Review
Immunology
Yazhi Xue, Mengyao Wang, Hongbing Han
Summary: This article summarizes the interactions between alveolar macrophages and epithelial cells during Mycoplasma pneumoniae infections, including cytokines-mediated communications, signal transduction by extracellular vesicles, surfactant associated proteins-mediated signal transmission, and establishment of intercellular gap junction channels.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Katie L. Collins, Usir S. Younis, Sasipa Tanyaratsrisakul, Robin Polt, Meredith Hay, Heidi M. Mansour, Julie G. Ledford
Summary: The peptide hormone Ang-(1-7) has been shown to have anti-inflammatory effects and reduce airway inflammation. It also plays a protective role in reducing lung infection burden and inflammation caused by Mycoplasma pneumonia, suggesting its potential therapeutic value in respiratory infections.
Article
Biotechnology & Applied Microbiology
Naiyu Zhang, Wuwei Zeng, Tingfeng Du, Hongjiang Wei, Wei Tian, Yan Meng, Guiting He, Aihua Lei, Cuiming Zhu
Summary: The aim of this study was to evaluate the protective effect of intestinal supplementation with Lacticaseibacillus casei CNRZ1874 on the inflammatory response induced by Mycoplasma pneumoniae in C57BL/6 J mice, and to provide a potential strategy for alleviating M. pneumoniae pneumonia. The results showed that treatment with L. casei CNRZ1874 significantly reduced M. pneumoniae loads in the lungs and alleviated the lung inflammation. Moreover, oral administration with L. casei CNRZ1874 promoted M1 alveolar macrophages activation and inhibited M2 alveolar macrophages activation, which contributed to the clearance of M. pneumoniae and attenuation of M. pneumoniae pneumonia.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Plant Sciences
Xiuzhen Mei, Jian Wang, Chao Zhang, Jiale Zhu, Beibei Liu, Qingyun Xie, Ting Yuan, Yuzi Wu, Rong Chen, Xing Xie, Yanna Wei, Li Wang, Guoqing Shao, Qiyan Xiong, Yefen Xu, Zhixin Feng, Zhenzhen Zhang
Summary: This study identified a novel mechanism of action for apigenin in reducing alveolar macrophage necroptosis via the PPAR gamma/Uhrf1/TNF-alpha pathway, which may have implications for the treatment of Mycoplasma pneumonia.
Article
Immunology
Tinashe K. Nyazika, Lusako Sibale, Joseph Phiri, Megan De Ste Croix, Zydrune Jasiunaite, Christopher Mkandawire, Rose Malamba, Anstead Kankwatira, Miriam Manduwa, Daniela M. Ferreira, Tonney S. Nyirenda, Marco R. Oggioni, Henry C. Mwandumba, Kondwani C. Jambo
Summary: Compared to HIV-uninfected adults, people living with HIV (PLHIV) have impaired ability of alveolar macrophages (AM) to eliminate S. pneumoniae, which may contribute to their increased risk of pneumococcal pneumonia.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Danlin Weng, Song Gao, Hailan Shen, Shifei Yao, Qi Huang, Yanyu Zhang, Wenjie Huang, Yan Wang, Xuemei Zhang, Yibing Yin, Wenchun Xu
Summary: This study found that CD5L has anti-inflammatory effects and regulates Th2 immune responses in allergic asthma through increasing CD11c(high) alveolar macrophages and inhibiting NLRP3 inflammasome activation. These findings suggest that CD5L may be a potential therapeutic target for asthma treatment.
Article
Immunology
Christina Draijer, Laura Florez-Sampedro, Catharina Reker-Smit, Eduard Post, Fransien van Dijk, Barbro N. Melgert
Summary: This study investigates the development of differentially polarized macrophages, specifically YM1+ and MHCII+ macrophages, in the development of house dust mite-induced allergic lung inflammation in mice. The findings suggest that the proliferation of nonpolarized tissue-resident macrophages and the recruitment of monocytes contribute to the development of a polarized macrophage pool during allergic inflammation. The polarization of macrophages is characterized by the upregulation of YM1 on alveolar macrophages and MHCII on interstitial macrophages.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Xiaoran Liu, Yanbo Wang, Chao Chen, Kun Liu
Summary: This review assessed the association between Mycoplasma pneumoniae infection and childhood asthma, and found that the infection may increase the risk of childhood asthma, especially in children with acute asthma. Further well-designed and controlled studies are needed to confirm this association and explore the underlying mechanisms.
MICROBIAL PATHOGENESIS
(2021)
Article
Multidisciplinary Sciences
Judy Chen, Jane C. Deng, Rachel L. Zemans, Karim Bahmed, Beata Kosmider, Min Zhang, Marc Peters-Golden, Daniel R. Goldstein
Summary: Aging impairs immune responses against influenza, and prostaglandin E-2 is identified as a factor that compromises host defense to influenza during aging.
NATURE COMMUNICATIONS
(2022)
Article
Pediatrics
Bing Wei, Yan-Hong Dang, Xiang-Ping Liu, Miao Li
Summary: This study aimed to investigate the differences in characteristics of Mycoplasma pneumoniae pneumonia (MPP) among children with and without asthma, as well as among children with asthma with and without inhaled corticosteroid (ICS) therapy. The study found that children with asthma had higher chances of wheezing compared to those without asthma. Furthermore, children with asthma who received ICS therapy had fewer and less severe exacerbations of MPP compared to those without ICS therapy. ICS therapy was identified as an independent protective factor against exacerbation.
FRONTIERS IN PEDIATRICS
(2022)
Editorial Material
Hematology
Wen Xuan Zhang, Paul Kubes
Summary: In this study, NOX2-deficient mice were used to investigate the underlying mechanisms of noninfectious inflammatory conditions in patients with CGD. The researchers identified a new population of AMs that exhibited significant inflammatory properties.
Article
Immunology
Yifan Zhu, Yingying Luo, Ling Li, Xinyi Jiang, Yi Du, Jing Wang, Huilin Li, Haiyan Gu, Daiying Li, Heng Tang, Houbing Qin, Changdi Xu, Yan Liu, Deyu Zhao, Yun Guo, Feng Liu
Summary: This study analyzed the microbiome and transcriptome of bronchoalveolar lavage fluid (BALF) from children with MPP and found that the progression of MPP is associated with the host immune response, especially the intrinsic immune response.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Allergy
Jiaying Luo, Huian Chen, Qiyong Zhang, Xinyun Huang, Xu Qin, Jing Li, Siyi Chen, Yongxin Xiao, Lihong Sun, Baoqing Sun
Summary: This study found that Mp infection can cause changes in the levels of various amino acids in asthmatic children, ultimately leading to increased airway inflammation. This is important for understanding the mechanism by which Mp infection exacerbates asthma in children and finding potential clinical treatment targets.
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH
(2022)
Article
Pediatrics
Xiao-Wen Zhan, Li-Ping Deng, Zhi-Yuan Wang, Ju Zhang, Meng-Zhu Wang, Shu-Jun Li
Summary: The mutation rate of drug-resistance genes is high in children with MPP, and it is associated with high inflammatory index and longer disease course. Children in the drug-resistance gene mutation group have more severe symptoms and changes. There is no significant correlation between drug-resistance gene mutations and RMPP.
ITALIAN JOURNAL OF PEDIATRICS
(2022)
Article
Pediatrics
Yanli Wang, Kai Liu, Chuangui Chen, Chengyun Zhang
Summary: This study aimed to examine the clinical impact of bronchoscope alveolar lavage (BAL) combination with budesonide, ambroxol + budesonide, or acetylcysteine + budesonide in the treatment of refractory Mycoplasma pneumoniae pneumonia (RMPP). The results showed that BAL-coupled acetylcysteine + budesonide was superior in enhancing the effectiveness of RMPP in children.
ITALIAN JOURNAL OF PEDIATRICS
(2023)