Article
Engineering, Biomedical
Guillermo Bauza-Mayol, Marcos Quintela, Ava Brozovich, Michael Hopson, Shazad Shaikh, Fernando Cabrera, Aaron Shi, Federica Banche Niclot, Francesca Paradiso, Emma Combellak, Tom Jovic, Paul Rees, Ennio Tasciotti, Lewis W. Francis, Patrick Mcculloch, Francesca Taraballi
Summary: The use of biomimetic scaffolds in cartilage tissue engineering shows promising results in enhancing cartilaginous tissue formation and suppressing host cartilage degeneration. This approach may provide a clinical solution for cartilage tissue repair by modulating the immune environment to favor regenerative processes and suppress cartilage degeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Engineering, Biomedical
Mahboubeh Sadat Mousavi, Ghassem Amoabediny, Seyed Hossein Mahfouzi, Seyed Hamid Safiabadi Tali
Summary: The study introduced a novel perfusion-based bioreactor (PBB) method for efficient decellularization of bovine articular cartilages, resulting in better preservation of the tissue structure and essential components while reducing harmful physical and chemical steps and process duration. The PBB method showed a 90% reduction in DNA content, significantly higher than the control method, and maintained around 50% of sulfated glycosaminoglycan (sGAG) content and 92% of compression properties, demonstrating efficient preservation of scaffold structure and components. Additionally, the PBB specimens supported cell adherence and proliferation effectively, showing promise for producing close-to-natural scaffolds for cartilage tissue engineering.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Review
Engineering, Multidisciplinary
Liangbin Zhou, Peng Guo, Matteo D'Este, Wenxue Tong, Jiankun Xu, Hao Yao, Martin J. Stoddart, Gerjo J. V. M. van Osch, Kevin Ki-Wai Ho, Zhen Li, Ling Qin
Summary: Articular cartilage (AC) is a flexible connective tissue located on the bone surface in the joints. AC defects are common in physically active individuals. Functionalized hydrogels have emerged as promising substitutes for damaged cartilage in AC repair due to their favorable properties. This article introduces the composition, structure, and function of AC and its defects, and reviews the design and fabrication of functionalized hydrogels for AC repair.
Article
Endocrinology & Metabolism
Stephanie Y. Jo, Ronnie A. Sebro
Summary: In vivo intra-articular contrast-enhanced mu CT can be used to image mouse cartilage, showing good agreement with histological assessment, making it a viable technique for evaluation.
Review
Engineering, Biomedical
Wenying Wei, Honglian Dai
Summary: Osteochondral defect regeneration remains a challenging issue in the musculoskeletal system, with traditional clinical treatments showing limited efficacy. However, the development of tissue engineering has provided more promising results in regenerating damaged osteochondral tissues.
BIOACTIVE MATERIALS
(2021)
Article
Engineering, Multidisciplinary
Xue Yang, Shuai Li, Ya Ren, Lei Qiang, Yihao Liu, Jinwu Wang, Kerong Dai
Summary: Three-dimensional printed hydrogel is a promising approach in cartilage tissue engineering due to its similarity to the extracellular matrix and its ability to fabricate 3D cell culture scaffolds. Various hydrogels, both natural and synthetic, have been tested for 3D printing in vitro articular cartilage tissues. The advancement in materials and printing techniques allows for the fabrication of delicate cartilage structures on multiple scales. Stimuli-responsive hydrogels and their application prospects in tissue engineering are also discussed in this review. The development of novel composite hydrogels that meet the requirements of native articular cartilage is crucial for further advancement in the field.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Biotechnology & Applied Microbiology
Nadine Frerker, Tommy A. A. Karlsen, Maria Stensland, Tuula A. A. Nyman, Simon Rayner, Jan E. E. Brinchmann
Summary: Focal lesions of articular cartilage can cause pain and reduced joint function, leading to osteoarthritis if untreated. In vitro generated, scaffold-free autologous cartilage discs made from articular chondrocytes were compared to those made from bone marrow-derived mesenchymal stromal cells. Articular chondrocytes produced more extracellular matrix and contained more articular cartilage proteins, while mesenchymal stromal cells had more proteins associated with cartilage hypertrophy and bone formation. MicroRNA analysis suggested that differential expression of microRNAs played a key role in the differential synthesis of proteins. Therefore, articular chondrocytes are preferred for engineering articular cartilage.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Zhengjie Zhou, Jingtong Zheng, Xiaoting Meng, Fang Wang
Summary: There is increasing evidence that chondrocytes within articular cartilage are affected by endogenous force-related electrical potentials. Furthermore, electrical stimulation (ES) promotes the proliferation of chondrocytes and the synthesis of extracellular matrix (ECM) molecules, which accelerate the healing of cartilage defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Rachel Cordeiro, Rui D. D. Alvites, Ana C. C. Sousa, Bruna Lopes, Patricia Sousa, Ana C. C. Mauricio, Nuno Alves, Carla Moura
Summary: Osteoarthritis is a prevalent disease causing cartilage loss, and tissue engineering with different cellulose incorporated poly(epsilon-caprolactone) (PCL) scaffolds shows promise for its repair. The study manufactured and characterized PCL scaffolds with various percentages of commercial cellulose (microcrystalline and methyl cellulose) or cellulose from agro-industrial residues (corncob). The results indicate that cellulose incorporation promotes cellular adhesion/proliferation, and methyl cellulose scaffolds demonstrate compressive properties closer to native cartilaginous tissue.
Review
Microbiology
Paolo Spinnato, Dakshesh B. Patel, Maddalena Di Carlo, Alessandra Bartoloni, Luca Cevolani, George R. Matcuk, Amandine Crombe
Summary: Musculoskeletal soft-tissue infections are common conditions encountered in emergency departments and clinical settings, and imaging plays a key role in diagnosis and assessment.
Article
Nanoscience & Nanotechnology
Zhiyao Liao, Liwei Fu, Pinxue Li, Jiang Wu, Xun Yuan, Chao Ning, Zhengang Ding, Xiang Sui, Shuyun Liu, Quanyi Guo
Summary: A bioactive multifunctional scaffold was developed using Mg2+ and aptamer Apt19S to promote articular cartilage regeneration and early inflammatory regulation, offering a promising strategy for AC defect treatment.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Frederico Barbosa, Frederico Castelo Ferreira, Joao Carlos Silva
Summary: Osteochondral tissue engineering is a promising strategy for treating diseases such as osteoarthritis. However, current research focuses mainly on the structural and mechanical properties of the tissue, while neglecting its piezoelectric properties. This review summarizes the recent advances in the application of piezoelectric electrospun scaffolds for replacing damaged osteochondral tissue and promoting its regeneration, and discusses the current challenges and future perspectives.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Maciej Baranowski, Monika Wasyleczko, Anna Kosowska, Andrzej Plichta, Sebastian Kowalczyk, Andrzej Chwojnowski, Wojciech Bielecki, Jaroslaw Czubak
Summary: The study demonstrates that different membranes implanted in rabbit articular cartilage defects support the regeneration process and degrade at an appropriate rate, aiding in cartilage regeneration.
Review
Polymer Science
Filipe Miguel, Frederico Barbosa, Frederico Castelo Ferreira, Joao Carlos Silva
Summary: Articular cartilage is a crucial tissue for healthy joint motion, but its limited regenerative capacities and degeneration are major causes of disability worldwide. Tissue engineering, particularly with hydrogels, offers a promising approach to create cartilage substitutes. Hydrogels can be customized to match the properties of native cartilage and combined with conductive materials to simulate its electrochemical properties. This review highlights the common conductive materials combined with hydrogels, their applications, and the current research on electrically conductive hydrogels for cartilage tissue engineering, as well as the challenges and future perspectives in repairing articular cartilage.
Review
Engineering, Biomedical
Saeed Taghizadeh, Lobat Tayebi, Majid Akbarzadeh, Parvin Lohrasbi, Amir Savardashtaki
Summary: Articular cartilage defects present a significant challenge due to the tissue's limited self-repair capability. Recent advancements in tissue engineering have introduced magnetically responsive hydrogels as a promising solution for creating the desired anisotropic architecture required for successful cartilage TE.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Analytical
Sayandev Chatterjee, Vanessa E. Holfeltz, Gabriel B. Hall, Isaac E. Johnson, Eric D. Walter, Sungsik Lee, Benjamin Reinhart, Wayne W. Lukens, Nicholas P. Machara, Tatiana G. Levitskaia
ANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Physical
Jiyu Cai, Benjamin Reinhart, Peter Eng, Yongqiang Liu, Cheng-Jun Sun, Hua Zhou, Yang Ren, Xiangbo Meng
Article
Chemistry, Physical
Galo Jaime Paez Fajardo, Sebastian A. Howard, Egor Evlyukhin, Matthew J. Wahila, Wasim Raja Mondal, Mateusz Zuba, Jos E. Boschker, Hanjong Paik, Darrell G. Schlom, Jerzy T. Sadowski, Samuel A. Tenney, Benjamin Reinhart, Wei-Cheng Lee, Louis F. J. Piper
Summary: Studying the metal to insulator transition of NbO2 using temperature-dependent X-ray spectroscopy, it was found that dimerization leads to the insulating phase, while an oxygen rich surface reconstruction at the topmost layers remains unchanged regardless of temperature.
CHEMISTRY OF MATERIALS
(2021)
Article
Chemistry, Physical
Abdoulaye Djire, Hanyu Zhang, Benjamin J. Reinhart, O. Charles Nwamba, Nathan R. Neale
Summary: MXenes, based on early transition-metal carbides and nitrides, exhibit highly tunable electrochemical properties suitable for various catalytic reactions. Research has shown that modifying these MXenes can enhance their catalytic activity, such as in the hydrogen evolution reaction. Mechanistic studies using in situ X-ray absorption spectroscopy indicate that the creation of oxygen vacancies on the basal planes is crucial for the catalytic activity, providing insight for future electrocatalysis and photocatalysis schemes.
Article
Chemistry, Physical
Melissa A. Smith, Min Chen, Zhenghong Dai, Cali Antolini, Gethmini K. Jayasekara, Srinivas K. Yadavalli, Benjamin J. Reinhart, Nitin P. Padture, Dugan Hayes
Summary: This study highlights the potential of Sn(II) halide perovskites as a less toxic alternative to Pb-based materials in perovskite solar cells, while also pointing out the challenges of oxidation to Sn(IV) and the need for improved stability. X-ray absorption spectroscopy, optical and X-ray diffraction studies, and Sn-119 Mossbauer spectroscopy are valuable techniques for studying oxidation kinetics, element specificity, and oxidation state sensitivity in Sn(II) perovskites.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Ramedy Flores, M. Abdul Momen, Mary R. Healy, Santa Jansone-Popova, Kevin L. Lyon, Benjamin Reinhart, Michael C. Cheshire, Bruce A. Moyer, Vyacheslav S. Bryantsev
Summary: This study introduces a low-cost model using porous resins to support DGAs, achieving the desired combination of solvent extraction selectivity and ease of operation of sorbent columns.
SOLVENT EXTRACTION AND ION EXCHANGE
(2022)
Article
Nanoscience & Nanotechnology
Denan Wang, Wenhui Hu, Benjamin J. Reinhart, Xiaoyi Zhang, Jier Huang
Summary: This study reports three novel one-dimensional π-d-conjugated coordination polymers (CCPs) and investigates the correlation between their structural parameters and photophysical and photocatalytic properties. The results demonstrate that altering the stacking of the polymer chains through structural modification impacts their crystallinity, charge separation, and charge transport property, ultimately affecting their photocatalytic performance for hydrogen evolution reaction.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Emily A. Sprague-Klein, Xiang He, Michael W. Mara, Benjamin J. Reinhart, Sungsik Lee, Lisa M. Utschig, Karen L. Mulfort, Lin X. Chen, David M. Tiede
Summary: The cobalt-phosphate amorphous oxyhydroxide water-splitting catalyst, CoPi, exhibits wavelength-dependent photo-electrochemical responses, with red light excitation enhancing the oxygen-evolution reaction (OER) and blue light excitation inhibiting OER and oxidative repair.
ACS ENERGY LETTERS
(2022)
Article
Nanoscience & Nanotechnology
Lingzhe Fang, Xingyi Lyu, Jason J. Xu, Yuzi Liu, Xiaobing Hu, Benjamin J. Reinhart, Tao Li
Summary: This study investigates the catalytic performance of SnO2 nanoparticles with controllable sizes on the conversion of CO2 to formate. It confirms the size-dependent effect of SnO2 during the reaction process and explores the evolution of SnO2 under working conditions using operando X-ray absorption spectroscopy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Engineering, Environmental
Ke Wen, Oliver A. Chadwick, Peter M. Vitousek, Elizabeth L. Paulus, Gautier Landrot, Ryan V. Tappero, John P. Kaszuba, George W. Luther, Zimeng Wang, Benjamin J. Reinhart, Mengqiang Zhu
Summary: Manganese oxidation states in highly weathered volcanic soils in Hawaii were studied across two rainfall gradients. It was found that as the mean annual precipitation increased, the soil redox conditions shifted from oxic to suboxic and to anoxic, resulting in decreased proportions of Mn(IV) and increased proportions of Mn(II). Mn(III), on the other hand, accumulated in soils with prevalent suboxic conditions at intermediate precipitation levels. The soil redox conditions and rainfall-driven leaching jointly controlled the concentration of exchangeable Mn(II) in soils.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Lingzhe Fang, Xingyi Lyu, Jason J. Xu, Yuzi Liu, Xiaobing Hu, Benjamin J. Reinhart, Tao Li
Summary: Tin-based SnO2 nanoparticles exhibit size-dependent catalytic performance in the reduction of CO2, with smaller particles showing higher selectivity and efficiency.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Xiaojuan Yu, Jeffrey D. Einkauf, Vyacheslav S. Bryantsev, Michael C. Cheshire, Benjamin J. Reinhart, Jochen Autschbach, Jonathan D. Burns
Summary: The coordination of crystalline products resulting from the co-crystallization of Np(vi), Pu(vi), Am(vi), and Np(v) with uranyl nitrate hexahydrate (UNH) was revealed through solid-state spectroscopic characterization. EXAFS spectroscopy showed similar coordination patterns between U(VI) in UNH and Np(vi) and Pu(vi), while Am exhibited similar coordination to Am(iii) due to reduction of Am(vi). The co-crystallization of oxidized transuranic species with UNH represents a significant advancement in nuclear fuel recycle and expands fundamental understanding of 5f electronic behavior in the solid-state.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Yunbo Zhang, Wenhui Hu, Denan Wang, Benjamin J. Reinhart, Jier Huang
Summary: This study presents the synthesis and photocatalytic performance of the TiO2/CuO heterostructure derived from mixed-phase MOFs. The results show significantly enhanced catalytic activity compared to metal oxides from single node MOFs, and the key intermediate species responsible for the exceptional photocatalytic activity of the heterostructure were identified using transient absorption spectroscopy.
JOURNAL OF MATERIALS CHEMISTRY A
(2021)
Article
Chemistry, Inorganic & Nuclear
Diana Stamberga, Mary R. Healy, Vyacheslav S. Bryantsev, Camille Albisser, Yana Karslyan, Benjamin Reinhart, Alena Paulenova, Mac Foster, Ilja Popovs, Kevin Lyon, Bruce A. Moyer, Santa Jansone-Popova
INORGANIC CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Erin R. Bertelsen, Nolan C. Kovach, Benjamin J. Reinhart, Brian G. Trewyn, Mark R. Antonio, Jenifer C. Shafer