Article
Environmental Sciences
Priya Nijhawan, Tapan Behl, Sridevi Chigurupati, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Aditi Sharma, Amira Saber Ahmed, Suprava Das, Vasanth Raj Palnimuthu, Saurabh Bhatia, Ahmed Al-Harrasi, Md Sohanur Rahman, Sandeep Arora, Simona Bungau
Summary: This study investigated the anti-obesity activity of Crinum latifolia leaf extract in obese rats. The results showed that the leaf extract reduced obesity symptoms, decreased angiogenesis and inflammation, and exhibited antioxidant properties. Therefore, Crinum latifolia leaf extract can be used as a therapeutic option for obesity management.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Medicine, General & Internal
Assunta Melaccio, Antonia Reale, Ilaria Saltarella, Vanessa Desantis, Aurelia Lamanuzzi, Sebastiano Cicco, Maria Antonia Frassanito, Angelo Vacca, Roberto Ria
Summary: Multiple myeloma (MM) is an incurable hematological malignancy. Researchers are actively searching for early and non-invasive biomarkers to predict clinical outcomes and therapeutic responses. The interaction between malignant plasma cells and bone marrow stromal cells plays a crucial role in MM progression. This article discusses the roles of cytokines and growth factors in the pathogenesis of MM and their potential as prognostic and predictive biomarkers. It also explores the potential of targeted drugs that can simultaneously block plasma cell proliferation and survival, plasma cell-bone marrow stromal cell interactions, and bone marrow stromal cell activity, which may be the future goal of MM therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Andrea M. Weckman, Robyn E. Elphinstone, John M. Ssenkusu, Vanessa Tran, Kathleen Zhong, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Andrea L. Conroy, Feiko O. Ter Kuile, Chloe R. McDonald, Kevin C. Kain
Summary: Preterm birth is a leading cause of death in children under five. Sequential disruptions to inflammatory and angiogenic pathways during pregnancy increase the risk of placental insufficiency and preterm labor. Study findings suggest a potential causal link between early inflammation, subsequent angiogenic dysregulation, and preterm birth, highlighting the importance of interventions before 24 weeks gestation.
Review
Biochemistry & Molecular Biology
Zhen-Ling Liu, Huan-Huan Chen, Li-Li Zheng, Li-Ping Sun, Lei Shi
Summary: Angiogenesis is a complex process regulated by various molecules and plays a crucial role in tumor growth and metastasis. Targeted therapeutic research based on these molecules has led to the emergence of promising anti-angiogenic strategies in cancer therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Allergy
Patrick Baum, Sudha Visvanathan, Sandra Garcet, Janine Roy, Ramona Schmid, Sebastian Bossert, Benjamin Lang, Herve Bachelez, Robert Bissonnette, Christian Thoma, James G. Krueger
Summary: This study revealed that the IL-36 pathway plays a significant role in the pathogenesis of generalized pustular psoriasis. Treatment with spesolimab, an anti-IL-36 receptor antibody, resulted in rapid improvement of skin and pustular symptoms in patients with GPP. The treatment also modulated dysregulated molecular pathways associated with GPP and PPP, leading to improved clinical outcomes.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Tomoko Tashiro, Yu Sawada
Summary: Psoriasis is not only a skin disease but can also cause systemic inflammatory diseases. Clinical and experimental studies have shown that there is an important interaction between psoriasis and systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kacey L. Sachen, Carrie N. Arnold Greving, Jennifer E. Towne
Summary: This review highlights the cellular source of IL-36 cytokines, the effects of IL-36 signaling across cell types, and the association of IL-36 with a spectrum of inflammatory skin diseases.
Editorial Material
Biochemistry & Molecular Biology
W. Brent Derry
Summary: Developmental programs are networks of signaling pathways that regulate the formation of tissues and organs during organismal development. Disruptions or activations of these programs can lead to diseases through abnormal growth, differentiation, or migration of cells. This collection of articles in The FEBS Journal highlights the role of deregulated signaling pathways in human diseases.
Review
Biochemistry & Molecular Biology
Jia Guo, Hanyi Zhang, Wenri Lin, Lixia Lu, Juan Su, Xiang Chen
Summary: This review article provides an overview of the epidemiology, clinical subtypes, pathophysiology, and comorbidities of psoriasis. It discusses the signaling pathways, metabolic and epigenetic mechanisms, as well as current treatment options and potential mechanisms of disease recurrence.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Environmental Sciences
Li-Chiu Yang, Yu-Chao Chang, Chen-Yu Chiang, Fu-Mei Huang, Ni-Yu Su, Yu-Hsiang Kuan
Summary: The study showed that wogonin, a natural dihydroxyl flavonoid compound, can inhibit the proinflammatory responses induced by BisGMA in macrophages. It achieves this by regulating the NF-κB pathway and its upstream factor, MAPK.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Dermatology
Claire Q. Wang, Sokol Haxhinasto, Sandra Garcet, Norma Kunjravia, Inna Cueto, Juana Gonzalez, Darshna Rambhia, Olivier Harari, Matthew A. Sleeman, Jennifer D. Hamilton, Wei Keat Lim, Jan Freudenberg, George D. Kalliolias, Paresh Thakker, Robert Bissonnette, James G. Krueger
Summary: Palmoplantar pustular psoriasis (PPPP) and non-pustular palmoplantar psoriasis (NPPP) are localized, debilitating forms of psoriasis. This study found that NPPP shows more pronounced T helper 1-mediated inflammation, while PPPP exhibits stronger neutrophil-associated activity.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nilofer Qureshi, Julia Desousa, Adeela Z. Siddiqui, David C. Morrison, Asaf A. Qureshi
Summary: Inflammation is associated with several diseases and can be influenced by proteasome modulators such as resveratrol and lectins. These modulators have the ability to alter gene expression involved in inflammation-induced signaling pathways in human peripheral blood mononuclear cells. The findings suggest that inflammation-based diseases may be prevented or reversed through dietary interventions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Husna Kadagothy, Shweta Nene, Etikala Amulya, Ganesh Vambhurkar, A. N. Rajalakshmi, Dharmendra Kumar Khatri, Shashi Bala Singh, Saurabh Srivastava
Summary: Psoriasis is a chronic, itchy and scaly skin disease that impacts public health significantly. It is characterized by excessive keratinization, thickening of the skin, scaling and red plaques. Biomarkers including interleukin-17, interleukin-12 and-23, and tumor necrosis factor-alpha are crucial drivers of psoriatic pathogenesis. The release of pro-inflammatory cytokines from up-regulated pathways leads to psoriatic inflammation. Biologics, small molecules, and herbal moieties are important in suppressing the development of psoriasis. This review highlights various pathological targets involved in psoriasis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Yashika Tomar, Srividya Gorantla, Gautam Singhvi
Summary: Psoriasis is a chronic autoimmune skin disorder with complex etiology. Significant progress has been made in understanding the pathogenesis and treatment of psoriasis, including the role of different signaling pathways and the development of new molecules. This review also highlights the potential of nanotherapeutics in improving the efficacy of psoriasis treatment.
DRUG DISCOVERY TODAY
(2023)
Article
Immunology
Yue Lu, Yuqi Yang, Junhong Zhang, Hongyu Zhang, Changju Ma, Xiaojuan Tang, Jingjing Wu, Li Li, Jianan Wei, Haiming Chen, Chuanjian Lu, Ling Han
Summary: PSORI-CM02 effectively inhibits psoriatic angiogenesis by reducing oxidative status and inflammation, suppressing the expression of angiogenesis-related molecules, and inhibiting the activation of the MAPK signalling pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
