Article
Pathology
Hanna Hametoja, Antti Makitie, Leif Back, Ilmo Leivo, Caj Haglund, Timo Sorsa, Jaana Hagstrom
Summary: In this study on adenoid cystic carcinoma (ACC), the expression of MMP-9 in pseudocysts and peritumoural inflammatory cells was found to be associated with better survival and fewer treatment failures. High tumoural MMP-7 and-25 were linked to better survival, while high tumoural MMP-15 was associated with poorer survival and high tumoural MMP-9 with advanced stage and regional recurrences. Tumour cells did not show MMP-8 immunopositivity. These results suggest potential roles for MMPs in ACC carcinogenesis and prognosis.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Article
Chemistry, Analytical
Yuhong Duan, Lu Xu, Wenyu Song, Hui Gao, Lina Sun, Fangfang Chen, Fen Ma
Summary: In this study, an electrogenerated chemiluminescence (ECL) biosensor based on heterodimerization interaction between CD44 and PEX-14 was developed for highly sensitive quantification of CD44. The biosensor exhibited excellent sensitivity and a wide linear range, making it suitable for detecting CD44 expression in living cells.
MICROCHEMICAL JOURNAL
(2022)
Article
Genetics & Heredity
Gang Wang, Wei Du, Lingyi Che, Xianzheng Gao, Ruihua Zhao, Juan Duan, Zhuoyu Gu, Qian Ma
Summary: PLAGL2 is implicated in the development and progression of various malignancies, including glioblastoma, with dysregulated expression commonly observed. Its overexpression in high-grade glioma (HGG) is associated with poor prognosis and potential therapeutic target, making it an independent prognostic biomarker in HGG patients.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Yuki Ohkawa, Pu Zhang, Hiroyuki Momota, Akira Kato, Noboru Hashimoto, Yuhsuke Ohmi, Robiul H. Bhuiyan, Yesmin Farhana, Atsushi Natsume, Toshihiko Wakabayashi, Keiko Furukawa, Koichi Furukawa
Summary: This study revealed that deficiency of GD3 synthase attenuated the progression of gliomas in a mouse model, leading to prolonged lifespan and low-grade pathology in generated gliomas. It also showed that GD3S enhances glioma progression through the Ap2 alpha-MMP9 axis, with associated alterations in gene expression levels.
Article
Oncology
Jinxu Wen, Xiaoru Qin, Jiayi Zhang, Xiaoyong Wu, Xuemin Yan, Kewen Lu, Pei Yang, Shuaichong Ji, Xiangdong Zhao, Yuexin Wang
Summary: This study investigated the relationship between MMP-9 expression and pathological indexes in PTC. Results showed that MMP-9 expression was significantly correlated with lymph node metastasis, tumor size, and TNM stage, but not with gender and age. MMP-9 may serve as a reliable prognostic biomarker for PTC patients.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Junhong Li, Huanhuan Fan, Xingwang Zhou, Yufan Xiang, Yanhui Liu
Summary: High expression of PLAU and PLAUR is associated with poor prognosis in glioma patients, especially in lower grade gliomas. PLAU and PLAUR affect the generation and progression of glioma by participating in inflammatory activities and tumor-related signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Wen Cheng, Yang-Yi Chen, Chien-Ju Lin, Yi-Ting Chen, Ann-Shung Lieu, Hung-Pei Tsai, Aij-Lie Kwan
Summary: The expression level of NLRP12 is closely associated with the malignancy and prognosis of gliomas. Knockdown of NLRP12 can reduce the proliferation, invasion, and migration of glioma cells, as well as downregulate the expression levels of VEGF, N-cadherin, and cyclin D1. Therefore, NLRP12 may serve as an independent prognostic factor and a potential target for the treatment of intracranial gliomas.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2023)
Article
Plant Sciences
Yang Gu, Shimeng Zhang, Xun Chen, Yong Li, Yun Liu
Summary: The study shows that LongShengZhi capsule (LSZ) can alleviate cardiac remodeling induced by Ang II by upregulating miR-150-5p to target MMP14. Administration of LSZ, upregulation of miR-150-5p, or targeting of MMP14 may be strategies for cardiac remodeling therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Na Liu, Liang Zhong, Guangcheng Ni, Jiao Lin, Liang Xie, Taiwen Li, Hongxia Dan, Qianming Chen
Summary: High expression of MMP28 in pancreatic adenocarcinoma is associated with cancer progression, invasion, and metastasis, indicating MMP28 may serve as an independent prognostic biomarker and a potential therapeutic target for PAAD.
ONCOTARGETS AND THERAPY
(2021)
Article
Neurosciences
Anne-Kathrin Lutz, Helen Friedericke Bauer, Valentin Ioannidis, Michael Schoen, Tobias M. Boeckers
Summary: This study validated a set of commercial and homemade SHANK3 antibodies in Western Blotting, synaptic immunocytochemistry, and immunohistochemistry, and found that only a small subset of the antibodies met the criteria of quality and specificity. The study highlights the importance of antibody specificity testing in the research field.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing Ma
Summary: Inhalational anesthetics sevoflurane and desflurane were found to inhibit glioma cell malignancy through upregulation of miRNAs and downregulation of their downstream effectors HIF-1 alpha and MMP9. Further studies are warranted to explore the implications of these findings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Monica Gelzo, Sara Cacciapuoti, Biagio Pinchera, Annunziata De Rosa, Gustavo Cernera, Filippo Scialo, Marika Comegna, Mauro Mormile, Gabriella Fabbrocini, Roberto Parrella, Gaetano Corso, Ivan Gentile, Giuseppe Castaldo
Summary: This study found that MMP3 and MMP9 may be associated with the severity of COVID-19. Serum MMP3 can help early prediction of the severity of COVID-19, while MMP9 may play an important role in the inflammatory process.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Ilias P. Nikas, Cheol Lee, Min Ji Song, Bohyun Kim, Han Suk Ryu
Summary: This study identified potential biomarker discrepancies between paired HGSOC primary tissues and metastatic peritoneal fluid cytology samples, suggesting that cytology from effusions could be considered for biomarker testing when tissue from the primary cancer is also available.
Article
Chemistry, Analytical
Yuhong Duan, Xinrui Qiao, Lu Xu, Lina Sun, Fen Ma
Summary: A novel sandwich structure electrogenerated chemiluminescence biosensor was developed for determination of matrix metalloproteinase and its expressing cancer cells. The biosensor exhibited excellent sensitivity and a wide linear range.
MICROCHEMICAL JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Patricia Llorente, Victor Mejias, Isabel Sastre, Maria Recuero, Jesus Aldudo, Maria J. Bullido
Summary: Growing evidence suggests that chronic or latent infection of the central nervous system, particularly from Herpes simplex virus type 1 (HSV-1), may be associated with Alzheimer's disease. The study highlights the potential role of MMP-14 in controlling HSV-1 infection efficiency and reducing neurodegenerative effects induced by the virus.
ANTIVIRAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Jinghui Liu, Chen Li, Yuan Wang, Peigang Ji, Shaochun Guo, Yulong Zhai, Na Wang, Miao Lou, Meng Xu, Min Chao, Yang Jiao, Wenjian Zhao, Fuqiang Feng, Yan Qu, Shunnan Ge, Liang Wang
Summary: The study found that more aggressive treatment regimens may prolong survival for elderly patients with glioblastoma (GBM), while further research and prospective randomized clinical trials are needed to determine the appropriate management, especially for patients with MGMT promoter methylation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Cell Biology
Liang Wang, Haiyan Cao, Ying Zhong, Peigang Ji, Fan Chen
Summary: This study reveals the important role of m6A modifications in GBM tumor microenvironment (TME) cell infiltration and stemness characteristics. The m6A modification patterns are correlated with TME cell infiltration characteristics, stemness characteristics, tumor clinical outcome, immune infiltration, and stemness. Assessing the m6A modification pattern of individual tumors can enhance our understanding of TME infiltration and stemness characteristics and contribute to the development of immunotherapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Yuan Xie, Liqun He, Yanyu Zhang, Hua Huang, Fan Yang, Min Chao, Haiyan Cao, Jianhao Wang, Yaling Li, Lingxue Zhang, Lele Xin, Bing Xiao, Xinxin Shi, Xue Zhang, Jiefu Tang, Lene Uhrbom, Anna Dimberg, Liang Wang, Lei Zhang
Summary: Inhibiting the Wnt signaling pathway can increase Temozolomide (TMZ) delivery and sensitize glioma to chemotherapy. Transcriptome analysis revealed that Wnt signaling inhibition enhances vascular transcytosis by upregulating PLVAP and downregulating MFSD2A. Additionally, Wnt signaling inhibition also enhances caveolae-mediated transcytosis in tumor endothelial cells (ECs). These findings suggest that Wnt signaling regulates MFSD2A-dependent TMZ delivery through a caveolae-mediated pathway, highlighting Wnt signaling as a promising therapeutic target for GBM treatment.
Article
Oncology
Jinghui Liu, Chen Li, Yuan Wang, Peigang Ji, Shaochun Guo, Yulong Zhai, Na Wang, Meng Xu, Julei Wang, Liang Wang
Summary: This study assessed the clinicopathological features and outcomes of secondary gliosarcomas (SGS) through retrospective analysis of data. The results showed that initial diagnosis of GBM was a poor prognostic factor for SGS. Patients with initial non-GBM diagnosis who underwent gross total resection and chemoradiation had better overall survival outcomes. Patients initially diagnosed with GBM who received both chemoradiotherapy and active therapy after disease progression to SGS had significantly longer overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biophysics
Yang Jiao, Tao Zhang, Chao Fan, Haiyan Cao, Min Chao, Liying Han, Weirui Zhang, Lei Mao, Ruigang Liu, Canhua Xu, Liang Wang
Summary: In this study, an improved magnetic induction tomography (MIT) data acquisition system was used to monitor traumatic brain injury (TBI) and distinguish different injury levels. The experiment used a pneumatically controlled cortical impactor to strike the parietal lobe of anesthetized rabbits and establish different TBI models. The MIT data acquisition system continuously monitored the brain for an hour and successfully observed targets with increased conductivity in the reconstructed images, indicating that MIT may facilitate early TBI monitoring and distinguish varying degrees of injuries.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Oncology
Kaiyue Xu, Kaiqian Zhang, Jiying Ma, Qianqian Yang, Ge Yang, Tingting Zong, Guowei Wang, Bo Yan, Jule Shengxia, Chao Chen, Liang Wang, Huijuan Wang
Summary: This study identified the elevated expression of CKAP4 in glioblastoma multiforme (GBM) and investigated its role in the development of the disease. CKAP4 was found to influence the malignant behavior of GBM through the regulation of the FOXM1 signaling pathway. The CKAP4-based prognostic model developed in this study could potentially guide individualized treatment decisions for glioma patients.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Cell Biology
Xing-gang Mao, Xiao-yan Xue, Rui Lv, Ang Ji, Ting-yu Shi, Xiao-yan Chen, Xiao-fan Jiang, Xiang Zhang
Summary: Hypoxia plays a critical role in glioblastoma by regulating the hypoxia-regulated genes (HRGs) network. CEBPD is identified as a key transcription factor that regulates a large number of hypoxia-regulated proteins (HRPs) and HRGs. CEBPD is up-regulated in glioblastoma and high levels are associated with poor prognosis. CEBPD activates the EGFR/PI3K pathway through ECM, particularly FN1-mediated EGFR phosphorylation.
CELL DEATH & DISEASE
(2023)
Article
Neuroimaging
Weirui Zhang, Yang Jiao, Tao Zhang, Xuechao Liu, Jianan Ye, Yuyan Zhang, Bin Yang, Meng Dai, Xuetao Shi, Feng Fu, Liang Wang, Canhua Xu
Summary: A cerebral contrast-enhanced electrical impedance tomography perfusion method was developed for the early detection of acute ischemic stroke during thrombolytic therapy. The method utilized stable and highly conductive contrast agents and showed significant improvement in detection ability compared to other agents tested. This method accurately detected the location and area of cerebral infarction lesions and can be applied as a rapid, bedside imaging method for suspected ischemic stroke patients.
NEUROIMAGE-CLINICAL
(2023)
Article
Clinical Neurology
Shaochun Guo, Ruili Han, Fan Chen, Peigang Ji, Jinghui Liu, Yulong Zhai, Min Chao, Wenjian Zhao, Yang Jiao, Chao Fan, Tao Huang, Na Wang, Shunnan Ge, Yan Qu, Yuan Wang, Liang Wang
Summary: Traumatic brain injury (TBI) is a global challenge associated with premature death and long-term disability. Analyzing the TBI rate and mortality trend can provide valuable diagnosis and treatment suggestions for the development of public health strategies.
FRONTIERS IN NEUROLOGY
(2023)
Review
Oncology
Tingyu Shi, Jun Zhu, Xiang Zhang, Xinggang Mao
Summary: Glioblastoma multiforme (GBM) is a highly malignant brain tumor characterized by a small population of glioblastoma stem-like cells (GSCs) that possess self-renewal, proliferative, invasive, and tumorigenic capabilities, leading to radio- and chemoresistance. Hypoxia inducible factors (HIFs) play a crucial role in the maintenance and progression of GSCs. This review summarizes the roles of hypoxia-associated GSCs in GBM development, including hypoxia-induced signatures, genes, pathways, and metabolic alterations. The concept of the hypoxic peri-arteriolar niche of GSCs is discussed. Autophagy and potential causes of therapeutic resistance in GBM are explored, along with chemotherapeutic agents to enhance the effectiveness of chemo-, radio-, or immunotherapy. Hyperbaric oxygen therapy (HBOT) is proposed as an adjuvant therapy to reverse the hypoxic microenvironment in GBM. Overall, understanding the intricate interactions between hypoxia and GSCs can lead to the development of novel therapeutic strategies to improve GBM patient survival.
Article
Oncology
Yuan Wang, Shaochun Guo, Na Wang, Jinghui Liu, Fan Chen, Yulong Zhai, Yue Wang, Yang Jiao, Wenjian Zhao, Chao Fan, Yanrong Xue, GuoDong Gao, Peigang Ji, Liang Wang
Summary: This study retrospectively analyzed the experience of a tertiary neurosurgical center in China over eight years in treating glioma patients with awake brain mapping. The results showed that awake brain mapping is a feasible and safe method for reducing the risk of neurological deficits, increasing extent of resection (EOR), and extending survival time. The MoCA test results indicated that brain mapping plays a critical role in preserving neurocognitive function during tumor resection.
FRONTIERS IN ONCOLOGY
(2023)
Article
Engineering, Biomedical
Luge Bai, Zhiyan Hao, Sen Wang, Jiajia Zhou, Siqi Yao, Na Pei, Hui Zhu, Kun Zhang, Rui L. Reis, J. Miguel Oliveira, Jiankang He, Dichen Li, Xinggang Mao, Ling Wang
Summary: In this study, an in vitro bioprinted 3D glioma model was proposed to simulate the natural glioma. Neurons could promote the proliferation of glioma cells and induce morphological changes in glioma cells to be neuron-like. Glioma cells, on the other hand, could maintain neuronal survival and promote neurite outgrowth.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Oncology
Yueyang Mou, Yaqin Hu, Guolian Xue, Wenjian Zhao, Yang Jiao, Chen Li, Haiyan Cao, Min Chao, Jianping Deng, Penggao Dai, Hongli Zhu, Liang Wang
Summary: ELK3 plays a crucial role in glioma angiogenesis by activating the HIF-1 alpha/VEGF-A signaling axis. It may serve as a prognostic marker for glioma angiogenesis and targeting ELK3 may improve the efficacy of anti-angiogenic therapies.
Article
Clinical Neurology
Yulong Zhai, Peigang Ji, Meng Xu, Min Chao, Na Wang, Jinghui Liu, Yuan Wang, Shaochun Guo, Chao Fan, Zhicheng Fan, Yunpeng Kou, Haiyan Cao, Yan Qu, Liang Wang
Summary: The study analyzed primary CNS tumors diagnosed pathologically in a single center in China from 2003 to 2019. The major tumor types identified were meningiomas, tumors of neuroepithelial tissue, and pituitary adenomas. The study found that grade 4 tumors of neuroepithelial tissue were more common in the temporal lobe, a finding that was rarely reported in previous articles.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Wenxing Cui, Yingwu Shi, Baocheng Zhao, Jianing Luo, Gang Zhu, Hao Guo, Bao Wang, Chen Yang, Zhihong Li, Liang Wang, Yan Qu, Shunnan Ge
Summary: This study investigated the correlation between quantitative cranial CT parameters and coagulopathy in patients with traumatic brain injury (TBI). The results showed that ICH/C volume was the main predictor for coagulopathy.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
