Article
Primary Health Care
Hillary R. Mount, Megan Rich, Michael S. Putnam
Summary: Venous thromboembolism (VTE) recurrence rates are higher in patients with chronic or no risk factors compared to those with transient risk factors after anticoagulation therapy. Age-appropriate screening is sufficient for evaluating occult malignancy in patients with unprovoked VTE. Routine thrombophilia evaluation has not shown improved outcomes and should be considered only in selected patients. A three-month course of anticoagulation therapy is recommended for VTE patients, with the decision to continue beyond three months based on the initial VTE context, bleeding and recurrence risk, and patient preference. Risk assessment models have shown promise for predicting recurrence risk but have not been incorporated into guidelines. Pregnant patients with a prior VTE should receive postpartum prophylaxis for six weeks, and antepartum prophylaxis is recommended for pregnant individuals with a history of unprovoked or hormonally induced VTE. High-risk surgical patients may require extended postoperative VTE prophylaxis. Copyright (C) 2022 American Academy of Family Physicians.
AMERICAN FAMILY PHYSICIAN
(2022)
Article
Medicine, General & Internal
Mattes Becher, Thomas Heller, Sarah Schwarzenboeck, Jens-Christian Kroeger, Marc-Andre Weber, Felix G. Meinel
Summary: In this study, the prevalence of negative venous leg ultrasound in acute PE was investigated, with almost half of patients showing no signs of DVT. Negative venous ultrasound was more common in patients without DVT history, lower D-dimer levels, PE diagnosed with V/P-SPECT rather than CT, and more peripherally located PE.
Article
Multidisciplinary Sciences
Yugo Yamashita, Takeshi Morimoto, Kazushige Kadota, Toru Takase, Seiichi Hiramori, Kitae Kim, Maki Oi, Masaharu Akao, Yohei Kobayashi, Mamoru Toyofuku, Moriaki Inoko, Tomohisa Tada, Po-Min Chen, Koichiro Murata, Yoshiaki Tsuyuki, Yuji Nishimoto, Jiro Sakamoto, Kiyonori Togi, Hiroshi Mabuchi, Kensuke Takabayashi, Takao Kato, Koh Ono, Takeshi Kimura
Summary: There is a lack of data on management strategies and clinical outcomes after recurrent venous thromboembolism (VTE). In this study, the population was divided into three groups and active cancer and sub-optimal intensity of anticoagulation therapy were identified as major factors contributing to recurrent VTE.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Daniele Pastori, Vito Maria Cormaci, Silvia Marucci, Giovanni Franchino, Francesco Del Sole, Alessandro Capozza, Alessia Fallarino, Chiara Corso, Emanuele Valeriani, Danilo Menichelli, Pasquale Pignatelli
Summary: Venous thromboembolism (VTE) is a common cause of death worldwide. The incidence varies between Western and Eastern countries, with Western countries having a higher incidence. Several risk factors have been identified, including male sex, diabetes, obesity, smoking, genetic mutations, oral contraceptives, long-haul flights, and medical conditions like cancer. This review provides a comprehensive summary of these risk factors and the potential mechanisms leading to VTE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Liqi Shu, Adam de Havenon, Ava L. Liberman, Nils Henninger, Eric Goldstein, Michael E. Reznik, Ali Mahta, Fawaz Al-Mufti, Jennifer Frontera, Karen Furie, Shadi Yaghi
Summary: This study evaluated the rates and risk factors for hospital readmissions with venous thromboembolism (VTE) after an intracerebral hemorrhage (ICH) or acute ischemic stroke (AIS) hospitalization. The results showed that the rate of VTE readmission was nearly three times higher in ICH patients compared to AIS patients, and the highest risk period for VTE readmission was within the first 4-6 weeks post-discharge. Therefore, there is a need to test short-term VTE prophylaxis beyond hospitalization in high-risk patients.
Article
Hematology
Lara De Lucchi, Chiara Nardin, Alessandra Sponchiado, Davide Raggi, Elisabetta Faggin, Elena Martini, Valeria Pagliara, Elena Callegari, Livio Caberlotto, Mario Plebani, Paolo Pauletto, Francesco Cinetto, Carlo Agostini, Sabina Villalta, Marcello Rattazzi
Summary: Elevated serum uric acid levels are associated with increased risk of future VTE recurrence independently from traditional risk factors. Patients in the lower tertile of SUA distribution had significantly lower risk of future VTE recurrence, while each additional unit of SUA (mg/dL) increased the hazard of VTE recurrence by 30%.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Babak B. Navi, Cenai Zhang, Carla P. Sherman, Richard Genova, Natalie M. LeMoss, Hooman Kamel, Scott T. Tagawa, Ashish Saxena, Allyson J. Ocean, Scott E. Kasner, Mary Cushman, Mitchell S. Elkind, Ellinor Peerschke, Lisa M. DeAngelis
Summary: Hematologic and embolic biomarkers soon after AIS in cancer patients may be associated with subsequent adverse clinical outcomes, particularly recurrent thromboembolism or death.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Biochemistry & Molecular Biology
Olga Porembskaya, Vsevolod Zinserling, Vladimir Tomson, Yana Toropova, Eleonora A. Starikova, Vitaliy V. Maslei, Nika Bulavinova, Olga Kirik, Marina A. Syrtsova, Leonid Laberko, Maxim Galchenko, Vyacheslav Kravchuk, Sergey Saiganov, Alexander Brill
Summary: This study demonstrated that thrombi in the lung vasculature can form in situ by mechanisms that require local neutrophil recruitment taking place in the deep vein thrombosis (DVT) setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Alexander G. G. Turpie, Alfredo E. Farjat, Sylvia Haas, Walter Ageno, Jeffrey Weitz, Samuel Z. Goldhaber, Shinya Goto, Pantep Angchaisuksiri, Gloria Kayani, Renato D. Lopes, Chern-En Chiang, Harry Gibbs, Eric Tse, Peter Verhamme, Hugo ten Cate, Juan Muntaner, Sebastian Schellong, Henri Bounameaux, Paolo Prandoni, Uma Maheshwari, Ajay K. Kakkar
Summary: GARFIELD-VTE is an observational study that aims to collect clinical data of patients with deep vein thrombosis and pulmonary embolism worldwide. The study found that the highest accumulation of events occurred within the first 12 months after diagnosis, which may help identify treatment gaps and improve patient outcomes.
THROMBOSIS RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ahmad Mahmoud, Katarina Glise Sandblad, Christina E. Lundberg, Gustaf Hellsen, Per Olof Hansson, Martin Adiels, Annika Rosengren
Summary: Overweight and obesity rates have increased, especially among the younger population. This study investigated the association between body mass index (BMI) in early pregnancy and the long-term risk of venous thromboembolism (VTE) in women. The results showed that higher BMI was associated with an increased risk of VTE. Even women with high normal BMI had a higher risk compared to lean women, while severe obesity was associated with a significantly elevated risk.
SCIENTIFIC REPORTS
(2023)
Article
Hematology
Shinya Goto, Alexander G. G. Turpie, Alfredo E. Farjat, Jeffrey Weitz, Sylvia Haas, Walter Ageno, Samuel Z. Goldhaber, Pantep Angchaisuksiri, Gloria Kayani, Peter MacCallum, Sebastian Schellong, Henri Bounameaux, Lorenzo G. Mantovani, Paolo Prandoni, Ajay K. Kakkar
Summary: This study found that venous thromboembolism patients with concomitant anemia had a higher risk of all-cause mortality and major bleeding over a 24-month follow-up compared to those without anemia.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Correa Lara Maximiliano, Garcia Chavez Jaime, Martinez Hernandez Erika
Summary: This study compared the efficacy of rivaroxaban plus aspirin with acenocoumarol in patients with recurrent venous thromboembolism despite ongoing anticoagulation with rivaroxaban. The results showed no significant differences in recurrent thromboembolic events and bleeding events between the two groups.
THROMBOSIS RESEARCH
(2023)
Article
Medicine, General & Internal
Ewa Jankowska, Iwona Bartoszuk, Katarzyna Lewandowska, Malgorzata Dybowska, Lucyna Opoka, Witold Tomkowski, Monika Szturmowicz
Summary: Acute Eosinophilic Pneumonia is a rare disease characterized by eosinophil accumulation in the lungs. Its onset is acute, and some patients may experience respiratory failure. Diagnosis is based on clinical symptoms, imaging studies, and eosinophilia in bronchoalveolar lavage or pleural fluid smear. Smokers are at an increased risk. We present a case of venous thromboembolic disease that developed during AEP in a previously healthy male smoker. The disease achieved complete remission with anticoagulation therapy and low-dose steroids. Surprisingly, further diagnostics revealed thrombophilia in the patient.
Review
Critical Care Medicine
Manila Gaddh, Rachel P. Rosovsky
Summary: VTE is a major global health issue, with up to 50% of patients having an underlying thrombophilic defect. While identifying hereditary thrombophilia alone may not change outcomes, a family history of VTE can significantly increase an individual's risk, regardless of detected inherited thrombophilia. Understanding the risks and benefits of testing, as well as following contemporary guidelines, is crucial in managing VTE effectively.
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Article
Obstetrics & Gynecology
Zhen-Yi Jin, Chun-Min Li, Kai Zheng, Hong Qu, Wen-Tao Yang, Jia-Hao Wen, Wang-De Zhang, Hua-Liang Ren
Summary: This study found a high incidence of isolated distal deep venous thrombosis (IDDVT) concurrent with pulmonary embolism (PE) in gynecologic inpatients. Glucocorticoid therapy, hypertension, diabetes, and body mass index (BMI) were identified as independent risk factors for IDDVT patients with PE. A nomogram risk prediction model based on these factors was developed to facilitate early detection of concurrent PE.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Article
Clinical Neurology
Angela Deya-Martinez, Yadira Gordon, Cristina Molina-Anguita, Alexandru Vlagea, Monica Piquer, Manel Juan, Ana Esteve-Sole, Jordi Anton, Alvaro Madrid, Ana Garcia-Garcia, Ana M. Plaza, Thais Armangue, Laia Alsina
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Editorial Material
Clinical Neurology
Marta Bodro, Yaroslau Compta, Laura Llanso, Diana Esteller, Antonio Doncel-Moriano, Alex Mesa, Alejandro Rodriguez, Jordi Sarto, Eugenia Martinez-Hernandez, Alexandru Vlagea, Natalia Egri, Xavier Filella, Manuel Morales-Ruiz, Jordi Yaguee, Alex Soriano, Francesc Graus, Felipe Garcia
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2020)
Article
Biophysics
A. Deya-Martinez, A. Alonso-Saladrigues, A. P. Garcia, A. Faura, M. Torrebadell, A. Vlagea, A. Catala, A. Esteve-Sole, M. Juan, S. Rives, L. Alsina
Summary: BCA occurs soon after CART19 infusion, with a progressive decrease in IgM and IgA, and less impairment of IgA, suggesting the possibility of an immune reservoir. Persistent B-cell dysfunction might persist after CART19 loss in this population.
BONE MARROW TRANSPLANTATION
(2021)
Article
Allergy
Ana Garcia-Garcia, Monserrat Buendia Arellano, Angela Deya-Martinez, Jaime Lozano Blasco, Mercedes Serrano, Ana van den Rym, Blanca Garcia-Solis, Ana Esteve-Sole, Luo Yiyi, Alexandru Vlagea, Xavier Solanich, Megan R. Fisher, Jonathan J. Lyons, Rebeca Perez de Diego, Laia Alsina
Summary: The study aimed to characterize individuals with compound heterozygous variants in PGM3, identifying mutations in the phosphate-binding domain of the enzyme. Patients from a non-consanguineous family presented with atopic dermatitis, elevated IgE levels, and CD4(+) lymphopenia, without dysmorphic features or neurocognitive impairment. Analysis revealed reduced L-PHA binding in naive-CD4+ cells, suggesting decreased residual PGM3 enzymatic activity and potential modifying effects of other gene variants in the N-glycosylation pathway on patient phenotypes. This study expands the clinical criteria for identifying PGM3 deficiency in individuals with hyper-IgE.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Review
Allergy
Natalia Egri, Ana Esteve-Sole, Angela Deya-Martinez, Inaki Ortiz de Landazuri, Alexandru Vlagea, A. P. Garcia, Celia Cardozo, Carolina Garcia-Vidal, Clara San Bartolome, Marta Espanol-Rego, L. Yiyi, Xavier Bosch-Amate, J. Ferrando, Jordi Yague, Manel Juan, Laia Alsina
Summary: Chronic mucocutaneous candidiasis (CMC) is a chronic or recurrent non-invasive infection caused by Candida albicans in skin, nails, and mucous membranes, potentially with autoimmune manifestations. The main immune defect is a disruption in the action of cytokine IL-17, commonly associated with STAT1 gene gain-of-function mutations. Initial treatment for fungal infections involves azoles, but drug resistance is a significant limitation.
ALLERGOLOGIA ET IMMUNOPATHOLOGIA
(2021)
Article
Pathology
Anna Merino, Alexandru Vlagea, Angel Molina, Natalia Egri, Javier Laguna, Kevin Barrera, Laura Boldu, Andrea Acevedo, Mar Diaz-Pavon, Francesc Sibina, Francisca Bascon, Oriol Sibila, Manel Juan, Jose Rodellar
Summary: This study found that COVID-19 reactive lymphocytes (COVID-19 RL) are associated with better outcomes and prognosis. They can be detected through morphology examination, and a computerized approach can be used for more objective recognition. Immunophenotypic analysis revealed that COVID-19 RL are mainly activated effector memory CD4 and CD8 T cells.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Letter
Hematology
Anna Merino, Javier Laguna, Angel Molina, Alexandru Vlagea, Oriol Sibila
INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY
(2022)
Article
Medicine, General & Internal
Cesar Picado, Inaki Ortiz de Landazuri, Alexandru Vlagea, Irina Bobolea, Ebymar Arismendi, Rosanel Amaro, Jacobo Sellares, Joan Bartra, Raimon Sanmarti, Jose Hernandez-Rodriguez, Jose-Manuel Mascaro, Jordi Colmenero, Eva C. Vaquero, Mariona Pascal
Summary: This study highlights the clinical manifestations of Selective IgE deficiency (SIgED), which include various infectious diseases, autoimmune conditions, eczematous dermatitis, and malignancies. Patients with SIgED have an increased risk of developing malignancies, warranting further prospective studies to better characterize this condition and determine its inclusion in the list of antibody deficiencies.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Allergy
C. Picado, J. M. Mascaro Jr, A. Vlagea, M. Pascal, R. Munoz-Cano, J. Bartra
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Baerbel Keller, Valentina Strohmeier, Ina Harder, Susanne Unger, Kathryn J. Payne, Geoffroy Andrieux, Melanie Boerries, Peter Tobias Felixberger, Jonathan J. M. Landry, Alexandra Nieters, Anne Rensing-Ehl, Ulrich Salzer, Natalie Frede, Susanne Usadel, Roland Elling, Carsten Speckmann, Ina Hainmann, Elizabeth Ralph, Kimberly Gilmour, Marjolein W. J. Wentink, Mirjam van der Burg, Hye Sun Kuehn, Sergio D. Rosenzweig, Uwe Kolsch, Horst von Bernuth, Petra Kaiser-Labusch, Florian Gothe, Sophie Hambleton, Alexandru Daniel Vlagea, Ana Garcia Garcia, Laia Alsina, Gasper Markelj, Tadej Avcin, Julia Vasconcelos, Margarida Guedes, Jing-Ya Ding, Cheng-Lung Ku, Bella Shadur, Danielle T. Avery, Nils Venhoff, Jens Thiel, Heiko Becker, Lucia Erazo-Borras, Claudia Milena Trujillo-Vargas, Jose Luis Franco, Claire Fieschi, Satoshi Okada, Paul E. Gray, Gulbu Uzel, Jean-Laurent Casanova, Manfred Fliegauf, Bodo Grimbacher, Hermann Eibel, Stephan Ehl, Reinhard E. Voll, Marta Rizzi, Polina Stepensky, Vladimir Benes, Cindy S. Ma, Claudia Bossen, Stuart G. Tangye, Klaus Warnatz
Summary: The accumulation of CD21(low) B cells in peripheral blood is a hallmark of chronic activation of the adaptive immune system in certain infections and autoimmune disorders. The transcription factor T-bet plays a prominent role in the regulation of T-bet(high)CD21(low) B cells, and essential signals such as BCR and IFN gamma R are crucial for the differentiation and expansion of these cells. Identification of important pathways provides potential targets for auto-reactive T-bet(high)CD21(low) B cells in autoimmune conditions.
SCIENCE IMMUNOLOGY
(2021)
Article
Hematology
Juan A. Pineyroa, Joan Cid, Alexandru Vlagea, Gloria Carbasse, Paola Henao, Noemi Bailo, Valentin Ortiz-Maldonado, Nuria Martinez-Cibrian, Marta Espanol, Julio Delgado, Alvaro Urbano-Ispizua, Miquel Lozano
Summary: This study retrospectively evaluated the impact of donor- and procedure-related characteristics on the collection efficiency of lymphocytes during the collection of autologous T lymphocytes. The results showed that the Amicus device was associated with higher collection efficiency of lymphocytes (p = 0.01) and lower collection efficiency of platelets (p < 0.01) compared to the Optia device.
Article
Immunology
Adriana Margarit-Soler, Angela Deya-Martinez, Juan Torres Canizales, Alexandru Vlagea, Ana Garcia-Garcia, Julia Marsal, Maria Trabazo Del Castillo, Silvia Planas, Silvia Simo, Ana Esteve-Sole, Maria Suarez-Lledo Grande, Isabel Badell, Montserrat Rovira Tarrats, Francesc Fernandez-Aviles, Laia Alsina
Summary: CTLA-4 haploinsufficiency is a T-cell hyperactivation disorder that can cause immunodeficiency and immune dysregulation. HSCT is a potentially curable treatment for treatment-resistant immune dysregulation, but there is limited experience in managing complications post-HSCT.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ana Garcia-Garcia, Claudia Fortuny, Victoria Fumado, Iolanda Jordan, Laura Ruiz-Lopez, Europa Azucena Gonzalez-Navarro, Natalia Egri, Ana Esteve-Sole, Yiyi Luo, Alexandru Vlagea, Manel Monsonis Cabedo, Cristian Launes, Aleix Soler, Anna Codina, Manel Juan, Mariona Pascal, Angela Deya-Martinez, Laia Alsina
Summary: This study compared the infection outcomes and immune responses to SARS-CoV-2 in unvaccinated individuals with inborn errors of immunity (IEI) and healthy individuals. The results showed that IEI patients had weaker immune responses in the acute phase of infection and lower immune responses at 6 months after infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Cesar Picado, Adriana P. Garcia-Herrera, Jose Hernandez-Rodriguez, Alexandru Vlagea, Mariona Pascal, Joan Bartra, Jose Manuel Mascaro
Summary: Selective immunoglobulin E deficiency (SIgED) is an unrecognized primary immunodeficiency that is associated with various skin manifestations and autoimmune diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Allergy
Yiyi Luo, Daniel Acevedo, Nuria Banos, Andrea Pluma, Raul Castellanos-Moreira, Estefania Moreno, Sebastian Rodriguez-Garcia, Angela Deya-Martinez, Ana Garcia-Garcia, Estefania Quesada-Masachs, Mireia Torres, Manel Casellas, Dolors Grados, Celia Marti-Castellote, Jordi Anton, Alexandru Vlagea, Manel Juan, Ana Esteve-Sole, Laia Alsina
Summary: The neonatal immune system develops during pregnancy to prepare the newborn for life outside the womb. It prioritizes certain immune responses to prevent excessive inflammation and ensure immune tolerance and homeostasis. Exposure to immune modulatory drugs during pregnancy can affect the development of the fetal immune system.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
