An insight into JAK-STAT signalling in dermatology

A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis

(2013) W.C. Ports et al.   BRITISH JOURNAL OF DERMATOLOGY

Tofacitinib (CP-690,550) in combination with methotrexate in patients with active rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitors: a randomised phase 3 trial

(2013) Gerd R Burmester et al.   LANCET

Efficacy and safety of tofacitinib, an oral Janus kinase inhibitor, in the treatment of psoriasis: a Phase 2b randomized placebo-controlled dose-ranging study

(2012) K.A. Papp et al.   BRITISH JOURNAL OF DERMATOLOGY

Pyoderma gangrenosum in association with Janus kinase 2 (JAK2V617F) mutation

(2012) J. A. Palanivel et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Incyte comes of age with JAK inhibitor approval

(2012) Nuala Moran   NATURE BIOTECHNOLOGY

Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate

(2011) Yoshiya Tanaka et al.   ARTHRITIS CARE & RESEARCH

Analysis of JAK2 and STAT3 polymorphisms in patients with ankylosing spondylitis in Chinese Han population

(2010) Chao Chen et al.   CLINICAL IMMUNOLOGY

Genetic factors in chronic inflammation: Single nucleotide polymorphisms in the STAT-JAK pathway, susceptibility to DNA damage and Crohn's disease in a New Zealand population

(2010) Lynnette R. Ferguson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Impaired STAT Phosphorylation in T Cells from Melanoma Patients in Response to IL-2: Association with Clinical Stage

(2009) R. Mortarini et al.   CLINICAL CANCER RESEARCH

JAK3 Inhibition Significantly Attenuates Psoriasiform Skin Inflammation in CD18 Mutant PL/J Mice

(2009) B. Y. Chang et al.   JOURNAL OF IMMUNOLOGY

Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Pharmacologic Effect of CP-690,550 in Patients With Psoriasis

(2009) Mary G. Boy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Investigation of Crohn's Disease Risk Loci in Ulcerative Colitis Further Defines Their Molecular Relationship

(2008) Carl A. Anderson et al.   GASTROENTEROLOGY

Cucurbitacin I Inhibits Stat3 and Induces Apoptosis in Sézary Cells

(2008) Marloes S. van Kester et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY