IGF1R signaling activation.
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bhumika Rajoria, Xihong Zhang, Douglas Yee
Summary: The Insulin-like Growth Factor (IGF) system has long been studied in breast cancer progression, but targeting it has not been successful due to the complexity and homology of its receptors. This study examined the metabolic phenotype of breast cancer cells upon stimulation with IGF-1 and insulin. The results showed that IGF-1R, but not IR, regulates ATP production, providing evidence of the relationship between metabolic dysfunction, cancer, and the IGF axis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Fa Zhang, Emrah Altindis, C. Ronald Kahn, Richard D. DiMarchi, Vasily Gelfanov
Summary: The study identified viral insulin-like peptides with unique biological functions, including one that acts as a potent and full antagonist of the IGF-1R. The results revealed the importance of the internal structure of VILPs in regulating their biological activities and discovered a set of potentially medicinally important antagonists.
MOLECULAR METABOLISM
(2021)
Review
Cell Biology
Christine Bojanic, Kendrick To, Adam Hatoum, Jessie Shea, K. T. Matthew Seah, Wasim Khan, Charles M. Malata
Summary: Scars resulting from abnormal wound repair processes like hypertrophic and keloid scars can significantly impair quality of life. While existing treatment options are unsatisfactory, there is increasing interest in using MSC therapy to address these abnormal scars, although human clinical trials are still lacking.
CELL AND TISSUE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Wael Alata, Alvaro Yogi, Eric Brunette, Christie E. Delaney, Henk van Faassen, Greg Hussack, Umar Iqbal, Kristin Kemmerich, Arsalan S. Haqqani, Maria J. Moreno, Danica B. Stanimirovic
Summary: The study demonstrates the development of technologies targeting the blood-brain barrier to allow drugs to enter the brain. Through in vitro and in vivo experiments, the researchers showed the effectiveness of these technologies and their potential in pain treatment.
Article
Dermatology
Lingxi Chen, Yingjun Su, Bin Yin, Shu Li, Xialin Cheng, Yan He, Chiyu Jia
Summary: LARP6 plays an important role in the proliferation and invasion process of keloid lesions.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Review
Physiology
Yixiu Zhong, Youfan Zhang, Aijiao Yu, Zhiwen Zhang, Zhenjun Deng, Kaifen Xiong, Qi Wang, Jianglin Zhang
Summary: This review mainly discusses the roles of mesenchymal stem cell-derived exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medical Laboratory Technology
Jason K. Y. Lee, Kendall Cradic, Ravinder J. Singh, JoAnna Jones, Jieli Li
Summary: This study compared the measurement of IGF-1 on four different platforms and found significant variations between them. These variations should be considered when managing patients with pituitary disorders.
CLINICA CHIMICA ACTA
(2023)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Medicine, General & Internal
Sha Yang, Yujia J. Luo, Cong Luo
Summary: The study recommends intralesional injection of TAC-BTA and TAC-5-FU combined therapies for the treatment of pathological scars, showing their superior efficacy. Other treatment strategies did not show significant differences in clinical efficiency. Further confirmation through randomized controlled trials is needed for these conclusions.
FRONTIERS IN MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Julian Bailes, Mikhail Soloviev
Summary: IGF-1, the principal mediator of GH, plays a crucial role in cell growth, differentiation, and apoptosis, with its bioavailability affected by IGFBPs. The varying expression levels of IGF-1 in clinical conditions and its misuse in sports have raised significant concerns.
Article
Geriatrics & Gerontology
Hiroyasu Sakai, Maho Asami, Hiroaki Naito, Satoko Kitora, Yuta Suzuki, Yu Miyauchi, Rei Tachinooka, Satoshi Yoshida, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei
Summary: Exogenous recombinant human IGF-1 attenuated cisplatin-induced muscle atrophy by restoring IGF-1/PI3K/Akt signaling pathway activity, inhibiting muscle protein degradation, and reducing muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)