Review
Medicine, General & Internal
Minjun Ma, Yu Li, Xiujuan Xu, Conghua Ji
Summary: The incidence of acute pulmonary embolism (APE) has been increasing annually, and the diagnosis of APE is a challenge for clinicians. This study evaluated multiple diagnostic indicators and found that lung imaging had the highest diagnostic value, followed by D-dimer, Geneva rules, and Wells rules. Clinical trials are recommended to establish an early decision-making model for the diagnosis of pulmonary embolism.
Review
Health Care Sciences & Services
Oana Sirbu, Victorita Sorodoc, Mariana Floria, Cristian Statescu, Radu Sascau, Catalina Lionte, Ovidiu Rusalim Petris, Raluca Ecaterina Haliga, Paula Cristina Morariu, Andreea Tirnoveanu, Vladut Mirel Burduloi, Corina Ursulescu, Laurentiu Sorodoc
Summary: Nontrombotic pulmonary embolism refers to the embolization of different types of materials into pulmonary circulation. Its clinical presentation and laboratory findings are nonspecific, leading to misdiagnosis as pulmonary thromboembolism. Understanding the risk factors and specific symptoms is crucial for rapid and correct diagnosis.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ilaria Vittoria de Martini, Adrian Raoul Kobe, Christian Roeren, Robert Manka, Andre Euler, Dagmar Keller, Frank Ruschitzka, Hatem Alkadhi, Matthias Eberhard
Summary: This study evaluated the feasibility and accuracy of using CT pulmonary angiography (CTPA) for diagnosing acute heart failure (HF) in emergency department patients. The results showed that both HUratio and HUdiff had a high sensitivity for diagnosing HF, indicating their potential as viable diagnostic markers.
EUROPEAN RADIOLOGY
(2022)
Article
Medicine, General & Internal
Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Olga Zdonczyk, Dominika Dabrowska, Marek Roik, Szymon Pacho, Maksymilian Bielecki, Piotr Pruszczyk
Summary: This study suggests that a Doppler index, TRPG/AcT, improves the assessment of symptomatic pulmonary embolism (PE) survivors. TRPG/AcT > 0.6 indicates a high probability of chronic thromboembolic pulmonary hypertension (CTEPH) or chronic thromboembolic pulmonary disease (CTED), while TRPG/AcT < 0.6 allows for the safe exclusion of CTEPH + CTED in patients with a low echocardiographic probability of pulmonary hypertension (PH).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pierre-Yves Le Roux, Pierre-Benoit Bonnefoy, Achraf Bahloul, Benoit Denizot, Bertrand Barres, Caroline Moreau-Triby, Astrid Girma, Amandine Pallardy, Quentin Ceyrat, Laure Sarda-Mantel, Micheline Razzouk-Cadet, Reka Zsigmond, Cachin Florent, Gilles Karcher, Pierre-Yves Salaun
Summary: This study assessed the role of ventilation imaging in COVID-19 patients undergoing lung scintigraphy for suspected pulmonary embolism (PE). The findings showed that in this population, only 57% of patients could confidently exclude PE without ventilation imaging, while 31% of patients required ventilation imaging to rule out PE. The study also revealed a low prevalence of PE (12%).
JOURNAL OF NUCLEAR MEDICINE
(2022)
Review
Medicine, General & Internal
Helia Robert-Ebadi, Thomas Moumneh, Gregoire Le Gal, Marc Righini
Summary: Pulmonary embolism (PE) is a common cause of maternal morbidity and mortality during pregnancy, but diagnosing it in pregnant women is difficult. Two prospective studies have demonstrated the safety of using clinical probability assessment, D-dimer, venous compression ultrasonography, and CT angiography to exclude PE without chest imaging. Implementing these validated diagnostic strategies in clinical practice should be a high priority goal, as pregnant women are at a high risk of inappropriate diagnostic management.
Article
Medicine, General & Internal
Jeong Ah Hwang, Younghoon Song, Jaeun Shin, Eunjung Cho, Shin Young Ahn, Gang Jee Ko, Young Joo Kwon, Ji Eun Kim
Summary: This study found a U-shaped relationship between mortality and CCR levels in normal renal function, as well as an increased risk of mortality in CKD patients with elevated CCR.
FRONTIERS IN MEDICINE
(2022)
Letter
Medicine, General & Internal
Theoharis C. Theoharides, Irene Tsilioni
Summary: We believe that the inferences made by Pottel et al. (1) are confusing. The National Kidney Foundation-American Society of Nephrology (NKF-ASN) Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease (2) argued that race is a societal, not genetic, construct and successfully eliminated it from kidney function estimation. The Task Force's approach was based on principles such as assay availability, ease of implementation, and the diverse population of the United States.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Sanket S. Dhruva, Rita F. Redberg
Summary: Over 500,000 U.S. patients are hospitalized with pulmonary embolism each year, with therapeutic anticoagulation being the standard of care, but adjunctive treatments are sometimes used.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Nutrition & Dietetics
Kuniaki Hirai, Akihiko Tanaka, Tetsuya Homma, Yuiko Goto, Kaho Akimoto, Tomoki Uno, Uchida Yoshitaka, Yoshito Miyata, Hideki Inoue, Shin Ohta, Shintaro Suzuki, Hironori Sagara
Summary: The serum Cr/CysC ratio is an effective indicator for evaluating sarcopenia in male patients with COPD, correlating with handgrip strength and muscle mass. It is a better predictor of sarcopenia compared to other biomarkers. Patients with Cr/CysC below 0.71 are at higher risk of severe acute COPD exacerbations, despite no significant difference in the frequency of acute exacerbations.
CLINICAL NUTRITION
(2021)
Article
Cardiac & Cardiovascular Systems
Aaron Shengting Mai, Andrija Matetic, Islam Y. Elgendy, Juan Lopez-Mattei, Rafail A. Kotronias, Louise Y. Sun, Jung Hahn Yong, Rodrigo Bagur, Harriette G. C. Van Spall, Mamas A. Mamas
Summary: This study evaluated the clinical care provided to cancer patients hospitalized for acute pulmonary embolism and assessed the association between type of cancer, in-hospital care, and clinical outcomes. The results showed that cancer patients were less likely to receive invasive management compared to non-cancer patients. Cancer patients had higher odds of mortality, with lung cancer patients having the highest mortality and hemorrhagic stroke risk, while colorectal cancer patients had the highest bleeding risk.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Health Care Sciences & Services
Androniki Gkana, Androniki Papadopoulou, Maria Mermiri, Eleftherios Beltsios, Dimitrios Chatzis, Foteini Malli, Antonis Adamou, Konstantinos Gourgoulianis, Georgios Mavrovounis, Ioannis Pantazopoulos
Summary: This article comprehensively reviews the research progress on novel diagnostic biomarkers for pulmonary embolism (PE), and discusses their application value in daily clinical practice.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Bryan F. Vaca-Cartagena, Candice Y. Lee, Hao A. Tran, Timothy Fernandes, Nick H. Kim, Victor Pretorius
Summary: Heart transplantation is the standard therapy for end-stage heart failure, but patients with submassive pulmonary embolism and heart failure typically need to wait for extended periods of time before being eligible for transplant surgery. In some cases, successful simultaneous pulmonary thromboendarterectomy and heart transplantation have been reported.
ANNALS OF THORACIC SURGERY
(2021)
Article
Microbiology
Hilary R. Teaford, Ryan W. Stevens, Andrew D. Rule, Kristin C. Mara, Kianoush B. Kashani, John C. Lieske, John O'Horo, Erin F. Barreto
Summary: In overweight or obese patients, using both cystatin C (cysC) and serum creatinine (SCr) can better predict the initial steady-state vancomycin troughs, resulting in a higher proportion of patients achieving the target trough range compared to using either biomarker alone. Prospective validation of dosing models based on cysC is needed to confirm these findings.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Dan Li, Linlu Zhao, Jin Qian, Heng Liu, Jinmao You, Ziyi Cheng, Fabiao Yu
Summary: In this paper, a surface-enhanced Raman scattering-based aptasensor is developed for duplex detection of protein biomarkers in acute kidney injury (AKI). The sensor utilizes the base-pairing specificity of nucleic acids to form a self-assembled structure and increases the Raman scattering signal through the release of gold nanoparticles, achieving high sensitivity analysis. Experimental results confirm the general applicability of this sensor in early diagnosis of AKI.
